Publication Date:
2003-09-23
Description:
Mammals can be trained to make a conditioned movement at a precise time, which is correlated to the interval between the conditioned stimulus and unconditioned stimulus during the learning. This learning-dependent timing has been shown to depend on an intact cerebellar cortex, but which cellular process is responsible for this form of learning remains to be demonstrated. Here, we show that protein kinase C-dependent long-term depression in Purkinje cells is necessary for learning-dependent timing of Pavlovian-conditioned eyeblink responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koekkoek, S K E -- Hulscher, H C -- Dortland, B R -- Hensbroek, R A -- Elgersma, Y -- Ruigrok, T J H -- De Zeeuw, C I -- New York, N.Y. -- Science. 2003 Sep 19;301(5640):1736-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14500987" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Blinking
;
Cerebellum/*physiology
;
*Conditioning, Eyelid
;
Electroshock
;
*Learning
;
*Long-Term Synaptic Depression
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Mutation
;
N-Methylaspartate/pharmacology
;
Protein Kinase C/genetics/metabolism
;
Purkinje Cells/*physiology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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