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  • Articles  (41)
  • Springer  (41)
  • 2005-2009  (2)
  • 1985-1989  (11)
  • 1970-1974  (11)
  • 1920-1924  (1)
  • 1905-1909  (16)
  • Chemistry and Pharmacology  (41)
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  • Articles  (41)
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  • 1
    Electronic Resource
    Electronic Resource
    Angle-resolved thermal desorption of atoms from solid surfaces: one-phonon mechanism (1987)
    Springer
    Theoretical chemistry accounts 72 (1987), S. 475-484 
    Details
    ISSN: 1432-2234
    Keywords: Desorption ; Phonons ; Thermal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A model for one-phonon thermal desorption is presented in which the structure of the substrate phonons, expressed as a projection on a surface atom of the phonon density of states, appears as a separate factor in the angle- and energy-resolved desorption rate. Desorption from both localized, and delocalized initioladatom states is considered. Under certain circumstances one can obtain the cosine-distribution of the equilibrium theory, but in general, the desorption flux from delocalized states deviates from the cosine law by being peaked away from the surface normal, whereas for localized initiol states, the flux is concentrated more in the normal direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01192236
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  • 2
    Electronic Resource
    Electronic Resource
    A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in Plasma (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 133-136 
    Details
    ISSN: 1573-904X
    Keywords: etintidine ; high-performance liquid chromatography (HPLC) ; solid extraction ; determination of etintidine in plasma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper describes a new, rapid solid extraction method for the determination of etintidine in plasma. The method employs a semiautomatic sample preparation system. Plasma samples and the internal standard (cimetidine) were applied onto octyl-bonded silica extraction columns. The extraction columns were then subjected to Tris buffer and water wash and were subsequently loaded onto an automatic sample injection system. The contents of the extraction columns were eluted on-line with a mobile phase of acetonitrile:methanol:0.1% ammonium hydroxide (85:10:5, by volume) onto a silica analytical column and detected by UV absorption at 229 nm. The chromatographic condition separates etintidine from some of its metabolites and other endogenous components in plasma. The detection limit for etintidine was 0.02–0.05 µg/ml when 0.2 ml of plasma was used. This method has been used for the determination of plasma etintidine levels in humans and mice after oral administration of etintidine and was found to be suitable for pharmacokinetic/bioavailability studies of etintidine in humans and animals. The method can also be used for the quantitative determination of cimetidine and certain metabolites of etintidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016419019715
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemical polymorphisms in feral and inbred mice (Mus musculus) (1971)
    Springer
    Biochemical genetics 5 (1971), S. 457-466 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Examination of the frequencies of several loci controlling isozymes in three geographically distinct feral populations of mice showed the average animal to be heterozygous at 10.3% of his loci. There was no evidence for interaction between loci, nor any evidence for inbreeding in the populations. Thirty-nine inbred strains, including four newly derived ones, were also characterized for their alleles for as many as 16 polymorphic loci. Among these strains, variability is at least as great as in any single feral population, but probably less than that found among all feral populations of the species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00487135
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  • 4
    Electronic Resource
    Electronic Resource
    Genetics of human-mouse somatic cell hybrids: Linkage of human genes for isocitrate dehydrogenase and malate dehydrogenase (1972)
    Springer
    Biochemical genetics 7 (1972), S. 193-204 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Based on somatic cell genetic analysis, autosomal gene linkage is reported for the supernatant enzymes of human isocitrate dehydrogenase (IDH) and malate dehydrogenase (MDH) in human-mouse cell hybrids. The IDH, MDH linkage was not linked to the X and E 17 chromosomes or to 12 additional human enzyme markers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484817
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  • 5
    Electronic Resource
    Electronic Resource
    Observations on the regulation of uricase activity during development of Drosophila melanogaster (1973)
    Springer
    Biochemical genetics 8 (1973), S. 37-45 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract To elucidate the mechanisms involved in the regulation of uricase activity in Drosophila melanogaster, a comparative analysis of the patterns of uricase activity during development was undertaken for the wild type, Ore-R, and the mutants ry 2 and ma-1. Uricase activity in ry 2 and ma-l, unlike that in Ore-R, increased rapidly following emergence of the adult. This study indicates that uricase in Drosophila, in contrast to that in several microorganisms, is not induced by uric acid, since ry 2 and ma-l with no detectable uric acid have higher activity than the wild type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00485555
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  • 6
    Electronic Resource
    Electronic Resource
    Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse (1970)
    Springer
    Biochemical genetics 4 (1970), S. 707-718 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Malate dehydrogenase and malic enzyme each possess supernatant and mitochondrial molecular forms which are structurally and genetically independent. We describe electrophoretic variants of the mitochondrial enzymes of malate dehydrogenase and malic enzyme in mice. Progeny testing from genetic crosses indicated that the genes which code for mitochondrial malate dehydrogenase and malic enzyme were not inherited maternally but as independent unlinked nuclear autosomal genes. The locus for mitochondrial malic enzyme was located on linkage group I. Linkage analysis with a third mitochondrial enzyme marker, glutamic oxaloacetic transaminase, showed that the nuclear genes which code for the three mitochondrial enzymes were not closely linked to each other. This evidence suggests that clusters of nuclear genes coding for mitochondrial function are unlikely in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486384
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  • 7
    Electronic Resource
    Electronic Resource
    Control of lysosomal acid phosphatase expression in man-mouse cell hybrids (1974)
    Springer
    Biochemical genetics 11 (1974), S. 121-139 
    Details
    ISSN: 1573-4927
    Keywords: gene expression ; gene mapping ; lysosomal enzymes ; cell fusion ; gel electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Lysosomal acid phosphatase activity in human and mouse cells was separated into multiple zones by starch gel electrophoresis. One of the two major zones in the mouse was apparently extinguished when genetic information from man and the mouse was combined in proliferating man-mouse somatic cell hybrids. The evidence suggested that the absence of the mouse lysosomal acid phosphatase (mAP-1) was influenced by the human genome. The gene coding for human acid phosphatase (hAP-1) was shown to be unlinked to the presumed human component which extinguished the mouse acid phosphatase (mAP-1). The mechanism of “extinction” is postulated to be a modification in the processing of the mouse lysosomal enzyme. A dimeric structure was suggested for acid phosphatase-1 of man, mouse, and rat since a single hybrid enzyme was expressed in man-mouse and mouse-rat somatic cell hybrids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00485769
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical trial of iproplatin (cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum IV, CHIP) in patients with advanced breast cancer (1988)
    Springer
    Investigational new drugs 6 (1988), S. 87-91 
    Details
    ISSN: 1573-0646
    Keywords: breast cancer ; Iproplatin ; CHIP ; phase II study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-five women with advanced breast cancer were treated in a phase II trial of iproplatin 275 mg/m2 administered intravenously every 4 weeks. All patients had measurable or evaluable indicator lesions, and had undergone treatment with no more than one previous chemotherapy regimen, including adjuvant chemotherapy. Two of the twenty-four evaluable patients (8%) experienced major therapeutic responses. One patient had a complete regression of pulmonary nodules lasting 18 + months; another had a partial regression of metastatic disease in the liver (4 months). The inevaluable patient was ineligible for the study because of previous radiation to the indicator lesions on her chest wall; nonetheless, she experienced a 10 month partial regression of those nodules. Myelosuppression was generally dose limiting; thrombocytopenia was more profound, but leukopenia was more prolonged. Nausea, vomiting, diarrhea, and general malaise were prominent toxicities, and led to discontinuation of therapy in 4 patients. Iproplatin has limited activity in previously treated women with advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195365
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  • 9
    Electronic Resource
    Electronic Resource
    A phase I trial of intraperitoneal recombinant interleukin 2 in patients with ovarian carcinoma (1988)
    Springer
    Investigational new drugs 6 (1988), S. 179-188 
    Details
    ISSN: 1573-0646
    Keywords: intraperitoneal interleukin 2 ; ovarian carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seven patients with refractory stage III ovarian carcinoma were treated with escalating doses of human recombinant interleukin 2 (rIL-2) administered via the intraperitoneal (IP) route in an attempt to establish a dose and schedule of rIL-2 suitable for prolonged outpatient IP administration. Three patients went on to receive outpatient maintenance treatment twice weekly for 2–3 months. Doses ranged from 105 to 5 × 107 U/m2. The dose found most suitable for twice weekly outpatient IP administration was 106 U/m2. Dose-limiting toxicities consisted of diarrhea resulting in hypovolemia (5 patients) fever and chills (4 patients), nausea and vomiting (1 patient), mental status changes (2 patients), and azotemia (1 patient). These side effects were not prevented by indomethacin. Significant hypotension was not observed. Pharmacokinetic studies revealed extremely high IP concentrations of IL-2 which persisted for more than 24 hours. After a dose of 106 U/m2, the IP concentrations ranged from 670 to 760 U/ml. In one patient in whom concurrent serum concentrations were determined, the IP concentrations were over 100-fold higher than serum levels. After a dose of 107 U/m2, the IP concentrations of IL-2 ranged from 8700 to 14000. Concurrent serum levels in one patient revealed IP concentrations over 500-fold higher than serum levels. There were no consistent changes in T cell surface and activation markers on mononuclear cells from peripheral blood in 3 patients tested. Natural killer cell (NK) activity in peripheral blood increased in the three patients in whom it was measured. Four of the 7 patients progressed on treatment; 3 patients remained stable. We conclude that 106 U/m2 of rIL-2 is well-tolerated when administered by the IP route and that concentrations of IL-2 well in excess of that required to enhance cell-mediated cytotoxicity in vitro persist in the IP fluid for at least 24 hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175395
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  • 10
    Electronic Resource
    Electronic Resource
    Phase I clinical trial of doxorubicin and iproplatin combination chemotherapy in patients with breast cancer (1989)
    Springer
    Investigational new drugs 7 (1989), S. 189-193 
    Details
    ISSN: 1573-0646
    Keywords: doxorubicin ; iproplatin ; breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Forty-eight patients with advanced breast cancer were treated in a disease-specific phase I trial of doxorubicin and iproplatin combination chemotherapy. The doses of doxorubicin ranged between 30 and 50 mg/m2, and the doses of iproplatin ranged between 150 and 250 mg/m2. Myelosuppression was observed at all levels, but was dose-limiting at the highest level. In addition, nausea, diarrhea and malaise were prominent toxicities. Neither cardiac nor renal toxicity was encountered. Nine of 26 (35%) of previously untreated patients, and 5 of 22 (23%) previously treated patients demonstrated partial or complete responses. Although this combination possesses therapeutic activity, given its toxicities, further evaluation of doxorubicin in combination with iproplatin is not recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170856
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