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  • 2010-2014  (79)
  • 2000-2004  (141)
  • 1980-1984  (2)
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  • 1
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    New Limits on Interactions between Weakly Interacting Massive Particles and Nucleons Obtained with CsI(Tl) Crystal Detectors (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-05-01
    Description: Author(s): S. C. Kim, H. Bhang, J. H. Choi, W. G. Kang, B. H. Kim, H. J. Kim, K. W. Kim, S. K. Kim, Y. D. Kim, J. Lee, J. H. Lee, J. K. Lee, M. J. Lee, S. J. Lee, J. Li, J. Li, X. R. Li, Y. J. Li, S. S. Myung, S. L. Olsen, S. Ryu, I. S. Seong, J. H. So, and Q. Yue (KIMS Collaboration) New limits are presented on the cross section for weakly interacting massive particle (WIMP) nucleon scattering in the KIMS CsI(T ℓ ) detector array at the Yangyang Underground Laboratory. The exposure used for these results is 24 524.3  kg·days . Nuclei recoiling from WIMP interactions are identified ... [Phys. Rev. Lett. 108, 181301] Published Mon Apr 30, 2012
    Keywords: Gravitation and Astrophysics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Economic Viability of Metallic Sodium-Cooled Faster Reactor Fuel in Korea (2013)
    Hindawi
    Details
    Publication Date: 2013-03-31
    Description: This paper evaluates whether SFR metallic nuclear fuel can be economical. To make this determination, the cost of SFCF (SFR fuel cycle facilities) was estimated, and the break-even point of the manufacturing cost of SFR metallic nuclear fuel for direct disposal option was then calculated. As a result of the cost estimation, the levelized unit cost (LUC) for SFCF was calculated to be 5,311 $/kgHM, and the break-even point was calculated to be $5,267/kgHM. Therefore, the cost difference between LUC and the break-even point is not only small but is also within the relevant range of the uncertainty level of Class 3 in accordance with a generic cost estimate classification matrix of AACE (the Association for the Advancement of Cost Engineering). This means it is very difficult to judge the economical feasibility of SFR metallic nuclear fuel because as of today there are no commercial facilities in Korea or the world. The economic feasibility of SFR metallic nuclear fuel, however, will be enhanced if the mass production of SFCF becomes possible in the future.
    Print ISSN: 1687-6075
    Electronic ISSN: 1687-6083
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Hindawi
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  • 3
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    Combined effects of pressure and Ru substitution on BaFe_{2}As_{2} (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-10-19
    Description: Author(s): S. K. Kim, M. S. Torikachvili, E. Colombier, A. Thaler, S. L. Bud'ko, and P. C. Canfield [Phys. Rev. B 84, 134525] Published Tue Oct 18, 2011
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation (2014)
    Oxford University Press
    Details
    Publication Date: 2014-04-03
    Description: In the present study, we investigated the 3' untranslated region (UTR) of the mouse core clock gene cryptochrome 1 ( Cry1 ) at the post-transcriptional level, particularly its translational regulation. Interestingly, the 3'UTR of Cry1 mRNA decreased its mRNA levels but increased protein amounts. The 3'UTR is widely known to function as a cis -acting element of mRNA degradation. The 3'UTR also provides a binding site for microRNA and mainly suppresses translation of target mRNAs. We found that AU-rich element RNA binding protein 1 (AUF1) directly binds to the Cry1 3'UTR and regulates translation of Cry1 mRNA. AUF1 interacted with eukaryotic translation initiation factor 3 subunit B and also directly associated with ribosomal protein S3 or ribosomal protein S14, resulting in translation of Cry1 mRNA in a 3'UTR-dependent manner. Expression of cytoplasmic AUF1 and binding of AUF1 to the Cry1 3'UTR were parallel to the circadian CRY1 protein profile. Our results suggest that the 3'UTR of Cry1 is important for its rhythmic translation, and AUF1 bound to the 3'UTR facilitates interaction with the 5' end of mRNA by interacting with translation initiation factors and recruiting the 40S ribosomal subunit to initiate translation of Cry1 mRNA.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Effects of chemical doping and pressure on CaFe_{4}As_{3} (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-09-29
    Description: Author(s): Liang L. Zhao, S. K. Kim, Gregory T. McCandless, Milton S. Torikachvili, P. C. Canfield, Julia Y. Chan, and E. Morosan The effects of chemical doping by P, Yb, Co, and Cu, and hydrostatic pressure on CaFe 4 As 3 , were studied on single-crystalline samples. While the former two dopants substitute the nonmagnetic ions, the latter two partially occupy the Fe sites within the magnetic sublattice. The incommensurate spin de... [Phys. Rev. B 84, 104444] Published Wed Sep 28, 2011
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    A gene-coexpression network for global discovery of conserved genetic modules (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-23
    Description: To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related. Many of these relationships provide strong evidence for the involvement of new genes in core biological functions such as the cell cycle, secretion, and protein expression. We experimentally confirmed the predictions implied by some of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stuart, Joshua M -- Segal, Eran -- Koller, Daphne -- Kim, Stuart K -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):249-55. Epub 2003 Aug 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X-215, Stanford, CA 94305-5329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12934013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Caenorhabditis elegans/genetics ; Cell Cycle/genetics ; Cell Division/genetics ; Computational Biology ; Conserved Sequence ; Databases, Genetic ; Drosophila melanogaster/genetics ; *Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation ; Genes, Fungal ; Genes, Helminth ; Genes, Insect ; Humans ; Models, Statistical ; Mutation ; *Oligonucleotide Array Sequence Analysis ; Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Signal Transduction/genetics ; Species Specificity ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Reading the worm genome (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S K -- New York, N.Y. -- Science. 2000 Jan 7;287(5450):52-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, CA 94305-5329, USA. kim@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10644223" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/*genetics/growth & development/*metabolism ; *Caenorhabditis elegans Proteins ; Female ; Genes, Helminth ; *Genome ; Helminth Proteins/genetics/*metabolism ; Protein Binding ; Repressor Proteins/genetics/metabolism ; Retinoblastoma Protein/metabolism ; Signal Transduction ; *Two-Hybrid System Techniques ; Vulva/growth & development ; Yeasts/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    A gene expression map for Caenorhabditis elegans (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-15
    Description: We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S K -- Lund, J -- Kiraly, M -- Duke, K -- Jiang, M -- Stuart, J M -- Eizinger, A -- Wylie, B N -- Davidson, G S -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2087-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA. kim@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557892" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Caenorhabditis elegans/*genetics/physiology ; *Computational Biology ; DNA Transposable Elements ; DNA, Complementary ; Databases, Factual ; Female ; *Gene Expression ; *Gene Expression Profiling ; Gene Expression Regulation ; *Genes, Helminth ; Genome ; *Genomics ; Helminth Proteins/biosynthesis/genetics ; Intestines/physiology ; Male ; Muscles/physiology ; Neurons/physiology ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Oocytes/physiology ; RNA, Helminth/genetics ; Software ; Spermatozoa/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-11
    Description: In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain. Here, we show that ablation of these IPCs causes developmental delay, growth retardation, and elevated carbohydrate levels in larval hemolymph. All of the defects were reversed by ectopic expression of a Drosophila insulin transgene. On the basis of these functional data and the observation that IPCs release insulin into the circulatory system, we conclude that brain IPCs are the main systemic supply of insulin during larval growth. We propose that IPCs and pancreatic islet beta cells are functionally analogous and may have evolved from a common ancestral insulin-producing neuron. Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rulifson, Eric J -- Kim, Seung K -- Nusse, Roel -- New York, N.Y. -- Science. 2002 May 10;296(5570):1118-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305-5329, USA. rulifson@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Blood Glucose/*metabolism ; Brain/cytology ; Cell Count ; Cell Size ; Diabetes Mellitus ; Drosophila/anatomy & histology/genetics/growth & development/*physiology ; Drosophila Proteins/genetics/*metabolism ; Gene Expression ; Heart/innervation ; Hemolymph ; Insect Hormones/genetics/metabolism ; Insulin/genetics/*metabolism ; Larva/growth & development ; Myocardium/metabolism ; Neurons/*metabolism ; Neurosecretory Systems/cytology/metabolism ; Oligopeptides/genetics/metabolism ; Phenotype ; Pyrrolidonecarboxylic Acid/analogs & derivatives ; RNA, Messenger/genetics/metabolism ; Transgenes ; Trehalose/*blood ; Wings, Animal/anatomy & histology/cytology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    PDGF signalling controls age-dependent proliferation in pancreatic beta-cells (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-10-14
    Description: Determining the signalling pathways that direct tissue expansion is a principal goal of regenerative biology. Vigorous pancreatic beta-cell replication in juvenile mice and humans declines with age, and elucidating the basis for this decay may reveal strategies for inducing beta-cell expansion, a long-sought goal for diabetes therapy. Here we show that platelet-derived growth factor receptor (Pdgfr) signalling controls age-dependent beta-cell proliferation in mouse and human pancreatic islets. With age, declining beta-cell Pdgfr levels were accompanied by reductions in beta-cell enhancer of zeste homologue 2 (Ezh2) levels and beta-cell replication. Conditional inactivation of the Pdgfra gene in beta-cells accelerated these changes, preventing mouse neonatal beta-cell expansion and adult beta-cell regeneration. Targeted human PDGFR-alpha activation in mouse beta-cells stimulated Erk1/2 phosphorylation, leading to Ezh2-dependent expansion of adult beta-cells. Adult human islets lack PDGF signalling competence, but exposure of juvenile human islets to PDGF-AA stimulated beta-cell proliferation. The discovery of a conserved pathway controlling age-dependent beta-cell proliferation indicates new strategies for beta-cell expansion.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503246/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503246/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Hainan -- Gu, Xueying -- Liu, Yinghua -- Wang, Jing -- Wirt, Stacey E -- Bottino, Rita -- Schorle, Hubert -- Sage, Julien -- Kim, Seung K -- R01 CA114102/CA/NCI NIH HHS/ -- R01 DK056709/DK/NIDDK NIH HHS/ -- R01 DK072184/DK/NIDDK NIH HHS/ -- R01 DK075919/DK/NIDDK NIH HHS/ -- T32 CA009302/CA/NCI NIH HHS/ -- U01 DK089532/DK/NIDDK NIH HHS/ -- U01 DK89532/DK/NIDDK NIH HHS/ -- U01 DK89572/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2011 Oct 12;478(7369):349-55. doi: 10.1038/nature10502.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21993628" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cell Proliferation ; Cells, Cultured ; Diabetes Mellitus, Experimental/pathology ; E2F Transcription Factors/metabolism ; Female ; Gene Expression Regulation, Enzymologic ; Gene Knockout Techniques ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Insulin-Secreting Cells/*cytology/enzymology/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Polycomb Repressive Complex 2 ; Receptors, Platelet-Derived Growth Factor/*metabolism ; Retinoblastoma Protein/metabolism ; *Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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