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  • Articles  (45)
  • Chemistry  (45)
  • Biochemistry and Biotechnology
  • 1985-1989  (23)
  • 1980-1984  (22)
  • 1970-1974
  • 1986  (23)
  • 1984  (22)
  • Technology  (39)
  • Natural Sciences in General  (6)
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  • Articles  (45)
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  • 1985-1989  (23)
  • 1980-1984  (22)
  • 1970-1974
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  • 1
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 1347-1357 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Ultra low temperature isotropic (ULTI) carbon-coated polyester suture material was evaluated histologically and mechanically in dogs. These results were compared to those obtainedfor uncoated polyester and polybutylate coated polyester. The suture materials were used in therepair of the surgically incised medical collateral ligament and subcutaneous tissues to evaluate the potential of the carbon-coated system for ligamentous repairs. Following surgery, the dogs were sacrificed at periods of 1-48 weeks postoperatively for evaluation of tissue biocompatibility and mechanical strength of the materials. The polybutylate-coated polyester suture broke at lower force levels than did comparable sizes of uncoated or carbon-coated polyester. All three types showed a high retention (〉98%) of mechanical strength at 48weeks, often exhibiting an increase in tensile strength due to tissue ingrowth. The histologic response to carbon-coated polyester was equal to or better than the response to either the uncoated polyester or polybutylate-coated polyester. A greater degree of tissue growth into the carbon-coated material was evident at most time periods following an initial acute inflammatory response which was also present in the other materials.
    Additional Material: 11 Ill.
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 1391-1400 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The objective of the investigation was to examine the reactions of mercury with silver-tin alloys with compositions spanning the phase fields β, (β + γ), γ, and (γ + Sn). The experimental methods employed include the application of light microscopy, scanning electron microscopy, and electron probe microanalysis. These techniques were used to investigate the mechanisms of reaction and to identify the nature and morphology of the reaction products formed on bulk specimens of the alloys. The progress and characteristics of the reactionsthat occur during hardening of amalgams prepared from powders of these alloys were monitored using a highsensitivity dilatometer. These results were correlated with direct observations on the development of the microstructures. The reaction of mercury with the β-phase alloy occurred rapidly and resulted in a very marked and rapid expansion during the initial stages of hardening. γ-Phase alloys, on the other hand, reacted more slowly and contracted markedly during hardening. The behavior of amalgams made from alloys with compositions lying between these two extremes appeared to be explicable in terms of the characteristics of the separate phases from which they were constituted.
    Additional Material: 10 Ill.
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  • 3
    Publication Date: 1986-05-30
    Description: For many drugs, only racemic mixtures are available for clinical use. Because different stereoisomers of drugs often cause different physiological responses, the use of pure isomers could elicit more exact therapeutic effects. Differential complexation of a variety of drug stereoisomers by immobilized beta-cyclodextrin was investigated. Chiral recognition and racemic resolution were observed with a number of compounds from such clinically useful classes as beta-blockers, calcium-channel blockers, sedative hypnotics, antihistamines, anticonvulsants, diuretics, and synthetic opiates. Separation of the diastereomers of the cardioactive and antimalarial cinchona alkaloids and of two antiestrogens was demonstrated as well. Three dimensional projections of beta-cyclodextrin complexes of propanolol, which is resolved by this technique, and warfarin, which is not, are compared. These studies have improved the understanding and application of the chiral interactions of beta-cyclodextrin, and they have demonstrated a means to measure optical purity and to isolate or produce pure enantiomers of drugs. In addition, this highly specific technique could also be used in the pharmacological evaluation of enantiomeric drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Armstrong, D W -- Ward, T J -- Armstrong, R D -- Beesley, T E -- RR1081/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1986 May 30;232(4754):1132-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704640" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Cinchona Alkaloids/isolation & purification ; *Cyclodextrins ; *Dextrins ; Propranolol/isolation & purification ; *Starch ; *Stereoisomerism ; Warfarin/isolation & purification ; *beta-Cyclodextrins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 413-425 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A complete study of the static and dynamic strength of complete maxillary dentures was undertaken. First, the denture base material was investigated in its various forms from the point of view of tension, creep, relaxation, fatigue, and the effect of a corrosive environment. Complete dentures were tested under static compression, and the distribution of stresses along the midline of the upper dentures was determined by means of strain rosettes and by reciprocating compression, the determination of their fatigue strength. The results were found to conform with experience as far as lifetime of complete dentures is concerned.
    Additional Material: 10 Ill.
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  • 5
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Although dogs have been used widely to study the healing of large caliber synthetic grafts, hypercoagulability probably makes the dog a poor model for studies of small caliber vascular prostheses. The baboon's coagulation system is similar to man's, but large caliber baboon grafts were reported to endothelialize rapidly. In this study the healing pattern of 4mm internal diameter Dacron carotid interpositon grafts in baboons was determined using specimens harvested at time points between 2 weeks and 18 months post-implantation and examined with light and scanning electron microscopy. The luminal surface of baboon grafts in the acute healing phase (〈1 month) was comparable to that reported in the literature for dogs. Baboon grafts did not completely endothelialize until 10-12 weeks post-implantation. For work with small caliber vascular protheses, the dog appears to have no advantage over the baboon as an animal model on the basis of graft healing.
    Additional Material: 6 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 601-607 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This study was undertaken to examine the effectiveness of a commercially available n-butyl-2-cyanoacrylate (Histoacryl blueTri-Hawk International, 1570 Barré, Montréal, H4L 4M6 Quebec.) as a local treatment for cutaneous ulcers. Two ulcers, approximately 0.5 cm2 each, were made on the backs of 30 hamsters. The right side was covered with a thin film of tissue adhesive, while the left side was left untreated as a control. Animals were sacrificed at various times post-operatively, the tissue excised, processed, and examined with the light microscope. Results showed that cyanoacrylate decreased the inflammatory exudate early in the experiment, and epithelial migration occurred slightly earlier in experimental tissue. Scab formation was absent in experimental sites until the layer of adhesive was lost. After 2 days, healing was comparable in both experimental and control, and the sites were indistinguishable histologically at day 5.
    Additional Material: 4 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 895-909 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An alternative to the usual technique of preclotting porous textile vascular prostheses prior to surgical implantation is to render them impermeable to blood by impregnation with a cross-linked albumin filler matrix. This material subsequently becomes the foundation for cellular development. The compatibility of such impregnated fabrics with newly formed endothelial cells has been evaluated by an in vitro organotypic culture method. This technique enables the characterization and numeration of cells that develop on blood contact surfaces and enables determination of their rate of development. Woven, knitted, and velour fabrics were evaluated folllowing coating with albumin and either storage in Tyrode solution or 40% ethanol or desiccation by critical point drying. Preclotted cardiovascular repair fabrics prepared according to conventional surgical protocol served as controls. The identification of the newly formed cells was confirmed histologically. The most extensive and rapid cellular development was observed on the woven fabric and is believed may have resulted from the smoother surface topography of this substrate. Good cellular development was noted particularly on fabrics which had been stored in Tyrode solution. Ethanol had a deleterious effect on the apparent compatibility.
    Additional Material: 6 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 771-779 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Few in vitro systems for testing dental restorative materials have taken into account the protection afforded by the residual dentine in vivo. In turn opinions differ as to whether an increase in residual dentine thickness increases this protection. In this study an increase in the depth of dentine powder beneath zinc oxide eugenol (ZOE) reduced its toxicity, while this was not the case with the glass ionomer cement. Compaction of the powder had no effect, suggesting that protection was due to binding of the toxicant to the dentine rather than it acting as a physical barrier. Protein was shown to be very important in moderating the cytotoxicity of ZOE. These results suggest that in vivo the irritancy of some materials may be related to the depth of residual dentine but not others. The effect of exposure period and volume of these materials on their cytotoxicity was also investigated. Increasing the volume of ZOE while retaining the same surface area increased the toxicity of ZOE, while with the glass ionomer it had no effect.
    Additional Material: 1 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 433-468 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Despite the use of polyurethanes in a number of blood-contacting applications, little is known about the contributing effects of the various polyurethane components in thrombogenesis. In order to investigate blood-polyurethane interactions, a number of different polyurethanes were examined in an acute canine ex vivo series shunt experiment. Multiprobe surface characterization techniques, including contact angle measurements, ESCA, ATR-IR, and SEM were used to obtain surface property information on the materials studied. The polyurethanes examined included several with different soft segment types, a series of materials with different hard segment diisocyanates and chain extenders, a series consisting of the same polymer cast from different solvents, a zwitterionomer, and a hard segment analog. Two commercial urethanes were also examined, and the effect of methanol extraction on these materials was studied.The blood-contact and surface characterization results indicated that both the surface concentration and type of hard segment were of importance in determining blood response. The relative concentration of hard segment on the polymer surface was found to affect the observed blood-material interaction, although the extent of this effect was found to depend on the hard and soft segment components of the copolymer system. Both the surface properties and thrombogenicity of a particular polyurethane were changed by casting from different solvents, indicating the need to optimize and control fabrication conditions. Methanol extraction was found to improve the thromboresistance of the commercial polyurethanes.
    Additional Material: 19 Ill.
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  • 10
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 861-865 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 1 Ill.
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