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  • Physical Chemistry  (3)
  • Antigen distribution  (1)
  • Brain Diseases/*microbiology  (1)
  • 1985-1989  (5)
  • 1925-1929
  • 1985  (5)
  • 1
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    HTLV-III infection in brains of children and adults with AIDS encephalopathy (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-11
    Description: Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, G M -- Harper, M E -- Hahn, B H -- Epstein, L G -- Gajdusek, D C -- Price, R W -- Navia, B A -- Petito, C K -- O'Hara, C J -- Groopman, J E -- New York, N.Y. -- Science. 1985 Jan 11;227(4683):177-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2981429" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/microbiology ; Adult ; Antibodies, Viral/analysis ; Brain Diseases/*microbiology ; Cerebral Cortex/analysis/*microbiology ; Child ; Deltaretrovirus/*isolation & purification ; Dementia/microbiology ; Female ; Humans ; Infant ; Male ; Middle Aged ; Nucleic Acid Hybridization ; RNA, Viral/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunological detection of a cysteine protease in the skin and other tissues (1985)
    Springer
    Cell & tissue research 240 (1985), S. 417-423 
    Details
    ISSN: 1432-0878
    Keywords: Cysteine protease ; Epidermal cells ; Antigen localization ; Cell differentiation ; Antigen distribution ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Monospecific antibody directed to cysteine protease of 2-day-old rat epidermis recently characterized as being different from the proteases previously reported was produced in rabbits. By immunofluorescence microscopy and immunoperoxidase staining with an avidin-biotin-peroxidase method the protease was found to be present in the epidermis of rodents of different ages as well as that of humans, but not in the dermis. The staining in germinative cells was more intense than in cells in the superficial layers. It appeared as irregular patches in the nuclei and stained more diffusely in the cytoplasm where small granular components, strongly stained, were identified. The staining patterns in granular cells showed accumulation of the antigen in a granular form. The morphology and distribution of granules resembled those of keratohyalin-like granules in the nucleus and dense homogenous deposits in the cytoplasm. In cornified cells the reaction product was localized by the plasma membrane where concentration of the dense homogenous deposits occurred, suggesting that the cysteine protease is one component of the unique and characteristic structure of differentiated keratinocytes. In addition, the cysteine protease antigen having the same molecular weight as the epidermal enzyme was detected in liver, kidney and lung indicating a wider tissue distribution of the protease. The significance of the protease in regulation of cellular functions remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222354
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  • 3
    Electronic Resource
    Electronic Resource
    Model study of synchronization and other phenomena in light perturbation of the Briggs-Rauscher reaction (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 345-354 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Calculations are performed to model several phenomena observed when a photosensitive oscillating chemical reaction, the Briggs-Rauscher (BR) reaction, is subject to irradiation in a continuous-flow stirred-tank reactor. The BR mechanism proposed earlier by De Kepper and Epstein is supplemented by additional steps involving the photogeneration and subsequent reaction of iodine atoms. The calculations show qualitative agreement with the following experimentally observed phenomena: (a) change in the period and amplitude of oscillation as a function of the intensity of constant illumination, (b) synchronization between periodically varying illumination and the period of chemical oscillation, (c) phase shifts induced by single light pulses, and (d) dark steady states which are excitable by single light pulses and become oscillatory at appropriate levels of constant illumination.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170311
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  • 4
    Electronic Resource
    Electronic Resource
    Complex dynamical behavior in a new chemical oscillator: The chlorite-thiourea reaction in a CSTRPart 25 in the series Systematic Design of Chemical Oscillators. (Part 24: E. Kumpinsky and I. R. Epstein, J. Chem. Phys., in press.) (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 429-439 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction between chlorite ion and thiourea has been studied both in a closed (batch) system and in a flow reactor (CSTR). The principal stoichiometry is given by \documentclass{article}\pagestyle{empty}\begin{document}$$ 2{\rm ClO}_{\rm 2} ^{\rm - } + {\rm CS(NH}_{\rm 2} {\rm)}_{\rm 2} + {\rm 2NH}_{\rm 4} ^ + + {\rm CO}_{\rm 2} + 2{\rm Cl}^{\rm - } + {\rm SO}_{\rm 4} ^{{\rm 2 - }} $$\end{document} In batch, the reaction displays an induction period, whose length is proportional to [CS(NH2)2]/[ClO2-] [H+], followed by the rapid buildup and disappearance of a ClO2 intermediate. At [ClO2-]/[CS(NH2)2] ratios between 2.5 and 3.5, a second peak in the ClO2 absorbance is observed. In the CSTR, this iodine-free system displays simple and complex periodic oscillation, bistability, aperiodic oscillation, and birhythmicity.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170409
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  • 5
    Electronic Resource
    Electronic Resource
    Autocatalysis and bistability in the reaction between nitric acid and thiocyanate (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 601-612 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction between nitric acid and thiocyanate has been studied both in batch and flow configurations. The batch reaction is autocatalytic with an induction period which is decreased by the addition of HNO2. At the nitric acid concentrations employed (1-10 M), a red NOSCNH+ intermediate is formed. The reaction in a flow reactor exhibits bistability. A model involving competitive reactions of SCN- and NOSCNH+ with NO2 is suggested, and computer simulations with this model give good agreement with both the batch and flow experiments.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170606
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