Publication Date:
2002-07-06
Description:
Drosophila host defense to fungal and Gram-positive bacterial infection is mediated by the Spaetzle/Toll/cactus gene cassette. It has been proposed that Toll does not function as a pattern recognition receptor per se but is activated through a cleaved form of the cytokine Spaetzle. The upstream events linking infection to the cleavage of Spaetzle have long remained elusive. Here we report the identification of a central component of the fungal activation of Toll. We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ligoxygakis, Petros -- Pelte, Nadege -- Hoffmann, Jules A -- Reichhart, Jean-Marc -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):114-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R. Descartes, F67084 Strasbourg Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098703" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Chromosome Mapping
;
Drosophila/genetics/immunology/*metabolism/*microbiology
;
Drosophila Proteins/*blood/chemistry/*genetics/*metabolism
;
Escherichia coli/physiology
;
Female
;
Gene Expression Regulation
;
Genes, Insect
;
Gram-Positive Cocci/physiology
;
Hemolymph/immunology/metabolism
;
Hypocreales/*physiology
;
Insect Proteins/genetics/metabolism
;
Male
;
Molecular Sequence Data
;
Mutation
;
Protein Sorting Signals
;
Protein Structure, Tertiary
;
Receptors, Cell Surface/genetics/*metabolism
;
Serine Endopeptidases/*blood/chemistry/*genetics
;
Toll-Like Receptors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink