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  • 1
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    A gene expression map for Caenorhabditis elegans (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-15
    Description: We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, S K -- Lund, J -- Kiraly, M -- Duke, K -- Jiang, M -- Stuart, J M -- Eizinger, A -- Wylie, B N -- Davidson, G S -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2087-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA. kim@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557892" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Caenorhabditis elegans/*genetics/physiology ; *Computational Biology ; DNA Transposable Elements ; DNA, Complementary ; Databases, Factual ; Female ; *Gene Expression ; *Gene Expression Profiling ; Gene Expression Regulation ; *Genes, Helminth ; Genome ; *Genomics ; Helminth Proteins/biosynthesis/genetics ; Intestines/physiology ; Male ; Muscles/physiology ; Neurons/physiology ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Oocytes/physiology ; RNA, Helminth/genetics ; Software ; Spermatozoa/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The homeotic gene lin-39 and the evolution of nematode epidermal cell fates (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-23
    Description: The fate of ventral epidermal cells differs among nematode species. Nonvulval cells fuse with the epidermis in Caenorhabditis elegans, whereas the homologous cells undergo apoptosis in Pristionchus pacificus. The homeotic gene lin-39 is involved in the regulation of these epidermal cell fates. In Caenorhabditis, lin-39 prevents cell fusion of potential vulval cells and specifies the vulva equivalence group. Pristionchus vulvaless mutants that displayed apoptosis of the vulval precursor cells were isolated, and point mutations in lin-39 were identified. Thus, the evolution of these epidermal cell fates is driven by different intrinsic properties of homologous cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eizinger, A -- Sommer, R J -- New York, N.Y. -- Science. 1997 Oct 17;278(5337):452-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck Institut fur Entwicklungsbiologie, Abteilung Zellbiologie, Spemannstrasse 35, 72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9334302" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Apoptosis ; Base Sequence ; *Biological Evolution ; Caenorhabditis elegans/cytology/genetics/growth & development ; Cell Fusion ; Cell Lineage ; Epidermis/cytology ; Exons ; Female ; *Genes, Helminth ; *Genes, Homeobox ; Molecular Sequence Data ; Mutation ; Phenotype ; Rhabditida/*cytology/*genetics ; Stem Cells/cytology ; Vulva/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The Homeotic Gene lin-39 and the Evolution of Nematode Epidermal Cell Fates (1997)
    American Association for the Advancement of Science
    Details
    Publication Date: 1997-10-17
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science
    Location Call Number Expected Availability
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