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  • 1
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    Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-17
    Beschreibung: The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2R gamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2R gamma to augment IL-4 binding affinity, and the requirement for IL-2R gamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, S M -- Keegan, A D -- Harada, N -- Nakamura, Y -- Noguchi, M -- Leland, P -- Friedmann, M C -- Miyajima, A -- Puri, R K -- Paul, W E -- New York, N.Y. -- Science. 1993 Dec 17;262(5141):1880-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266078" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cell Line ; Cell Line, Transformed ; Genetic Linkage ; Humans ; Insulin Receptor Substrate Proteins ; Interleukin-4/metabolism ; L Cells (Cell Line) ; Mice ; Molecular Sequence Data ; Phosphoproteins/metabolism ; Phosphorylation ; Receptors, Interleukin-2/chemistry/genetics/*metabolism ; Receptors, Interleukin-4 ; Receptors, Mitogen/chemistry/genetics/*metabolism ; Severe Combined Immunodeficiency/genetics/immunology ; Signal Transduction ; Transfection ; X Chromosome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1993-12-17
    Beschreibung: The interleukin-2 receptor gamma chain (IL-2R gamma) is a necessary component of functional IL-2 receptors. IL-2R gamma mutations result in X-linked severe combined immunodeficiency (XSCID) in humans, a disease characterized by the presence of few or no T cells. In contrast, SCID patients with IL-2 deficiency and IL-2-deficient mice have normal numbers of T cells, suggesting that IL-2R gamma is part of more than one cytokine receptor. By using chemical cross-linking, IL-2R gamma was shown to be physically associated with the IL-7 receptor. The presence of IL-2R gamma augmented both IL-7 binding affinity and the efficiency of internalization of IL-7. These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, M -- Nakamura, Y -- Russell, S M -- Ziegler, S F -- Tsang, M -- Cao, X -- Leonard, W J -- New York, N.Y. -- Science. 1993 Dec 17;262(5141):1877-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266077" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; B-Lymphocytes/immunology ; Cell Line ; Genetic Linkage ; Interleukin-7/*metabolism ; L Cells (Cell Line) ; Mice ; Receptors, Interleukin/chemistry/genetics/*metabolism ; Receptors, Interleukin-2/chemistry/genetics/*metabolism ; Receptors, Interleukin-7 ; Severe Combined Immunodeficiency/genetics/immunology ; T-Lymphocytes/immunology ; Transfection ; X Chromosome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1994-11-11
    Beschreibung: Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains. Mutations of gamma c can result in X-linked severe combined immunodeficiency (XSCID). IL-2, IL-4, IL-7 (whose receptors are known to contain gamma c), and IL-9 (whose receptor is shown here to contain gamma c) induced the tyrosine phosphorylation and activation of the Janus family tyrosine kinases Jak1 and Jak3. Jak1 and Jak3 associated with IL-2R beta and gamma c, respectively; IL-2 induced Jak3-IL-2R beta and increased Jak3-gamma c associations. Truncations of gamma c, and a gamma c, point mutation causing moderate X-linked combined immunodeficiency (XCID), decreased gamma c-Jak3 association. Thus, gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCID-like phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, S M -- Johnston, J A -- Noguchi, M -- Kawamura, M -- Bacon, C M -- Friedmann, M -- Berg, M -- McVicar, D W -- Witthuhn, B A -- Silvennoinen, O -- P30 CA21765/CA/NCI NIH HHS/ -- R01 DK42932/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1994 Nov 11;266(5187):1042-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973658" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Enzyme Activation ; Humans ; Interleukin-2/pharmacology ; Janus Kinase 1 ; Janus Kinase 3 ; Mutation ; Phosphorylation ; Point Mutation ; Protein-Tyrosine Kinases/genetics/*metabolism ; Receptors, Interleukin-2/genetics/*metabolism ; Severe Combined Immunodeficiency/genetics/*immunology/metabolism ; Transfection ; Tyrosine/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    A mechanism of lithium storage in disordered carbons (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1994-04-22
    Beschreibung: High-resolution electron microscopy and lithium-7 nuclear magnetic resonance measurements were carried out for a disordered carbon material, prepared by heat treatment of polyphenylene, in which lithium was stored electrochemically. The nuclear magnetic resonance spectrum suggests the existence of Li(2) covalent molecules in the carbon material. This extra covalent site of lithium storage promises extraordinarily high energy density for secondary batteries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sato, K -- Noguchi, M -- Demachi, A -- Oki, N -- Endo, M -- New York, N.Y. -- Science. 1994 Apr 22;264(5158):556-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17732740" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Antigen–specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 7 (1994), S. 13-21 
    Details
    ISSN: 1546-1718
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] We describe a strategy for producing human monoclonal antibodies in mice by introducing large segments of the human heavy and κ light chain loci contained on yeast artificial chromosomes into the mouse germline. Such mice produce a diverse repertoire of human heavy and light chains, and upon ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/ng0594-13
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Lifetime spectra of positrons in ionic compounds (1974)
    Springer
    Applied physics 3 (1974), S. 383-385 
    Details
    ISSN: 1432-0630
    Schlagwort(e): Positron-lifetime ; Ionic compounds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract Lifetime spectra of some sulphides, AlN, and SiC consist of two components. Temperature dependences of the spectra of Sb2S3 were investigated from 296–723 K and analyzed with a non-trapping model. It was estimated that cation vacancies due to nonstoichiometry were responsible for the τ2 component.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00885843
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Lifetime spectra of positrons in deformed Ge (1974)
    Springer
    Applied physics 4 (1974), S. 41-45 
    Details
    ISSN: 1432-0630
    Schlagwort(e): Positron lifetime ; Semiconductor dislocation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract Positron lifetime measurements have been performed inn-type andp-type germanium single crystals deformed by compression. The results are compared with those of deformed GaAs single crystals obtained by the authors previously. In bothn andp-type germanium the lifetime τ1 and its intensityI 1 decreased with deformation. Using the trapping model, the trapping rates of positrons by dislocations are obtained, which in turn gave the cross width of the dislocation as 20.0 Å and 8.2 Å forn-type andp-type germanium, respectively. In terms of Read's model the fraction of the dangling bonds occupied by electrons is obtained to 0.26 in then-type germanium. This value was smaller than those obtained forn-type GaAs, i.e., 0.46 and 0.50 for Ga- and As-dislocation, respectively. It is found that doping causes the trapping of positrons. Inp-type germanium the fractionf was determined to 0.25 in terms of Schröter and Labusch's model.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00884151
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  • 8
    Digitale Medien
    Digitale Medien
    Gas flow in a two component galactic disk (1994)
    Springer
    Astrophysics and space science 216 (1994), S. 347-351 
    Details
    ISSN: 1572-946X
    Schlagwort(e): gas dynamics ; galactic disks ; bar instability ; nuclear activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Numerical simulations of two-component (stars + gas) self-gravitating galactic disks show that the interstellar gas can significantly affect the dynamical evolution of the disk even if its mass fraction (relative to the total galaxy mass) is as low as several percent. Aided by efficient energy dissipation, the gas becomes gravitationally unstable onlocal scale and forms massive clumps. Gravitational scattering of stars by these clumps leads to suppression of bar instability usually seen in heavy stellar disks. In this case, gas inflow towards the galactic center is driven by dynamical friction which gas clumps suffer instead of bar forcing.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00982516
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Acoustic emission monitoring during partial compression to detect early stages of decay (1992)
    Springer
    Wood science and technology 26 (1992), S. 279-287 
    Details
    ISSN: 1432-5225
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Maschinenbau
    Notizen: Summary The acoustic emissions (AEs) under partially compression were monitored with two softwood and one hardwood specimens in very eary stages of decay by a brown- and a white-rot fungus. Even slightly decayed specimens emitted AEs immediately after beginning of loading, typically when partial compression stress was applied to brown-rotted wood with the flat-headed attachment. With sound specimens of three wood species, only a few AEs were generated until the load reached at the proportional limit. These results suggest that AE monitoring will be one of the feasible means to detect the incipient stages of decay in a field test.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00200163
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  • 10
    Digitale Medien
    Digitale Medien
    Application of thermography to the deforming process of paper materials (1993)
    Springer
    Journal of materials science 28 (1993), S. 4549-4552 
    Details
    ISSN: 1573-4803
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract A method is described, in which infrared thermography is used to detect changes in the temperature image occurring in paper during a tensile test. Thermography has been found to be useful instead of calorimetry for detecting the local variations in surface temperature and the thermal energy transfer in paper under strain. The changes in temperature images during the course of tensile straining can facilitate the study of the local deformation process of paper.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00414241
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