Abstract
Based on somatic cell genetic analysis, autosomal gene linkage is reported for the supernatant enzymes of human isocitrate dehydrogenase (IDH) and malate dehydrogenase (MDH) in human-mouse cell hybrids. The IDH, MDH linkage was not linked to the X and E 17 chromosomes or to 12 additional human enzyme markers.
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Boone, C., Chen, T. R., and Ruddle, F. H. (1972). Proc. Natl. Acad. Sci. 69510.
Brewer, G. J. (1967). Am. J. Hum. Genet. 19674.
Chen, S. H., Malcom, L. A., Yoshida, A., and Gibletti, E. R. (1971). Am. J. Hum. Genet. 2387.
Davidson, R. G., and Cortner, J. A. (1967). Science 1571569.
Davidson, R. G., and Cortner, J. A., Rattazzi, M. C., Ruddle, F. H., and Lubs, H. A. (1970). Science 169391.
Detter, J. C., Ways, P. O., Giblett, E. R., Baughan, M. A., Hopkinson, D. A., Povery, S., and Harris, H. (1968). Ann. Hum. Genet. 31329.
Files, R. A., and Harris, H. (1966). Nature 209261.
Hayflick, L., and Moorhead, P. S. (1961). Exptl. Cell Res. 25585.
Henderson, N. S. (1965). J. Exptl. Zool. 158263.
Kao, F. T., and Puck, T. T. (1970). Nature 228329.
Kit, S., Dubbs, D. R., Piekarski, L. J., and Hsu, T. C. (1963). Exptl. Cell Res. 31297.
Klebe, R. J., Chen, T. R., and Ruddle, F. H. (1970a). J. Cell Biol. 4574.
Klebe, R. J., Chen, T. R., and Ruddle, F. H. (1970b). Proc. Natl. Acad. Sci. 661220.
Komma, D. J. (1963). J. Histochem. Cytochem. 11619.
Lewis, W. H. P., and Harris, H. (1967). Nature 215351.
Littlefield, J. W. (1964). Science 145709.
Matsuga, Y., Green, H., and Basilico, C. (1968). Nature 220119.
Meera Kahn, P., and Westerveld, A. (1971). Excerpa Med. 233120.
Migeon, B. R., and Childs, B. (1970). Progr. Med. Genet. VII1.
Migeon, B. R., and Miller, C. S. (1968). Science 1621005.
Miller, O. J., Allderdice, P. W., Miller, D. A., Breg, W. R., and Migeon, B. R. (1971a). Science 173244.
Miller, D. J., Cook, P. R., Khan, P. M., Shin, S., and Siniscalco, M. (1971b). Proc. Natl. Acad. Sci. 68116.
Nyhan, W. L., Barkay, B., Connor, J. D., Marks, J. F., and Keele, D. K. (1970). Proc. Natl. Acad. Sci. 65214.
Puck, T. T., Marcus, P. T., and Cieciura, S. J. (1956). J. Exptl. Med. 103273.
Ruddle, F. H., Chapman, V. M., Chen, T. R., and Klebe, R. J. (1970). Nature 227251.
Ruddle, F. H., Chapman, V. M., Ricciuti, F., Murnane, M., Klebe, R., and Meera Kahn, P. (1971) Nature 23269.
Santachiara, A. S., Nabholz, M., Miggiano, V., Darlington, A. J., and Bodmer, W. (1970). Nature 227248.
Shows, T. B. (1971). Excerpta Med. 233165.
Shows, T. B. (1972). Proc. Natl. Acad. Sci. 69348.
Shows, T. B., and Ruddle, F. H. (1968). Proc. Natl. Acad. Sci. 61574.
Shows, T. B., Tashian, R. E., Brewer, G. J., and Dern, R. J. (1964). Science 1451056.
Shows, T. B., Ruddle, F. H., and Roderick, T. H. (1969). Biochem. Genet. 325.
Shows, T. B., Chapman, V. M., and Ruddle, F. H. (1970). Biochem. Genet. 4707.
Siniscalco, M. (1970). Symposia of the International Society for Cell Biology, Academic Press, New York, Vol. 9, p. 205.
Van Gong, N., Billardon, C., Picard, J.-Y., Feingold, J., and Frezal, J. (1971). Excerpta Med. 233132.
Westerveld, A., Visser, R. P. L. S., Meera Kahn, P., and Bootsma, D. (1971). Nature 23420.
Weiss, M. C., and Green, H. (1967). Proc. Natl. Acad. Sci. 581104.
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This work was supported in part by grants from the U.S. Public Health Service (Child Health and Human Development) and the United Health Foundation of Western New York.
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Shows, T.B. Genetics of human-mouse somatic cell hybrids: Linkage of human genes for isocitrate dehydrogenase and malate dehydrogenase. Biochem Genet 7, 193–204 (1972). https://doi.org/10.1007/BF00484817
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DOI: https://doi.org/10.1007/BF00484817