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  • American Association for the Advancement of Science (AAAS)  (7)
  • 2015-2019
  • 2005-2009  (7)
  • 2008  (7)
  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-01-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelly, William G Jr -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):158-9. doi: 10.1126/science.319.5860.158b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187640" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information/*legislation & jurisprudence ; Federal Government ; Information Dissemination/*legislation & jurisprudence ; *Tobacco Industry ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guntheroth, Warren G -- New York, N.Y. -- Science. 2008 Nov 7;322(5903):856-7; author reply 856-7. doi: 10.1126/science.322.5903.856.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18988825" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autonomic Nervous System/metabolism ; Bradycardia ; Disease Models, Animal ; Humans ; Hypothermia ; Infant ; Mice ; Receptors, Serotonin/metabolism ; Serotonin/*metabolism ; Sudden Infant Death/*etiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guntheroth, Warren G -- New York, N.Y. -- Science. 2008 Aug 1;321(5889):639. doi: 10.1126/science.321.5889.639a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18669840" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Early Diagnosis ; Humans ; Lung/*radiography ; Lung Neoplasms/*radiography ; Mass Screening/*economics ; Risk Factors ; Smoking ; Tomography, X-Ray Computed/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2008-02-16
    Description: Searches for extrasolar planets have uncovered an astonishing diversity of planetary systems, yet the frequency of solar system analogs remains unknown. The gravitational microlensing planet search method is potentially sensitive to multiple-planet systems containing analogs of all the solar system planets except Mercury. We report the detection of a multiple-planet system with microlensing. We identify two planets with masses of approximately 0.71 and approximately 0.27 times the mass of Jupiter and orbital separations of approximately 2.3 and approximately 4.6 astronomical units orbiting a primary star of mass approximately 0.50 solar mass at a distance of approximately 1.5 kiloparsecs. This system resembles a scaled version of our solar system in that the mass ratio, separation ratio, and equilibrium temperatures of the planets are similar to those of Jupiter and Saturn. These planets could not have been detected with other techniques; their discovery from only six confirmed microlensing planet detections suggests that solar system analogs may be common.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaudi, B S -- Bennett, D P -- Udalski, A -- Gould, A -- Christie, G W -- Maoz, D -- Dong, S -- McCormick, J -- Szymanski, M K -- Tristram, P J -- Nikolaev, S -- Paczynski, B -- Kubiak, M -- Pietrzynski, G -- Soszynski, I -- Szewczyk, O -- Ulaczyk, K -- Wyrzykowski, L -- OGLE Collaboration -- Depoy, D L -- Han, C -- Kaspi, S -- Lee, C-U -- Mallia, F -- Natusch, T -- Pogge, R W -- Park, B-G -- MuFUN Collaboration -- Abe, F -- Bond, I A -- Botzler, C S -- Fukui, A -- Hearnshaw, J B -- Itow, Y -- Kamiya, K -- Korpela, A V -- Kilmartin, P M -- Lin, W -- Masuda, K -- Matsubara, Y -- Motomura, M -- Muraki, Y -- Nakamura, S -- Okumura, T -- Ohnishi, K -- Rattenbury, N J -- Sako, T -- Saito, To -- Sato, S -- Skuljan, L -- Sullivan, D J -- Sumi, T -- Sweatman, W L -- Yock, P C M -- MOA Collaboration -- Albrow, M D -- Allan, A -- Beaulieu, J-P -- Burgdorf, M J -- Cook, K H -- Coutures, C -- Dominik, M -- Dieters, S -- Fouque, P -- Greenhill, J -- Horne, K -- Steele, I -- Tsapras, Y -- PLANET and RoboNet Collaborations -- Chaboyer, B -- Crocker, A -- Frank, S -- Macintosh, B -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):927-30. doi: 10.1126/science.1151947.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210, USA. gaudi@astronomy.ohio-state.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276883" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2008-03-08
    Description: Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is dependent on constitutive activation of the nuclear factor-kappaB (NF-kappaB) signaling pathway. In normal B cells, antigen receptor-induced NF-kappaB activation requires CARD11, a cytoplasmic scaffolding protein. To determine whether CARD11 contributes to tumorigenesis, we sequenced the CARD11 gene in human DLBCL tumors. We detected missense mutations in 7 of 73 ABC DLBCL biopsies (9.6%), all within exons encoding the coiled-coil domain. Experimental introduction of CARD11 coiled-coil domain mutants into lymphoma cell lines resulted in constitutive NF-kappaB activation and enhanced NF-kappaB activity upon antigen receptor stimulation. These results demonstrate that CARD11 is a bona fide oncogenein DLBCL, providing a genetic rationale for the development of pharmacological inhibitors of the CARD11 pathway for DLBCL therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lenz, Georg -- Davis, R Eric -- Ngo, Vu N -- Lam, Lloyd -- George, Thaddeus C -- Wright, George W -- Dave, Sandeep S -- Zhao, Hong -- Xu, Weihong -- Rosenwald, Andreas -- Ott, German -- Muller-Hermelink, Hans Konrad -- Gascoyne, Randy D -- Connors, Joseph M -- Rimsza, Lisa M -- Campo, Elias -- Jaffe, Elaine S -- Delabie, Jan -- Smeland, Erlend B -- Fisher, Richard I -- Chan, Wing C -- Staudt, Louis M -- UO1-CA84967/CA/NCI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1676-9. doi: 10.1126/science.1153629. Epub 2008 Mar 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Metabolism Branch, Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18323416" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apoptosis Regulatory Proteins/chemistry/*genetics/metabolism ; CARD Signaling Adaptor Proteins/chemistry/*genetics/metabolism ; Cell Line, Tumor ; Cytoplasm/metabolism ; Guanylate Cyclase/chemistry/*genetics/metabolism ; Humans ; I-kappa B Kinase/metabolism ; Jurkat Cells ; Lymphoma, Large B-Cell, Diffuse/*genetics ; Molecular Sequence Data ; *Mutation, Missense ; NF-kappa B ; *Oncogenes ; Protein Structure, Tertiary ; Receptors, Antigen, B-Cell/physiology ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2008-10-25
    Description: Recent findings suggest important roles for nuclear organization in gene expression. In contrast, little is known about how nuclear organization contributes to genome stability. Epistasis analysis (E-MAP) using DNA repair factors in yeast indicated a functional relationship between a nuclear pore subcomplex and Slx5/Slx8, a small ubiquitin-like modifier (SUMO)-dependent ubiquitin ligase, which we show physically interact. Real-time imaging and chromatin immunoprecipitation confirmed stable recruitment of damaged DNA to nuclear pores. Relocation required the Nup84 complex and Mec1/Tel1 kinases. Spontaneous gene conversion can be enhanced in a Slx8- and Nup84-dependent manner by tethering donor sites at the nuclear periphery. This suggests that strand breaks are shunted to nuclear pores for a repair pathway controlled by a conserved SUMO-dependent E3 ligase.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518492/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518492/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagai, Shigeki -- Dubrana, Karine -- Tsai-Pflugfelder, Monika -- Davidson, Marta B -- Roberts, Tania M -- Brown, Grant W -- Varela, Elisa -- Hediger, Florence -- Gasser, Susan M -- Krogan, Nevan J -- R01 GM084448/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 24;322(5901):597-602. doi: 10.1126/science.1162790.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18948542" target="_blank"〉PubMed〈/a〉
    Keywords: Chromatin Immunoprecipitation ; *DNA Breaks, Double-Stranded ; DNA Repair ; DNA, Fungal/genetics/*metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Gene Conversion ; Genes, Fungal ; Immunoprecipitation ; Intracellular Signaling Peptides and Proteins/metabolism ; Kinetics ; Nuclear Pore/*metabolism ; Nuclear Pore Complex Proteins/genetics/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Recombination, Genetic ; Saccharomyces cerevisiae/genetics/*metabolism ; Saccharomyces cerevisiae Proteins/genetics/*metabolism ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Ubiquitin-Protein Ligases/*metabolism ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2008-12-06
    Description: Transcription initiation by RNA polymerase II (RNAPII) is thought to occur unidirectionally from most genes. Here, we present evidence of widespread divergent transcription at protein-encoding gene promoters. Transcription start site-associated RNAs (TSSa-RNAs) nonrandomly flank active promoters, with peaks of antisense and sense short RNAs at 250 nucleotides upstream and 50 nucleotides downstream of TSSs, respectively. Northern analysis shows that TSSa-RNAs are subsets of an RNA population 20 to 90 nucleotides in length. Promoter-associated RNAPII and H3K4-trimethylated histones, transcription initiation hallmarks, colocalize at sense and antisense TSSa-RNA positions; however, H3K79-dimethylated histones, characteristic of elongating RNAPII, are only present downstream of TSSs. These results suggest that divergent transcription over short distances is common for active promoters and may help promoter regions maintain a state poised for subsequent regulation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692996/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692996/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seila, Amy C -- Calabrese, J Mauro -- Levine, Stuart S -- Yeo, Gene W -- Rahl, Peter B -- Flynn, Ryan A -- Young, Richard A -- Sharp, Phillip A -- 5-F32-HD051190/HD/NICHD NIH HHS/ -- F32 HD051190-03/HD/NICHD NIH HHS/ -- HG002668/HG/NHGRI NIH HHS/ -- P01 CA042063/CA/NCI NIH HHS/ -- P01 CA042063-20/CA/NCI NIH HHS/ -- P01-CA42063/CA/NCI NIH HHS/ -- P30 CA014051/CA/NCI NIH HHS/ -- P30 CA014051-35/CA/NCI NIH HHS/ -- P30-CA14051/CA/NCI NIH HHS/ -- R01 GM034277/GM/NIGMS NIH HHS/ -- R01 GM034277-24/GM/NIGMS NIH HHS/ -- R01 HG002668/HG/NHGRI NIH HHS/ -- R01 HG002668-05/HG/NHGRI NIH HHS/ -- R01-GM34277/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2008 Dec 19;322(5909):1849-51. doi: 10.1126/science.1162253. Epub 2008 Dec 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056940" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryonic Stem Cells/metabolism ; Gene Expression Regulation ; HeLa Cells ; Histones/metabolism ; Humans ; Methylation ; Mice ; *Promoter Regions, Genetic ; RNA/*genetics/metabolism ; RNA, Antisense/*genetics/metabolism ; Transcription Factors/metabolism ; Transcription Initiation Site ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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