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  • 1
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    Activation of dormant genes in specialized cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: In several experimental systems the genomic capacity in specialized cells can be assessed by examining the activation of dormant genes. Since some of these specialized cells can be induced to change cell phenotype, all cell specializations do not necessarily involve irreversible genetic changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiBerardino, M A -- Hoffner, N J -- Etkin, L D -- GM 23635/GM/NIGMS NIH HHS/ -- GM 31479/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):946-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719127" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; *Cell Differentiation ; Cell Fusion ; Cell Transformation, Neoplastic/metabolism ; Chickens ; Chromatin/physiology ; DNA/genetics/metabolism ; Drosophila ; Embryo, Mammalian/physiology ; Embryo, Nonmammalian ; Extremities/growth & development ; *Gene Expression Regulation ; Humans ; Hybrid Cells ; Iris/growth & development ; Methylation ; Mice ; Nuclear Transfer Techniques ; Phenotype ; Rats ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Developmental potential of somatic nuclei transplanted into meiotic oocytes of Rana pipiens (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Somatic nuclei, when transplanted into oocytes at the stage of first meiotic metaphase, were induced to undergo chromosome condensation and alignment on spindles. When the oocytes completed maturity in vitro and were activated, the somatic nuclei transformed into "fertilization" nuclei and promoted development through embryogenesis. Thus somatic nuclei can reversibly respond to cytoplasms directing either meiotic or mitotic events, and somatic nuclei from differentiated cells may be reversed by conditioning in oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffner, N J -- DiBerardino, M A -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6967227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Blastocyst/physiology ; Cell Nucleus/physiology ; Female ; Larva/physiology ; *Meiosis/drug effects ; Metaphase ; *Nuclear Transfer Techniques ; Oocytes/*physiology ; Ovum/*physiology ; Pituitary Gland/physiology ; Progesterone/pharmacology ; Rana pipiens ; Tissue Extracts/pharmacology ; Transplantation, Autologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Gene reactivation in erythrocytes: nuclear transplantation in oocytes and eggs of Rana (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-18
    Description: Adult erythrocyte nuclei of Rana, transplanted and incubated in the cytoplasm of maturing oocytes, direct matured oocytes to form swimming tadpoles. These results demonstrate that nuclei of noncycling and terminally differentiated erythrocytes contain the genes to specify tadpole development, and conditioning these nuclei in the cytoplasm of oocytes leads to a widespread reactivation of dormant genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiBerardino, M A -- Hoffner, N J -- GM-23635/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):862-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6600520" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/physiology ; Erythrocytes/*physiology ; Female ; *Gene Expression Regulation ; Nuclear Transfer Techniques ; Oocytes/*physiology ; Ovum/*physiology ; Rana pipiens/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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