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  • Animals  (5)
  • United States  (3)
  • American Association for the Advancement of Science (AAAS)  (8)
  • 2000-2004  (4)
  • 1980-1984  (4)
  • 1950-1954
  • 1
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    Biomedicine. Do G quartets orchestrate fragile X pathology? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moine, H -- Mandel, J L -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2487-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UPR9002 CNRS, 67084 Strasbourg Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752559" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Brain/metabolism ; Crystallography, X-Ray ; Fragile X Mental Retardation Protein ; Fragile X Syndrome/genetics/*metabolism ; Gene Expression Regulation ; Humans ; Mice ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Nucleic Acid Conformation ; Oligonucleotide Array Sequence Analysis ; Protein Biosynthesis ; Protein Structure, Tertiary ; RNA, Messenger/*chemistry/genetics/*metabolism ; *RNA-Binding Proteins ; Synapses/physiology ; Untranslated Regions
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    NIH budget grows, but not R01 success rates (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- Vesell, E S -- New York, N.Y. -- Science. 2001 Oct 5;294(5540):54-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11589231" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; Peer Review, Research ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Biomedicine. Huntingtin--profit and loss (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trottier, Y -- Mandel, J L -- New York, N.Y. -- Science. 2001 Jul 20;293(5529):445-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IGBMC-CNRS-INSERM-ULP, Illkirch Cedex 67404, C.U. de Strasbourg, France. yvon@titus.u-strasbg.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11463904" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Brain-Derived Neurotrophic Factor/genetics/*metabolism ; CREB-Binding Protein ; Caspases/metabolism ; Cells, Cultured ; Cerebral Cortex/*metabolism/pathology ; Corpus Striatum/*metabolism/pathology ; Gene Expression Regulation ; Humans ; Huntington Disease/genetics/*metabolism/pathology ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/chemistry/genetics/*physiology ; Neurons/*metabolism/pathology ; Nuclear Proteins/chemistry/genetics/metabolism/*physiology ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Corepressor-dependent silencing of chromosomal regions encoding neuronal genes (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-26
    Description: The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lunyak, Victoria V -- Burgess, Robert -- Prefontaine, Gratien G -- Nelson, Charles -- Sze, Sing-Hoi -- Chenoweth, Josh -- Schwartz, Phillip -- Pevzner, Pavel A -- Glass, Christopher -- Mandel, Gail -- Rosenfeld, Michael G -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1747-52. Epub 2002 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093-0648, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399542" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Carrier Proteins ; Cell Line ; *Chromosomal Proteins, Non-Histone ; Chromosomes/*genetics/metabolism ; Chromosomes, Human/genetics/metabolism ; Co-Repressor Proteins ; Computational Biology ; CpG Islands ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; *Gene Silencing ; Histone Deacetylases/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Methyl-CpG-Binding Protein 2 ; Mice ; Models, Genetic ; NAV1.2 Voltage-Gated Sodium Channel ; Nerve Growth Factors/genetics ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Neurons/*metabolism ; Promoter Regions, Genetic ; Protein Structure, Tertiary ; Rats ; Repressor Proteins/chemistry/*metabolism ; Sodium Channels/genetics ; Transcription Factors/chemistry/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Funding more NIH research grants (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-22
    Description: Because of the prospect of a serious decline in the nation's biomedical research capacity owing to diminished federal appropriations, temporary measures should be initiated promptly by the National Institutes of Health to preserve the stability of resources and diversity of research required for future productivity. It is recommended that the available funds be distributed in such a way as to permit some support for 50 percent of competing grant applications approved by the National Institutes of Health study sections. Measures proposed for consideration are a sliding scale for funding, a greater across-the-board reduction, a limit on support for an individual laboratory, and a review of indirect costs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):338-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867712" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.)/organization & administration ; *Research Support as Topic/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Amiloride inhibited the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. Measurements of the ouabain-sensitive QO2 in the presence of nystatin, the tissue sodium and potassium contents of the tubules in suspension, and the sodium- and potassium-dependent adenosinetriphosphatase (Na,K-ATPase) activity of lysed tubule membranes indicated that the effect of amiloride was due to a direct inhibition of the Na,K-ATPase activity of the proximal tubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soltoff, S P -- Mandel, L J -- AM26816/AM/NIADDK NIH HHS/ -- GM29256/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):957-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302840" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Ion Channels/drug effects ; Kidney Tubules, Proximal/drug effects/*enzymology ; Nystatin/pharmacology ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Pyrazines/*pharmacology ; Rabbits ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Crisis in NIH funding (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesell, E S -- Mandel, H G -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063837" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; Research Support as Topic/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Oxygen consumption and cellular ion transport: evidence for adenosine triphosphate to O2 ratio near 6 in intact cell (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: Oxygen (O2) consumption and net K+ uptake were measured simultaneously upon reintroduction of K+ into a K+-depleted suspension of renal tubules. The K+/O2 stoichiometries of 11.8 +/- 0.2 and 8.4 +/- 0.6 were obtained for reduced nicotinamide adenine dinucleotide- and flavoprotein-linked substrates, respectively. These values complement classical K+ to adenosine triphosphate (ATP) and ATP/O2 stoichiometries, thereby demonstrating a remarkably efficient coupling between the processes of Na+- and K+-dependent adenosinetriphosphatase-mediated ion transport and oxidative phosphorylation within the intact cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, S I -- Balaban, R S -- Mandel, L J -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1148-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246581" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*metabolism ; Animals ; Biological Transport, Active ; Kidney Tubules/metabolism ; Mitochondria/metabolism ; NAD/metabolism ; Ouabain/pharmacology ; *Oxidative Phosphorylation ; *Oxygen Consumption/drug effects ; Potassium/*metabolism ; Rabbits ; Sodium-Potassium-Exchanging ATPase/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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