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  • American Association for the Advancement of Science (AAAS)  (1,052)
  • 2005-2009
  • 1985-1989  (1,052)
  • 1989  (349)
  • 1987  (352)
  • 1986  (351)
  • 1
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    Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-08-25
    Description: Activation of protein kinase C (PKC) can mimic the biophysical effects of associative learning on neurons. Furthermore, classical conditioning of the rabbit nictitating membrane (a form of associative learning) produces translocation of PKC activity from the cytosolic to the membrane compartments of the CA1 region of the hippocampus. Evidence is provided here for a significant change in the amount and distribution of PKC within the CA1 cell field of the rabbit hippocampus that is specific to learning. This change is seen at 1 day after learning as focal increments of [3H]phorbol-12,13-dibutyrate binding to PKC in computer-generated images produced from coronal autoradiographs of rabbit brain. In addition, 3 days after learning, the autoradiographs suggest a redistribution of PKC within CA1 from the cell soma to the dendrites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olds, J L -- Anderson, M L -- McPhie, D L -- Staten, L D -- Alkon, D L -- New York, N.Y. -- Science. 1989 Aug 25;245(4920):866-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular and Cellular Neurobiology, National Institute of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2772638" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Hippocampus/*enzymology ; *Memory ; Phorbol 12,13-Dibutyrate/metabolism ; Protein Kinase C/*analysis ; Rabbits
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Response: the myeloperoxidase gene in acute promyelocytic leukemia (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weil, S C -- Reid, M S -- Nilles, L A -- Chisholm, R L -- Rosner, G L -- Swanson, M S -- Carrino, J J -- Diaz, M O -- LE Beau, M M -- New York, N.Y. -- Science. 1989 May 19;244(4906):825-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17802240" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-28
    Description: Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's disease. Whether amyloid itself contributes to the neurodegenerative process or is simply a by-product of that process is unknown. Pheochromocytoma (PC12) and fibroblast (NIH 3T3) cell lines were transfected with portions of the gene for the human amyloid precursor protein. Stable PC12 cell transfectants expressing a specific amyloid-containing fragment of the precursor protein gradually degenerated when induced to differentiate into neuronal cells with nerve growth factor. Conditioned medium from these cells was toxic to neurons in primary hippocampal cultures, and the toxic agent could be removed by immunoabsorption with an antibody directed against the amyloid polypeptide. Thus, a peptide derived from the amyloid precursor may be neurotoxic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yankner, B A -- Dawes, L R -- Fisher, S -- Villa-Komaroff, L -- Oster-Granite, M L -- Neve, R L -- HD 18655/HD/NICHD NIH HHS/ -- HD 18658/HD/NICHD NIH HHS/ -- NS 01240/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1989 Jul 28;245(4916):417-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Harvard Medical School, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2474201" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*etiology/pathology ; Amyloid/genetics/*physiology ; Blotting, Northern ; Cell Line ; Fibroblasts ; Gene Expression Regulation ; Humans ; Immunoblotting ; Neurons/pathology ; Nucleic Acid Hybridization ; Pheochromocytoma ; Protein Precursors/genetics/*physiology ; RNA/analysis/genetics ; Restriction Mapping ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-02-27
    Description: The circumsporozoite (CS) protein of Plasmodium falciparum is the focus of intense efforts to develop an antisporozoite malaria vaccine. Localization of sites for T-cell recognition on this molecule is critical for vaccine design. By using an algorithm designed to predict T-cell sites and a large panel of H-2 congenic mice, a major nonrepetitive T-cell site was located. When a synthetic peptide corresponding to this site was covalently linked to the major B-cell site on the molecule, an immunogen capable of eliciting a high-titer antibody response was formed. This peptide sequence could prime helper T cells for a secondary response to the intact CS protein. The new helper T-cell site is located outside the repetitive region of the CS protein and appears to be the immunodominant T site on the molecule. This approach should be useful in the rational design and construction of vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Good, M F -- Maloy, W L -- Lunde, M N -- Margalit, H -- Cornette, J L -- Smith, G L -- Moss, B -- Miller, L H -- Berzofsky, J A -- New York, N.Y. -- Science. 1987 Feb 27;235(4792):1059-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2434994" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibody Formation ; Antigens, Protozoan/immunology ; Antigens, Surface/*immunology ; B-Lymphocytes/immunology ; Epitopes/*immunology ; Mice ; Peptide Fragments/chemical synthesis/*immunology ; Plasmodium falciparum/*immunology ; *Protozoan Proteins ; Receptors, Antigen, B-Cell/immunology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes, Helper-Inducer/*immunology ; Vaccines/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Determination of Venus Winds by Ground-Based Radio Tracking of the VEGA Balloons (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-21
    Description: A global array of 20 radio observatories was used to measure the three-dimensional position and velocity of the two meteorological balloons that were injected into the equatorial region of the Venus atmosphere near Venus midnight by the VEGA spacecraft on 11 and 15 June 1985. Initial analysis of only radial velocities indicates that each balloon was blown westward about 11,500 kilometers (8,000 kilometers on the night side) by zonal winds with a mean speed of about 70 meters per second. Excursions of the data from a model of constant zonal velocity were generally less than 3 meters per second; however, a much larger variation was evident near the end of the flight of the second balloon. Consistent systematic trends in the residuals for both balloons indicate the possibility of a solar-fixed atmospheric feature. Rapid variations in balloon velocity were often detected within a single transmission (330 seconds); however, they may represent not only atmospheric motions but also self-induced aerodynamic motions of the balloon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preston, R A -- Hildebrand, C E -- Purcell, G H Jr -- Ellis, J -- Stelzried, C T -- Finley, S G -- Sagdeev, R Z -- Linkin, V M -- Kerzhanovich, V V -- Altunin, V I -- Kogan, L R -- Kostenko, V I -- Matveenko, L I -- Pogrebenko, S V -- Strukov, I A -- Akim, E L -- Alexandrov, Y N -- Armand, N A -- Bakitko, R N -- Vyshlov, A S -- Bogomolov, A F -- Gorchankov, Y N -- Selivanov, A S -- Ivanov, N M -- Tichonov, V F -- Blamont, J E -- Boloh, L -- Laurans, G -- Boischot, A -- Biraud, F -- Ortega-Molina, A -- Rosolen, C -- Petit, G -- New York, N.Y. -- Science. 1986 Mar 21;231(4744):1414-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17748082" target="_blank"〉PubMed〈/a〉
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  • 6
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    Photometry from voyager 2: initial results from the uranian atmosphere, satellites, and rings (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-04
    Description: The Voyager 2 photopolarimeter successfully completed the Uranus encounter, acquiring new data on the planet's atmosphere, its principal satellites, and its ring system. Spatially resolved photometry of the atmosphere at 0.27 micrometer shows no enhancement in absorption toward the pole, unlike the case for Jupiter and Saturn. Stellar occultation measurements indicate the temperature at the 1-millibar level over the north pole is near 90 kelvins. The geometric albedos of the five large satellites of Uranus were measured at 0.27 and 0.75 micrometer and indicate the presence of low albedo, spetrally flat absorbing material. Titania seems to have a fluffy surface, as indicated by its phase curve. The nine ground-based rings were detected, and their internal structure, optical depths, and positions were determined. The sharp edges of the in ring made it possible to measure its edge thickness (less than 150 meters) and particle sizes (less than 30 meters); little or no dust was detcted. New narrow rings and partial rings (arcs) were measured, and the narrow component of the eta ring was found to be discontinuous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, A L -- Hord, C W -- West, R A -- Esposito, L W -- Simmons, K E -- Nelson, R M -- Wallis, B D -- Buratti, B J -- Horn, L J -- Graps, A L -- Pryor, W R -- New York, N.Y. -- Science. 1986 Jul 4;233(4759):65-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812890" target="_blank"〉PubMed〈/a〉
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  • 7
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    Very long baseline interferometric observations made with an orbiting radio telescope (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-10
    Description: An orbiting spacecraft and ground observatories have been used to obtain interferometric observations of cosmic radio sources. The Tracking and Data Relay Satellite System (TDRSS) was used as the orbiting observatory in conjunction with two 64- meter radio telescopes at ground observatories, one in Australia and one in Japan. The quasars 1730-130 (NRAO 530), 1510-089, and 1741-038 were observed at a frequency of 2.3 gigahertz, and a maximum projected baseline of 1.4 earth diameters was achieved. All quasar observations for which valid data were acquired resulted in detected fringes. Many of the techniques proposed for a dedicated very long baseline interferometry observatory in space were used successfully in this experiment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, G S -- Linfield, R P -- Ulvestad, J S -- Edwards, C D -- Jordan, J F Jr -- DI Nardo, S J -- Christensen, C S -- Preston, R A -- Skjerve, L J -- Stavert, L R -- Burke, B F -- Whitney, A R -- Cappallo, R J -- Rogers, A E -- Blaney, K B -- Maher, M J -- Ottenhoff, C H -- Jauncey, D L -- Peters, W L -- Nishimura, T -- Hayashi, T -- Takano, T -- Yamada, T -- Hirabayashi, H -- Morimoto, M -- Inoue, M -- Shiomi, T -- Kawaguchi, N -- Kunimori, H -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):187-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17746478" target="_blank"〉PubMed〈/a〉
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  • 8
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    An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-04-21
    Description: A specific assay has been developed for a blood-borne non-A, non-B hepatitis (NANBH) virus in which a polypeptide synthesized in recombinant yeast clones of the hepatitis C virus (HCV) is used to capture circulating viral antibodies. HCV antibodies were detected in six of seven human sera that were shown previously to transmit NANBH to chimpanzees. Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses. About 80 percent of chronic, post-transfusion NANBH (PT-NANBH) patients from Italy and Japan had circulating HCV antibody; a much lower frequency (15 percent) was observed in acute, resolving infections. In addition, 58 percent of NANBH patients from the United States with no identifiable source of parenteral exposure to the virus were also positive for HCV antibody. These data indicate that HCV is a major cause of NANBH throughout the world.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuo, G -- Choo, Q L -- Alter, H J -- Gitnick, G L -- Redeker, A G -- Purcell, R H -- Miyamura, T -- Dienstag, J L -- Alter, M J -- Stevens, C E -- New York, N.Y. -- Science. 1989 Apr 21;244(4902):362-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chiron Corporation, Emeryville, CA 94608.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2496467" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/*analysis ; Blood Donors ; Blood Transfusion ; Hepatitis C/*immunology/transmission ; Hepatitis Viruses/*immunology ; Hepatitis, Viral, Human/*immunology ; Humans ; Italy ; Japan ; United States
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  • 9
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    Photometry from voyager 2: initial results from the neptunian atmosphere, satellites, and rings (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-12-15
    Description: The Voyager photopolarimeter successfully accomplished its objectives for the Neptune encounter, performing measurements on the planet, several of its satellites, and its ring system. A photometric map of Neptune at 0.26 micrometer (microm) shows the planet to be bland, with no obvious contrast features. No polar haze was observed. At 0.75 microm, contrast features are observed, with the Great Dark Spot appearing as a low-albedo region and the bright companion as being substantially brighter than its surroundings, implying it to be at a higher altitude than the Great Dark Spot. Triton's linear phase coefficients of 0.011 magnitudes per degree at 0.26 microm and 0.013 magnitudes per degree at 0.75 microm are consistent with a solid-surface object possessing high reflectivity. Preliminary geometric albedos for Triton, Nereid, and 1989N2 were obtained at 0.26 and 0.75 microm. Triton's rotational phase curve shows evidence of two major compositional units on its surface. A single stellar occultation of the Neptune ring system elucidated an internal structure in 1989N1R, in the approximately 50-kilometer region of modest optical depth. 1989N2R may have been detected. The deficiency of material in the Neptune ring system, when compared to Uranus', may imply the lack of a "recent" moon-shattering event.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, A L -- West, R A -- Hord, C W -- Nelson, R M -- Simmons, K E -- Pryor, W R -- Eposito, L W -- Horn, L J -- Wallis, B D -- Buratti, B J -- Brophy, T G -- Yanamandra-Fisher, P -- Colwell, J E -- Bliss, D A -- Mayo, M J -- Smythe, W D -- New York, N.Y. -- Science. 1989 Dec 15;246(4936):1450-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17755998" target="_blank"〉PubMed〈/a〉
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  • 10
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    Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-07
    Description: Basic fibroblast growth factor (bFGF) participates in many processes including early developmental events, angiogenesis, wound healing, and maintenance of neuronal cell viability. A 130-kilodalton protein was isolated on the basis of its ability to specifically bind to bFGF. A complementary DNA clone was isolated with an oligonucleotide probe corresponding to determined amino acid sequences of tryptic peptide fragments of the purified protein. The putative bFGF receptor encoded by this complementary DNA is a transmembrane protein that contains three extracellular immunoglobulin-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain. These domains are arranged in a pattern that is different from that of any growth factor receptor described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, P L -- Johnson, D E -- Cousens, L S -- Fried, V A -- Williams, L T -- CA 21765/CA/NCI NIH HHS/ -- R01 HL32898/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jul 7;245(4913):57-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2544996" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cells, Cultured ; Chick Embryo ; *Cloning, Molecular ; DNA/*genetics ; Fibroblast Growth Factors/*genetics ; Kinetics ; Mice ; Molecular Sequence Data ; Peptide Fragments/analysis ; Receptors, Cell Surface/*genetics/metabolism ; Receptors, Fibroblast Growth Factor ; Recombinant Proteins/metabolism
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