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  • 1
    Publication Date: 1989-06-16
    Description: A technique for the transfer of endothelial cells and expression of recombinant genes in vivo could allow the introduction of proteins of therapeutic value in the management of cardiovascular diseases. Porcine endothelial cells expressing recombinant beta-galactosidase from a murine amphotropic retroviral vector were introduced with a catheter into denuded iliofemoral arteries of syngeneic animals. Arterial segments explanted 2 to 4 weeks later contained endothelial cells expressing beta-galactosidase, an indication that they were successfully implanted on the vessel wall.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabel, E G -- Plautz, G -- Boyce, F M -- Stanley, J C -- Nabel, G J -- New York, N.Y. -- Science. 1989 Jun 16;244(4910):1342-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0650.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2499928" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catheterization, Peripheral ; DNA, Recombinant ; Endothelium, Vascular/*cytology/enzymology/transplantation ; Female ; Galactosidases/*biosynthesis ; Genetic Vectors ; Iliac Artery/cytology ; Retroviridae ; Swine ; Swine, Miniature ; beta-Galactosidase/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1989-12-15
    Description: Voyager 2 images of Neptune reveal a windy planet characterized by bright clouds of methane ice suspended in an exceptionally clear atmosphere above a lower deck of hydrogen sulfide or ammonia ices. Neptune's atmosphere is dominated by a large anticyclonic storm system that has been named the Great Dark Spot (GDS). About the same size as Earth in extent, the GDS bears both many similarities and some differences to the Great Red Spot of Jupiter. Neptune's zonal wind profile is remarkably similar to that of Uranus. Neptune has three major rings at radii of 42,000, 53,000, and 63,000 kilometers. The outer ring contains three higher density arc-like segments that were apparently responsible for most of the ground-based occultation events observed during the current decade. Like the rings of Uranus, the Neptune rings are composed of very dark material; unlike that of Uranus, the Neptune system is very dusty. Six new regular satellites were found, with dark surfaces and radii ranging from 200 to 25 kilometers. All lie inside the orbit of Triton and the inner four are located within the ring system. Triton is seen to be a differentiated body, with a radius of 1350 kilometers and a density of 2.1 grams per cubic centimeter; it exhibits clear evidence of early episodes of surface melting. A now rigid crust of what is probably water ice is overlain with a brilliant coating of nitrogen frost, slightly darkened and reddened with organic polymer material. Streaks of organic polymer suggest seasonal winds strong enough to move particles of micrometer size or larger, once they become airborne. At least two active plumes were seen, carrying dark material 8 kilometers above the surface before being transported downstream by high level winds. The plumes may be driven by solar heating and the subsequent violent vaporization of subsurface nitrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B A -- Soderblom, L A -- Banfield, D -- Barnet, C -- Basilevsky, A T -- Beebe, R F -- Bollinger, K -- Boyce, J M -- Brahic, A -- Briggs, G A -- Brown, R H -- Chyba, C -- Collins, S A -- Colvin, T -- Cook, A F 2nd -- Crisp, D -- Croft, S K -- Cruikshank, D -- Cuzzi, J N -- Danielson, G E -- Davies, M E -- De Jong, E -- Dones, L -- Godfrey, D -- Goguen, J -- Grenier, I -- Haemmerle, V R -- Hammel, H -- Hansen, C J -- Helfenstein, C P -- Howell, C -- Hunt, G E -- Ingersoll, A P -- Johnson, T V -- Kargel, J -- Kirk, R -- Kuehn, D I -- Limaye, S -- Masursky, H -- McEwen, A -- Morrison, D -- Owen, T -- Owen, W -- Pollack, J B -- Porco, C C -- Rages, K -- Rogers, P -- Rudy, D -- Sagan, C -- Schwartz, J -- Shoemaker, E M -- Showalter, M -- Sicardy, B -- Simonelli, D -- Spencer, J -- Sromovsky, L A -- Stoker, C -- Strom, R G -- Suomi, V E -- Synott, S P -- Terrile, R J -- Thomas, P -- Thompson, W R -- Verbiscer, A -- Veverka, J -- New York, N.Y. -- Science. 1989 Dec 15;246(4936):1422-49.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17755997" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1986-07-04
    Description: Voyager 2 images of the southern hemisphere of Uranus indicate that submicrometersize haze particles and particles of a methane condensation cloud produce faint patterns in the atmosphere. The alignment of the cloud bands is similar to that of bands on Jupiter and Saturn, but the zonal winds are nearly opposite. At mid-latitudes (-70 degrees to -27 degrees ), where winds were measured, the atmosphere rotates faster than the magnetic field; however, the rotation rate of the atmosphere decreases toward the equator, so that the two probably corotate at about -20 degrees . Voyager images confirm the extremely low albedo of the ring particles. High phase angle images reveal on the order of 10(2) new ringlike features of very low optical depth and relatively high dust abundance interspersed within the main rings, as well as a broad, diffuse, low optical depth ring just inside the main rings system. Nine of the newly discovered small satellites (40 to 165 kilometers in diameter) orbit between the rings and Miranda; the tenth is within the ring system. Two of these small objects may gravitationally confine the e ring. Oberon and Umbriel have heavily cratered surfaces resembling the ancient cratered highlands of Earth's moon, although Umbriel is almost completely covered with uniform dark material, which perhaps indicates some ongoing process. Titania and Ariel show crater populations different from those on Oberon and Umbriel; these were probably generated by collisions with debris confined to their orbits. Titania and Ariel also show many extensional fault systems; Ariel shows strong evidence for the presence of extrusive material. About halfof Miranda's surface is relatively bland, old, cratered terrain. The remainder comprises three large regions of younger terrain, each rectangular to ovoid in plan, that display complex sets of parallel and intersecting scarps and ridges as well as numerous outcrops of bright and dark materials, perhaps suggesting some exotic composition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, B A -- Soderblom, L A -- Beebe, R -- Bliss, D -- Boyce, J M -- Brahic, A -- Briggs, G A -- Brown, R H -- Collins, S A -- Cook, A F 2nd -- Croft, S K -- Cuzzi, J N -- Danielson, G E -- Davies, M E -- Dowling, T E -- Godfrey, D -- Hansen, C J -- Harris, C -- Hunt, G E -- Ingersoll, A P -- Johnson, T V -- Krauss, R J -- Masursky, H -- Morrison, D -- Owen, T -- Plescia, J B -- Pollack, J B -- Porco, C C -- Rages, K -- Sagan, C -- Shoemaker, E M -- Sromovsky, L A -- Stoker, C -- Strom, R G -- Suomi, V E -- Synnott, S P -- Terrile, R J -- Thomas, P -- Thompson, W R -- Veverka, J -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):43-64.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812889" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 34 (1988), S. 469-473 
    ISSN: 1432-1041
    Keywords: xamoterol ; cardiac failure ; beta1-adrenoceptor partial agonist ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of xamoterol, a β-adrenoceptor partial agonist under clinical evaluation for the treatment of mild to moderate heart failure, have been studied in 12 healthy male subjects. They received 14 mg i.v. and oral doses of 50 and 200 mg as a tablet and 200 mg as a solution in a 4 way cross-over design. After i.v. dosing the elimination half-life was 7.7 h, the total body clearance was 224 ml·min−1 and the volume of distribution at steady-state (Vss) was 48 l. Sixty-two percent of the dose was recovered unchanged in urine. After oral doses, the absolute bioavailability of xamoterol was shown to be 5% irrespective of whether the dose was administered as a tablet or solution. Peak plasma concentrations occurred at about 2 h for the tablet dose and slightly earlier (1.4 h) for the solution. Peak plasma concentration, AUC and urinary recovery of unchanged drug increased in proportion to dose. The apparent elimination half-life after oral doses (16 h) was significantly longer than that observed after an intravenous dose. Despite the low bioavailability, the degree of inter-subject variability of oral bioavailability was small probably indicating that the controlling factor is the hydrophilic nature of the molecule rather than extensive first pass metabolism or poor dissolution of xamoterol from the tablet formulation.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 1988-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 6
    Publication Date: 2006-10-26
    Description: Spacecraft guidance - multistage rocket trajectories
    Keywords: SPACE RADIATION
    Format: text
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