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  • Wiley-Blackwell  (6)
  • Woods Hole Oceanographic Institution  (4)
  • 2020-2023  (4)
  • 2000-2004  (1)
  • 1975-1979  (3)
  • 1955-1959  (2)
  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 18 (1976), S. 1497-1506 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A chemostat in which mammalian cells can be raised in continuous suspension culture is described. It is constructed from commercially available parts. This apparatus has the advantage over earlier models in that the medium can be pumped off free of cells, thus suddenly increasing the cell concentration in the culture. The apparatus has been successfully used in studies on contact inhibition.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 2000 (2000), S. 1113-1120 
    ISSN: 1434-193X
    Keywords: Peptidomimetics ; Reverse turn mimetics ; Glycomimetics ; Heterocycles ; Lactams ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -D-Glucurono-3,6-lactone and L-cysteine combine in a highly stereoselective manner to give the 7,5-bicyclic thiazolidinlactam 2. The α-hydroxy group of the D-glucurono-3,6-lactone was exchanged for an amino function (to give 13) and, after condensation with L-cysteine methyl ester, the polyol dipeptide 7 was obtained. Peptide couplings proceed without the need to protect the three secondary hydroxy groups of the seven-membered ring. The amino group of 7 was deprotected and selectively elongated to the pseudo-tripeptide 16. The depsipeptide 17 was obtained by condensation of Boc-Ala-OH with the polyol 2. Elongation at the carboxy terminus yielded 19 and 20. The bicyclic scaffold populates a well-defined solution conformation; the hydroxy groups mimic the side chains of hydrophilic amino acids and can be further functionalized.
    Additional Material: 1 Ill.
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 90 (1957), S. 1153-1161 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Salze von Aminosäuren werden mit reduzierenden Zuckern in wasserfreiem Methanol umgesetzt und die Kondensationsprodukte als Metallkomplexe isoliert. Das Verfahren gestattet erstmalig die Gewinnung kristallisierter N-Glyko-side aliphatischer Aminosäuren in Form ihrer Komplexsalze. Mg-, Ca-, Fe-, Co-, Cu- und Zn-N-Glykoside von Glycin, Alanin, Glutaminsäure und Methionin werden in z. T. annähernd quantitativen Ausbeuten erhalten. Das zentrale Kation des Komplexes stabilisiert die N-glykosidische Bindung; z. B. ist der hydrolytische Zerfall des N-Glykosids in wäßriger Lösung stark verzögert.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 613 (1958), S. 137-144 
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Zur Bestimmung der Reduzierbarkeit von Tetrazoliumsalzen werden diese mit halbreduzierten Redoxfarbstoffen in modifizierten THUNBERG-Gefäßen zusammengebracht. Das Eintreten oder Ausbleiben der Färbung zeigt an, zwischen welchen Redox-Potentialwerten das Tetrazoliumsalz einzuordnen ist. Auf Grund der Eigenschaft der Tetrazoliumsalze, in ihrer Reduzierbarkeit weitgehend pH-unabhängig zu sein, während das Potential des Bezugssystems pH-abhängig ist, bieten sich mit einem Redox-Farbstoff zahlreiche zur nahen Potentialeingrenzung geeignete Bezugs-Redoxpotentiale. Je nach Tetrazoliumsalz wurden Potentiale der Reduzierbarkeit zwischen  -  290 und + 110mV gemessen.
    Additional Material: 1 Ill.
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  • 5
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Surface Compounds of Transition Metals. XIV. Coordinatively Unsaturated Surface Compounds of Vanadium(III) on SilicagelVanadium(V) reacts with silicagel (aqueous impregnation, activation in O2 at 800°C) to a colourless highly dispersed surface compound, which can be reduced by CO to coordinatively unsaturated violet surface vanadium(III). Reoxydation with O2 forms a deep-blue surface peroxide under chemiluminescence; heat treatment at 300°C reconstitutes the original vanadium(V) surface compound with simultaneous loss of 1/2 O2.
    Notes: Vanadium(V) bildet bei wäßriger Dotierung und nachfolgender Aktivierung (O2, 800°C) auf Silicagel farblose, hochdisperse Oberflächenverbindungen, die sich mit CO zu koordinativ ungesättigtem, violettem Oberflächen-Vanadium(III) reduzieren lassen. Reoxydation mit O2 führt unter Chemilumineszenz zunächst zu einem tiefblauen Oberflächen-Peroxid , das beim Erwärmen auf 300°C unter Abgabe von 1/2 O2 vollständig in das ursprüngliche Vanadium(V) übergeht.
    Additional Material: 2 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 451 (1979), S. 82-92 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On the Preparation and Suitability of Microspherical Silicas for the Column ChromatographyMicrospherical silicas with particle sizes up to 1 m̈m having nonspherical portions of ≤ 1 percent have been prepared using polyethoxysiloxane (polyester). An acid treatment of the hydrogels resulted in larger specific surfaces of the final products.The synthetized silica gels are excellently suitable for chromatographic purposes in dependence on their specific surface and their average pore diameter, resp.For the rapid determination of types of compounds by means of the micro fluorescent indicator adsorption analysis (MFIA) already crude gels could be used without any fractionation. Their specific surfaces had to be within the range of 500 ± 200 m2 g-1. For the use in the high performance liquid chromatography (HPLC) efficient supports should have specific surfaces in the range of 500 ± 300 m2 g-1. In this case the lower limiting value is determined by the capacity factors of the separation problem.Spheroids with surfaces of 200 ± 150 m2 g-1 have been obtained following the gel synthesis by hydrothermal treatment. These gels, however, were characterized by greater heights for theoretical plates in comparison with the initial gel.With gels, having surfaces in the range of 200 and 840 m2 g-1, the chromatographic investigation resulted in selectivity factors being independent of the surface. The capacity factors were strictly proportional to the specific surface of the support.
    Notes: Es wurde mikrosphärisches Silicagel mit Korngrößen bis zu 1 m̈m bei nichtsphärischen Anteilen ≤ 1% unter Verwendung von Polyäthoxysiloxan (Polyester) hergestellt. Saure Behandlung der Hydrogele führte zu höheren spezifischen Oberflächen der Endprodukte.Die synthetisierten Silicagele eigneten sich in Abhängigkeit von ihrer spezifischen Oberfläche bzw. ihrem mittleren Porendurchmesser ausgezeichnet zur Chromatographie.Für die schnelle Stoffgruppenbestimmung mittels Mikro-Fluoreszenzindikator-Adsorptionsanalyse (MFIA) konnten bereits Rohgele ohne Fraktionsierung Verwendung finden. Ihre spezifischen Oberflächen mußten innerhalb 500 ± 200 m2 g-1 liegen. Zum Einsatz in der schnellen Flüssigchromatographie (HPLC) sollten leistungsfähige Träger spezifische Oberflächen im Bereich 500 ± 300 m2 g-1 aufweisen. Hier richtet sich der untere Grenzwert nach den Kapazitätsfaktoren des Trennproblems.Sphäroide mit Oberflächen von 200 ± 150 m2 g-1 wurden im Anschluß an die Gelsynthese durch hydrothermales Altern gewonnen. Diese Gele zeigten jedoch im Vergleich zum Ausgangsgel größere theroretische Trennstufenhöhen.Die chromatographische Untersuchung ergab an Gelen mit Oberflächen zwischen 200 und 840 m2 g-1 oberflächenunabhängige Selektivitätsfaktoren. Die Kapazitätsfaktoren waren der spezifischen Trägeroberfläche streng proportional.
    Additional Material: 9 Ill.
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  • 7
    Publication Date: 2022-06-14
    Description: This project investigated the distribution of low dissolved oxygen bottom waters (hypoxia) in southern Cape Cod Bay. Hypoxia was documented for the first time in late summer 2019 and 2020 despite extensive monitoring for the past decade. The data include: 1) measurements of bottom dissolved oxygen collected in 2019 by the Massachusetts Division of Marine Fisheries (MDMF) and the Center for Coastal Studies (CCS) ; 2) full water column profiles of temperature, salinity, chlorophyll fluorescence, dissolved oxygen concentration and optical backscatter collected in late summer 2020 by the Woods Hole Oceanographic Institution (WHOI); 3) monthly water quality data including CTD with dissolved oxygen and chlorophyll fluorescence and discrete bottom samples analyzed for dissolved nutrients collected by the CCS for the period 2011-2020; 4) inorganic nutrients from discrete surface and bottom samples collected monthly for the period 2006-2020; 5) bottom temperature data collected the Wreck of Mars location by the MDMF over the period 1991-2021. There are four separate data sets included: 1) MDMF and CCS bottom dissolved oxygn from 2019; 2) CTD and ancillary data collected by WHOI in 2019; 3) CCS monthly survey data from 2011-2020; and 4) bottom temperature data collected by MDMF for 1991-2021. 1) MDMF/CCS dissolved oxygen data was collected from ship-based surveys using an YSI 6920 V2-2 data sonde; 2) WHOI CTD data was collected from vertical casts made from a small research vessel using an RBR CTD; 3) CCS CTD data was collected from vertical casts made from a small research vessel using a SeaBird Electronics CTD; 4) MDMF temperature data was collected from a bottom mounted temperature logger. Related Publications: Scully, M.E., W.R. Geyer, D. Borkman, T.L. Pouch, A. Costa, and O.C. Nichols, in press. Unprecedented summer hypoxia in southern Cape Cod Bay: An ecological response to regional climate change? Biogeosciences.
    Description: National Science Foundation - OCE- 2053240 NOAA Seagrant - NA20OAR4170506
    Keywords: Hypoxia ; Harmful Algal Blooms ; Climate Change ; Thermal stratification
    Repository Name: Woods Hole Open Access Server
    Type: Dataset
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  • 8
    Publication Date: 2022-05-26
    Description: These are the observational data collected in 2017 from the North River estuary. Data files include the long-term (LT) CTD and Aquadopp measurements from April to July, the short-term (STI from April to May and STII in late July) CTD measurements, eight shipboard CTD and ADCP surveys in April, May and July, the ADV measurements in late July, the North River mid-estuary region bathymetry, and the North River discharge (from USGS measurements).
    Description: National Science Foundation#1634480
    Repository Name: Woods Hole Open Access Server
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  • 9
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    Woods Hole Oceanographic Institution
    Publication Date: 2022-10-21
    Description: The salinity distribution of an estuary depends on the balance between the river outflow, which is seaward, and a dispersive salt flux, which is landward. The dispersive salt flux at a fixed cross-section can be divided into shear dispersion, which is caused by spatial correlations of the cross-sectionally varying velocity and salinity, and the tidal oscillatory salt flux, which results from the tidal correlation between the cross-section averaged, tidally varying components of velocity and salinity. The theoretical moving plane analysis of Dronkers and van de Kreeke (1986) indicates that the oscillatory salt flux is exactly equal to the difference between the “local” shear dispersion at a fixed location and the shear dispersion which occurred elsewhere within a tidal excursion – therefore, they refer to the oscillatory salt flux as “nonlocal” dispersion. We apply their moving plane analysis to a numerical model of a short, tidally dominated estuary and provide the first quantitative confirmation of the theoretical result that the spatiotemporal variability of shear dispersion accounts for the oscillatory salt flux. Shear dispersion is localized in space and time and is most pronounced near regions of flow separation. Notably, we find that dispersive processes near the mouth contribute significantly to the overall salt balance, especially under strong river and tidal forcing. Furthermore, while mechanisms of vertical shear dispersion produce the majority of the dispersive salt flux during neap tide and high river flow, lateral mechanisms associated with flow separation provide the dominant mode of dispersion during spring tide and low flow. Dataset used in support of manuscript "Tidal dispersion in short estuaries". The dataset includes the model output from the idealized estuary for 16 different forcing conditions, corresponding to 4 tidal conditions (weak〈neap〈intm〈spring) and 4 river flow conditions (q01〈q03〈q10〈q30), as well as along-channel salinity measurements in the North River (Marshfield, MA, USA) during a 2017 field campaign.
    Description: This work was funded under NSF Grant OCE-1634490 and NSF Graduate Research Fellowship, Grant No. #1122374
    Keywords: Shear dispersion ; Estuary
    Repository Name: Woods Hole Open Access Server
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  • 10
    Publication Date: 2022-10-21
    Description: Delaware Bay is a large estuary with a deep, relatively narrow channel and wide, shallow banks, providing a clear example of a “channel-shoal” estuary. This numerical modeling study addresses the exchange flow in this channel-shoal estuary, specifically to examine how the lateral geometry affects the strength and mechanisms of exchange flow. We find that the exchange flow is exclusively confined to the channel region during spring tides, when stratification is weak, and it broadens laterally over the shoals during the more stratified neap tides, but still occupies a small fraction of the total width of the estuary. Exchange flow is relatively weak during spring tides, resulting from oscillatory shear dispersion in the channel augmented by weak Eulerian exchange flow. During neap tides, stratification and shear increase markedly, resulting in a strong Eulerian residual shear flow, with a net exchange flow roughly 5 times that of the spring tide. During both spring and neap tides, lateral salinity gradients generated by differential advection at the edge of the channel drive a tidally oscillating cross-channel flow, which strongly influences the stratification, along-estuary salt balance and momentum balance. The lateral flow also causes the phase variation in salinity that results in oscillatory shear dispersion during both spring and neap tides and is a significant advective momentum source driving the residual circulation. Thus, although the shoals make a negligible direct contribution to the exchange flow, the salinity gradients between the channel and the shoal are critical to the stratification and exchange flow within the estuarine channel.
    Description: National Science Foundation (NSF): OCE-1325136; National Science Foundation (NSF): OCE-1634490; National Science Foundation (NSF): Jia-Lin Chen OCE-1736539
    Keywords: Estuarine circulation ; Tidal dispersion ; Lateral circulation
    Repository Name: Woods Hole Open Access Server
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