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  • Animals  (13)
  • Life Sciences (General)  (8)
  • 2000-2004  (15)
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  • 1
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    Livestock diseases and human health (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-10-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zinsstag, J -- Weiss, M G -- New York, N.Y. -- Science. 2001 Oct 19;294(5542):477.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11641468" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Animal Diseases/prevention & control/transmission ; Animal Husbandry ; Animal Welfare ; Animals ; *Animals, Domestic ; Cattle ; Encephalopathy, Bovine Spongiform/prevention & control/transmission ; Foot-and-Mouth Disease/prevention & control/transmission ; *Health ; *Health Policy ; Humans
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Why stem cells? (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-02-26
    Beschreibung: Stem cells are viewed from the perspectives of their function, evolution, development, and cause. Counterintuitively, most stem cells may arise late in development, to act principally in tissue renewal, thus ensuring an organism's long-term survival. Surprisingly, recent reports suggest that tissue-specific adult stem cells have the potential to contribute to replenishment of multiple adult tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Kooy, D -- Weiss, S -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1439-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada. derek.van.der.kooy@utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688784" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Bone Marrow Cells/cytology/physiology ; Cell Differentiation ; Cell Division ; Cell Lineage ; Embryo, Mammalian/cytology ; Germ Cells/cytology/physiology ; Hematopoietic Stem Cells/cytology/physiology ; Humans ; Neurons/cytology ; Stem Cells/cytology/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Food science. Why is a soggy potato chip unappetizing? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-09-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, G -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546850" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cooking ; Elasticity ; Fats/metabolism ; *Food ; Food Analysis ; *Food Preferences/physiology/psychology ; Hot Temperature ; Humans ; Perception ; *Research ; *Sensation ; Smell ; Taste ; Viscosity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-11-25
    Beschreibung: Calcium ion (Ca2+) influx through voltage-gated Ca2+ channels is important for the regulation of vascular tone. Activation of L-type Ca2+ channels initiates muscle contraction; however, the role of T-type Ca2+ channels (T-channels) is not clear. We show that mice deficient in the alpha1H T-type Ca2+ channel (alpha(1)3.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from alpha(1)3.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Chien-Chang -- Lamping, Kathryn G -- Nuno, Daniel W -- Barresi, Rita -- Prouty, Sally J -- Lavoie, Julie L -- Cribbs, Leanne L -- England, Sarah K -- Sigmund, Curt D -- Weiss, Robert M -- Williamson, Roger A -- Hill, Joseph A -- Campbell, Kevin P -- New York, N.Y. -- Science. 2003 Nov 21;302(5649):1416-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14631046" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/pharmacology ; Animals ; Arteries/drug effects/*physiology ; Calcium/*metabolism ; Calcium Channels, T-Type/genetics/*physiology ; Coronary Vessels/drug effects/pathology/*physiology ; Echocardiography ; Electrocardiography ; Endothelium, Vascular/drug effects/physiology ; Female ; Fibrosis ; Ganglia, Spinal/cytology ; Gene Targeting ; Heart/physiology ; Heart Rate ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Smooth, Vascular/physiology ; Myocardium/pathology ; Neurons/metabolism ; Nickel/pharmacology ; Nitric Oxide/physiology ; Nitric Oxide Donors/pharmacology ; Nitroprusside/pharmacology ; Patch-Clamp Techniques ; Vasoconstriction/drug effects ; *Vasodilation/drug effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-01-04
    Beschreibung: Neurogenesis occurs in the olfactory system of the adult brain throughout life, in both invertebrates and vertebrates, but its physiological regulation is not understood. We show that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin. The progenitors then migrate to produce new olfactory interneurons, a process likely to be important for maternal behavior, because olfactory discrimination is critical for recognition and rearing of offspring. Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shingo, Tetsuro -- Gregg, Christopher -- Enwere, Emeka -- Fujikawa, Hirokazu -- Hassam, Rozina -- Geary, Colleen -- Cross, James C -- Weiss, Samuel -- New York, N.Y. -- Science. 2003 Jan 3;299(5603):117-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genes & Development Research Group, Department of Cell Biology and Anatomy, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12511652" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Division ; Cell Movement ; Cells, Cultured ; Choroid Plexus/metabolism ; Dentate Gyrus/cytology ; Epidermal Growth Factor/pharmacology ; Estradiol/administration & dosage/pharmacology ; Female ; Interneurons/cytology/*physiology ; Male ; Mice ; Neurons/cytology/*physiology ; Olfactory Bulb/*cytology ; Pregnancy ; Progesterone/administration & dosage/pharmacology ; Prolactin/administration & dosage/blood/pharmacology/*physiology ; Prosencephalon/*cytology/*physiology ; Pseudopregnancy ; Receptors, Prolactin/genetics/metabolism ; Signal Transduction ; Stem Cells/*cytology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Neutrophil extracellular traps kill bacteria (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-03-06
    Beschreibung: Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkmann, Volker -- Reichard, Ulrike -- Goosmann, Christian -- Fauler, Beatrix -- Uhlemann, Yvonne -- Weiss, David S -- Weinrauch, Yvette -- Zychlinsky, Arturo -- AI037720/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001782" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Appendicitis/immunology ; Bacterial Proteins/metabolism ; Blood Bactericidal Activity ; Cytochalasin D/pharmacology ; Cytoplasmic Granules/metabolism ; DNA/analysis/metabolism ; Dysentery, Bacillary/immunology ; Endopeptidases/metabolism ; Histones/analysis/metabolism ; Humans ; *Immunity, Innate ; Leukocyte Elastase/analysis/metabolism ; Microscopy, Electron ; *Neutrophil Activation ; Neutrophils/chemistry/*immunology/physiology/ultrastructure ; Phagocytosis ; Rabbits ; Salmonella typhimurium/immunology/*physiology ; Shigella flexneri/immunology/*physiology ; Staphylococcus aureus/immunology/*physiology ; Virulence Factors/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Cancer risks. Acrylamide in food: uncharted territory (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-07-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, Giselle -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098675" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acrylamide/*adverse effects/*analysis/metabolism ; Advisory Committees ; Animals ; *Carcinogens/analysis ; *Cooking ; *Food ; Food Analysis ; Humans ; Neurons/metabolism ; Protein Binding ; Proteins/metabolism ; Temperature ; World Health Organization
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Human T cell leukemia viruses use a receptor determined by human chromosome 17 (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1988-12-16
    Beschreibung: Human T cell leukemia viruses (HTLV-I and HTLV-II) can infect many cell types in vitro. HTLV-I and HTLV-II use the same cell surface receptor, as shown by interference with syncytium formation and with infection by vesicular stomatitis virus (VSV) pseudotypes bearing the HTLV envelope glycoproteins. Human-mouse somatic cell hybrids were used to determine which human chromosome was required to confer susceptibility to VSV(HTLV) infection. The only human chromosome common to all susceptible cell hybrids was chromosome 17, and the receptor gene was localized to 17cen-qter. Antibodies to surface antigens known to be determined by genes on 17q did not block the HTLV receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sommerfelt, M A -- Williams, B P -- Clapham, P R -- Solomon, E -- Goodfellow, P N -- Weiss, R A -- New York, N.Y. -- Science. 1988 Dec 16;242(4885):1557-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chester Beatty Laboratories, Institute of Cancer Research, London, U.K.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3201246" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cattle ; Cell Line ; Chromosome Mapping ; *Chromosomes, Human, Pair 17 ; Cricetinae ; *Genes ; Human T-lymphotropic virus 1/*physiology ; Human T-lymphotropic virus 2/*physiology ; Humans ; Hybrid Cells/cytology/microbiology ; Mice ; Rats ; Receptors, Virus/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Beta-N-methylamino-L-alanine neurotoxicity: requirement for bicarbonate as a cofactor (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1988-08-19
    Beschreibung: Ingestion of the excitotoxic cycad seed amino acid beta-N-methylamino-L-alanine may be responsible for the neuronal degeneration associated with Guam amyotrophic lateral sclerosis-parkinsonism-dementia in man. However, the basis for the central neurotoxicity of beta-N-methylamino-L-alanine has been unclear, as it lacks the omega acidic (or equivalent electronegative) moiety characteristic of other excitatory amino acids. beta-N-methylamino-L-alanine produced neurotoxic and neuroexcitatory effects in murine cortical cell cultures only when physiological concentrations of bicarbonate were available in the extracellular bathing medium. Bicarbonate may interact noncovalently with beta-N-methylamino-L-alanine to produce, in combination, a molecular configuration that activates glutamate receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, J H -- Choi, D W -- NS12151/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Aug 19;241(4868):973-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Stanford University Medical Center, Stanford 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3136549" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acids, Diamino/*toxicity ; Animals ; Bicarbonates/*metabolism ; Cells, Cultured ; Cerebral Cortex/*drug effects ; Electrophysiology ; Hydrogen-Ion Concentration ; Mice ; Microelectrodes ; Neurons/*drug effects ; Oxadiazoles/toxicity ; Quisqualic Acid ; beta-Alanine/analogs & derivatives/toxicity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1986-05-23
    Beschreibung: Infection of the central nervous system by mouse hepatitis virus strain A59, a murine neurotropic coronavirus, induces class I major histocompatibility complex antigens on mouse oligodendrocytes and astrocytes, cells that do not normally express these antigens on their surfaces. This induction, which occurs through soluble factors elaborated by infected glial cells, potentially allows immunocytes to interact with the glial cells and may play a critical role in the pathogenesis of virus-induced, immune-mediated demyelination in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suzumura, A -- Lavi, E -- Weiss, S R -- Silberberg, D H -- NS11037/NS/NINDS NIH HHS/ -- NS21954/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1986 May 23;232(4753):991-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3010460" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Astrocytes/*immunology ; Cells, Cultured ; Fluorescent Antibody Technique ; H-2 Antigens/*immunology ; Hepatitis, Viral, Animal/*immunology ; Macrophages/immunology ; Mice ; Murine hepatitis virus/immunology ; Neuroglia/*immunology ; Oligodendroglia/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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