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  • Lunar and Planetary Science and Exploration  (9)
  • Electronics and Electrical Engineering  (4)
  • Female
  • Humans
  • Life and Medical Sciences
  • 2000-2004  (15)
  • 1
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    Recent segmental duplications in the human genome (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-08-10
    Beschreibung: Primate-specific segmental duplications are considered important in human disease and evolution. The inability to distinguish between allelic and duplication sequence overlap has hampered their characterization as well as assembly and annotation of our genome. We developed a method whereby each public sequence is analyzed at the clone level for overrepresentation within a whole-genome shotgun sequence. This test has the ability to detect duplications larger than 15 kilobases irrespective of copy number, location, or high sequence similarity. We mapped 169 large regions flanked by highly similar duplications. Twenty-four of these hot spots of genomic instability have been associated with genetic disease. Our analysis indicates a highly nonrandom chromosomal and genic distribution of recent segmental duplications, with a likely role in expanding protein diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailey, Jeffrey A -- Gu, Zhiping -- Clark, Royden A -- Reinert, Knut -- Samonte, Rhea V -- Schwartz, Stuart -- Adams, Mark D -- Myers, Eugene W -- Li, Peter W -- Eichler, Evan E -- CA094816/CA/NCI NIH HHS/ -- GM58815/GM/NIGMS NIH HHS/ -- HG002318/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):1003-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Center for Computational Genomics, and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169732" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Base Sequence ; Biological Evolution ; Chromosomes, Human/genetics ; Computational Biology ; Databases, Nucleic Acid ; Exons ; Expressed Sequence Tags ; *Gene Duplication ; Gene Rearrangement ; *Genes, Duplicate ; Genetic Diseases, Inborn/genetics ; *Genome, Human ; Humans ; Models, Genetic ; Polymorphism, Single Nucleotide ; Proteome ; Recombination, Genetic ; Sequence Alignment
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Strand-specific postreplicative processing of mammalian telomeres (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-09-29
    Beschreibung: Telomeres are specialized nucleoprotein structures that stabilize the ends of linear eukaryotic chromosomes. In mammalian cells, abrogation of telomeric repeat binding factor TRF2 or DNA-dependent protein kinase (DNA-PK) activity causes end-to-end chromosomal fusion, thus establishing an essential role for these proteins in telomere function. Here we show that TRF2-mediated end-capping occurs after telomere replication. The postreplicative requirement for TRF2 and DNA-PKcs, the catalytic subunit of DNA-PK, is confined to only half of the telomeres, namely, those that were produced by leading-strand DNA synthesis. These results demonstrate a crucial difference in postreplicative processing of telomeres that is linked to their mode of replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailey, S M -- Cornforth, M N -- Kurimasa, A -- Chen, D J -- Goodwin, E H -- AG-917709/AG/NIA NIH HHS/ -- CA50519/CA/NCI NIH HHS/ -- CA76260/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2001 Sep 28;293(5539):2462-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11577237" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Division ; Cell Line ; Chromatids/physiology/ultrastructure ; Chromosomes/physiology/ultrastructure ; *DNA Replication ; DNA-Activated Protein Kinase ; DNA-Binding Proteins/genetics/*metabolism ; Humans ; In Situ Hybridization ; Mice ; Mitosis ; Mutation ; Nuclear Proteins ; Protein-Serine-Threonine Kinases/deficiency/metabolism ; Telomere/*metabolism ; Telomeric Repeat Binding Protein 2 ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Differential Scanning Calorimetry and Evolved Gas Analysis at Mars Ambient Conditions Using the Thermal Evolved Gas Analyser (TEGA) (2000)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-03
    Beschreibung: Differential Scanning Calorimetry (DSC) combined with evolved gas analysis (EGA) is a well developed technique for the analysis of a wide variety of sample types with broad application in material and soil sciences. However, the use of the technique for samples under conditions of pressure and temperature as found on other planets is one of current development and cutting edge research. The Thermal Evolved Gas Analyzer (TEGA), which was designed, built and tested at the University of Arizona's Lunar and Planetary Lab (LPL), utilizes DSC/EGA. TEGA, which was sent to Mars on the ill-fated Mars Polar Lander, was to be the first application of DSC/EGA on the surface of Mars as well as the first direct measurement of the volatile-bearing mineralogy in martian soil. Additional information is available in the original extended abstract.
    Schlagwort(e): Lunar and Planetary Science and Exploration
    Materialart: International Conference on Mars Polar Science and Exploration; 133-134; LPI-Contrib-1057
    Format: text
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  • 4
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    The Search for Water and Other Volatiles in Martian Surface Materials: The Thermal Evolved Gas Analyzer (TEGA) (2000)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-03
    Beschreibung: Volatile-bearing minerals and phases (e.g., Fe-oxyhydroxides, phyllosilicates, carbonates, sulfates, palagonites, glasses) may be important components of the Martian regolith. However, essentially no information exists on the mineralogical composition of volatile-bearing phases in the regolith. The Thermal Evolved Gas Analyzer (TEGA), which was part of the Mars Polar Lander payload, was to determine the abundances of two of the most important volatile compounds (i.e., water and carbon dioxide) in the martian soil and to identify the minerals or phases that harbor these volatiles. The TEGA instrument was composed of a differential scanning calorimeter (DSC) interfaced with evolved gas analysis (EGA). The EGA consisted of a Herriott cell of a tunable-diode laser (TDL) spectrometer that determines CO2 and H2O abundances. The sample chamber was to operate at about 100 mbar (-76 torr) with a N2 carrier gas flow of 0.4 sccm. Specifications of TEGA are described in detail elsewhere in this volume.
    Schlagwort(e): Lunar and Planetary Science and Exploration
    Materialart: Concepts and Approaches for Mars Exploration; Part 2; 225-226; LPI-Contrib-1062-Pt-2
    Format: text
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  • 5
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    Differential Scanning Calorimetry and Evolved Gas Analysis at Mars Ambient Conditions Using the Thermal Evolved Gas Analyser (TEGA) (2000)
    In:  Other Sources
    Details
    Publikationsdatum: 2017-10-02
    Beschreibung: We are conducting DSC/EGA experiments at Mars ambient temperature and pressure using the TEGA engineering model. These tests illustrate the outstanding capabilities of a TEGA-like instrument on the surface of Mars.
    Schlagwort(e): Lunar and Planetary Science and Exploration
    Materialart: Lunar and Planetary Science XXXI; LPI-Contrib-1000
    Format: text
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  • 6
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    Thermionic Emission of Single-Wall Carbon Nanotubes Measured (2004)
    In:  CASI
    Details
    Publikationsdatum: 2018-06-02
    Beschreibung: Researchers at the NASA Glenn Research Center, in collaboration with the Rochester Institute of Technology, have investigated the thermionic properties of high-purity, single-wall carbon nanotubes (SWNTs) for use as electron-emitting electrodes. Carbon nanotubes are a recently discovered material made from carbon atoms bonded into nanometer-scale hollow tubes. Such nanotubes have remarkable properties. An extremely high aspect ratio, as well as unique mechanical and electronic properties, make single-wall nanotubes ideal for use in a vast array of applications. Carbon nanotubes typically have diameters on the order of 1 to 2 nm. As a result, the ends have a small radius of curvature. It is these characteristics, therefore, that indicate they might be excellent potential candidates for both thermionic and field emission.
    Schlagwort(e): Electronics and Electrical Engineering
    Materialart: Research and Technology 2003; NASA/TM-2004-212729
    Format: application/pdf
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  • 7
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    Options and Risk for Qualification of Electric Propulsion System (2002)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-18
    Beschreibung: Electric propulsion vehicle systems envelop a wide range of propulsion alternatives including solar and nuclear, which present unique circumstances for qualification. This paper will address the alternatives for qualification of electric propulsion spacecraft systems. The approach taken will be to address the considerations for qualification at the various levels of systems definition. Additionally, for each level of qualification the system level risk implications will be developed. Also, the paper will explore the implications of analysis verses test for various levels of systems definition, while retaining the objectives of a verification program. The limitations of terrestrial testing will be explored along with the risk and implications of orbital demonstration testing. The paper will seek to develop a template for structuring of a verification program based on cost, risk and value return. A successful verification program should establish controls and define objectives of the verification compliance program. Finally the paper will seek to address the political and programmatic factors, which may impact options for system verification.
    Schlagwort(e): Electronics and Electrical Engineering
    Materialart: 28th International Electric Propulsion Conference; Mar 17, 2003 - Mar 21, 2003; Toulouse; France
    Format: text
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  • 8
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    Nanostructured Materials for Solar Cells (2003)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-19
    Beschreibung: The use of both inorganic and organic nanostructured materials in producing high efficiency photovoltaics is discussed in this paper. Recent theoretical results indicate that dramatic improvements in device efficiency may be attainable through the use of semiconductor quantum dots in an ordinary p-i-n solar cell. In addition, it has also recently been demonstrated that quantum dots can also be used to improve conversion efficiencies in polymeric thin film solar cells. A similar improvement in these types of cells has also been observed by employing single wall carbon nanotubes. This relatively new carbon allotrope may assist both in the disassociation of excitons as well as carrier transport through the composite material. This paper reviews the efforts that are currently underway to produce and characterize these nanoscale materials and to exploit their unique properties.
    Schlagwort(e): Electronics and Electrical Engineering
    Materialart: 3rd World Conference of Photovoltaic Energy Conversion; May 12, 2003 - May 16, 2003; Osaka; Japan|Photovoltaic Energy Conversion; 3; 2690-2693
    Format: application/pdf
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  • 9
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    Hypervelocity Microparticle Impact Studies: Simulating Cosmic Dust Impacts on the Dustbuster (2002)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-18
    Beschreibung: Iron and copper microparticles accelerated to 2-20 km/s in a 2 MV Van de Graaff accelerator were used to test a recently-developed cosmic dust mass spectrometer, known as the Dustbuster. Additional information is contained in the original extended abstract.
    Schlagwort(e): Lunar and Planetary Science and Exploration
    Materialart: Lunar and Planetary Science XXXIII; LPI-Contrib-1109
    Format: text
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  • 10
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    Metal/Silicate Partitioning of P, Ga, and W at High Pressures and Temperatures: Dependence on Silicate Melt Composition (2004)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-10
    Beschreibung: The distinctive pattern of element concentrations in the upper mantle provides essential evidence in our attempts to understand the accretion and differentiation of the Earth (e.g., Drake and Righter, 2002; Jones and Drake, 1986; Righter et al., 1997; Wanke 1981). Core formation is best investigated through use of metal/silicate partition coefficients for siderophile elements. The variables influencing partition coefficients are temperature, pressure, the major element compositions of the silicate and metal phases, and oxygen fugacity. Examples of studies investigating the effects of these variables on partitioning behavior are: composition of the metal phase by Capobianco et al. (1999) and Righter et al. (1997); silicate melt composition by Watson (1976), Walter and Thibault (1995), Hillgren et al. (1996), Jana and Walker (1997), and Jaeger and Drake (2000); and oxygen fugacity by Capobianco et al. (1999), and Walter and Thibault (1995). Here we address the relative influences of silicate melt composition, pressure and temperature.
    Schlagwort(e): Lunar and Planetary Science and Exploration
    Materialart: Lunar and Planetary Science XXXV: Terrestrial Planets: Building Blocks and Differentiation; LPI-Contrib-1197
    Format: text
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