Publication Date:
2011-10-21
Description:
Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368121/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368121/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greer, Eric L -- Maures, Travis J -- Ucar, Duygu -- Hauswirth, Anna G -- Mancini, Elena -- Lim, Jana P -- Benayoun, Berenice A -- Shi, Yang -- Brunet, Anne -- ARRA-AG31198/AG/NIA NIH HHS/ -- F32-AG037254/AG/NIA NIH HHS/ -- R01 AG031198/AG/NIA NIH HHS/ -- R01-AG31198/AG/NIA NIH HHS/ -- R01-GM058012/GM/NIGMS NIH HHS/ -- T32 CA009302/CA/NCI NIH HHS/ -- T32-CA009361/CA/NCI NIH HHS/ -- T32-MH020016/MH/NIMH NIH HHS/ -- England -- Nature. 2011 Oct 19;479(7373):365-71. doi: 10.1038/nature10572.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22012258" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Caenorhabditis elegans/*genetics/*physiology
;
Caenorhabditis elegans Proteins/genetics/metabolism
;
Chromatin/metabolism
;
Epigenesis, Genetic/*genetics
;
Female
;
Gene Expression Regulation
;
Gene Knockdown Techniques
;
Histone Demethylases/genetics/metabolism
;
Histone-Lysine N-Methyltransferase/deficiency/genetics/metabolism
;
Histones
;
*Inheritance Patterns
;
Longevity/*genetics/physiology
;
Male
;
Methylation
;
Mutation/genetics
;
Nuclear Proteins/genetics/metabolism
;
Pedigree
;
Retinoblastoma-Binding Protein 2/genetics/metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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