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  • Humans  (102)
  • Rats  (73)
  • Adult  (9)
  • American Association for the Advancement of Science (AAAS)  (170)
  • American Chemical Society
  • 1980-1984  (99)
  • 1975-1979  (71)
  • 1982  (99)
  • 1979  (71)
Sammlung
Schlagwörter
Verlag/Herausgeber
  • American Association for the Advancement of Science (AAAS)  (170)
  • American Chemical Society
Erscheinungszeitraum
  • 1980-1984  (99)
  • 1975-1979  (71)
Jahr
  • 1
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    Nonpneumonic, short-incubation-period Legionellosis (Pontiac fever) in men who cleaned a steam turbine condenser (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-08-17
    Beschreibung: Pontiac fever affected ten men who had cleaned a steam turbine condenser with compressed air. Previous epidemics of Pontiac fever and Legionnaires' disease--both caused by Legionella Pneumophila (proposed sp. nov.)--involved "airborne spread" from air-conditioning cooling towers or evaporative condensers. Aerosols of contaminated water in heat-rejection systems appear to be important sources of epidemic legionellosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraser, D W -- Deubner, D C -- Hill, D L -- Gilliam, D K -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):690-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462175" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Air Microbiology ; Humans ; Legionnaires' Disease/*etiology/microbiology/transmission ; Male ; Occupational Medicine ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-02-26
    Beschreibung: The glucagon analog [l-N alpha-trinitrophenylhistidine, 12-homoarginine]-glucagon (THG) was examined for its ability to lower blood glucose concentrations in rats made diabetic with streptozotocin. In vitro, THG is a potent antagonist of glucagon activation of the hepatic adenylate cyclase assay system. Intravenous bolus injections of THG caused rapid decreases (20 to 35 percent) of short duration in blood glucose. Continuous infusion of low concentrations of the inhibitor led to larger sustained decreases in blood glucose (30 to 65 percent). These studies demonstrate that a glucagon receptor antagonist can substantially reduce blood glucose levels in diabetic animals without addition of exogenous insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, D G -- Goebel, C U -- Hruby, V J -- Bregman, M D -- Trivedi, D -- AM21085/AM/NIADDK NIH HHS/ -- AM25318/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1115-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278587" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Diabetes Mellitus, Experimental/*drug therapy ; Glucagon/*analogs & derivatives/*antagonists & inhibitors/therapeutic use ; Hyperglycemia/*drug therapy ; Male ; Rats ; Receptors, Cell Surface/*drug effects ; Receptors, Glucagon ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Sex and handedness differences in cerebral blood flow during rest and cognitive activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-08-13
    Beschreibung: Cognitive activity resulted in increased flow of blood to the cerebral hemispheres. The increase was greater to the left hemisphere for a verbal task and greater to the right hemisphere for a spatial task. The direction and degree of hemispheric flow asymmetry were influenced by sex and handedness, females having a higher rate of blood flow per unit weight of brain, and females and left-handers having a greater percentage of fast-clearing tissue, presumably gray matter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gur, R C -- Gur, R E -- Obrist, W D -- Hungerbuhler, J P -- Younkin, D -- Rosen, A D -- Skolnick, B E -- Reivich, M -- MH 30456/MH/NIMH NIH HHS/ -- NS-10939-09/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089587" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Brain/metabolism/*physiology ; *Cerebrovascular Circulation ; *Cognition ; Female ; *Functional Laterality ; Humans ; Male ; Metabolic Clearance Rate ; Rest ; *Sex Characteristics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Digitalis genin activity: side-group carbonyl oxygen position is a major determinant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-08-31
    Beschreibung: The Na+,k+-adenosine triphosphatase-inhibiting activity of digitalis genins and their analogs is a function of side-group carbonyl (C = O) oxygen position. For each 2.2 angstroms that this oxygen is displaced from its position in digitoxigenin, activity drops by one order of magnitude. This quantitative relation resolves previously proposed models which have attempted to describe the molecular basis of genin activity. A multidisciplinary (crystallographic, conformational energy, synthetic, biological) approach to structure-activity relations is described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fullerton, D S -- Yoshioka, K -- Rohrer, D C -- From, A H -- Ahmed, K -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):917-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224455" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/enzymology ; Digitalis Glycosides/*pharmacology ; Molecular Conformation ; Rats ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    On the nature of human interlimb coordination (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-03-09
    Beschreibung: Movement time varies as a function of amplitude and requirements for precision, according to Fitts' law, but when subjects perform two-handed movements to targets of widely disparate difficulty they do so simultaneously. The hand moving to an "easy" target moves more slowly to accommodate its "difficult" counterpart, yet both hands reach peak velocity and acceleration synchronously. This result suggests that the brain produces simultaneity of action not by controlling each limb independently, but by organizing functional groupings of muscles that are constrained to act as a single unit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelso, J A -- Southard, D L -- Goodman, D -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424729" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Brain/physiology ; Functional Laterality ; Hand/physiology ; Humans ; Motor Skills/*physiology ; *Movement
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with Parkinson's disease (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-05-11
    Beschreibung: A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrsopinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lovenberg, W -- Levine, R A -- Robinson, D S -- Ebert, M -- Williams, A C -- Calne, D B -- New York, N.Y. -- Science. 1979 May 11;204(4393):624-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432666" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biopterin/analogs & derivatives/analysis/*cerebrospinal fluid ; Homovanillic Acid/cerebrospinal fluid ; Humans ; Methods ; Parkinson Disease/*cerebrospinal fluid ; Pteridines/*cerebrospinal fluid
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-07-23
    Beschreibung: Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, R D -- Manian, A A -- Harcus, J L -- Hall, D -- Hewlett, E L -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):369-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124040" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antipsychotic Agents/*pharmacology/therapeutic use ; Chlorpromazine/pharmacology ; Cricetinae ; Humans ; Leishmania/*drug effects ; Leishmaniasis, Visceral/*drug therapy ; Macrophages/microbiology ; Mesocricetus
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-10-29
    Beschreibung: Qualitatively distinct patterns of cardiovascular and neuroendocrine responses were observed in male college students during mental work and during sensory intake task performance. During mental work, Type A (coronary-prone) subjects showed greater muscle vasodilatation and more enhanced secretion of norepinephrine, epinephrine, and cortisol than Type B subjects. During sensory intake, Type A hyperresponsivity was found for testosterone and, among those subjects with a positive family history of hypertension, for cortisol. As a demonstration of combined cardiovascular, sympathetic nervous system, and neuroendocrine hyperresponsivity to specific cognitive tasks in Type A subjects, this study breaks ground in the search for mechanisms mediating the increased coronary disease risk among Type A persons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, R B Jr -- Lane, J D -- Kuhn, C M -- Melosh, W -- White, A D -- Schanberg, S M -- HL-22740/HL/NHLBI NIH HHS/ -- MH-6489/MH/NIMH NIH HHS/ -- MH-70482/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):483-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123248" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Behavior/*physiology ; Blood Pressure ; Cardiovascular Diseases/etiology ; Cognition/*physiology ; Hemodynamics ; Hormones/blood ; Humans ; Hydrocortisone/blood ; Risk
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    N-nitrosamines in the rubber and tire industry (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-09-21
    Beschreibung: Airborne N-nitrosomorpholine (0 to 27 micrograms per cubic meter) was found in two of four rubber industry factories. N-Nitrosodimethylamine was also found in two factories, but at lower levels. These findings may be relevant to the reported increased risk of certain types of cancer in rubber workers in some of the same areas where the N-nitrosomorpholine levels were highest.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fajen, J M -- Carson, G A -- Rounbehler, D P -- Fan, T Y -- Vita, R -- Goff, U E -- Wolf, M H -- Edwards, G S -- Fine, D H -- Reinhold, V -- Biemann, K -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1262-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472741" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/*analysis ; Air Pollutants, Occupational/*analysis ; Dimethylnitrosamine/analysis ; Environmental Exposure ; Humans ; Morpholines/analysis ; Nitrosamines/*analysis ; *Occupational Medicine ; *Rubber
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: possible hormone receptor system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-10-15
    Beschreibung: A protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17 beta-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feldman, D -- Do, Y -- Burshell, A -- Stathis, P -- Loose, D S -- GM28825/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 15;218(4569):297-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289434" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding, Competitive ; Chromatography, High Pressure Liquid ; Cytosol/metabolism ; Female ; Ligands ; Rats ; Receptors, Cell Surface/metabolism ; Receptors, Estrogen/*analysis ; Saccharomyces cerevisiae/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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