Publication Date:
2004-07-24
Description:
The hippocampus has differentiated into an extensively connected recurrent stage (CA3) followed by a feed-forward stage (CA1). We examined the function of this structural differentiation by determining how cell ensembles in rat CA3 and CA1 generate representations of rooms with common spatial elements. In CA3, distinct subsets of pyramidal cells were activated in each room, regardless of the similarity of the testing enclosure. In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leutgeb, Stefan -- Leutgeb, Jill K -- Treves, Alessandro -- Moser, May-Britt -- Moser, Edvard I -- New York, N.Y. -- Science. 2004 Aug 27;305(5688):1295-8. Epub 2004 Jul 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15272123" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Brain Mapping
;
Cues
;
Electrodes, Implanted
;
Entorhinal Cortex/physiology
;
Hippocampus/cytology/*physiology
;
Male
;
*Memory
;
Nerve Net/*physiology
;
Neurons/*physiology
;
Pyramidal Cells/*physiology
;
Rats
;
Rats, Long-Evans
;
*Space Perception
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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