Publication Date:
1980-06-13
Description:
In a dye-sensitized photooxidation system, lens crystallin polypeptides become cross-linked, and a blue fluorescence that is associated with the proteins is produced. These changes are similar to those seen in vivo in the aging human lens. Evidence implicating singlet oxygen as the causative agent of the effects in vitro is presented, and the possibility that this species may play a role in aging and cataractogenesis in vivo is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goosey, J D -- Zigler, J S Jr -- Kinoshita, J H -- New York, N.Y. -- Science. 1980 Jun 13;208(4449):1278-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375939" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Cataract/etiology
;
Cattle
;
Crystallins/*radiation effects
;
Disease Models, Animal
;
Fluorescence
;
Light
;
Methylene Blue
;
Oxidation-Reduction
;
Oxygen
;
Photochemistry
;
Riboflavin
;
Rose Bengal
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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