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  • American Physical Society (APS)  (6)
  • Nature Publishing Group (NPG)  (4)
  • Public Library of Science  (4)
  • Nature Publishing Group
  • 2010-2014  (14)
  • 2014  (4)
  • 2013  (10)
  • 1
    Publication Date: 2013-10-04
    Description: Author(s): F. Capitani, M. Höppner, B. Joseph, L. Malavasi, G. A. Artioli, L. Baldassarre, A. Perucchi, M. Piccinini, S. Lupi, P. Dore, L. Boeri, and P. Postorino We present high-quality optical data and density functional perturbation theory calculations for the vibrational spectrum of solid picene (C 22 H 14 ) under pressure up to 8 GPa. First-principles calculations reproduce with a remarkable accuracy the pressure effects on both frequency and intensities of ... [Phys. Rev. B 88, 144303] Published Thu Oct 03, 2013
    Keywords: Dynamics, dynamical systems, lattice effects
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2014-01-17
    Description: Author(s): Daniel Grin, Duncan Hanson, Gilbert P. Holder, Olivier Doré, and Marc Kamionkowski Primordial isocurvature fluctuations between photons and either neutrinos or nonrelativistic species such as baryons or dark matter are known to be subdominant to adiabatic fluctuations. Perturbations in the relative densities of baryons and dark matter (known as compensated isocurvature perturbatio... [Phys. Rev. D 89, 023006] Published Thu Jan 16, 2014
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 3
    Publication Date: 2014-02-26
    Description: Author(s): C. Rodríguez-Tajes, F. Farget, X. Derkx, M. Caamaño, O. Delaune, K.-H. Schmidt, E. Clément, A. Dijon, A. Heinz, T. Roger, L. Audouin, J. Benlliure, E. Casarejos, D. Cortina, D. Doré, B. Fernández-Domínguez, B. Jacquot, B. Jurado, A. Navin, C. Paradela, D. Ramos, P. Romain, M. D. Salsac, and C. Schmitt Inelastic and multinucleon transfer reactions between a 238U beam, accelerated at 6.14 MeV/u, and a 12C target were used for the production of neutron-rich, fissioning systems from U to Cm. A Si telescope, devoted to the detection of the targetlike nuclei, provided a characterization of the fissioni... [Phys. Rev. C 89, 024614] Published Mon Feb 24, 2014
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 4
    Publication Date: 2013-07-19
    Description: Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the amino-terminal extracellular domain, thus providing little understanding of the membrane-spanning signal transduction domain. The corticotropin-releasing factor receptor type 1 is a class B receptor which mediates the response to stress and has been considered a drug target for depression and anxiety. Here we report the crystal structure of the transmembrane domain of the human corticotropin-releasing factor receptor type 1 in complex with the small-molecule antagonist CP-376395. The structure provides detailed insight into the architecture of class B receptors. Atomic details of the interactions of the receptor with the non-peptide ligand that binds deep within the receptor are described. This structure provides a model for all class B GPCRs and may aid in the design of new small-molecule drugs for diseases of brain and metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hollenstein, Kaspar -- Kean, James -- Bortolato, Andrea -- Cheng, Robert K Y -- Dore, Andrew S -- Jazayeri, Ali -- Cooke, Robert M -- Weir, Malcolm -- Marshall, Fiona H -- England -- Nature. 2013 Jul 25;499(7459):438-43. doi: 10.1038/nature12357. Epub 2013 Jul 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23863939" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Aminopyridines/chemistry/metabolism/pharmacology ; Binding Sites ; Conserved Sequence ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Ligands ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Corticotropin-Releasing Hormone/antagonists & ; inhibitors/*chemistry/*classification/metabolism ; Receptors, Dopamine D3/antagonists & inhibitors/chemistry/classification
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2013-08-30
    Description: Complex gene-environment interactions are considered important in the development of obesity. The composition of the gut microbiota can determine the efficacy of energy harvest from food and changes in dietary composition have been associated with changes in the composition of gut microbial populations. The capacity to explore microbiota composition was markedly improved by the development of metagenomic approaches, which have already allowed production of the first human gut microbial gene catalogue and stratifying individuals by their gut genomic profile into different enterotypes, but the analyses were carried out mainly in non-intervention settings. To investigate the temporal relationships between food intake, gut microbiota and metabolic and inflammatory phenotypes, we conducted diet-induced weight-loss and weight-stabilization interventions in a study sample of 38 obese and 11 overweight individuals. Here we report that individuals with reduced microbial gene richness (40%) present more pronounced dys-metabolism and low-grade inflammation, as observed concomitantly in the accompanying paper. Dietary intervention improves low gene richness and clinical phenotypes, but seems to be less efficient for inflammation variables in individuals with lower gene richness. Low gene richness may therefore have predictive potential for the efficacy of intervention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cotillard, Aurelie -- Kennedy, Sean P -- Kong, Ling Chun -- Prifti, Edi -- Pons, Nicolas -- Le Chatelier, Emmanuelle -- Almeida, Mathieu -- Quinquis, Benoit -- Levenez, Florence -- Galleron, Nathalie -- Gougis, Sophie -- Rizkalla, Salwa -- Batto, Jean-Michel -- Renault, Pierre -- ANR MicroObes consortium -- Dore, Joel -- Zucker, Jean-Daniel -- Clement, Karine -- Ehrlich, Stanislav Dusko -- England -- Nature. 2013 Aug 29;500(7464):585-8. doi: 10.1038/nature12480.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut National de la Sante et de la Recherche Medicale, U872, Nutriomique, Equipe 7, Centre de Recherches des Cordeliers, Paris 75006, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23985875" target="_blank"〉PubMed〈/a〉
    Keywords: Basal Metabolism ; Body Weight/drug effects ; *Diet ; Diet, Carbohydrate-Restricted ; Dietary Fiber/pharmacology/therapeutic use ; Dietary Proteins/pharmacology ; Eating ; Energy Intake ; Female ; Fruit ; Gastrointestinal Tract/drug effects/*microbiology ; Gene-Environment Interaction ; Genes, Bacterial/genetics ; Humans ; Inflammation/microbiology ; Male ; Metagenome/drug effects/*genetics ; Obesity/diet therapy/microbiology ; Overweight/diet therapy/microbiology ; Vegetables ; Weight Loss/drug effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2014-07-22
    Description: Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate. Structural studies have been restricted to the amino-terminal extracellular domain, providing little understanding of the membrane-spanning signal transduction domain. Metabotropic glutamate receptor 5 is of considerable interest as a drug target in the treatment of fragile X syndrome, autism, depression, anxiety, addiction and movement disorders. Here we report the crystal structure of the transmembrane domain of the human receptor in complex with the negative allosteric modulator, mavoglurant. The structure provides detailed insight into the architecture of the transmembrane domain of class C receptors including the precise location of the allosteric binding site within the transmembrane domain and key micro-switches which regulate receptor signalling. This structure also provides a model for all class C G-protein-coupled receptors and may aid in the design of new small-molecule drugs for the treatment of brain disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dore, Andrew S -- Okrasa, Krzysztof -- Patel, Jayesh C -- Serrano-Vega, Maria -- Bennett, Kirstie -- Cooke, Robert M -- Errey, James C -- Jazayeri, Ali -- Khan, Samir -- Tehan, Ben -- Weir, Malcolm -- Wiggin, Giselle R -- Marshall, Fiona H -- England -- Nature. 2014 Jul 31;511(7511):557-62. doi: 10.1038/nature13396. Epub 2014 Jul 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK [2]. ; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25042998" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Binding Sites ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; *Models, Molecular ; Protein Structure, Tertiary ; Receptor, Metabotropic Glutamate 5/*chemistry ; Rhodopsin/chemistry
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2013-08-30
    Description: We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Le Chatelier, Emmanuelle -- Nielsen, Trine -- Qin, Junjie -- Prifti, Edi -- Hildebrand, Falk -- Falony, Gwen -- Almeida, Mathieu -- Arumugam, Manimozhiyan -- Batto, Jean-Michel -- Kennedy, Sean -- Leonard, Pierre -- Li, Junhua -- Burgdorf, Kristoffer -- Grarup, Niels -- Jorgensen, Torben -- Brandslund, Ivan -- Nielsen, Henrik Bjorn -- Juncker, Agnieszka S -- Bertalan, Marcelo -- Levenez, Florence -- Pons, Nicolas -- Rasmussen, Simon -- Sunagawa, Shinichi -- Tap, Julien -- Tims, Sebastian -- Zoetendal, Erwin G -- Brunak, Soren -- Clement, Karine -- Dore, Joel -- Kleerebezem, Michiel -- Kristiansen, Karsten -- Renault, Pierre -- Sicheritz-Ponten, Thomas -- de Vos, Willem M -- Zucker, Jean-Daniel -- Raes, Jeroen -- Hansen, Torben -- MetaHIT consortium -- Bork, Peer -- Wang, Jun -- Ehrlich, S Dusko -- Pedersen, Oluf -- England -- Nature. 2013 Aug 29;500(7464):541-6. doi: 10.1038/nature12506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INRA, Institut National de la Recherche Agronomique, US1367 Metagenopolis, 78350 Jouy en Josas, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23985870" target="_blank"〉PubMed〈/a〉
    Keywords: Adiposity ; Adult ; Bacteria/classification/genetics/*isolation & purification ; Biomarkers/*metabolism ; Body Mass Index ; Case-Control Studies ; Diet ; Dyslipidemias/microbiology ; Energy Metabolism ; Europe/ethnology ; European Continental Ancestry Group ; Female ; Gastrointestinal Tract/*microbiology ; Genes, Bacterial ; Humans ; Inflammation/microbiology ; Insulin Resistance ; Male ; *Metagenome/genetics ; Obesity/metabolism/microbiology ; Overweight/metabolism/microbiology ; Phylogeny ; Thinness/microbiology ; Weight Gain ; Weight Loss
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2013-07-04
    Description: Author(s): J. Rouquette, J. Haines, A. Al-Zein, Ph. Papet, F. Damay, J. Bourgeois, T. Hammouda, F. Dore, A. Maignan, M. Hervieu, and C. Martin [Phys. Rev. Lett. 111, 019904] Published Wed Jul 03, 2013
    Keywords: Errata
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 9
    Publication Date: 2013-11-08
    Description: Author(s): Jannis Bielefeld, W. L. Kimmy Wu, Robert R. Caldwell, and Olivier Doré A phenomenological model of dark energy that tracks the baryonic and cold dark matter at early times but resembles a cosmological constant at late times is explored. In the transition between these two regimes, the dark energy density drops rapidly as if it were a relic species that freezes out, dur... [Phys. Rev. D 88, 103004] Published Thu Nov 07, 2013
    Keywords: Astrophysics & Cosmology
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 10
    Publication Date: 2013-11-13
    Description: Author(s): M. Bendele, C. Marini, B. Joseph, G. M. Pierantozzi, A. S. Caporale, A. Bianconi, E. Pomjakushina, K. Conder, A. Krzton-Maziopa, T. Irifune, T. Shinmei, S. Pascarelli, P. Dore, N. L. Saini, and P. Postorino The local structure and electronic properties of Rb 1− x Fe 2− y Se 2 are investigated by means of site selective polarized x-ray absorption spectroscopy at the iron and selenium K edges as a function of pressure. A combination of dispersive geometry and a nanodiamond anvil pressure cell has permitted us t... [Phys. Rev. B 88, 180506] Published Tue Nov 12, 2013
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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