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  • Bücher
  • Artikel  (8)
  • Signal Transduction  (5)
  • Extraterrestrial Environment  (3)
  • 2000-2004  (8)
  • 1
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    Neurobiology. Learning how a fruit fly forgets (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-08-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waddell, S -- Quinn, W G -- New York, N.Y. -- Science. 2001 Aug 17;293(5533):1271-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. waddell@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11509718" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Afferent Pathways/physiology ; Animals ; Brain/physiology ; Cyclic AMP/metabolism ; Drosophila/genetics/*physiology ; *Drosophila Proteins ; Dynamins ; Electroshock ; GTP Phosphohydrolases/genetics/physiology ; Genes, Insect ; Learning/*physiology ; Memory/*physiology ; Mental Recall/physiology ; Models, Neurological ; Neurons/*physiology ; Neuropeptides/genetics/physiology ; Odors ; Presynaptic Terminals/physiology ; Second Messenger Systems ; Signal Transduction ; *Synaptic Transmission ; Temperature ; Transgenes
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Positioning of longitudinal nerves in C. elegans by nidogen (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-07
    Beschreibung: Basement membranes can help determine pathways of migrating axons. Although members of the nidogen (entactin) protein family are structural components of basement membranes, we find that nidogen is not required for basement membrane assembly in the nematode Caenorhabditis elegans. Nidogen is localized to body wall basement membranes and is required to direct longitudinal nerves dorsoventrally and to direct axons at the midlines. By examining migration of a single axon in vivo, we show that nidogen is required for the axon to switch from circumferential to longitudinal migration. Specialized basement membranes may thus regulate nerve position.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S -- Wadsworth, W G -- New York, N.Y. -- Science. 2000 Apr 7;288(5463):150-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10753123" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Motifs ; Animals ; Animals, Genetically Modified ; Axons/*physiology ; Basement Membrane/*physiology ; Body Patterning ; Caenorhabditis elegans/anatomy & histology/embryology/genetics/*growth & ; development ; *Caenorhabditis elegans Proteins ; Cell Adhesion Molecules/genetics/physiology ; Cell Movement ; Cloning, Molecular ; Gene Expression ; Genes, Helminth ; In Situ Hybridization ; Intestines/cytology/metabolism ; Membrane Glycoproteins/analysis/chemistry/genetics/*physiology ; Motor Neurons/physiology/ultrastructure ; Muscles/metabolism ; Nervous System/anatomy & histology/embryology/growth & development/ultrastructure ; Neurons/metabolism ; Phenotype ; Protein Structure, Tertiary ; Receptors, Cell Surface/genetics/physiology ; Signal Transduction
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-16
    Beschreibung: Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors. In adult SHIP-/- mice, the NK compartment is dominated by cells that express two inhibitory receptors capable of binding either self or allogeneic MHC ligands. This promiscuous repertoire has significant functional consequences, because SHIP-/- mice fail to reject fully mismatched allogeneic marrow grafts and show enhanced survival after such transplants. Thus, SHIP plays an important role in two processes that limit the success of allogeneic marrow transplantation: graft rejection and graft-versus-host disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Jia-Wang -- Howson, Julie M -- Ghansah, Tomar -- Desponts, Caroline -- Ninos, John M -- May, Sarah L -- Nguyen, Kim H T -- Toyama-Sorimachi, Noriko -- Kerr, William G -- P01 NS27405/NS/NINDS NIH HHS/ -- R01 DK54767/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2094-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology Program, H. Lee Moffitt Comprehensive Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896280" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD/metabolism ; *Antigens, Ly ; Bone Marrow Transplantation/*immunology ; Cell Survival ; Graft Rejection/*immunology ; Graft Survival ; Graft vs Host Disease/*immunology ; H-2 Antigens/immunology/metabolism ; Haplotypes ; Histocompatibility Antigens Class I/immunology/metabolism ; Killer Cells, Natural/enzymology/*immunology/metabolism ; *Lectins, C-Type ; Ligands ; Lymphocyte Count ; Lymphocyte Subsets/immunology/metabolism ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred A ; Mice, Inbred BALB C ; NK Cell Lectin-Like Receptor Subfamily D ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoric Monoester Hydrolases/chemistry/genetics/*metabolism ; Phosphorylation ; *Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt ; Receptors, Immunologic/metabolism ; Receptors, NK Cell Lectin-Like ; Signal Transduction ; Transplantation, Homologous ; src Homology Domains
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-11
    Beschreibung: The ubiquitination of the hypoxia-inducible factor (HIF) by the von Hippel-Lindau tumor suppressor (pVHL) plays a central role in the cellular response to changes in oxygen availability. pVHL binds to HIF only when a conserved proline in HIF is hydroxylated, a modification that is oxygen-dependent. The 1.85 angstrom structure of a 20-residue HIF-1alpha peptide-pVHL-ElonginB-ElonginC complex shows that HIF-1alpha binds to pVHL in an extended beta strand-like conformation. The hydroxyproline inserts into a gap in the pVHL hydrophobic core, at a site that is a hotspot for tumorigenic mutations, with its 4-hydroxyl group recognized by buried serine and histidine residues. Although the beta sheet-like interactions contribute to the stability of the complex, the hydroxyproline contacts are central to the strict specificity characteristic of signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Min, Jung-Hyun -- Yang, Haifeng -- Ivan, Mircea -- Gertler, Frank -- Kaelin, William G Jr -- Pavletich, Nikola P -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1886-9. Epub 2002 May 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cellular Biochemistry and Biophysics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004076" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Binding Sites ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Hydroxylation ; Hydroxyproline/*metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit ; Ligases/*chemistry/genetics/metabolism ; Macromolecular Substances ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Signal Transduction ; Transcription Factors/*chemistry/metabolism ; *Tumor Suppressor Proteins ; *Ubiquitin-Protein Ligases ; Von Hippel-Lindau Tumor Suppressor Protein
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Human hypertension caused by mutations in WNK kinases (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-08-11
    Beschreibung: Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion. Both genes encode members of the WNK family of serine-threonine kinases. Disease-causing mutations in WNK1 are large intronic deletions that increase WNK1 expression. The mutations in WNK4 are missense, which cluster in a short, highly conserved segment of the encoded protein. Both proteins localize to the distal nephron, a kidney segment involved in salt, K+, and pH homeostasis. WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, F H -- Disse-Nicodeme, S -- Choate, K A -- Ishikawa, K -- Nelson-Williams, C -- Desitter, I -- Gunel, M -- Milford, D V -- Lipkin, G W -- Achard, J M -- Feely, M P -- Dussol, B -- Berland, Y -- Unwin, R J -- Mayan, H -- Simon, D B -- Farfel, Z -- Jeunemaitre, X -- Lifton, R P -- New York, N.Y. -- Science. 2001 Aug 10;293(5532):1107-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute; Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11498583" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human, Pair 12/genetics ; Chromosomes, Human, Pair 17/genetics ; Cytoplasm/enzymology ; Female ; Gene Expression Regulation, Enzymologic ; Genetic Linkage ; Humans ; Hypertension/enzymology/*genetics/physiopathology ; Intercellular Junctions/enzymology ; Intracellular Signaling Peptides and Proteins ; Introns ; Kidney Tubules, Collecting/enzymology/ultrastructure ; Kidney Tubules, Distal/enzymology/ultrastructure ; Male ; Membrane Proteins/metabolism ; Microscopy, Fluorescence ; Molecular Sequence Data ; *Mutation ; Mutation, Missense ; Pedigree ; Phosphoproteins/metabolism ; Protein-Serine-Threonine Kinases/chemistry/*genetics/metabolism ; Pseudohypoaldosteronism/enzymology/*genetics/physiopathology ; Sequence Deletion ; Signal Transduction ; Zonula Occludens-1 Protein
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-12-04
    Beschreibung: The Alpha Particle X-ray Spectrometer on the Opportunity rover determined major and minor elements of soils and rocks in Meridiani Planum. Chemical compositions differentiate between basaltic rocks, evaporite-rich rocks, basaltic soils, and hematite-rich soils. Although soils are compositionally similar to those at previous landing sites, differences in iron and some minor element concentrations signify the addition of local components. Rocky outcrops are rich in sulfur and variably enriched in bromine relative to chlorine. The interaction with water in the past is indicated by the chemical features in rocks and soils at this site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rieder, R -- Gellert, R -- Anderson, R C -- Bruckner, J -- Clark, B C -- Dreibus, G -- Economou, T -- Klingelhofer, G -- Lugmair, G W -- Ming, D W -- Squyres, S W -- d'Uston, C -- Wanke, H -- Yen, A -- Zipfel, J -- New York, N.Y. -- Science. 2004 Dec 3;306(5702):1746-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Chemie, J. J. Becher-Weg 27, D-55128 Mainz, Germany. rieder@mpch-mainz.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15576611" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alpha Particles ; Bromine ; Chlorine ; Elements ; Extraterrestrial Environment ; Ferric Compounds ; Geologic Sediments ; Iron ; Magnesium ; *Mars ; Minerals ; Silicates ; Spacecraft ; Spectrometry, X-Ray Emission ; Sulfates ; Sulfur ; Water
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Chemistry of rocks and soils in Gusev Crater from the alpha particle x-ray spectrometer (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-08-07
    Beschreibung: The alpha particle x-ray spectrometer on the Spirit rover determined major and minor elements of soils and rocks in Gusev crater in order to unravel the crustal evolution of planet Mars. The composition of soils is similar to those at previous landing sites, as a result of global mixing and distribution by dust storms. Rocks (fresh surfaces exposed by the rock abrasion tool) resemble volcanic rocks of primitive basaltic composition with low intrinsic potassium contents. High abundance of bromine (up to 170 parts per million) in rocks may indicate the alteration of surfaces formed during a past period of aqueous activity in Gusev crater.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gellert, R -- Rieder, R -- Anderson, R C -- Bruckner, J -- Clark, B C -- Dreibus, G -- Economou, T -- Klingelhofer, G -- Lugmair, G W -- Ming, D W -- Squyres, S W -- D'Uston, C -- Wanke, H -- Yen, A -- Zipfel, J -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):829-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Chemie, J. J. Becher-Weg 27, D-55128 Mainz, Germany. gellert@mpch-mainz.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297665" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alpha Particles ; Bromine ; *Elements ; Evolution, Planetary ; Extraterrestrial Environment ; Geologic Sediments ; *Mars ; Potassium ; Spectrum Analysis ; Water
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Global distribution of neutrons from Mars: results from Mars odyssey (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-06-01
    Beschreibung: Global distributions of thermal, epithermal, and fast neutron fluxes have been mapped during late southern summer/northern winter using the Mars Odyssey Neutron Spectrometer. These fluxes are selectively sensitive to the vertical and lateral spatial distributions of H and CO2 in the uppermost meter of the martian surface. Poleward of +/-60 degrees latitude is terrain rich in hydrogen, probably H2O ice buried beneath tens of centimeter-thick hydrogen-poor soil. The central portion of the north polar cap is covered by a thick CO2 layer, as is the residual south polar cap. Portions of the low to middle latitudes indicate subsurface deposits of chemically and/or physically bound H2O and/or OH.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feldman, W C -- Boynton, W V -- Tokar, R L -- Prettyman, T H -- Gasnault, O -- Squyres, S W -- Elphic, R C -- Lawrence, D J -- Lawson, S L -- Maurice, S -- McKinney, G W -- Moore, K R -- Reedy, R C -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):75-8. Epub 2002 May 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Los Alamos National Laboratory, Los Alamos, NM 87545, USA. wfeldman@lanl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040088" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Dry Ice ; Extraterrestrial Environment ; Gamma Rays ; *Hydrogen ; Ice ; *Mars ; *Neutrons ; Spacecraft ; Spectrometry, Gamma ; Spectrum Analysis ; Temperature ; Water
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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