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  • Humans  (116)
  • Chemical Engineering  (78)
  • METEOROLOGY AND CLIMATOLOGY
  • 1985-1989  (231)
  • 1980-1984
  • 1970-1974
  • 1988  (231)
  • 1
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    Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-16
    Description: Alzheimer's disease is the most common form of dementia among the elderly population. Although the etiology is unknown, inheritance plays a role in the pathogenesis of the disease. Recent work indicates that an autosomal dominant gene for Alzheimer's disease is located on chromosome 21 at band q21. In the present study of a group of autopsy-documented kindreds, no evidence for linkage was found between familial Alzheimer's disease (FAD) and chromosome 21q21 markers (D21S1/D21S72 and the amyloid beta gene). Linkage to the D21S1/D21S72 locus was excluded at recombination fractions (theta) up to 0.17. Linkage to the amyloid gene was excluded at theta = 0.10. Apparent recombinants were noted in two families for the amyloid gene and in five families for the D21S1/D21S72 locus. These data indicate that FAD is genetically heterogeneous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schellenberg, G D -- Bird, T D -- Wijsman, E M -- Moore, D K -- Boehnke, M -- Bryant, E M -- Lampe, T H -- Nochlin, D -- Sumi, S M -- Deeb, S S -- AG 00057/AG/NIA NIH HHS/ -- AG 05136/AG/NIA NIH HHS/ -- GM 15253/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 16;241(4872):1507-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neurology, University of Washington, Seattle 98195.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3420406" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*genetics ; Chromosome Mapping ; *Chromosomes, Human, Pair 21 ; Genetic Linkage ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A larger spectrum of severe HIV-1--related disease in intravenous drug users in New York City (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-11-11
    Description: Increasing mortality in intravenous (IV) drug users not reported to surveillance as acquired immunodeficiency syndrome (AIDS) has occurred in New York City coincident with the AIDS epidemic. From 1981 to 1986, narcotics-related deaths increased on average 32% per year from 492 in 1981 to 1996 in 1986. This increase included deaths from AIDS increasing from 0 to 905 and deaths from other causes, many of which were infectious diseases, increasing from 492 to 1091. Investigations of these deaths suggest a causal association with human immunodeficiency virus (HIV) infection. These deaths may represent a spectrum of HIV-related disease that has not been identified through AIDS surveillance and has resulted in a large underestimation of the impact of AIDS on IV drug users and blacks and Hispanics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stoneburner, R L -- Des Jarlais, D C -- Benezra, D -- Gorelkin, L -- Sotheran, J L -- Friedman, S R -- Schultz, S -- Marmor, M -- Mildvan, D -- Maslansky, R -- New York, N.Y. -- Science. 1988 Nov 11;242(4880):916-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉AIDS Research Unit, New York City Department of Health, NY 10013.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3187532" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/complications/*epidemiology/microbiology ; Cause of Death ; Endocarditis/complications ; Hiv ; HIV Seropositivity ; Homosexuality ; Humans ; Male ; New York City ; Pneumonia/complications ; Substance-Related Disorders/*complications/epidemiology/mortality ; Tuberculosis/complications
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Concerted nonsyntenic allelic loss in human colorectal carcinoma (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-08-19
    Description: Familial polyposis coli (FPC) is caused by an autosomal dominant gene on chromosome 5, and it has been proposed that colorectal cancer in the general population arises from loss or inactivation of the FPC gene, analogous to recessive tumor genes in retinoblastoma and Wilms' tumor. Since allelic loss can be erroneously scored in nonhomogeneous samples, tumor cell populations were first microdissected from 24 colorectal carcinomas, an additional nine cancers were engrafted in nude mice, and nuclei were flow-sorted from an additional two. Of 31 cancers informative for chromosome 5 markers, only 6 (19%) showed loss of heterozygosity of chromosome 5 alleles, compared to 19 of 34 (56%) on chromosome 17, and 17 of 33 (52%) on chromosome 18. Therefore, it appears that (i) FPC is a true dominant for adenomatosis but not a common recessive gene for colon cancer; and (ii) simple Mendelian models involving loss of alleles at a single locus may be inappropriate for understanding common human solid tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Law, D J -- Olschwang, S -- Monpezat, J P -- Lefrancois, D -- Jagelman, D -- Petrelli, N J -- Thomas, G -- Feinberg, A P -- New York, N.Y. -- Science. 1988 Aug 19;241(4868):961-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2841761" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/genetics ; Adenoma/genetics ; Adenomatous Polyposis Coli/*genetics ; *Alleles ; Animals ; Chromosomes, Human, Pair 17 ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, Pair 5 ; Colonic Neoplasms/*genetics ; DNA, Neoplasm/analysis ; Genes, Dominant ; *Genetic Linkage ; Humans ; Mice ; Precancerous Conditions/genetics ; Rectal Neoplasms/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Type-restricted neutralization of molecular clones of human immunodeficiency virus (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-07-15
    Description: In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such "clonal restriction" of neutralizing activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Looney, D J -- Fisher, A G -- Putney, S D -- Rusche, J R -- Redfield, R R -- Burke, D S -- Gallo, R C -- Wong-Staal, F -- New York, N.Y. -- Science. 1988 Jul 15;241(4863):357-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Viral Diseases, Walter Reed Army Institute of Research, Washington, DC 20307.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3388046" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antibodies, Viral/*immunology ; Binding, Competitive ; Cloning, Molecular ; HIV/genetics/*immunology ; HIV Seropositivity/immunology ; Humans ; Molecular Sequence Data ; Neutralization Tests ; Oligopeptides/chemical synthesis/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Autologous red cell agglutination assay for HIV-1 antibodies: simplified test with whole blood (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-09
    Description: An antibody detection procedure based on agglutination of autologous red cells has been developed for samples of whole blood. A nonagglutinating monoclonal antibody to human red blood cells conjugated to a synthetic peptide antigen (in this case residues 579 to 601 of the HIV-1 envelope precursor, Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gly-Ile-Trp- Gly-Cys - Ser-Gly-Lys) permitted the detection of antibodies to the human immunodeficiency virus type 1 (HIV-1) in 10 microliters of whole blood within 2 minutes. Agglutination was specifically inhibited by addition of synthetic peptide antigen but not by unrelated peptides. The frequency of false positive results was 0.1% with HIV-1 seronegative blood donors (n = 874). The false negative results were approximately 1% (n = 81). The autologous red cell agglutination test is potentially suitable for simple, rapid, qualitative screening for antibodies to a variety of antigens of medical and veterinary diagnostic significance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kemp, B E -- Rylatt, D B -- Bundesen, P G -- Doherty, R R -- McPhee, D A -- Stapleton, D -- Cottis, L E -- Wilson, K -- John, M A -- Khan, J M -- New York, N.Y. -- Science. 1988 Sep 9;241(4871):1352-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Melbourne, Repatriation General Hospital, Victoria, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3413497" target="_blank"〉PubMed〈/a〉
    Keywords: *Agglutination Tests ; Antibodies, Viral/*analysis ; Antibody Specificity ; Glycoproteins/immunology ; HIV/*immunology ; HIV Seropositivity/*diagnosis ; Humans ; Oligopeptides/immunology ; Retroviridae Proteins/immunology ; Viral Envelope Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    ER-2 lidar observations from the October 1986 fire cirrus experiment (1988)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A description of the ER-2 lidar data characteristics and available products, plus flight times and locations is presented for the FIRE cirrus experiment of October 13 through November 2, 1986. The CALS airborne lidar was flown for this experiment on the NASA ER-2 high altitude aircraft. The primary objectives of the CALS observations were to intensively measure cirrus cloud top height and structure for basic cirrus studies and for validation of satellite cloud retrievals.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: NASA-TM-100704 , NAS 1.15:100704
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 7
    Electronic Resource
    Electronic Resource
    Sorption and diffusion of benzene in HZSM-5 and silicalite crystals (1988)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 34 (1988), S. 1713-1717 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690341016
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  • 8
    Electronic Resource
    Electronic Resource
    Theoretical study of interfacial transport in gas-liquid flows (1988)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 34 (1988), S. 1789-1802 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Mass transfer in sheared, concurrent gas-liquid flows is investigated theoretically using solutions to the unaveraged advection-diffusion equation. For sufficiently thick films, the resistance to mass transfer is shown to be confined completely within a thin region in the liquid near the interface and mass transfer coefficients are accurately predicted by an improved numerical technique that uses a velocity field derived from an Orr-Sommerfeld equation with the time-varying velocity computed directly from measurements of interfacial waves. The mass transfer coefficients are shown to depend on the magnitude and frequency content of the velocity fluctuations normal to the interface. As the film thickness decreases, transfer resistance extends throughout the film and turbulent mixing in the middle of the film controls the transfer rates. For this region, limiting values of transfer coefficients are predicted well by analytical solutions to the advection-diffusion equation, which assume a laminar flow.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690341105
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  • 9
    Electronic Resource
    Electronic Resource
    Acceleration of chlorination of alumina using supercritical CCl4 (1988)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 34 (1988), S. 669-671 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690340416
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  • 10
    Electronic Resource
    Electronic Resource
    Micellar-enhanced ultrafiltration of chromate anion from aqueous streams (1988)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 34 (1988), S. 189-194 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Micellar-enhanced ultrafiltration can be used to remove multivalent anions or cations from aqueous streams. In the removal of chromate ions (CrO42-), the cationic surfactant hexadecylpyridinium chloride is added to the solution, and the chromate ions preferentially adsorb at the surface of the highly charged surfactant micelles. The solution is processed by ultrafiltration, using a membrane with pore sizes small enough to block the passage of the micelles and adsorbed ions. The permeate solution has a chromate concentration less than 0.1% that in the original stream. A new equilibrium model, combining the simple two-phase polyelectrolyte theory of Oosawa with thermodynamic activity, material-balance, and charge-balance equations, successfully correlates ultrafiltration and equilibrium dialysis results for chromate solutions.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690340203
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