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  • Computational Chemistry and Molecular Modeling  (3)
  • 2-hydroxypropyl β-CD
  • Petrocoptis
  • 2005-2009
  • 1990-1994  (6)
  • 1975-1979
Collection
Keywords
Publisher
Years
  • 2005-2009
  • 1990-1994  (6)
  • 1975-1979
Year
  • 1
    Electronic Resource
    Electronic Resource
    Isolation and characterization of two new N-glycosidase type-1 ribosome-inactivating proteins, unrelated in amino-acid sequence, fromPetrocoptis species (1994)
    Springer
    Planta 194 (1994), S. 487-491 
    Details
    ISSN: 1432-2048
    Keywords: Petrocoptis ; Petroglaucin ; Petrograndin ; Ribosome-inactivating protein ; rRNA N-glycosidase ; Translation (inhibition)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two new N-glycosidase type-1 ribosome-inactivating proteins (RIPs), denoted petroglaucin 1 and petrograndin, respectively, were isolated from the plantsPetrocoptis glaucifolia (Lag.) Boiss sp.viscosa (Rothm.) Laínz andPetrocoptis grandiflora Rothm. These new RIPs do not share H2N-terminal amino-acid sequence homology with petroglaucin (now denoted as petroglaucin 2), the only other type-1 RIP to be isolated fromP. glaucifolia (Arias et al. (1992) Planta186, 532–540). Petroglaucin 1 shares amino-acid sequence homology with RIPs from Cucurbitaceae while petroglaucin 2 and petrograndin do so with saporins and dianthin 30 (Caryophyllaceae). The new RIPs strongly inhibited protein synthesis at subnanomolar concentrations in rabbit reticulocyte lysates and other eukaryotic cell-free systems, but they were inactive on bacterial ribosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00714460
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation and partial characterization of a new ribosome-inactivating protein from Petrocoptis glaucifolia (Lag.) Boiss (1992)
    Springer
    Planta 186 (1992), S. 532-540 
    Details
    ISSN: 1432-2048
    Keywords: Petrocoptis ; Protein synthesis inhibitor ; Ribosome inactivating protein ; Translation (inhibition)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Petrocoptis glaucifolia, a paleoendemic member of the Caryophyllaceae from the North of Spain, was found to contain at least five proteins that inhibit protein synthesis in a rabbit reticulocyte lysate. One of them, for which the name petroglaucin is proposed, was purified to apparent electrophoretic homogeneity by chromatography through S-Sepharose Fast Flow, Sephadex G-75 and CM-Sepharose Fast Flow. The apparent Mr of the preparation was 27500. This protein does not contain appreciable glycan chains and displays 45.8% of NH2-terminal amino-acid sequence homology with some ribosome-inactivating proteins from Saponaria officinalis, another member of the Caryophyllaceae. Petroglaucin shows the following functional properties: (i) it strongly inhibits the rabbit-reticulocyte-lysate system and Vicia sativa cell-free extracts, both coded by endogenous messengers, and also inhibits poly(U)-directed polyphenylalanine synthesis by Vicia sativa cell-free extracts and purified rat-liver ribosomes; (ii) it shows much less inhibitory capacity in wheat-germ, Cucumis sativus and rat-liver cell-free systems coded by endogenous messengers; (iii) the inhibitory effects on purified rat-liver ribosomes were irreversible; (vi) it promotes the release of adenine from purified rat-liver ribosomes. The total activity of this translational inhibitor has been found to increase up to 11-fold during its purification, indicating that some regulatory factor that normally blocks the translational inhibitory activity of the ribosome-inactivating protein in crude extracts of the plant is removed during purification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198033
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  • 3
    Electronic Resource
    Electronic Resource
    Kinematic distribution function to calculate rotational populations of photofragments from photodissociation of triatomic molecules (1991)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 40 (1991), S. 359-370 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A general procedure to evaluate the rotational state population distributions of the nascent photofragments from the photodissociation of polyatomic molecules has been implemented with the use of the kinematic distribution function developed by Chen and Pei [Chem. Phys. Lett. 124, 365 (1986)]. Numerical evaluations of rotational state population distributions of diatomic photofragments from photodissociation of the general class of triatomic molecules are presented. The calculated rotational state population distributions are compared with the most recent experimental data on OH and SH photofragments to obtain the information on the kinematic aspects of the photodissociating H2O and H2S molecules.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560400835
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  • 4
    Electronic Resource
    Electronic Resource
    Basic studies of the influence ofβ-cyclodextrin and 2-hydroxypropylβ-cyclodextrin on the photo-oxidation reaction of phenothiazine in inclusion complexes, using fluorescence detection (1994)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 18 (1994), S. 69-79 
    Details
    ISSN: 1573-1111
    Keywords: β-cyclodextrin ; 2-hydroxypropyl β-CD ; phenothiazine ; photochemically-induced fluorescence spectroscopy ; molecular absorption spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The photo-oxidation reaction of phenothiazine has been studied in the presence ofβ-cyclodextrin (β-CD) and 2-hydroxypropylβ-cyclodextrin (HP β-CD). The influence of these organized media on the formation of the oxidation photoproduct upon UV irradiation has been investigated. Phenothiazine forms an inclusion complex with the cyclodextrins. The stoichiometry and formation constant of the complex formed with 2-hydroxypropyl β-CD have been calculated using the changes of the fluorescence emission signal and of the absorbance of the drug upon inclusion. An increase of the fluorescence intensity of the photogenerated product is attained when it becomes included inside the cyclodextrin cavity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706940
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  • 5
    Electronic Resource
    Electronic Resource
    Theoretical calculations of β-lactam antibiotics. III. AM1, MNDO, and MINDO/3 calculations of hydrolysis of β-lactam compound (azetidin-2-one ring) (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 13 (1992), S. 681-692 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: Semiempirical AM1, MINDO/3, and MNDO methods have been used in the study of the alkaline hydrolysis of β-lactam antibiotics through a base-catalyzed, acyl-cleavage, bimolecular mechanism. In this work, the hydroxyl ion has been chosen as nucleophilic agent and the azetidin-2-one ring like a model of β-lactam antibiotic. The MINDO/3 method does not predict correctly the energies of small rings. This, together with the fact that, like MNDO, it cannot detect the occurrence of hydrogen bonds, gives rise to uncertain estimates of energy barriers. The AM1 method can be considered the most suitable for studying the hydrolysis of β-lactam compounds.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540130603
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  • 6
    Electronic Resource
    Electronic Resource
    Theoretical calculations of β-lactam antibiotics. V. AM1 calculations of hydrolysis of cephalothin in gaseous phase and influence of the solvent (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 14 (1993), S. 1545-1552 
    Details
    ISSN: 0192-8651
    Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Computer Science
    Notes: A comprehensive study on the gas-phase alkaline hydrolysis of cephalosporins by using the semiempirical AM1 method was carried out. Cephalothin was the model compound used on account of the presence of a good leaving group at C(3′). According to the results obtained, the hydrolysis process takes place via a twostep reaction mechanism that involves the formation of an intermediate with a fully open β-lactam ring that still preserves the acetate group. Likewise, the exo methylene end product is chiefly formed by nucleophilic attack on the β-lactam carbonyl group of cephalosporins containing a good leaving group at C(3′). On the other hand, the alternative mechanism involving hydrolysis of the ester function in the side chain at 3′ and subsequent hydrolysis of the resulting β-lactam yieds essentially the corresponding enamine. The presence of a first solvation layer consisting of five water molecules showed that, even though some potential barriers are slightly increased, the mechanism involved is identical to that of the gas-phase hydrolysis of this antibiotic. © John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcc.540141217
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