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  • Cell & Developmental Biology  (648)
  • FLUID MECHANICS AND HEAT TRANSFER  (572)
  • 1985-1989  (818)
  • 1975-1979  (330)
  • 1960-1964  (31)
  • 1950-1954  (41)
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Keywords
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 39 (1989), S. 47-53 
    Details
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240390106
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    Paper (German National Licenses)
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  • 2
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    Hypersonic heat-transfer and transition correlations for a roughened shuttle orbiter (1976)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The effect of roughness on the heat transfer distributions and the transition criteria for the windward pitch plane of the shuttle orbiter at an angle of attack of 30 deg was studied using data obtained in hypersonic wind tunnels. The heat transfer distributions and the transition locations for the roughened models were compared with the corresponding data for smooth models. The data were correlated using theoretical solutions for a nonsimilar, laminar boundary layer subject to two different flow field models for the orbiter.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: an. In Eng. Sci., Vol. 4; p 1615-1627
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Effects of multiple rows and noncircular orifices on dilution jet mixing (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Propulsion and Power (ISSN 0748-4658); 3; 219-226
    Format: text
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    NASA TECHNICAL REPORTS
  • 4
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    Laminar flow integration: Flight tests status and plans (1986)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Under the Aircraft Energy Efficiency - Laminar Flow Control Program, there are currently three flight test programs under way to address critical issues concerning laminar flow technology application to commercial transports. The Leading-Edge Flight Test (LEFT) with a JetStar aircraft is a cooperative effort with the Ames/Dryden Flight Research Facility to provide operational experience with candidate leading-edge systems representative of those that might be used on a future transport. In the Variable Sweep Transition Flight Experiment (VSTFE), also a cooperative effort between Langley and Ames/Dryden, basic transition data on an F-14 wing with variable sweep will be obtained to provide a data base for laminar flow wing design. Finally, under contract to the Boeing Company, the acoustic environment on the wing of a 757 aircraft will be measured and the influence of engine noise on laminar flow determined with a natural laminar flow glove on the wing. The status and plans for these programs are reported.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Langley Symposium on Aerodynamics, Volume 1; p 485-518
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Structure of unsteady flows at leading- and trailing-edges: Flow visualization and its interpretation (1987)
    In:  CASI
    Details
    Publication Date: 2017-10-02
    Description: Unsteady two- and three-dimensional flow structure at leading and trailing edges of bodies can be characterized effectively using recently developed techniques for acquisition and interpretation of flow visualization. The techniques addressed here include: flow image/surface pressure correlations; 3-D reconstruction of flow structure from flow images; and interactive interpretation of flow images with theoretical simulations. These techniques can be employed in conjunction with: visual correlation and ensemble-averaging, both within a given image and between images; recognition of patterns from images; and estimates of velocity eigenfunctions from images.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AGARD, Aerodynamic and Related Hydrodynamic Studies Using Water Facilities; 13 p
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    Heat transfer characteristics for inline and staggered arrays of circular jets with crossflow of spent air (1978)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Heat transfer characteristics were measured for two dimensional arrays of jets impinging on a surface parallel to the jet orifice plate. The impinging flow was constrained to exit in a single direction along the channel formed by the jet plate and the heat transfer surface. Both mean Nusselt numbers and streamwise Nusselt number profiles are presented as a function of Reynolds number and geometric parameters. These are the streamwise and transverse hole spacings ranging from 5 to 10 and 4 to 8 jet orifice diameters, respectively; the channel height ranging from 1 to 6 diameters; and the hole pattern which includes both inline and staggered arrays. The results show that significant periodic variations occur in the streamwise Nusselt number profiles, persisting downstream for at least ten rows of jet holes. Channel height can have a significant effect on the chordwise profiles, smoothed across the periodic variations. For the smaller channel heights, Nusselt numbers first decrease and then increase downstream. Where significant differences exist, inline hole patterns provide better heat transfer than staggered ones. These and other effects of the geometric parameters are presented and discussed.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Gas turbine heat transfer 1978; Dec 10, 1978 - Dec 15, 1978; San Francisco, CA
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
    Electronic Resource
    Electronic Resource
    Lymph heart musculature in birds (1987)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 191 (1987), S. 77-87 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Development and innervation of the lymph heart musculature of chicken, emu, rhea, and duck was studied by electron microscopy at posthatch ages from 3 days to adulthood. Development of innervation was monitored by acetylcholinesterase staining. Horseradish peroxidase was used to determine the extent of the transverse tubule network. Chickens were unusual among these birds in that lymph heart myocytes had already undergone a definitive differentiation and degeneration by 3 days. In ducks and ratite birds, lymph heart myocytes more slowly but progressively differentiate a cytomorphology that does not conform in all characteristics to cardiac or skeletal muscle and even resembles in some aspects, smooth muscle. Myofibrils become the dominant cytoplasmic structure, transverse tubules form ‘internal couplings’ with agranular reticulum cisternae, and ‘external couplings’ are formed between myocytes at myomyal junctions. The myomyal junctions also contain AChE-positive reaction product and some subplasmalemmal vesicles that lack a dense core. The lymph heart myocardium of ducks of 2 weeks demonstrated mitotic figures. In adult ducks the myosatellite cell numbers diminish and a characteristic pattern of myocyte degeneration appears. In juvenile ducks and ratites some myocytes differentiate to conductile cells, much as the conductile myocytes and myofibers of the blood heart. The lymph heart innervation is described, and the role of nerve in differentiation and maintenance of myocyte morphology in the lymph heart is discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051910108
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  • 8
    Electronic Resource
    Electronic Resource
    Partial regeneration of the above-elbow amputated rat forelimb. II. Electrical and mechanical facilitationSupported by the Veterans Administration Medical Research Program Project Number 7004-04 and a Medical Investigatorship Award to P.P. (1979)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 159 (1979), S. 439-451 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: This investigation was undertaken to examine the observations of Becker ('72) pertaining to the electrical facilitation of partial limb regenerative responses by means of Ag-Pt wire couples applied to the limb stumps of young, forelimb-amputated white rats. Additionally, in order to examine the possible role of mechanical effects of such device implantations, we have employed uncoupled devices delivering no current or potential difference. In the present experiments, in response to coupled device implantation, cartilage and bone were actively formed in the vicinity of the Pt electrode tip. These tissues contributed to the lengthwise extension of the limb and to the partial restoration of the distal humeral extremity. In limbs bearing the uncoupled electrical devices, qualitatively similar responses were noted, but osteogenesis was diminished in extent compared to that seen in limbs bearing the active or coupled devices. It is therefore necessary to consider the role of mechanical factors in the elicitation of the observed regenerative responses. Myogenesis was enhanced in electrically stimulated limbs, but not in those rats bearing uncoupled devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051590309
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  • 9
    Electronic Resource
    Electronic Resource
    Cytotoxicity of gelonin and its conjugates with antibodies is determined by the extent of their endocytosis (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 141 (1989), S. 222-234 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Conjugates of the single-chain ribosome-inactivating protein gelonin with ligands that bind to cell surface molecules vary greatly in their cytotoxicity. Conjugates that are not endocytosed after binding to cells exhibit low cytotoxicity similar to that of free gelonin, while conjugates that are endocytosed demonstrate enhanced cytotoxicity relative to free gelonin. However, the number of internalized gelonin molecules needed to intoxicate cells to the same degree has been found to be similar for all conjugates and for free gelonin. The intracellular concentration of gelonin has to be between 2,000-10,000 molecules/cell to achieve a surviving fraction of 0.37. Our studies revealed the presence of three distinct categories of cell surface molecules, those that are efficient in mediating endocytosis of im-munotoxins, those that are only moderately efficient, and those that seem not to cause internalization of bound immunotoxins.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041410129
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  • 10
    Electronic Resource
    Electronic Resource
    Bone marrow-derived stromal cell line expressing osteoblastic phenotype in vitro and osteogenic capacity in vivo (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 140 (1989), S. 1-7 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Marrow stroma has been shown to have osteogenic potential. Here we report the characterization of a unique stromal cell line derived from mouse bone marrow (MBA-15), which expresses osteoblastic phenotype in vitro and forms bone in vivo. More than 70% of cells in culture were histochemically positive for alkaline phosphatase. The enzyme levels were enhanced threefold when cultures were treated with dexamethasone. Gel electrophoresis of [3H]-proline-labeled cultures showed that MBA-15 cells produced only type I collagen. These cells were responsive to PTH, as indicated by a 50-fold increase in intracellular cAMP. Prostaglandin E2, but not calcitonin, stimulated cAMP up to 70-fold. When cultures were grown to confluence and fed daily with ascorbic acid and β-glycerophosphate, the cells formed a Von Kossa positive, thick extracellular matrix, shown to contain hydroxyapatite crystals. MBA-15 cells produced mineralized bone when implanted in diffusion chambers. These results indicate that the MBA-15 cell line possesses osteoblastic features in vitro and osteogenic capacity in vivo.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041400102
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