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  • Animals  (10)
  • General Chemistry
  • Life Sciences (General)
  • Molecular Sequence Data
  • 2000-2004  (13)
  • 2001  (13)
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  • 2000-2004  (13)
Year
  • 1
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    ENSO-like forcing on oceanic primary production during the Late Pleistocene (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-29
    Description: Late Pleistocene changes in oceanic primary productivity along the equator in the Indian and Pacific oceans are revealed by quantitative changes in nanoplankton communities preserved in nine deep-sea cores. We show that variations in equatorial productivity are primarily caused by glacial-interglacial variability and by precession-controlled changes in the east-west thermocline slope of the Indo-Pacific. The precession-controlled variations in productivity are linked to processes similar to the Southern Oscillation phenomenon, and they precede changes in the oxygen isotopic ratio, which indicates that they are not the result of ice sheet fluctuations. The 30,000-year spectral peak in the tropical Indo-Pacific Ocean productivity records is also present in the Antarctica atmospheric CO2 record, suggesting an important role for equatorial biological productivity in modifying atmospheric CO2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beaufort, L -- de Garidel-Thoron, T -- Mix, A C -- Pisias, N G -- New York, N.Y. -- Science. 2001 Sep 28;293(5539):2440-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS-CEREGE, BP 80, 13545 Aix-en-Provence Cedex 04, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11577233" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Carbon Dioxide ; *Climate ; *Ecosystem ; *Eukaryota ; *Fossils ; Indian Ocean ; Light ; Marine Biology ; Oxygen Isotopes ; Pacific Ocean ; *Plankton ; Seawater ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sequence interpretation. Functional annotation of mouse genome sequences (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, J H -- Balling, R -- Barsh, G -- Beier, D -- Brown, S D -- Bucan, M -- Camper, S -- Carlson, G -- Copeland, N -- Eppig, J -- Fletcher, C -- Frankel, W N -- Ganten, D -- Goldowitz, D -- Goodnow, C -- Guenet, J L -- Hicks, G -- Hrabe de Angelis, M -- Jackson, I -- Jacob, H J -- Jenkins, N -- Johnson, D -- Justice, M -- Kay, S -- Kingsley, D -- Lehrach, H -- Magnuson, T -- Meisler, M -- Poustka, A -- Rinchik, E M -- Rossant, J -- Russell, L B -- Schimenti, J -- Shiroishi, T -- Skarnes, W C -- Soriano, P -- Stanford, W -- Takahashi, J S -- Wurst, W -- Zimmer, A -- International Mouse Mutagenesis Consortium -- New York, N.Y. -- Science. 2001 Feb 16;291(5507):1251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, BRB 624, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. jhn4@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11233449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Computational Biology ; Costs and Cost Analysis ; Genes/physiology ; Genetic Techniques ; *Genome ; *Genomics ; International Cooperation ; Mice/*genetics ; Mutagenesis ; Mutation ; Phenotype ; Private Sector ; Public Sector ; Research Support as Topic ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Phylogenetics. Which mammalian supertree to bark up? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Springer, M S -- de Jong, W W -- New York, N.Y. -- Science. 2001 Mar 2;291(5509):1709-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Riverside, CA 92521 USA. springer@citrus.ucr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11253193" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; DNA, Mitochondrial/genetics ; Genomics ; Humans ; Mammals/anatomy & histology/*classification/genetics ; Meta-Analysis as Topic ; Pedigree ; *Phylogeny ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-05
    Description: We report a flexible strategy for transducing ligand-binding events into electrochemical responses for a wide variety of proteins. The method exploits ligand-mediated hinge-bending motions, intrinsic to the bacterial periplasmic binding protein superfamily, to establish allosterically controlled interactions between electrode surfaces and redox-active, Ru(II)-labeled proteins. This approach allows the development of protein-based bioelectronic interfaces that respond to a diverse set of analytes. Families of these interfaces can be generated either by exploiting natural binding diversity within the superfamily or by reengineering the specificity of individual proteins. These proteins may have numerous medical, environmental, and defense applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benson, D E -- Conrad, D W -- de Lorimier, R M -- Trammell, S A -- Hellinga, H W -- New York, N.Y. -- Science. 2001 Aug 31;293(5535):1641-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Box 3711, Duke University Medical Center, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11533486" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Allosteric Site ; Animals ; Beer ; *Biosensing Techniques ; Blood Glucose/analysis ; Carrier Proteins/*chemistry/genetics/*metabolism ; Electrochemistry ; Electrodes ; Ligands ; Maltose/analysis ; Maltose-Binding Proteins ; Monosaccharide Transport Proteins/chemistry/metabolism ; Mutation ; Oxidation-Reduction ; Protein Conformation ; *Protein Engineering ; Rats ; *Ruthenium ; Signal Transduction ; Thermodynamics ; Zinc/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Taxing debate for taxonomists (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Queiroz, K -- Donoghue, M -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2249-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11424941" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biology/*methods ; Classification/*methods ; *Terminology as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Development. Epithelial cell differentiation--a Mather of choice (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Den Brink, G R -- de Santa Barbara, P -- Roberts, D J -- New York, N.Y. -- Science. 2001 Dec 7;294(5549):2115-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Academic Medical Center, Department of Experimental Internal Medicine in the Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11739944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Basic Helix-Loop-Helix Transcription Factors ; *Cell Differentiation ; Cell Division ; Cell Lineage ; Enterocytes/cytology ; Enteroendocrine Cells/cytology ; Epithelial Cells/cytology ; Goblet Cells/cytology ; Helix-Loop-Helix Motifs ; Homeodomain Proteins/metabolism ; Intestinal Mucosa/*cytology/metabolism ; Mice ; Paneth Cells/cytology ; Signal Transduction ; Stem Cells/*cytology ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Ecology. Can protected areas be expanded in Africa? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Musters, C J -- de Graaf, H J -- ter Keurs, W J -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1759-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Biology, Institute of Evolutionary and Ecological Sciences, University of Leiden, Leiden, Netherlands. musters@rulsfb.leidenuniv.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10755927" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Agriculture ; Animals ; *Conservation of Natural Resources ; Economics ; *Ecosystem ; Humans ; Population Growth
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Cell biology. Telomere capping--one strand fits all (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Lange, T -- New York, N.Y. -- Science. 2001 May 11;292(5519):1075-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA. delange@mail.rockefeller.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11352055" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular ; *Conserved Sequence ; DNA, Single-Stranded/genetics/*metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Humans ; Oxytricha/genetics ; Saccharomyces cerevisiae/genetics ; Schizosaccharomyces/genetics ; Substrate Specificity ; Telomere/*genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-21
    Description: Aminoacyl transfer RNA (tRNA) synthetases establish the rules of the genetic code by catalyzing the aminoacylation of tRNAs. For some synthetases, accuracy depends critically on an editing function at a site distinct from the aminoacylation site. Mutants of Escherichia coli that incorrectly charge tRNA(Val) with cysteine were selected after random mutagenesis of the whole chromosome. All mutations obtained were located in the editing site of valyl-tRNA synthetase. More than 20% of the valine in cellular proteins from such an editing mutant organism could be replaced with the noncanonical aminobutyrate, sterically similar to cysteine. Thus, the editing function may have played a central role in restricting the genetic code to 20 amino acids. Disabling this editing function offers a powerful approach for diversifying the chemical composition of proteins and for emulating evolutionary stages of ambiguous translation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doring, V -- Mootz, H D -- Nangle, L A -- Hendrickson, T L -- de Crecy-Lagard, V -- Schimmel, P -- Marliere, P -- GM23562/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 20;292(5516):501-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Evologic SA, 4 rue Pierre Fontaine, 91000 Evry, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11313495" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Sequence ; Amino Acid Substitution ; Aminobutyrates/*metabolism ; Binding Sites ; Codon ; Cysteine/metabolism ; Escherichia coli/*genetics/growth & development/metabolism ; *Genetic Code ; Molecular Sequence Data ; Mutagenesis ; Phenotype ; *Protein Biosynthesis ; RNA, Bacterial/genetics/metabolism ; RNA, Transfer, Val/*metabolism ; Suppression, Genetic ; Threonine/metabolism ; Transfer RNA Aminoacylation ; Valine/metabolism ; Valine-tRNA Ligase/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Genetics. The land between Mendelian and multifactorial inheritance (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burghes, A H -- Vaessin, H E -- de La Chapelle, A -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2213-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43210, USA. burghes.1@osu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567125" target="_blank"〉PubMed〈/a〉
    Keywords: Adenomatous Polyposis Coli/genetics ; Alleles ; Animals ; Bardet-Biedl Syndrome/*genetics ; Genes, APC ; Genes, Dominant ; Genes, Recessive ; Genetic Predisposition to Disease ; Genotype ; Humans ; *Multifactorial Inheritance ; Muscular Atrophy, Spinal/genetics ; Mutation ; Phenotype ; Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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