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  • 1
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    Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: A specific DNA probe was used to study the effect of recombinant rat, mouse, and human gamma-interferon (gamma-IFN) on the course of sporozoite-induced malaria infections. In mice and rats infected with sporozoites of Plasmodium berghei, mouse and rat gamma-IFN's strongly inhibited the development of the exoerythrocytic forms in the liver liver cells of the hosts, but not the development of the erythrocytic stages. The degree of inhibition of the exoerythrocytic forms was proportional to the dose of gamma-IFN administered, but was independent of the number of sporozoites used for challenge. A 30 percent reduction in the development of exoerythrocytic forms in rat liver was achieved when 150 units (about 15 nanograms of protein) of rat gamma-IFN were injected a few hours before sporozoite challenge; the reduction was 90 percent or more with higher doses of gamma-IFN. The effect was less pronounced if the gamma-IFN was administered 18 hours before or a few hours after challenge. Human gamma-IFN also diminished the parasitemia in chimpanzees infected with sporozoites of the human malaria parasite Plasmodium vivax. The target of gamma-IFN activity may be the infected hepatocytes themselves, as shown by in vitro experiments in which small doses of the human lymphokine inhibited the development of exoerythrocytic forms of Plasmodium berghei in a human hepatoma cell line. These results suggest that immunologically induced interferon may be involved in controlling malaria infection under natural conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferreira, A -- Schofield, L -- Enea, V -- Schellekens, H -- van der Meide, P -- Collins, W E -- Nussenzweig, R S -- Nussenzweig, V -- New York, N.Y. -- Science. 1986 May 16;232(4752):881-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3085218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Humans ; Interferon-gamma/pharmacology/*therapeutic use ; Liver/cytology ; Malaria/*drug therapy ; Mice ; Pan troglodytes ; Plasmodium berghei/drug effects ; Plasmodium vivax/drug effects ; Toxoplasma/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Diels-Alder-Reaktionen 17-substituierter Östra-1,3,5(10), 16-tetraene mit 1,3-Dienen unter hohem DruckHerrn Professor Dr. Dr. Klaus Schreiber zum 60. Geburtstag gewidmet (1986)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 328 (1986), S. 903-905 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Diels-Alder-Reactions 17-Substituted Estra-1,3,5(10), 16-tetraenes with 1,3-Dienes under High Pressure
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19863280532
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  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Spin-Trapping-Kinetik in Systemen von Radikalen unterschiedlicher Reaktivität. Die Photolyse von α-Phenylbenzoin in Gegenwart von Benzyliden-tert.-butylamin-N-oxid (1985)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 327 (1985), S. 749-758 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Investigations on Spin-Trapping Kineties in Radical Systems with Different Reactivity. Photolyses of α-Phenylbenzoine in the Presence of Benzylideneter. -butylamine N-oxideAs a model system to study the spin-trapping kinetics of systems forming two radicals of different reactivity α-phenylbenzoine (PhB) was chosen. The photolysis of PhB forms benzoyl (B·) and diphenylketylradikals (K·), respectively, which can be trapped by benzylidene-tert-butyl-amine N-oxide (PBN), as a spin trap. The rate constants of radical addition to PBN and their reactions with the spin adducts were determined by means of flash photolysis and kinetic calculations of the PBN concentration dependence. For B· and K· addtion rate constants to PBN of k1 = 8,1 × 105 M-1s-1, and k2 = 5,8 · 104 M-1s-1, respectively, were found. The rate constants for the reactions of B· and K· with the spin adducts are in the order of 109…1010 M-1s-1.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19853270507
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  • 4
    Electronic Resource
    Electronic Resource
    Synthetic and structural studies of some tetracoordinated Boron Complexes of bifunctional tridentate schiff bases (1989)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 331 (1989), S. 690-696 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19893310423
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  • 5
    Electronic Resource
    Electronic Resource
    Über die Thermische Umsetzung von Mono-n-alkylbenzenen (1987)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 329 (1987), S. 824-832 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Thermal Reaction of Mono-n-alkyl-benzenesThe pyrolysis of ethyl-(1), n-propyl-(2), n-hexyl-(3) and n-octylbenzene (4) has been studied under conditions of steam cracking (600 to 800°C) in a laboratory scale tubular reactor. The overall activation energies determined for (1) to (4) were found to be nearly identical (221 to 227 kJ · mol-1) obviously caused by similar initial steps. The main liquid product observed was styren accompanied by ω-phenyl-1-alkenes and α-olefins. Benzene is an important side product of 1. It might be formed mainly by a hydrogen assisted dealkylation via a cyclohexadienyl type radical as reactive intermediate.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19873290511
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  • 6
    Electronic Resource
    Electronic Resource
    Besonderheiten des Pyrolyseverhaltens von Isoalkylaromaten (1989)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 331 (1989), S. 61-68 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Special Features in Pyrolysis Behaviour of IsoalkylaromaticsThe pyrolysis of cumene, sec. butyl- and tert. butylbenzene proceeds in a laboratory scale quartz vessel in the temperature range 600-750°C. Conversion occurs mainly via a radical-chain mechanism in the side chain in proportions, determined by the dissociation energies of the C—C- and C—H-bonds. Dealkylation was observed in greater amounts than for n-alkylbenzenes. It is interpreted by H-atom addition to the aromatic nucleus, followed by β-scission to benzene and isoalkenes. It was be shown, that H-atoms are formed by unusual reactions such as neophyl rearrangement and homolytic rupture of C—C-bonds in the side chain.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19893310110
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  • 7
    Electronic Resource
    Electronic Resource
    Dipole Moment, Dynamic NMR, and Molecular Structure of Vinylogous 4H-Pyrones (1985)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1985 (1985), S. 1587-1595 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Dipolmoment, dynamische NMR-Spektroskopie und Molekülstruktur von vinylogen 4H-PyronenDie Molekülstruktur des vinylogen 4H-Pyrons 2,6-Dimethyl-4-(2-oxopropyliden)-4H-pyran (1) wurde durch Röntgenstrukturanalyse bestimmt. Das Molekül ist nahezu eben und besitzt s-cis-Konformation. Das experimentell bestimmte Dipolmoment (3.71 D) von 1 stimmt mit dem berechneten Wert von 3.54 D (CNDO/2) für die s-cis-Konformation 1 überein und schließt somit die s-trans-Konformation 2 aus. Für das zweifach vinyloge 4H-Pyran 4 (Ar = p-C6H4Cl) wurde ein Dipolmoment von 5.65 D gemessen. Die korrigierten 13C-Verschiebungen der Ring-β- und besonders der -α-Kohlenstoffe nehmen in der Reihenfolge 10 → 1 → 4 ab, woraus folgt, daß bei den höheren Vinylogen dipolare Resonanzformeln weniger am elektronischen Grundzustand beteiligt sind. Dynamische 1H-NMR-Spektren (2D-Technik) belegen, daß in 1 Rotation um die exocyclische C = C-Bindung mit einer Freien Aktivierungsenthalpie von ΔG± = 22.4 kcal/mol stattfindet (in [D6]DMSO).
    Notes: The molecular structure of the vinylogous 4H-pyrone 2,6-dimethyl-4-(2-oxopropylidene)-4H-pyran (1) was determined by X-ray diffraction. The molecule is practically planar and has the s-cis conformation. The experimental dipole moment (3.71 D) of 1 agrees with the CNDO/2 calculated value (3.54 D) for the s-cis conformation 1 and rules out the s-trans conformation 2. The doubly vinylogous 4H-pyrone 4, Ar = p-C6H4Cl, has an experimental dipole moment of 5.65 D. Corrected 13C chemical shifts of the ring β- and especially α-carbons decrease in the series 2,6-dimethyl-4H-pyrone (10) to 1 to 4, indicating that the higher vinylogs have decreased contributions of the dipolar canonical structures. Dynamic 1H NMR data, obtained using the two-dimensional accordion technique, indicate that 1 undergoes rotation around the exocyclic C = C bond with a free energy of activation ΔG± = 22.4 kcal/mol in [D6]DMSO.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198519850807
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  • 8
    Electronic Resource
    Electronic Resource
    An improved method for the polymerization of ethynylferrocene. Conducting properties of doped polyethynylferrocene (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 2 (1988), S. 533-537 
    Details
    ISSN: 0268-2605
    Keywords: Polymerization ; ethynylferrocene ; conductivity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The catalytic activity of the [Rh(cod)Cl]2 complex (cod = cis, cis-cyclo-octa-1,5-diene) with respect to the polymerization of ethynylferrocene (EFc) was examined. A good yield (about 80%) of polyethynylferrocene (PEFc) was obtained in benzene by addition of sodium hydroxide as co-catalyst. PEFc was insoluble in most organic solvents. The conductivity (s̰) of the undoped polymer is about 10-11 ohm-1 cm-1; upon doping PEFc with iodine in tetrahydrofuran the conductivity can be increased to 10-100 ohm-1 cm-1. The influence of other doping agents was also examined.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aoc.590020606
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  • 9
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    Targeting of nonexpressed genes in embryonic stem cells via homologous recombination (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-09-15
    Description: Gene targeting via homologous recombination-mediated disruption in murine embryonic stem (ES) cells has been described for a number of different genes expressed in these cells; it has not been reported for any nonexpressed genes. Pluripotent stem cell lines were isolated with homologously recombined insertions at three different loci: c-fos, which is expressed at a low level in ES cells, and two genes, adipsin and adipocyte P2 (aP2), which are transcribed specifically in adipose cells and are not expressed at detectable levels in ES cells. The frequencies at which homologous recombination events occurred did not correlate with levels of expression of the targeted genes, but did occur at rates comparable to those previously reported for genes that are actively expressed in ES cells. Injection of successfully targeted cells into mouse blastocysts resulted in the formation of chimeric mice. These studies demonstrate the feasibility of altering genes in ES cells that are expressed in a tissue-specific manner in the mouse, in order to study their function at later developmental stages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, R S -- Sheng, M -- Greenberg, M E -- Kolodner, R D -- Papaioannou, V E -- Spiegelman, B M -- DK 31405/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 15;245(4923):1234-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2506639" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/cytology ; Animals ; Blotting, Northern ; Blotting, Southern ; Carrier Proteins/biosynthesis/*genetics ; Cell Line ; Chimera ; Complement Factor D ; DNA, Recombinant ; DNA-Binding Proteins/biosynthesis/genetics ; Fatty Acid-Binding Proteins ; Fatty Acids/metabolism ; *Gene Expression Regulation ; Genetic Vectors ; Mice ; *Neoplasm Proteins ; *Nerve Tissue Proteins ; Proto-Oncogene Proteins/biosynthesis/*genetics ; Proto-Oncogene Proteins c-fos ; RNA, Messenger/biosynthesis/genetics ; *Recombination, Genetic ; Serine Endopeptidases/*genetics ; Stem Cells/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-07
    Description: Basic fibroblast growth factor (bFGF) participates in many processes including early developmental events, angiogenesis, wound healing, and maintenance of neuronal cell viability. A 130-kilodalton protein was isolated on the basis of its ability to specifically bind to bFGF. A complementary DNA clone was isolated with an oligonucleotide probe corresponding to determined amino acid sequences of tryptic peptide fragments of the purified protein. The putative bFGF receptor encoded by this complementary DNA is a transmembrane protein that contains three extracellular immunoglobulin-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain. These domains are arranged in a pattern that is different from that of any growth factor receptor described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, P L -- Johnson, D E -- Cousens, L S -- Fried, V A -- Williams, L T -- CA 21765/CA/NCI NIH HHS/ -- R01 HL32898/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jul 7;245(4913):57-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2544996" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cells, Cultured ; Chick Embryo ; *Cloning, Molecular ; DNA/*genetics ; Fibroblast Growth Factors/*genetics ; Kinetics ; Mice ; Molecular Sequence Data ; Peptide Fragments/analysis ; Receptors, Cell Surface/*genetics/metabolism ; Receptors, Fibroblast Growth Factor ; Recombinant Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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