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  • Animals  (9)
  • Civilization, Classical.
  • Geodynamics and Tectonics
  • 2000-2004  (10)
  • 1
    Unknown
    Oxford [England] ; New York : Oxford University Press
    American classical studies  
    Keywords: Greece, History, To 146 B.C. ; Grèce, Histoire, Jusqu'à 146 av. J.-C. ; Rome, Histoire. ; Rome, History. ; Civilisation ancienne. ; Civilization, Classical.
    Pages: xi, 151 p.
    ISBN: 0-19-518490-4
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  • 2
    Publication Date: 2002-03-09
    Description: Time courses of translocation of fluorescently conjugated proteins to the plasma membrane were simultaneously measured in thousands of individual rat basophilic leukemia cells. We found that the C2 domain---a calcium-sensing, lipid-binding protein module that is an essential regulator of protein kinase C and numerous other proteins---targeted proteins to the plasma membrane transiently if calcium was released from internal stores, and persistently in response to entry of extracellular calcium across the plasma membrane. The C2 domain translocation time courses of stimulated cells clustered into only two primary modes. Hence, the reversible recruitment of families of signaling proteins from one cellular compartment to another is a rapid bifurcation mechanism for inducing discrete states of cellular signaling networks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teruel, Mary N -- Meyer, Tobias -- CA83229/CA/NCI NIH HHS/ -- GM062144/GM/NIGMS NIH HHS/ -- HG00057/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1910-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Pharmacology, Stanford University Medical School, 269 Campus Drive, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins ; Calcium/*metabolism ; *Calcium Signaling ; Cell Membrane/*metabolism ; Cytosol/metabolism ; Fluorescence ; Fluorescent Dyes ; Isoenzymes/chemistry/*metabolism ; Kinetics ; Luminescent Proteins ; Platelet Activating Factor/pharmacology ; Protein Binding ; Protein Kinase C/chemistry/*metabolism ; Protein Structure, Tertiary ; *Protein Transport ; Rats ; Receptors, Cell Surface/*metabolism ; Recombinant Fusion Proteins/metabolism ; Software ; Thapsigargin/pharmacology ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2000-04-15
    Description: We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers. Cantilevers in an array were functionalized with a selection of biomolecules. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite large nonspecific responses of individual cantilevers. Hybridization of complementary oligonucleotides shows that a single base mismatch between two 12-mer oligonucleotides is clearly detectable. Similar experiments on protein A-immunoglobulin interactions demonstrate the wide-ranging applicability of nanomechanical transduction to detect biomolecular recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fritz, J -- Baller, M K -- Lang, H P -- Rothuizen, H -- Vettiger, P -- Meyer, E -- Guntherodt, H -- Gerber, C -- Gimzewski, J K -- New York, N.Y. -- Science. 2000 Apr 14;288(5464):316-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IBM Research, Zurich Research Laboratory, Saumerstrasse 4, CH-8803 Ruschlikon, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10764640" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Base Pair Mismatch ; Base Pairing ; Chemistry, Physical ; Goats ; Gold/*chemistry ; Hydrogen Bonding ; Immunoglobulin Constant Regions/*chemistry ; Ligands ; *Nucleic Acid Hybridization ; Oligodeoxyribonucleotides/*chemistry ; Physicochemical Phenomena ; Rabbits ; Silicon/*chemistry ; Staphylococcal Protein A/*chemistry ; Static Electricity ; Stress, Mechanical ; Thionucleotides/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2001-04-09
    Description: A comparative (15)N-tracer study of nitrogen dynamics in headwater streams from biomes throughout North America demonstrates that streams exert control over nutrient exports to rivers, lakes, and estuaries. The most rapid uptake and transformation of inorganic nitrogen occurred in the smallest streams. Ammonium entering these streams was removed from the water within a few tens to hundreds of meters. Nitrate was also removed from stream water but traveled a distance 5 to 10 times as long, on average, as ammonium. Despite low ammonium concentration in stream water, nitrification rates were high, indicating that small streams are potentially important sources of atmospheric nitrous oxide. During seasons of high biological activity, the reaches of headwater streams typically export downstream less than half of the input of dissolved inorganic nitrogen from their watersheds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peterson, B J -- Wollheim, W M -- Mulholland, P J -- Webster, J R -- Meyer, J L -- Tank, J L -- Marti, E -- Bowden, W B -- Valett, H M -- Hershey, A E -- McDowell, W H -- Dodds, W K -- Hamilton, S K -- Gregory, S -- Morrall, D D -- New York, N.Y. -- Science. 2001 Apr 6;292(5514):86-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ecosystems Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11292868" target="_blank"〉PubMed〈/a〉
    Keywords: Absorption ; Animals ; Bacteria/metabolism ; Biofilms ; *Ecosystem ; Eukaryota/metabolism ; *Fresh Water ; Fungi/metabolism ; Geologic Sediments ; Nitrates/metabolism ; Nitrogen/*metabolism ; Oxidation-Reduction ; Photosynthesis ; Quaternary Ammonium Compounds/metabolism ; Seasons ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2002-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Zhixiong -- Dullmann, Jochen -- Schiedlmeier, Bernd -- Schmidt, Manfred -- von Kalle, Christof -- Meyer, Johann -- Forster, Martin -- Stocking, Carol -- Wahlers, Anke -- Frank, Oliver -- Ostertag, Wolfram -- Kuhlcke, Klaus -- Eckert, Hans-Georg -- Fehse, Boris -- Baum, Christopher -- New York, N.Y. -- Science. 2002 Apr 19;296(5567):497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Heinrich-Pette-Institute, D-20251 Hamburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11964471" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells/metabolism ; Bone Marrow Transplantation ; DNA-Binding Proteins/genetics/metabolism ; *Gene Transfer, Horizontal ; Genetic Therapy ; *Genetic Vectors ; Hematopoiesis, Extramedullary ; Leukemia, Monocytic, Acute/*etiology ; Mice ; Mice, Inbred C57BL ; Preleukemia/*etiology ; *Proto-Oncogenes ; Receptor, Nerve Growth Factor ; Receptor, trkA/genetics/metabolism ; Receptors, Nerve Growth Factor/*genetics/metabolism ; Retroviridae/*genetics ; Transcription Factors/genetics ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2000-10-29
    Description: An unusual property of the circadian timekeeping systems of animals is rhythm "splitting," in which a single daily period of physical activity (usually measured as wheel running) dissociates into two stably coupled components about 12 hours apart; this behavior has been ascribed to a clock composed of two circadian oscillators cycling in antiphase. We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally "split" hamsters housed in constant light. The results show that the two oscillators underlying the split condition correspond to the left and right sides of the bilaterally paired SCN.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de la Iglesia, H O -- Meyer, J -- Carpino, A Jr -- Schwartz, W J -- R01 NS24542/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):799-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. hacho@bio.umass.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11052942" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors ; Animals ; Arginine Vasopressin/genetics/metabolism ; Basic Helix-Loop-Helix Transcription Factors ; Biological Clocks/*physiology ; Cell Cycle Proteins ; Circadian Rhythm/*physiology ; Cricetinae ; *Gene Expression ; Helix-Loop-Helix Motifs ; In Situ Hybridization ; Light ; Male ; Mesocricetus ; Motor Activity ; Nuclear Proteins/genetics/metabolism ; Period Circadian Proteins ; Suprachiasmatic Nucleus/metabolism/*physiology ; Transcription Factors/genetics/metabolism
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2004-02-21
    Description: To achieve X-chromosome dosage compensation, organisms must distinguish X chromosomes from autosomes. We identified multiple, cis-acting regions that recruit the Caenorhabditis elegans dosage compensation complex (DCC) through a search for regions of X that bind the complex when detached from X. The DCC normally assembles along the entire X chromosome, but not all detached regions recruit the complex, despite having genes known to be dosage compensated on the native X. Thus, the DCC binds first to recruitment sites, then spreads to neighboring X regions to accomplish chromosome-wide gene repression. From a large chromosomal domain, we defined a 793-base pair fragment that functions in vivo as an X-recognition element to recruit the DCC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Csankovszki, Gyorgyi -- McDonel, Patrick -- Meyer, Barbara J -- F32-GM065007/GM/NIGMS NIH HHS/ -- R37-GM30702/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 20;303(5661):1182-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976312" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Base Sequence ; Binding Sites ; Caenorhabditis elegans/*genetics/metabolism ; Caenorhabditis elegans Proteins/*metabolism ; Carrier Proteins/metabolism ; Chromosomes/metabolism ; Cosmids ; DNA-Binding Proteins/metabolism ; Disorders of Sex Development ; *Dosage Compensation, Genetic ; Female ; In Situ Hybridization, Fluorescence ; Male ; Models, Genetic ; Molecular Sequence Data ; Nuclear Proteins/metabolism ; Repetitive Sequences, Nucleic Acid ; X Chromosome/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-11-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, Guido -- Brose, Nils -- New York, N.Y. -- Science. 2003 Nov 21;302(5649):1341-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Neuroscience, Max Planck Institute for Experimental Medicine, D-37075 Gottingen, Germany. gmeyer@em.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14631024" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; COS Cells ; Cell Cycle ; Cells, Cultured ; Cysteine Endopeptidases/metabolism ; Dendrites/*physiology/ultrastructure ; Down-Regulation ; GTPase-Activating Proteins/chemistry/*metabolism ; Hippocampus/cytology/metabolism ; Multienzyme Complexes/metabolism ; Nerve Tissue Proteins/metabolism ; Neuronal Plasticity/*physiology ; Phosphorylation ; Proteasome Endopeptidase Complex ; Protein Kinases/*metabolism ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases ; Recombinant Proteins/metabolism ; Signal Transduction ; Synapses/*physiology ; Two-Hybrid System Techniques ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2004-05-29
    Description: Cytokinesis is the essential process that partitions cellular contents into daughter cells. To identify and characterize cytokinesis proteins rapidly, we used a functional proteomic and comparative genomic strategy. Midbodies were isolated from mammalian cells, proteins were identified by multidimensional protein identification technology (MudPIT), and protein function was assessed in Caenorhabditis elegans. Of 172 homologs disrupted by RNA interference, 58% displayed defects in cleavage furrow formation or completion, or germline cytokinesis. Functional dissection of the midbody demonstrated the importance of lipid rafts and vesicle trafficking pathways in cytokinesis, and the utilization of common membrane cytoskeletal components in diverse morphogenetic events in the cleavage furrow, the germline, and neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679889/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679889/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skop, Ahna R -- Liu, Hongbin -- Yates, John 3rd -- Meyer, Barbara J -- Heald, Rebecca -- F32 GM064159/GM/NIGMS NIH HHS/ -- F32 GM064159-01/GM/NIGMS NIH HHS/ -- F32 GM064159-02/GM/NIGMS NIH HHS/ -- F32 GM064159-03/GM/NIGMS NIH HHS/ -- F32 GM64159-01/GM/NIGMS NIH HHS/ -- P41 RR011823/RR/NCRR NIH HHS/ -- RR1823/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 2;305(5680):61-6. Epub 2004 May 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA. skop@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166316" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CHO Cells ; Caenorhabditis elegans/cytology/genetics/physiology ; Carrier Proteins/analysis/isolation & purification/physiology ; Cell Cycle/physiology ; *Cell Division ; Cell Fractionation ; Cell Membrane/physiology ; Computational Biology ; Cricetinae ; Cytoskeletal Proteins/analysis/isolation & purification/physiology ; Cytoskeleton/physiology ; Germ Cells/physiology ; HeLa Cells ; Humans ; Membrane Microdomains/physiology ; Morphogenesis ; Organelles/chemistry/*physiology ; Protein Transport ; Proteins/analysis/isolation & purification/*physiology ; Proteome/*analysis ; Proteomics ; Signal Transduction ; Spindle Apparatus/physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2003-03-22
    Description: Lake Victoria harbors a unique species-rich flock of more than 500 endemic haplochromine cichlid fishes. The origin, age, and mechanism of diversification of this extraordinary radiation are still debated. Geological evidence suggests that the lake dried out completely about 14,700 years ago. On the basis of phylogenetic analyses of almost 300 DNA sequences of the mitochondrial control region of East African cichlids, we find that the Lake Victoria cichlid flock is derived from the geologically older Lake Kivu. We suggest that the two seeding lineages may have already been lake-adapted when they colonized Lake Victoria. A haplotype analysis further shows that the most recent desiccation of Lake Victoria did not lead to a complete extinction of its endemic cichlid fauna and that the major lineage diversification took place about 100,000 years ago.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verheyen, Erik -- Salzburger, Walter -- Snoeks, Jos -- Meyer, Axel -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):325-9. Epub 2003 Mar 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vertebrate Department, Royal Belgian Institute of Natural Sciences, Vautierstraat 29, 1000 Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12649486" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Eastern ; Animals ; *Biological Evolution ; Cichlids/*genetics/physiology ; DNA, Mitochondrial/genetics ; Ecosystem ; Fresh Water ; *Genetic Variation ; Geography ; Haplotypes ; Phylogeny ; Sequence Analysis, DNA ; Tanzania ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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