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  • United States  (12)
  • American Association for the Advancement of Science (AAAS)  (11)
  • Nature Publishing Group (NPG)  (1)
  • American Geophysical Union (AGU)
  • American Physical Society
  • Springer
  • 2005-2009  (12)
  • 1935-1939
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (11)
  • Nature Publishing Group (NPG)  (1)
  • American Geophysical Union (AGU)
  • American Physical Society
  • Springer
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Year
  • 1
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    Proportionally more deleterious genetic variation in European than in African populations (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-02-22
    Description: Quantifying the number of deleterious mutations per diploid human genome is of crucial concern to both evolutionary and medical geneticists. Here we combine genome-wide polymorphism data from PCR-based exon resequencing, comparative genomic data across mammalian species, and protein structure predictions to estimate the number of functionally consequential single-nucleotide polymorphisms (SNPs) carried by each of 15 African American (AA) and 20 European American (EA) individuals. We find that AAs show significantly higher levels of nucleotide heterozygosity than do EAs for all categories of functional SNPs considered, including synonymous, non-synonymous, predicted 'benign', predicted 'possibly damaging' and predicted 'probably damaging' SNPs. This result is wholly consistent with previous work showing higher overall levels of nucleotide variation in African populations than in Europeans. EA individuals, in contrast, have significantly more genotypes homozygous for the derived allele at synonymous and non-synonymous SNPs and for the damaging allele at 'probably damaging' SNPs than AAs do. For SNPs segregating only in one population or the other, the proportion of non-synonymous SNPs is significantly higher in the EA sample (55.4%) than in the AA sample (47.0%; P 〈 2.3 x 10(-37)). We observe a similar proportional excess of SNPs that are inferred to be 'probably damaging' (15.9% in EA; 12.1% in AA; P 〈 3.3 x 10(-11)). Using extensive simulations, we show that this excess proportion of segregating damaging alleles in Europeans is probably a consequence of a bottleneck that Europeans experienced at about the time of the migration out of Africa.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923434/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923434/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lohmueller, Kirk E -- Indap, Amit R -- Schmidt, Steffen -- Boyko, Adam R -- Hernandez, Ryan D -- Hubisz, Melissa J -- Sninsky, John J -- White, Thomas J -- Sunyaev, Shamil R -- Nielsen, Rasmus -- Clark, Andrew G -- Bustamante, Carlos D -- P50 GM065509/GM/NIGMS NIH HHS/ -- P50 GM065509-070006/GM/NIGMS NIH HHS/ -- R01 HG003229/HG/NHGRI NIH HHS/ -- R01 HG003229-03/HG/NHGRI NIH HHS/ -- R01 HL072904/HL/NHLBI NIH HHS/ -- England -- Nature. 2008 Feb 21;451(7181):994-7. doi: 10.1038/nature06611.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18288194" target="_blank"〉PubMed〈/a〉
    Keywords: Africa/ethnology ; Alleles ; Computational Biology ; Emigration and Immigration ; Europe/ethnology ; Exons/genetics ; Genome, Human/*genetics ; Heterozygote ; Homozygote ; Humans ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide/*genetics ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    An open letter to Elias Zerhouni (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altman, Sidney -- Bassler, Bonnie L -- Beckwith, Jon -- Belfort, Marlene -- Berg, Howard C -- Bloom, Barry -- Brenchley, Jean E -- Campbell, Allan -- Collier, R John -- Connell, Nancy -- Cozzarelli, Nicholas R -- Craig, Nancy L -- Darst, Seth -- Ebright, Richard H -- Elledge, Stephen J -- Falkow, Stanley -- Galan, Jorge E -- Gottesman, Max -- Gourse, Richard -- Grindley, Nigel D F -- Gross, Carol A -- Grossman, Alan -- Hochschild, Ann -- Howe, Martha -- Hurwitz, Jerard -- Isberg, Ralph R -- Kaplan, Samuel -- Kornberg, Arthur -- Kustu, Sydney G -- Landick, Robert C -- Landy, Arthur -- Levy, Stuart B -- Losick, Richard -- Long, Sharon R -- Maloy, Stanley R -- Mekalanos, John J -- Neidhardt, Frederick C -- Pace, Norman R -- Ptashne, Mark -- Roberts, Jeffrey W -- Roth, John R -- Rothman-Denes, Lucia B -- Salyers, Abigail -- Schaechter, Moselio -- Shapiro, Lucy -- Silhavy, Thomas J -- Simon, Melvin I -- Walker, Graham -- Yanofsky, Charles -- Zinder, Norton -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1409-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15746409" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare ; *Biomedical Research/economics ; *Bioterrorism ; Financing, Government ; *Microbiology ; *National Institutes of Health (U.S.) ; Peer Review, Research ; Public Health ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Epidemiology. DNA identifications after the 9/11 World Trade Center attack (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-19
    Description: The attack on the World Trade Center on 9/11/2001 challenged current approaches to forensic DNA typing methods. The large number of victims and the extreme thermal and physical conditions of the site necessitated special approaches to the DNA-based identification. Because of these and many additional challenges, new procedures were created or modified from routine forensic protocols. This effort facilitated the identification of 1594 of the 2749 victims. In this Policy Forum, the authors, who were were members of the World Trade Center Kinship and Data Analysis Panel, review the lessons of the attack response from the perspective of DNA forensic identification and suggest policies and procedures for future mass disasters or large-scale terrorist attacks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biesecker, Leslie G -- Bailey-Wilson, Joan E -- Ballantyne, Jack -- Baum, Howard -- Bieber, Frederick R -- Brenner, Charles -- Budowle, Bruce -- Butler, John M -- Carmody, George -- Conneally, P Michael -- Duceman, Barry -- Eisenberg, Arthur -- Forman, Lisa -- Kidd, Kenneth K -- Leclair, Benoit -- Niezgoda, Steven -- Parsons, Thomas J -- Pugh, Elizabeth -- Shaler, Robert -- Sherry, Stephen T -- Sozer, Amanda -- Walsh, Anne -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1122-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293742" target="_blank"〉PubMed〈/a〉
    Keywords: Dna ; *DNA Fingerprinting/methods ; DNA, Mitochondrial ; Disaster Planning ; Family ; Female ; Forecasting ; Genetic Markers ; Humans ; Male ; *September 11 Terrorist Attacks ; Specimen Handling ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Retrospective: Stanley Joel Korsmeyer (1950-2005) (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ley, Timothy J -- New York, N.Y. -- Science. 2005 May 6;308(5723):803-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine and Genetics, Washington University, St. Louis, MO 63110, USA. tley@im.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879200" target="_blank"〉PubMed〈/a〉
    Keywords: Apoptosis ; B-Lymphocytes/physiology ; Cell Survival ; *Genes, bcl-2 ; History, 20th Century ; History, 21st Century ; Molecular Biology/history ; Neoplasms/physiopathology ; Proto-Oncogene Proteins c-bcl-2/physiology ; T-Lymphocytes/physiology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Oceans. U.S. ocean fish recovery: staying the course (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Safina, Carl -- Rosenberg, Andrew A -- Myers, Ransom A -- Quinn, Terrance J 2nd -- Collie, Jeremy S -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):707-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marine Sciences Research Center, Stony Brook University, Stony Brook NY 11794, USA. csafina@blueocean.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051773" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conservation of Natural Resources/*legislation & jurisprudence ; *Ecosystem ; Fisheries/*legislation & jurisprudence ; *Fishes ; Guidelines as Topic ; Oceans and Seas ; Population Dynamics ; *Seawater ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    U.S. concerns over bluetongue (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-05-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbs, E Paul J -- Tabachnick, Walter J -- Holt, Thomas J -- Stallknecht, David E -- New York, N.Y. -- Science. 2008 May 16;320(5878):872. doi: 10.1126/science.320.5878.872a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18487171" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic/virology ; Animals, Wild/virology ; Bluetongue/epidemiology/*virology ; Bluetongue virus/classification/*isolation & purification ; Hemorrhagic Disease Virus, Epizootic/classification/*isolation & purification ; Population Surveillance ; Reoviridae Infections/epidemiology/*veterinary/virology ; Serotyping ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Sociology. The gender gap in NIH grant applications (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-12-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ley, Timothy J -- Hamilton, Barton H -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1472-4. doi: 10.1126/science.1165878.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Washington University Medical School, St. Louis, MO 63130, USA. timley@wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056961" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research/economics ; *Career Mobility ; Education, Graduate ; Education, Medical ; Female ; Humans ; Male ; National Institutes of Health (U.S.)/economics/*statistics & numerical data ; Research Support as Topic/*statistics & numerical data ; Sex Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Robot inventors: patently impossible? (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevenson, Robert W -- Murphy, Joseph F -- Clare, Thomas J -- New York, N.Y. -- Science. 2009 May 22;324(5930):1014. doi: 10.1126/science.324_1014a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Caesar, Rivise, Bernstein, Cohen, and Pokotilow, Ltd., 1635 Market Street, 11th Floor, Philadelphia, PA 19103, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19460985" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; Patents as Topic/*legislation & jurisprudence ; *Robotics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Resource policy. Wood energy in America (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richter, Daniel Deb Jr -- Jenkins, Dylan H -- Karakash, John T -- Knight, Josiah -- McCreery, Lew R -- Nemestothy, Kasimir P -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1432-3. doi: 10.1126/science.1166214.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University Program in Ecology, Southern Center for Sustainable Forests, Nicholas School of the Environment, Duke University, Durham, NC 27708, USA. drichter@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286539" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources ; Ecosystem ; *Energy-Generating Resources ; Europe ; *Trees ; United States ; *Wood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    A lupus drug and FDA approval (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merrill, Joan T -- Raymond, Sandra -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):497; author reply 497.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845832" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; *Drug Approval ; Drug Industry ; Humans ; Lupus Erythematosus, Systemic/*drug therapy ; Lupus Nephritis/*drug therapy ; Oligonucleotides/*therapeutic use ; United States ; *United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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