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  • Hybrid Cells  (6)
  • American Association for the Advancement of Science (AAAS)  (6)
  • American Institute of Physics
  • 2020-2022
  • 1995-1999
  • 1980-1984  (6)
  • 1940-1944
  • 1984  (6)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (6)
  • American Institute of Physics
Years
  • 2020-2022
  • 1995-1999
  • 1980-1984  (6)
  • 1940-1944
Year
  • 1
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    Interferon-beta-related DNA is dispersed in the human genome (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-23
    Description: Interferon-beta 1 (IFN-beta 1) complementary DNA was used as a hybridization probe to isolate human genomic DNA clones lambda B3 and lambda B4 from a human genomic DNA library. Blot-hybridization procedures and partial nucleotide sequencing revealed that lambda B3 is related to IFN-beta 1 (and more distantly to IFN-alpha 1). Analyses of DNA obtained from a panel of human-rodent somatic cell hybrids that were probed with DNA derived from lambda B3 showed that lambda B3 is on human chromosome 2. Similar experiments indicated that lambda B4 is not on human chromosomes 2, 5, or 9. The finding that DNA related to the IFN-beta 1 gene (and IFN-alpha 1 gene) is dispersed in the human genome raises new questions about the origins of the interferon genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sagar, A D -- Sehgal, P B -- May, L T -- Inouye, M -- Slate, D L -- Shulman, L -- Ruddle, F H -- AI-16262/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1312-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6546621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human/*analysis ; Chromosomes, Human, 1-3 ; Chromosomes, Human, 4-5 ; Chromosomes, Human, 6-12 and X ; Cloning, Molecular ; Cricetinae ; DNA/*analysis ; *Genes ; Humans ; Hybrid Cells ; Interferon Type I/*genetics ; Mice ; Nucleic Acid Hybridization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Chromosomal location of human T-cell receptor gene Ti beta (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, P E -- Ruddle, F H -- Royer, H D -- Acuto, O -- Reinherz, E L -- AI 21226/AI/NIAID NIH HHS/ -- GM-09966/GM/NIGMS NIH HHS/ -- R0 1 AI 19807/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):348-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6435246" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; Cloning, Molecular ; Dna ; *Genes ; Genetic Linkage ; Humans ; Hybrid Cells ; Immunoglobulin kappa-Chains/genetics ; Major Histocompatibility Complex ; Mice ; Nucleic Acid Hybridization ; Receptors, Antigen, T-Cell/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Activation of dormant genes in specialized cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: In several experimental systems the genomic capacity in specialized cells can be assessed by examining the activation of dormant genes. Since some of these specialized cells can be induced to change cell phenotype, all cell specializations do not necessarily involve irreversible genetic changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiBerardino, M A -- Hoffner, N J -- Etkin, L D -- GM 23635/GM/NIGMS NIH HHS/ -- GM 31479/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):946-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719127" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; *Cell Differentiation ; Cell Fusion ; Cell Transformation, Neoplastic/metabolism ; Chickens ; Chromatin/physiology ; DNA/genetics/metabolism ; Drosophila ; Embryo, Mammalian/physiology ; Embryo, Nonmammalian ; Extremities/growth & development ; *Gene Expression Regulation ; Humans ; Hybrid Cells ; Iris/growth & development ; Methylation ; Mice ; Nuclear Transfer Techniques ; Phenotype ; Rats ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11 (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-06
    Description: A rapid gene-mapping system uses a high-resolution, dual-laser sorter to identify genes from separate human chromosomes prepared with a new stain combination. This system was used to sort 21 unique chromosome types onto nitrocellulose filter papers. Several labeled gene probes hybridized to the sorted chromosomal DNA types predicted by their previous chromosome assignments. The skeletal muscle glycogen phosphorylase gene was then mapped to a portion of chromosome 11 by spot blotting normal and translocated chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lebo, R V -- Gorin, F -- Fletterick, R J -- Kao, F T -- Cheung, M C -- Bruce, B D -- Kan, Y W -- AM32822/AM/NIADDK NIH HHS/ -- HD02081/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):57-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6587566" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; Cricetinae ; Cricetulus ; DNA/*metabolism ; Glycogen Storage Disease/*genetics ; Glycogen Storage Disease Type V/*genetics ; Humans ; Hybrid Cells ; Karyotyping ; Male ; Nucleic Acid Hybridization ; Phosphorylases/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Duchenne muscular dystrophy involving translocation of the dmd gene next to ribosomal RNA genes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-29
    Description: Duchenne muscular dystrophy (DMD) is a severe X-linked disorder leading to early death of affected males. Females with the disease are rare, but seven are known to be affected because of a chromosomal rearrangement involving a site at or near the dmd gene on the X chromosome. One of the seven has a translocation between the X and chromosome 21. The translocation-derived chromosomes from this patient have been isolated, and the translocation is shown to have split the block of genes encoding ribosomal RNA on the short arm of chromosome 21. Thus ribosomal RNA gene probes may be used to identify a junction fragment from the translocation site, allowing access to cloned segments of the X at or near the dmd gene and presenting a new approach to the study of this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Worton, R G -- Duff, C -- Sylvester, J E -- Schmickel, R D -- Willard, H F -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1447-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729462" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Child ; DNA/genetics ; Female ; Genes ; Humans ; Hybrid Cells ; Male ; Mice ; Muscular Dystrophies/*genetics ; RNA, Ribosomal/*genetics ; *Translocation, Genetic ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Chromosomal location of human metallothionein genes: implications for Menkes' disease (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: Human metallothioneins are encoded by a complex multigene family. The chromosomal location of these genes has been determined by gel transfer hybridization analysis of the DNA from human-rodent cell hybrids. Chromosome 16 contains a cluster of metallothionein sequences, including two functional metallothionein I genes and a functional metallothionein II gene. The remaining sequences, including a processed pseudogene, are dispersed to at least four other autosomes. The absence of metallothionein sequences from the X chromosome indicates that Menkes' disease, an X-linked disorder of copper metabolism, affects metallothionein expression by a trans-acting mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, C J -- Hamer, D H -- McBride, O W -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1104-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Diseases, Metabolic/*genetics ; *Chromosome Mapping ; Chromosomes, Human, 16-18 ; Copper/metabolism ; Cricetinae ; Cricetulus ; Humans ; Hybrid Cells ; Menkes Kinky Hair Syndrome/*genetics ; Metallothionein/*genetics ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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