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  • 1
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    Visualization of viral clearance in the living animal (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-04-24
    Description: The early events in viral dissemination via the bloodstream were identified by monitoring the fate of 123I-radiolabeled reovirus after it was injected intravenously in rats. Continuous scintillation camera imaging showed that reovirus serotypes 1 and 3 were cleared from the circulation in less than 10 minutes by specific and distinct target organs. Reovirus serotype 1 accumulated predominantly in the lungs and the liver, whereas serotype 3 accumulated in the liver and the spleen with very little virus uptake by the lungs. Incubation of reovirus serotype 1 with a monoclonal antibody directed against the viral hemagglutinin before injection totally inhibited the clearance of the virus by the lungs. Similar results were obtained when viruses biolabeled with 35S were used. These results demonstrate that viruses can be rapidly transported through the bloodstream to specific target organs and that the localization of the viruses depends on the interaction between specific viral surface components and the target organ.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verdin, E M -- Maratos-Flier, E -- Kahn, C R -- Sodoyez, J C -- Sodoyez-Goffaux, F -- De Vos, C J -- Lynn, S P -- Fields, B N -- AI 3178/AI/NIAID NIH HHS/ -- AM 01252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1987 Apr 24;236(4800):439-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3031817" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Complex ; Iodine Radioisotopes ; Mammalian orthoreovirus 3/physiology ; Reoviridae/immunology/*physiology ; Reoviridae Infections/*microbiology ; Time Factors ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Structurally distinct, stage-specific ribosomes occur in Plasmodium (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-11-13
    Description: Two structurally distinct nuclear genes code for cytoplasmic small subunit ribosomal RNA's in the parasite Plasmodium berghei. Stable transcripts from one of the ribosomal RNA genes are found almost exclusively in those stages of the life cycle that develop in the mosquito. When the parasite infects the mammalian host, transcripts from the second gene become the predominant small subunit ribosomal RNA species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gunderson, J H -- Sogin, M L -- Wollett, G -- Hollingdale, M -- de la Cruz, V F -- Waters, A P -- McCutchan, T F -- GM 32964/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1987 Nov 13;238(4829):933-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3672135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Genes ; Molecular Sequence Data ; Nucleic Acid Conformation ; Plasmodium/*genetics/growth & development ; RNA, Ribosomal/*genetics ; Ribosomes/*physiology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21 (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-10-23
    Description: The p21 products of ras proto-oncogenes are thought to be important components in pathways regulating normal cell proliferation and differentiation. These proteins acquire transforming properties as a result of activating lesions that convert ras genes to oncogenes in a wide array of malignancies. In Xenopus laevis oocytes, microinjection of transforming ras p21 is a potent inducer of maturation, whereas microinjection of a monoclonal antibody to ras p21 inhibits normal maturation induced by hormones. The phosphoinositide pathway is a ubiquitous system that appears to play a key role in diverse cellular functions. By use of the Xenopus oocyte system, it was possible to quantitate the effects of ras p21 microinjection on individual components of the phosphoinositide pathway. Within 20 minutes of microinjection, levels of phosphatidylinositol 4,5-bisphosphate, inositol 1-phosphate, and inositol bisphosphate increased 1.5- to 2-fold. The most striking effects were on diacylglycerol, which increased 5-fold under the same conditions. In contrast, the normal ras p21 protein induced no detectable alteration in any of the metabolites analyzed. The earliest effects of the transforming p21 on phosphoinositol turnover were observable within 2 minutes, implying a very rapid effect of ras p21 on the enzymes involved in phospholipid metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lacal, J C -- de la Pena, P -- Moscat, J -- Garcia-Barreno, P -- Anderson, P S -- Aaronson, S A -- New York, N.Y. -- Science. 1987 Oct 23;238(4826):533-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2821623" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diglycerides/*biosynthesis ; Female ; Glycerides/*biosynthesis ; Glycerol/metabolism ; Inositol/metabolism ; Inositol Phosphates/biosynthesis ; Kinetics ; Microinjections ; Oocytes/drug effects/*metabolism ; Phosphatidylinositol 4,5-Diphosphate ; Phosphatidylinositols/biosynthesis/*metabolism ; Proto-Oncogene Proteins/*pharmacology ; Proto-Oncogene Proteins p21(ras) ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Superspecies Pyrgus Malvae (Lepidoptera: Hesperiidae) in the East Mediterranean, with notes on Phylogenetic and Biological relationships (1987)
    In:  Zoologische Mededelingen vol. 61 no. 34, pp. 483-500
    Details
    Publication Date: 2024-01-12
    Description: The possible zone of contact between Pyrgus (malvae) malvae Linnaeus, 1758, and P. (malvae) melotis Duponchel, 1832, is re-examined. The two taxa apparently meet (in the subspecies malvae and ponticus Reverdin, 1914, respectively) in N. and W. Turkey and possibly in S. Russia north of the Caucasus. There are, however, only few localities or areas from where both are known: Amasya and north of Ankara in N. Turkey and Izmir in W. Turkey. In these areas the two taxa do not seem to recognize each other as belonging to the same species. A population with an intermediate character is known to occur in the Boz Dagh area east of Izmir. The population seems remarkably constant in this character. Its origin is obscure. The available data do not prompt us to change our view on the superspecies status of Pyrgus (malvae). Notes are added on the apparent incongruence of phylogenetic and biological relationships in this case. P. (malvae) melotis is widely distributed in Turkey, extending east to N. Iran, north to north of the Caucasus and south to Israel. Old records of melotis from Greece or the Aegean islands are highly improbable and should be omitted from further literature records. On the basis of external characters two subspecies are distinguished: melotis and ponticus.
    Keywords: Lepidoptera ; Hesperiidae ; Pyrgus ; malvae ; melotis ; superspecies
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 5
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    Cutting the Nomenclatural Gordian Knot around Pyrgus Carthami (H\xc3\xbcbner) (Lepidoptera: Hesperiidae) (1987)
    In:  Zoologische Mededelingen vol. 61 no. 26, pp. 371-385
    Details
    Publication Date: 2024-01-12
    Description: The name Papilio fritillarius Poda, 1761, is shown to be a nomen dubium. It has caused much confusion and has been applied to five or six different species since the first publication and to three different species in the last 40 years. To put an end to the confusion a neotype is designated.\nFor the neotype a specimen has been selected of the species currently known as Pyrgus malvae (Linnaeus), thus making Papilio fritillarius Poda, 1761, a junior subjective synonym of Papilio malvae Linnaeus, 1758. Consequently, Poda\'s name can no longer be used for the species named Papilio carthami by H\xc3\xbcbner, [1813] and now currently placed in the genus Pyrgus. The same species was named Papilio malvae maior by Fabricius (1787) and for reasons of priority H\xc3\xbcbner\'s name should fall for it. However, maior Fabricius has never been used as the valid name for the species and in this century has only been mentioned three times in synonymy. Therefore, a request will be submitted to the International Commission of Zoological Nomenclature to suppress the name, thus not only saving Papilio carthami H\xc3\xbcbner (now placed in Pyrgus) but also Syrichthus serratulae major Staudinger, 1878 (currently considered a subspecies of Pyrgus serratulae (Ramburs)), which would be in need of another name if Pyrgus maior (Fabricius) would remain the senior synonym of Pyrgus carthami (H\xc3\xbcbner).
    Keywords: nomenclature ; neotype ; suppression ; Hesperiidae ; Pyrgus ; fritillarius ; carthami ; maior ; malvae
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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