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  • Disease Models, Animal  (6)
  • American Association for the Advancement of Science (AAAS)  (6)
  • Cambridge University Press
  • 1980-1984  (6)
  • 1940-1944
  • 1980  (6)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (6)
  • Cambridge University Press
Years
  • 1980-1984  (6)
  • 1940-1944
Year
  • 1
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    Mebendazole therapy of parenteral trichinellosis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCracken, R O -- Taylor, D D -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355285" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Benzimidazoles/*therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Larva ; Male ; Mebendazole/administration & dosage/*therapeutic use ; Mice ; Muscles/parasitology ; Trichinella/drug effects ; Trichinellosis/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Functional development of grafted vasopressin neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-19
    Description: Vasopressin neurons, transplanted from normal rat fetuses into the third ventricle of adult Brattleboro rats, alleviate the polydipsia and polyuria of the hosts. Determination of the antidiuretic activity of grafted neurons in hosts with congenital diabetes insipidus provides a convenient model for analyzing the development, plasticity, and function of transplanted central nervous system neurons in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gash, D -- Sladek, J R Jr -- Sladek, C D -- AM 16166/AM/NIADDK NIH HHS/ -- NS 15109/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 19;210(4476):1367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Insipidus/physiopathology/*therapy ; Disease Models, Animal ; Drinking Behavior/physiology ; Hypothalamus/cytology/embryology/*transplantation ; Kidney Concentrating Ability ; Rats ; Transplantation, Homologous ; Vasopressins/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Animal anorexias (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-22
    Description: Eating very little in the presence of food or failure to serach for food has been documented in various species during the hibernation season, incubation, molting, and defense of the territory or harem. At these times feeding competes with other, more important activities. One way to avoid conflicts between feeding and these other activities to lower the programmed weight or set-point for body fat. Experiments on mammalian hibernators and incubating birds provide evidence that set-points are indeed lowered. Failure to eat in these two examples depends on anorexia, loss of appetite. A review of other examples suggests that conceptualization in terms of lowered set-points provides a unified and testable way of understanding many naturally occurring instances of fasting in the animal kingdom. Finally, spontaneous animal anorexias are contrasted with attempts by people to lose weight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mrosovsky, N -- Sherry, D F -- New York, N.Y. -- Science. 1980 Feb 22;207(4433):837-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928327" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anorexia/*veterinary ; Anorexia Nervosa/physiopathology ; Behavior, Animal/*physiology ; Birds/physiology ; Body Weight ; Disease Models, Animal ; Energy Metabolism ; Feeding Behavior/*physiology ; Feeding and Eating Disorders/*veterinary ; Hibernation ; Humans ; Maternal Behavior/physiology ; Obesity/physiopathology ; Rodentia/physiology ; Territoriality
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Teratogenic effects of alcohol in humans and laboratory animals (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-18
    Description: The teratogenicity of alcohol has been demonstrated in humans through clinical studies, behavioral studies, and epidemiologic studies, and in animals through controlled laboratory experiments. In humans exposed to alcohol during gestation the effects can range from fetal alcohol syndrome in some offspring of chronic alcoholic women to reduced average birth weight in offspring of women reporting an average consumption of two to three drinks or more per day. The behavioral effects of such exposure may range from mental retardation in children with fetal alcohol syndrome to milder developmental and behavioral effects in infants born to social drinkers. In animals, exposure to alcohol in utero may result in death, malformation, and growth deficiency as well as behavioral and developmental abnormalities. The mechanisms of impairment and related risk factors are yet to be elucidated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streissguth, A P -- Landesman-Dwyer, S -- Martin, J C -- Smith, D W -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):353-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6992275" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced ; Alcohol Drinking ; Brain/pathology ; Disease Models, Animal ; *Ethanol/pharmacology ; Female ; Fetal Alcohol Spectrum Disorders/*physiopathology ; Humans ; Hyperkinesis/chemically induced ; Infant, Low Birth Weight ; Infant, Newborn ; Pregnancy ; Sucking Behavior/drug effects ; *Teratogens
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Rat model for carcinogenesis in ureterosigmoidostomy (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-07
    Description: A rat model is used to study the carcinogenesis that occurs when urine is surgically diverted into the fecal stream, as in ureterosigmoidostomy. Adenocarcinoma of the colon occurs adjacent to the urine inlet. It is completely prevented by proximal diversion of the feces, implying that fecal carcinogens are activated locally by the urine or the urothelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crissey, M M -- Steele, G D -- Gittes, R F -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1079-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355272" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*etiology ; Animals ; Biotransformation ; Carcinogens ; Colon, Sigmoid/metabolism/*surgery ; Disease Models, Animal ; Rats ; Sigmoid Neoplasms/*etiology ; Ureter/*surgery ; Urinary Diversion/*adverse effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Cross-linking of lens crystallins in a photodynamic system: a process mediated by singlet oxygen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-13
    Description: In a dye-sensitized photooxidation system, lens crystallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goosey, J D -- Zigler, J S Jr -- Kinoshita, J H -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1278-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375939" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Cataract/etiology ; Cattle ; Crystallins/*radiation effects ; Disease Models, Animal ; Fluorescence ; Light ; Methylene Blue ; Oxidation-Reduction ; Oxygen ; Photochemistry ; Riboflavin ; Rose Bengal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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