ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    An essential role for ectodomain shedding in mammalian development (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-13
    Description: The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGFalpha). The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peschon, J J -- Slack, J L -- Reddy, P -- Stocking, K L -- Sunnarborg, S W -- Lee, D C -- Russell, W E -- Castner, B J -- Johnson, R S -- Fitzner, J N -- Boyce, R W -- Nelson, N -- Kozlosky, C J -- Wolfson, M F -- Rauch, C T -- Cerretti, D P -- Paxton, R J -- March, C J -- Black, R A -- CA43793/CA/NCI NIH HHS/ -- DK53804/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 13;282(5392):1281-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunex Corporation, Seattle, WA 98101, USA. peschon@immunex.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9812885" target="_blank"〉PubMed〈/a〉
    Keywords: ADAM Proteins ; Amino Acid Sequence ; Animals ; Catalytic Domain ; Cell Membrane/*metabolism ; Cells, Cultured ; Crosses, Genetic ; *Embryonic and Fetal Development ; L-Selectin/metabolism ; Ligands ; Membrane Proteins/*metabolism ; Metalloendopeptidases/chemistry/genetics/*metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Mutation ; Phenotype ; Protein Processing, Post-Translational ; Receptors, Tumor Necrosis Factor/metabolism ; Transforming Growth Factor alpha/metabolism ; Tumor Necrosis Factor-alpha/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-11
    Description: The gastric stomach of humans is a barrier to food-borne pathogens, but Escherichia coli can survive at pH 2.0 if it is grown under mildly acidic conditions. Cattle are a natural reservoir for pathogenic E. coli, and cattle fed mostly grain had lower colonic pH and more acid-resistant E. coli than cattle fed only hay. On the basis of numbers and survival after acid shock, cattle that were fed grain had 10(6)-fold more acid-resistant E. coli than cattle fed hay, but a brief period of hay feeding decreased the acid-resistant count substantially.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diez-Gonzalez, F -- Callaway, T R -- Kizoulis, M G -- Russell, J B -- New York, N.Y. -- Science. 1998 Sep 11;281(5383):1666-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, Section of Microbiology, Cornell University and Agricultural Research Service, U.S. Department of Agriculture, Ithaca, NY 14853-8101, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9733511" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Feed ; Animal Husbandry ; Animals ; Bacteria, Anaerobic/growth & development ; Cattle/*microbiology ; Colon/chemistry/*microbiology ; Colony Count, Microbial ; Culture Media ; Diet ; *Edible Grain ; Escherichia coli/*growth & development ; Fatty Acids, Volatile/analysis ; Hydrogen-Ion Concentration ; Lactic Acid/analysis ; *Poaceae ; Random Allocation ; Rumen/chemistry/microbiology ; Succinates/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77) (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-07-28
    Description: T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4+ peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, S L -- Wesselschmidt, R L -- Linette, G P -- Kanagawa, O -- Russell, J H -- Milbrandt, J -- P01 CA49712/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 Jul 28;269(5223):532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624775" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Antigens, CD3/immunology/physiology ; *Apoptosis ; Cells, Cultured ; Clonal Deletion ; Crosses, Genetic ; DNA-Binding Proteins/genetics/*physiology ; Female ; Gene Targeting ; Hybridomas ; Male ; Mice ; Mice, Transgenic ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Receptors, Antigen, T-Cell, alpha-beta/*physiology ; Receptors, Cytoplasmic and Nuclear ; Receptors, Steroid/genetics/*physiology ; Stem Cells ; T-Lymphocyte Subsets/cytology ; T-Lymphocytes/*cytology/immunology ; Thymus Gland/cytology ; Transcription Factors/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-03
    Description: Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common cytokine receptor gamma chain (gamma c) gene that encodes a shared, essential component of the receptors of interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15. The Janus family tyrosine kinase Jak3 is the only signaling molecule known to be associated with gamma c, so it was hypothesized that defects in Jak3 might cause an XSCID-like phenotype. A girl with immunological features indistinguishable from those of XSCID was therefore selected for analysis. An Epstein-Barr virus (EBV)-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished Jak3 messenger RNA. Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the Jak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain. The lack of Jak3 expression correlated with impaired B cell signaling, as demonstrated by the inability of IL-4 to activate Stat6 in the EBV-transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, S M -- Tayebi, N -- Nakajima, H -- Riedy, M C -- Roberts, J L -- Aman, M J -- Migone, T S -- Noguchi, M -- Markert, M L -- Buckley, R H -- O'Shea, J J -- Leonard, W J -- M01-RR30/RR/NCRR NIH HHS/ -- R37AI18613-13/AI/NIAID NIH HHS/ -- T32 CA09058/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 3;270(5237):797-800.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; B-Lymphocytes/*immunology ; Base Sequence ; Cell Line, Transformed ; Female ; Frameshift Mutation ; Genetic Linkage ; Humans ; Infant ; Interleukin-4/pharmacology ; Janus Kinase 3 ; Molecular Sequence Data ; Phenotype ; Point Mutation ; Protein-Tyrosine Kinases/deficiency/genetics/*physiology ; RNA, Messenger/genetics/metabolism ; Receptors, Interleukin/physiology ; STAT6 Transcription Factor ; Severe Combined Immunodeficiency/*enzymology/genetics/immunology ; Signal Transduction ; T-Lymphocytes/*immunology ; Trans-Activators/metabolism ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Comparison of HALOE O3 and H2O observations from UARS with ground and balloonborne measurements (1995)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: The HALogen Occultation Experiment (HALOE) was launched on the Upper Atmosphere Research Satellite (UARS) by the Space Shuttle Discovery at 7:11:04 EDT on September 12, 1991. After allowing for a period of outgassing, HALOE began taking routine science observations on October 11. HALOE uses the experiment approach of solar occultation and the gas filter and broad band radiometer instruments techniques to measure vertical profiles of HCl, HF, CH4, NO, NO2, H2O, O3, aerosol, and temperature versus pressure. The measurements cover a broad altitude range from the upper troposphere in some cases to the lower thermosphere in the case of nitric oxide. Latitude coverage provided by the occultation geometry ranges from 80 deg S to 80 deg N over the course of one year. The experiment has operated essentially without flaw for more than three years. Instrument stability over this time, as judged by the maximum signal change when viewing the sun exoatmospherically is less than or equal to 2 to 3%.
    Keywords: Geophysics
    Type: ; 22-23
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unknown
    An overview of the SABER experiment for the TIMED mission (1995)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: The Sounding of the Atmosphere Using Broadband Emission Radiometry (SABER) experiment has been selected for flight on the Thermosphere-Ionosphere-Mesosphere Energetics and Dynamics (TIMED) mission expected to fly in the latter part of this decade. The primary science goal of SABER is to achieve fundamental and important advances in understanding of the energetics, chemistry, and dynamics, in the atmospheric region extending from 60 km to 180 km altitude, which has not been comprehensively observed on a global basis. This will be accomplished using the space flight proven experiment approach of broad spectral band limb emission radiometry. SABER will scan the horizon in 12 selected bands ranging from 1.27 microns to 17 microns wavelength. The observed vertical horizon emission profiles will be mathematically inverted in ground data processing to provide vertical profiles with 2 km vertical resolution, of temperature, O3, H2O, NO, NO2, CO, and CO2. SABER will also observe key emissions needed for energetics studies at 1.27 microns (O2((sup 1)delta)), 2 microns (OH(v = 7,8,9)) 1.6 microns (OH(v = 3,4,5)), 4.3 microns (CO2(v(sub 3))) 5.3 microns (NO) 9.6 microns (O3), and 15 microns (CO2(v(sub 2))). These measurements will be used to infer atomic hydrogen and atomic oxygen, the latter inferred three different ways using only SABER observations. Measurements will be made both night and day over the latitude range from the southern to northern polar regions.
    Keywords: Geophysics
    Type: ; 5-7
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 7
    facet.materialart.
    Unknown
    LASE measurements of aerosols and water vapor during TARFOX (1998)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Description: The TARFOX (Tropospheric Aerosol Radiative Forcing Observational Experiment) intensive field campaign was designed to reduce uncertainties in estimates of the effects of anthropogenic aerosols on climate by measuring direct radiative effects and the optical, physical, and chemical properties of aerosols [1]. TARFOX was conducted off the East Coast of the United States between July 10-31, 1996. Ground, aircraft, and satellite-based sensors measured the sensitivity of radiative fields at various atmospheric levels to aerosol optical properties (i.e., optical thickness, phase function, single-scattering albedo) and to the vertical profile of aerosols. The LASE (Lidar Atmospheric Sensing Experiment) instrument, which was flown on the NASA ER-2 aircraft, measured vertical profiles of total scattering ratio and water vapor during a series of 9 flights. These profiles were used in real-time to help direct the other aircraft to the appropriate altitudes for intensive sampling of aerosol layers. We have subsequently used the LASE aerosol data to derive aerosol backscattering and extinction profiles. Using these aerosol extinction profiles, we derived estimates of aerosol optical thickness (AOT) and compared these with measurements of AOT from both ground and airborne sun photometers and derived from the ATSR-2 (Along Track and Scanning Radiometer 2) sensor on ERS-2 (European Remote Sensing Satellite-2). We also used the water vapor mixing ratio profiles measured simultaneously by LASE to derive precipitable water vapor and compare these to ground based measurements.
    Keywords: Geophysics
    Type: Nineteenth International Laser Radar Conference; 11-14; NASA/CP-1998-207671/PT1
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 8
    facet.materialart.
    Unknown
    Ground-based Observations of Arctic O(sub 3) Loss During Spring and Summer 1997 (1999)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: Ground-based solar absorption spectra were measured from Fairbanks, Alaska (65 degrees North, 148 degrees West) and from Ny Alesund, Spitsbergen, (79 degrees North, 12 degrees East) from March to September 1997 by Fourier Transform Infra-Red (FTIR) spectrometers.
    Keywords: Geophysics
    Type: Journal of Geophysical Research (Atmospheres)
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 9
    facet.materialart.
    Unknown
    Variations in the Free Chlorine Content of the Stratosphere (1991-1997): Anthropogenic an Volcanic Influences (1999)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: Remote sensing of chlorine monoxide (CIO) by the Microwave Limb Sounder (MLS) experiment aboard the Upper Atmosphere Research Satellite (UARS) has provided global measurements of variations in stratospheric free chlorine (for 1991 to 1997).
    Keywords: Geophysics
    Type: Journal of Geophysical Research
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 10
    facet.materialart.
    Unknown
    Growth of Lower Stratospheric HCl/Cly Since 1993: Observations from Aircraft (ALIAS), Balloon (MarkIV, FIRS-2), Space Shuttle (ATMOS), and Satellite (HALOE) Measurements (1998)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: Measurements of HCl in the lower stratosphere (15-21 km) from aircraft, balloon, Space Shuttle, and satellite reveal a growth in its mean abundance relative to that of total inorganic chlorine (Cly) from HCl/Cly = 57(+/-5)% in early 1993 to 75(+/-7)% by the end of 1997.
    Keywords: Geophysics
    Type: Geophysical Research Letters
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...