ALBERT

Beschreibung: Stable isotope ratios of H, C, and O are powerful indicators of a wide variety of planetary geophysical processes, and for Mars they reveal the record of loss of its atmosphere and subsequent interactions with its surface such as carbonate formation. We report in situ measurements of the isotopic ratios of D/H and (18)O/(16)O in water and (13)C/(12)C, (18)O/(16)O, (17)O/(16)O, and (13)C(18)O/(12)C(16)O in carbon dioxide, made in the martian atmosphere at Gale Crater from the Curiosity rover using the Sample Analysis at Mars (SAM)'s tunable laser spectrometer (TLS). Comparison between our measurements in the modern atmosphere and those of martian meteorites such as ALH 84001 implies that the martian reservoirs of CO2 and H2O were largely established ~4 billion years ago, but that atmospheric loss or surface interaction may be still ongoing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Webster, Chris R -- Mahaffy, Paul R -- Flesch, Gregory J -- Niles, Paul B -- Jones, John H -- Leshin, Laurie A -- Atreya, Sushil K -- Stern, Jennifer C -- Christensen, Lance E -- Owen, Tobias -- Franz, Heather -- Pepin, Robert O -- Steele, Andrew -- MSL Science Team -- Achilles, Cherie -- Agard, Christophe -- Alves Verdasca, Jose Alexandre -- Anderson, Robert -- Anderson, Ryan -- Archer, Doug -- Armiens-Aparicio, Carlos -- Arvidson, Ray -- Atlaskin, Evgeny -- Aubrey, Andrew -- Baker, Burt -- Baker, Michael -- Balic-Zunic, Tonci -- Baratoux, David -- Baroukh, Julien -- Barraclough, Bruce -- Bean, Keri -- Beegle, Luther -- Behar, Alberto -- Bell, James -- Bender, Steve -- Benna, Mehdi -- Bentz, Jennifer -- Berger, Gilles -- Berger, Jeff -- Berman, Daniel -- Bish, David -- Blake, David F -- Blanco Avalos, Juan J -- Blaney, Diana -- Blank, Jen -- Blau, Hannah -- Bleacher, Lora -- Boehm, Eckart -- Botta, Oliver -- Bottcher, Stephan -- Boucher, Thomas -- Bower, Hannah -- Boyd, Nick -- Boynton, Bill -- Breves, Elly -- Bridges, John -- Bridges, Nathan -- Brinckerhoff, William -- Brinza, David -- Bristow, Thomas -- Brunet, Claude -- Brunner, Anna -- Brunner, Will -- Buch, Arnaud -- Bullock, Mark -- Burmeister, Sonke -- Cabane, Michel -- Calef, Fred -- Cameron, James -- Campbell, John -- Cantor, Bruce -- Caplinger, Michael -- Caride Rodriguez, Javier -- Carmosino, Marco -- Carrasco Blazquez, Isaias -- Charpentier, Antoine -- Chipera, Steve -- Choi, David -- Clark, Benton -- Clegg, Sam -- Cleghorn, Timothy -- Cloutis, Ed -- Cody, George -- Coll, Patrice -- Conrad, Pamela -- Coscia, David -- Cousin, Agnes -- Cremers, David -- Crisp, Joy -- Cros, Alain -- Cucinotta, Frank -- d'Uston, Claude -- Davis, Scott -- Day, Mackenzie -- de la Torre Juarez, Manuel -- DeFlores, Lauren -- DeLapp, Dorothea -- DeMarines, Julia -- DesMarais, David -- Dietrich, William -- Dingler, Robert -- Donny, Christophe -- Downs, Bob -- Drake, Darrell -- Dromart, Gilles -- Dupont, Audrey -- Duston, Brian -- Dworkin, Jason -- Dyar, M Darby -- Edgar, Lauren -- Edgett, Kenneth -- Edwards, Christopher -- Edwards, Laurence -- Ehlmann, Bethany -- Ehresmann, Bent -- Eigenbrode, Jen -- Elliott, Beverley -- Elliott, Harvey -- Ewing, Ryan -- Fabre, Cecile -- Fairen, Alberto -- Farley, Ken -- Farmer, Jack -- Fassett, Caleb -- Favot, Laurent -- Fay, Donald -- Fedosov, Fedor -- Feldman, Jason -- Feldman, Sabrina -- Fisk, Marty -- Fitzgibbon, Mike -- Floyd, Melissa -- Fluckiger, Lorenzo -- Forni, Olivier -- Fraeman, Abby -- Francis, Raymond -- Francois, Pascaline -- Freissinet, Caroline -- French, Katherine Louise -- Frydenvang, Jens -- Gaboriaud, Alain -- Gailhanou, Marc -- Garvin, James -- Gasnault, Olivier -- Geffroy, Claude -- Gellert, Ralf -- Genzer, Maria -- Glavin, Daniel -- Godber, Austin -- Goesmann, Fred -- Goetz, Walter -- Golovin, Dmitry -- Gomez Gomez, Felipe -- Gomez-Elvira, Javier -- Gondet, Brigitte -- Gordon, Suzanne -- Gorevan, Stephen -- Grant, John -- Griffes, Jennifer -- Grinspoon, David -- Grotzinger, John -- Guillemot, Philippe -- Guo, Jingnan -- Gupta, Sanjeev -- Guzewich, Scott -- Haberle, Robert -- Halleaux, Douglas -- Hallet, Bernard -- Hamilton, Vicky -- Hardgrove, Craig -- Harker, David -- Harpold, Daniel -- Harri, Ari-Matti -- Harshman, Karl -- Hassler, Donald -- Haukka, Harri -- Hayes, Alex -- Herkenhoff, Ken -- Herrera, Paul -- Hettrich, Sebastian -- Heydari, Ezat -- Hipkin, Victoria -- Hoehler, Tori -- Hollingsworth, Jeff -- Hudgins, Judy -- Huntress, Wesley -- Hurowitz, Joel -- Hviid, Stubbe -- Iagnemma, Karl -- Indyk, Steve -- Israel, Guy -- Jackson, Ryan -- Jacob, Samantha -- Jakosky, Bruce -- Jensen, Elsa -- Jensen, Jaqueline Klovgaard -- Johnson, Jeffrey -- Johnson, Micah -- Johnstone, Steve -- Jones, Andrea -- Joseph, Jonathan -- Jun, Insoo -- Kah, Linda -- Kahanpaa, Henrik -- Kahre, Melinda -- Karpushkina, Natalya -- Kasprzak, Wayne -- Kauhanen, Janne -- Keely, Leslie -- Kemppinen, Osku -- Keymeulen, Didier -- Kim, Myung-Hee -- Kinch, Kjartan -- King, Penny -- Kirkland, Laurel -- Kocurek, Gary -- Koefoed, Asmus -- Kohler, Jan -- Kortmann, Onno -- Kozyrev, Alexander -- Krezoski, Jill -- Krysak, Daniel -- Kuzmin, Ruslan -- Lacour, Jean Luc -- Lafaille, Vivian -- Langevin, Yves -- Lanza, Nina -- Lasue, Jeremie -- Le Mouelic, Stephane -- Lee, Ella Mae -- Lee, Qiu-Mei -- Lees, David -- Lefavor, Matthew -- Lemmon, Mark -- Lepinette Malvitte, Alain -- Leveille, Richard -- Lewin-Carpintier, Eric -- Lewis, Kevin -- Li, Shuai -- Lipkaman, Leslie -- Little, Cynthia -- Litvak, Maxim -- Lorigny, Eric -- Lugmair, Guenter -- Lundberg, Angela -- Lyness, Eric -- Madsen, Morten -- Maki, Justin -- Malakhov, Alexey -- Malespin, Charles -- Malin, Michael -- Mangold, Nicolas -- Manhes, Gerard -- Manning, Heidi -- Marchand, Genevieve -- Marin Jimenez, Mercedes -- Martin Garcia, Cesar -- Martin, Dave -- Martin, Mildred -- Martinez-Frias, Jesus -- Martin-Soler, Javier -- Martin-Torres, F Javier -- Mauchien, Patrick -- Maurice, Sylvestre -- McAdam, Amy -- McCartney, Elaina -- McConnochie, Timothy -- McCullough, Emily -- McEwan, Ian -- McKay, Christopher -- McLennan, Scott -- McNair, Sean -- Melikechi, Noureddine -- Meslin, Pierre-Yves -- Meyer, Michael -- Mezzacappa, Alissa -- Miller, Hayden -- Miller, Kristen -- Milliken, Ralph -- Ming, Douglas -- Minitti, Michelle -- Mischna, Michael -- Mitrofanov, Igor -- Moersch, Jeff -- Mokrousov, Maxim -- Molina Jurado, Antonio -- Moores, John -- Mora-Sotomayor, Luis -- Morookian, John Michael -- Morris, Richard -- Morrison, Shaunna -- Mueller-Mellin, Reinhold -- Muller, Jan-Peter -- Munoz Caro, Guillermo -- Nachon, Marion -- Navarro Lopez, Sara -- Navarro-Gonzalez, Rafael -- Nealson, Kenneth -- Nefian, Ara -- Nelson, Tony -- Newcombe, Megan -- Newman, Claire -- Newsom, Horton -- Nikiforov, Sergey -- Nixon, Brian -- Noe Dobrea, Eldar -- Nolan, Thomas -- Oehler, Dorothy -- Ollila, Ann -- Olson, Timothy -- de Pablo Hernandez, Miguel Angel -- Paillet, Alexis -- Pallier, Etienne -- Palucis, Marisa -- Parker, Timothy -- Parot, Yann -- Patel, Kiran -- Paton, Mark -- Paulsen, Gale -- Pavlov, Alex -- Pavri, Betina -- Peinado-Gonzalez, Veronica -- Peret, Laurent -- Perez, Rene -- Perrett, Glynis -- Peterson, Joe -- Pilorget, Cedric -- Pinet, Patrick -- Pla-Garcia, Jorge -- Plante, Ianik -- Poitrasson, Franck -- Polkko, Jouni -- Popa, Radu -- Posiolova, Liliya -- Posner, Arik -- Pradler, Irina -- Prats, Benito -- Prokhorov, Vasily -- Purdy, Sharon Wilson -- Raaen, Eric -- Radziemski, Leon -- Rafkin, Scot -- Ramos, Miguel -- Rampe, Elizabeth -- Raulin, Francois -- Ravine, Michael -- Reitz, Gunther -- Renno, Nilton -- Rice, Melissa -- Richardson, Mark -- Robert, Francois -- Robertson, Kevin -- Rodriguez Manfredi, Jose Antonio -- Romeral-Planello, Julio J -- Rowland, Scott -- Rubin, David -- Saccoccio, Muriel -- Salamon, Andrew -- Sandoval, Jennifer -- Sanin, Anton -- Sans Fuentes, Sara Alejandra -- Saper, Lee -- Sarrazin, Philippe -- Sautter, Violaine -- Savijarvi, Hannu -- Schieber, Juergen -- Schmidt, Mariek -- Schmidt, Walter -- Scholes, Daniel -- Schoppers, Marcel -- Schroder, Susanne -- Schwenzer, Susanne -- Sebastian Martinez, Eduardo -- Sengstacken, Aaron -- Shterts, Ruslan -- Siebach, Kirsten -- Siili, Tero -- Simmonds, Jeff -- Sirven, Jean-Baptiste -- Slavney, Susie -- Sletten, Ronald -- Smith, Michael -- Sobron Sanchez, Pablo -- Spanovich, Nicole -- Spray, John -- Squyres, Steven -- Stack, Katie -- Stalport, Fabien -- Stein, Thomas -- Stewart, Noel -- Stipp, Susan Louise Svane -- Stoiber, Kevin -- Stolper, Ed -- Sucharski, Bob -- Sullivan, Rob -- Summons, Roger -- Sumner, Dawn -- Sun, Vivian -- Supulver, Kimberley -- Sutter, Brad -- Szopa, Cyril -- Tan, Florence -- Tate, Christopher -- Teinturier, Samuel -- ten Kate, Inge -- Thomas, Peter -- Thompson, Lucy -- Tokar, Robert -- Toplis, Mike -- Torres Redondo, Josefina -- Trainer, Melissa -- Treiman, Allan -- Tretyakov, Vladislav -- Urqui-O'Callaghan, Roser -- Van Beek, Jason -- Van Beek, Tessa -- VanBommel, Scott -- Vaniman, David -- Varenikov, Alexey -- Vasavada, Ashwin -- Vasconcelos, Paulo -- Vicenzi, Edward -- Vostrukhin, Andrey -- Voytek, Mary -- Wadhwa, Meenakshi -- Ward, Jennifer -- Weigle, Eddie -- Wellington, Danika -- Westall, Frances -- Wiens, Roger Craig -- Wilhelm, Mary Beth -- Williams, Amy -- Williams, Joshua -- Williams, Rebecca -- Williams, Richard B -- Wilson, Mike -- Wimmer-Schweingruber, Robert -- Wolff, Mike -- Wong, Mike -- Wray, James -- Wu, Megan -- Yana, Charles -- Yen, Albert -- Yingst, Aileen -- Zeitlin, Cary -- Zimdar, Robert -- Zorzano Mier, Maria-Paz -- New York, N.Y. -- Science. 2013 Jul 19;341(6143):260-3. doi: 10.1126/science.1237961.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. chris.r.webster@jpl.nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23869013" target="_blank"〉PubMed〈/a〉

Beschreibung: We report on results of an all-sky search for high-energy neutrino events interacting within the IceCube neutrino detector conducted between May 2010 and May 2012. The search follows up on the previous detection of two PeV neutrino events, with improved sensitivity and extended energy coverage down to about 30 TeV. Twenty-six additional events were observed, substantially more than expected from atmospheric backgrounds. Combined, both searches reject a purely atmospheric origin for the 28 events at the 4sigma level. These 28 events, which include the highest energy neutrinos ever observed, have flavors, directions, and energies inconsistent with those expected from the atmospheric muon and neutrino backgrounds. These properties are, however, consistent with generic predictions for an additional component of extraterrestrial origin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉IceCube Collaboration -- Aartsen, M G -- Abbasi, R -- Abdou, Y -- Ackermann, M -- Adams, J -- Aguilar, J A -- Ahlers, M -- Altmann, D -- Auffenberg, J -- Bai, X -- Baker, M -- Barwick, S W -- Baum, V -- Bay, R -- Beatty, J J -- Bechet, S -- Becker Tjus, J -- Becker, K-H -- Benabderrahmane, M L -- BenZvi, S -- Berghaus, P -- Berley, D -- Bernardini, E -- Bernhard, A -- Bertrand, D -- Besson, D Z -- Binder, G -- Bindig, D -- Bissok, M -- Blaufuss, E -- Blumenthal, J -- Boersma, D J -- Bohaichuk, S -- Bohm, C -- Bose, D -- Boser, S -- Botner, O -- Brayeur, L -- Bretz, H-P -- Brown, A M -- Bruijn, R -- Brunner, J -- Carson, M -- Casey, J -- Casier, M -- Chirkin, D -- Christov, A -- Christy, B -- Clark, K -- Clevermann, F -- Coenders, S -- Cohen, S -- Cowen, D F -- Cruz Silva, A H -- Danninger, M -- Daughhetee, J -- Davis, J C -- Day, M -- De Clercq, C -- De Ridder, S -- Desiati, P -- de Vries, K D -- de With, M -- DeYoung, T -- Diaz-Velez, J C -- Dunkman, M -- Eagan, R -- Eberhardt, B -- Eichmann, B -- Eisch, J -- Ellsworth, R W -- Euler, S -- Evenson, P A -- Fadiran, O -- Fazely, A R -- Fedynitch, A -- Feintzeig, J -- Feusels, T -- Filimonov, K -- Finley, C -- Fischer-Wasels, T -- Flis, S -- Franckowiak, A -- Frantzen, K -- Fuchs, T -- Gaisser, T K -- Gallagher, J -- Gerhardt, L -- Gladstone, L -- Glusenkamp, T -- Goldschmidt, A -- Golup, G -- Gonzalez, J G -- Goodman, J A -- Gora, D -- Grandmont, D T -- Grant, D -- Gross, A -- Ha, C -- Haj Ismail, A -- Hallen, P -- Hallgren, A -- Halzen, F -- Hanson, K -- Heereman, D -- Heinen, D -- Helbing, K -- Hellauer, R -- Hickford, S -- Hill, G C -- Hoffman, K D -- Hoffmann, R -- Homeier, A -- Hoshina, K -- Huelsnitz, W -- Hulth, P O -- Hultqvist, K -- Hussain, S -- Ishihara, A -- Jacobi, E -- Jacobsen, J -- Jagielski, K -- Japaridze, G S -- Jero, K -- Jlelati, O -- Kaminsky, B -- Kappes, A -- Karg, T -- Karle, A -- Kelley, J L -- Kiryluk, J -- Klas, J -- Klein, S R -- Kohne, J-H -- Kohnen, G -- Kolanoski, H -- Kopke, L -- Kopper, C -- Kopper, S -- Koskinen, D J -- Kowalski, M -- Krasberg, M -- Krings, K -- Kroll, G -- Kunnen, J -- Kurahashi, N -- Kuwabara, T -- Labare, M -- Landsman, H -- Larson, M J -- Lesiak-Bzdak, M -- Leuermann, M -- Leute, J -- Lunemann, J -- Madsen, J -- Maggi, G -- Maruyama, R -- Mase, K -- Matis, H S -- McNally, F -- Meagher, K -- Merck, M -- Meures, T -- Miarecki, S -- Middell, E -- Milke, N -- Miller, J -- Mohrmann, L -- Montaruli, T -- Morse, R -- Nahnhauer, R -- Naumann, U -- Niederhausen, H -- Nowicki, S C -- Nygren, D R -- Obertacke, A -- Odrowski, S -- Olivas, A -- O'Murchadha, A -- Paul, L -- Pepper, J A -- Perez de los Heros, C -- Pfendner, C -- Pieloth, D -- Pinat, E -- Posselt, J -- Price, P B -- Przybylski, G T -- Radel, L -- Rameez, M -- Rawlins, K -- Redl, P -- Reimann, R -- Resconi, E -- Rhode, W -- Ribordy, M -- Richman, M -- Riedel, B -- Rodrigues, J P -- Rott, C -- Ruhe, T -- Ruzybayev, B -- Ryckbosch, D -- Saba, S M -- Salameh, T -- Sander, H-G -- Santander, M -- Sarkar, S -- Schatto, K -- Scheriau, F -- Schmidt, T -- Schmitz, M -- Schoenen, S -- Schoneberg, S -- Schonwald, A -- Schukraft, A -- Schulte, L -- Schulz, O -- Seckel, D -- Sestayo, Y -- Seunarine, S -- Shanidze, R -- Sheremata, C -- Smith, M W E -- Soldin, D -- Spiczak, G M -- Spiering, C -- Stamatikos, M -- Stanev, T -- Stasik, A -- Stezelberger, T -- Stokstad, R G -- Stossl, A -- Strahler, E A -- Strom, R -- Sullivan, G W -- Taavola, H -- Taboada, I -- Tamburro, A -- Tepe, A -- Ter-Antonyan, S -- Tesic, G -- Tilav, S -- Toale, P A -- Toscano, S -- Unger, E -- Usner, M -- van Eijndhoven, N -- Van Overloop, A -- van Santen, J -- Vehring, M -- Voge, M -- Vraeghe, M -- Walck, C -- Waldenmaier, T -- Wallraff, M -- Weaver, Ch -- Wellons, M -- Wendt, C -- Westerhoff, S -- Whitehorn, N -- Wiebe, K -- Wiebusch, C H -- Williams, D R -- Wissing, H -- Wolf, M -- Wood, T R -- Woschnagg, K -- Xu, D L -- Xu, X W -- Yanez, J P -- Yodh, G -- Yoshida, S -- Zarzhitsky, P -- Ziemann, J -- Zierke, S -- Zoll, M -- New York, N.Y. -- Science. 2013 Nov 22;342(6161):1242856. doi: 10.1126/science.1242856.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24264993" target="_blank"〉PubMed〈/a〉

Beschreibung: A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) approximately 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximately 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rietveld, Cornelius A -- Medland, Sarah E -- Derringer, Jaime -- Yang, Jian -- Esko, Tonu -- Martin, Nicolas W -- Westra, Harm-Jan -- Shakhbazov, Konstantin -- Abdellaoui, Abdel -- Agrawal, Arpana -- Albrecht, Eva -- Alizadeh, Behrooz Z -- Amin, Najaf -- Barnard, John -- Baumeister, Sebastian E -- Benke, Kelly S -- Bielak, Lawrence F -- Boatman, Jeffrey A -- Boyle, Patricia A -- Davies, Gail -- de Leeuw, Christiaan -- Eklund, Niina -- Evans, Daniel S -- Ferhmann, Rudolf -- Fischer, Krista -- Gieger, Christian -- Gjessing, Hakon K -- Hagg, Sara -- Harris, Jennifer R -- Hayward, Caroline -- Holzapfel, Christina -- Ibrahim-Verbaas, Carla A -- Ingelsson, Erik -- Jacobsson, Bo -- Joshi, Peter K -- Jugessur, Astanand -- Kaakinen, Marika -- Kanoni, Stavroula -- Karjalainen, Juha -- Kolcic, Ivana -- Kristiansson, Kati -- Kutalik, Zoltan -- Lahti, Jari -- Lee, Sang H -- Lin, Peng -- Lind, Penelope A -- Liu, Yongmei -- Lohman, Kurt -- Loitfelder, Marisa -- McMahon, George -- Vidal, Pedro Marques -- Meirelles, Osorio -- Milani, Lili -- Myhre, Ronny -- Nuotio, Marja-Liisa -- Oldmeadow, Christopher J -- Petrovic, Katja E -- Peyrot, Wouter J -- Polasek, Ozren -- Quaye, Lydia -- Reinmaa, Eva -- Rice, John P -- Rizzi, Thais S -- Schmidt, Helena -- Schmidt, Reinhold -- Smith, Albert V -- Smith, Jennifer A -- Tanaka, Toshiko -- Terracciano, Antonio -- van der Loos, Matthijs J H M -- Vitart, Veronique -- Volzke, Henry -- Wellmann, Jurgen -- Yu, Lei -- Zhao, Wei -- Allik, Juri -- Attia, John R -- Bandinelli, Stefania -- Bastardot, Francois -- Beauchamp, Jonathan -- Bennett, David A -- Berger, Klaus -- Bierut, Laura J -- Boomsma, Dorret I -- Bultmann, Ute -- Campbell, Harry -- Chabris, Christopher F -- Cherkas, Lynn -- Chung, Mina K -- Cucca, Francesco -- de Andrade, Mariza -- De Jager, Philip L -- De Neve, Jan-Emmanuel -- Deary, Ian J -- Dedoussis, George V -- Deloukas, Panos -- Dimitriou, Maria -- Eiriksdottir, Guethny -- Elderson, Martin F -- Eriksson, Johan G -- Evans, David M -- Faul, Jessica D -- Ferrucci, Luigi -- Garcia, Melissa E -- Gronberg, Henrik -- Guethnason, Vilmundur -- Hall, Per -- Harris, Juliette M -- Harris, Tamara B -- Hastie, Nicholas D -- Heath, Andrew C -- Hernandez, Dena G -- Hoffmann, Wolfgang -- Hofman, Adriaan -- Holle, Rolf -- Holliday, Elizabeth G -- Hottenga, Jouke-Jan -- Iacono, William G -- Illig, Thomas -- Jarvelin, Marjo-Riitta -- Kahonen, Mika -- Kaprio, Jaakko -- Kirkpatrick, Robert M -- Kowgier, Matthew -- Latvala, Antti -- Launer, Lenore J -- Lawlor, Debbie A -- Lehtimaki, Terho -- Li, Jingmei -- Lichtenstein, Paul -- Lichtner, Peter -- Liewald, David C -- Madden, Pamela A -- Magnusson, Patrik K E -- Makinen, Tomi E -- Masala, Marco -- McGue, Matt -- Metspalu, Andres -- Mielck, Andreas -- Miller, Michael B -- Montgomery, Grant W -- Mukherjee, Sutapa -- Nyholt, Dale R -- Oostra, Ben A -- Palmer, Lyle J -- Palotie, Aarno -- Penninx, Brenda W J H -- Perola, Markus -- Peyser, Patricia A -- Preisig, Martin -- Raikkonen, Katri -- Raitakari, Olli T -- Realo, Anu -- Ring, Susan M -- Ripatti, Samuli -- Rivadeneira, Fernando -- Rudan, Igor -- Rustichini, Aldo -- Salomaa, Veikko -- Sarin, Antti-Pekka -- Schlessinger, David -- Scott, Rodney J -- Snieder, Harold -- St Pourcain, Beate -- Starr, John M -- Sul, Jae Hoon -- Surakka, Ida -- Svento, Rauli -- Teumer, Alexander -- LifeLines Cohort Study -- Tiemeier, Henning -- van Rooij, Frank J A -- Van Wagoner, David R -- Vartiainen, Erkki -- Viikari, Jorma -- Vollenweider, Peter -- Vonk, Judith M -- Waeber, Gerard -- Weir, David R -- Wichmann, H-Erich -- Widen, Elisabeth -- Willemsen, Gonneke -- Wilson, James F -- Wright, Alan F -- Conley, Dalton -- Davey-Smith, George -- Franke, Lude -- Groenen, Patrick J F -- Hofman, Albert -- Johannesson, Magnus -- Kardia, Sharon L R -- Krueger, Robert F -- Laibson, David -- Martin, Nicholas G -- Meyer, Michelle N -- Posthuma, Danielle -- Thurik, A Roy -- Timpson, Nicholas J -- Uitterlinden, Andre G -- van Duijn, Cornelia M -- Visscher, Peter M -- Benjamin, Daniel J -- Cesarini, David -- Koellinger, Philipp D -- AA09367/AA/NIAAA NIH HHS/ -- AA11886/AA/NIAAA NIH HHS/ -- BB/F019394/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- CZB/4/710/Chief Scientist Office/United Kingdom -- DA024417/DA/NIDA NIH HHS/ -- DA029377/DA/NIDA NIH HHS/ -- DA05147/DA/NIDA NIH HHS/ -- DA13240/DA/NIDA NIH HHS/ -- ETM/55/Chief Scientist Office/United Kingdom -- F31 DA029377/DA/NIDA NIH HHS/ -- G0600705/Medical Research Council/United Kingdom -- G0700704/Medical Research Council/United Kingdom -- G9815508/Medical Research Council/United Kingdom -- K05 AA017688/AA/NIAAA NIH HHS/ -- MC_PC_U127561128/Medical Research Council/United Kingdom -- MC_UU_12013/1/Medical Research Council/United Kingdom -- MC_UU_12013/3/Medical Research Council/United Kingdom -- MC_UU_12013/5/Medical Research Council/United Kingdom -- MH016880/MH/NIMH NIH HHS/ -- MH066140/MH/NIMH NIH HHS/ -- MR/K026992/1/Medical Research Council/United Kingdom -- P01 AG005842/AG/NIA NIH HHS/ -- P01 CA089392/CA/NCI NIH HHS/ -- P01 GM099568/GM/NIGMS NIH HHS/ -- P01-AG005842/AG/NIA NIH HHS/ -- P01-AG005842-20S2/AG/NIA NIH HHS/ -- P30 AG012810/AG/NIA NIH HHS/ -- P30-AG012810/AG/NIA NIH HHS/ -- R01 AA009367/AA/NIAAA NIH HHS/ -- R01 AA011886/AA/NIAAA NIH HHS/ -- R01 DA013240/DA/NIDA NIH HHS/ -- R01 HL090620/HL/NHLBI NIH HHS/ -- R01 HL105756/HL/NHLBI NIH HHS/ -- R01 HL111314/HL/NHLBI NIH HHS/ -- R01 MH066140/MH/NIMH NIH HHS/ -- R37 DA005147/DA/NIDA NIH HHS/ -- T32 AG000186/AG/NIA NIH HHS/ -- T32 MH016880/MH/NIMH NIH HHS/ -- T32-AG000186-23/AG/NIA NIH HHS/ -- U01 AG009740/AG/NIA NIH HHS/ -- U01 DA024417/DA/NIDA NIH HHS/ -- Z01 AG001050-01/Intramural NIH HHS/ -- ZIA AG000196-03/Intramural NIH HHS/ -- ZIA AG000196-04/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23722424" target="_blank"〉PubMed〈/a〉

Beschreibung: Indications of a GeV component in the emission from gamma-ray bursts (GRBs) are known since the Energetic Gamma-Ray Experiment Telescope observations during the 1990s and they have been confirmed by the data of the Fermi satellite. These results have, however, shown that our understanding of GRB physics is still unsatisfactory. The new generation of Cherenkov observatories and in particular the MAGIC telescope, allow for the first time the possibility to extend the measurement of GRBs from several tens up to hundreds of GeV energy range. Both leptonic and hadronic processes have been suggested to explain the possible GeV/TeV counterpart of GRBs. Observations with ground-based telescopes of very high energy (VHE) photons ( E  〉 30 GeV) from these sources are going to play a key role in discriminating among the different proposed emission mechanisms, which are barely distinguishable at lower energies. MAGIC telescope observations of the GRB 090102 ( z  = 1.547) field and Fermi Large Area Telescope data in the same time interval are analysed to derive upper limits of the GeV/TeV emission. We compare these results to the expected emissions evaluated for different processes in the framework of a relativistic blastwave model for the afterglow. Simultaneous upper limits with Fermi and a Cherenkov telescope have been derived for this GRB observation. The results we obtained are compatible with the expected emission although the difficulties in predicting the HE and VHE emission for the afterglow of this event makes it difficult to draw firmer conclusions. Nonetheless, MAGIC sensitivity in the energy range of overlap with space-based instruments (above about 40 GeV) is about one order of magnitude better with respect to Fermi . This makes evident the constraining power of ground-based observations and shows that the MAGIC telescope has reached the required performance to make possible GRB multiwavelength studies in the VHE range.

Beschreibung: Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ~100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae . More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector–human and vector–parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi .

Beschreibung: The observations of the exceptionally bright gamma-ray burst (GRB) 130427A by the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the nature of these unique astrophysical sources. GRB 130427A had the largest fluence, highest-energy photon (95 GeV), longest gamma-ray duration (20 hours), and one of the largest isotropic energy releases ever observed from a GRB. Temporal and spectral analyses of GRB 130427A challenge the widely accepted model that the nonthermal high-energy emission in the afterglow phase of GRBs is synchrotron emission radiated by electrons accelerated at an external shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ackermann, M -- Ajello, M -- Asano, K -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Bechtol, K -- Bellazzini, R -- Bissaldi, E -- Bonamente, E -- Bregeon, J -- Brigida, M -- Bruel, P -- Buehler, R -- Burgess, J Michael -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Cecchi, C -- Chaplin, V -- Charles, E -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Chiaro, G -- Ciprini, S -- Claus, R -- Cleveland, W -- Cohen-Tanugi, J -- Collazzi, A -- Cominsky, L R -- Connaughton, V -- Conrad, J -- Cutini, S -- D'Ammando, F -- de Angelis, A -- DeKlotz, M -- de Palma, F -- Dermer, C D -- Desiante, R -- Diekmann, A -- Di Venere, L -- Drell, P S -- Drlica-Wagner, A -- Favuzzi, C -- Fegan, S J -- Ferrara, E C -- Finke, J -- Fitzpatrick, G -- Focke, W B -- Franckowiak, A -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gehrels, N -- Germani, S -- Gibby, M -- Giglietto, N -- Giles, M -- Giordano, F -- Giroletti, M -- Godfrey, G -- Granot, J -- Grenier, I A -- Grove, J E -- Gruber, D -- Guiriec, S -- Hadasch, D -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Horan, D -- Hughes, R E -- Inoue, Y -- Jogler, T -- Johannesson, G -- Johnson, W N -- Kawano, T -- Knodlseder, J -- Kocevski, D -- Kuss, M -- Lande, J -- Larsson, S -- Latronico, L -- Longo, F -- Loparco, F -- Lovellette, M N -- Lubrano, P -- Mayer, M -- Mazziotta, M N -- McEnery, J E -- Michelson, P F -- Mizuno, T -- Moiseev, A A -- Monzani, M E -- Moretti, E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nemmen, R -- Nuss, E -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orienti, M -- Paneque, D -- Pelassa, V -- Perkins, J S -- Pesce-Rollins, M -- Petrosian, V -- Piron, F -- Pivato, G -- Porter, T A -- Racusin, J L -- Raino, S -- Rando, R -- Razzano, M -- Razzaque, S -- Reimer, A -- Reimer, O -- Ritz, S -- Roth, M -- Ryde, F -- Sartori, A -- Parkinson, P M Saz -- Scargle, J D -- Schulz, A -- Sgro, C -- Siskind, E J -- Sonbas, E -- Spandre, G -- Spinelli, P -- Tajima, H -- Takahashi, H -- Thayer, J G -- Thayer, J B -- Thompson, D J -- Tibaldo, L -- Tinivella, M -- Torres, D F -- Tosti, G -- Troja, E -- Usher, T L -- Vandenbroucke, J -- Vasileiou, V -- Vianello, G -- Vitale, V -- Winer, B L -- Wood, K S -- Yamazaki, R -- Younes, G -- Yu, H-F -- Zhu, S J -- Bhat, P N -- Briggs, M S -- Byrne, D -- Foley, S -- Goldstein, A -- Jenke, P -- Kippen, R M -- Kouveliotou, C -- McBreen, S -- Meegan, C -- Paciesas, W S -- Preece, R -- Rau, A -- Tierney, D -- van der Horst, A J -- von Kienlin, A -- Wilson-Hodge, C -- Xiong, S -- Cusumano, G -- La Parola, V -- Cummings, J R -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):42-7. doi: 10.1126/science.1242353. Epub 2013 Nov 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24263133" target="_blank"〉PubMed〈/a〉

Beschreibung: A deep observation campaign carried out by the High Energy Stereoscopic System (HESS) on Centaurus A enabled the discovery of -rays from the blazar 1ES 1312–423, 2° away from the radio galaxy. With a differential flux at 1 TeV of (1 TeV) = (1.9 ± 0.6 stat  ± 0.4 sys )  x 10 –13 cm –2 s –1 TeV –1 corresponding to 0.5 per cent of the Crab nebula differential flux and a spectral index  = 2.9 ± 0.5 stat  ± 0.2 sys , 1ES 1312–423 is one of the faintest sources ever detected in the very high energy ( E  〉 100 GeV) extragalactic sky. A careful analysis using three and a half years of Fermi Large Area Telescope ( Fermi -LAT) data allows the discovery at high energies (E 〉 100 MeV) of a hard spectrum ( = 1.4 ± 0.4 stat  ± 0.2 sys ) source coincident with 1ES 1312–423. Radio, optical, UV and X-ray observations complete the spectral energy distribution of this blazar, now covering 16 decades in energy. The emission is successfully fitted with a synchrotron self-Compton model for the non-thermal component, combined with a blackbody spectrum for the optical emission from the host galaxy.

Beschreibung: Gamma-ray burst (GRB) 130427A is one of the most energetic GRBs ever observed. The initial pulse up to 2.5 seconds is possibly the brightest well-isolated pulse observed to date. A fine time resolution spectral analysis shows power-law decays of the peak energy from the onset of the pulse, consistent with models of internal synchrotron shock pulses. However, a strongly correlated power-law behavior is observed between the luminosity and the spectral peak energy that is inconsistent with curvature effects arising in the relativistic outflow. It is difficult for any of the existing models to account for all of the observed spectral and temporal behaviors simultaneously.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preece, R -- Burgess, J Michael -- von Kienlin, A -- Bhat, P N -- Briggs, M S -- Byrne, D -- Chaplin, V -- Cleveland, W -- Collazzi, A C -- Connaughton, V -- Diekmann, A -- Fitzpatrick, G -- Foley, S -- Gibby, M -- Giles, M -- Goldstein, A -- Greiner, J -- Gruber, D -- Jenke, P -- Kippen, R M -- Kouveliotou, C -- McBreen, S -- Meegan, C -- Paciesas, W S -- Pelassa, V -- Tierney, D -- van der Horst, A J -- Wilson-Hodge, C -- Xiong, S -- Younes, G -- Yu, H-F -- Ackermann, M -- Ajello, M -- Axelsson, M -- Baldini, L -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Bellazzini, R -- Bissaldi, E -- Bonamente, E -- Bregeon, J -- Brigida, M -- Bruel, P -- Buehler, R -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Cecchi, C -- Charles, E -- Chekhtman, A -- Chiang, J -- Chiaro, G -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Cominsky, L R -- Conrad, J -- D'Ammando, F -- de Angelis, A -- de Palma, F -- Dermer, C D -- Desiante, R -- Digel, S W -- Di Venere, L -- Drell, P S -- Drlica-Wagner, A -- Favuzzi, C -- Franckowiak, A -- Fukazawa, Y -- Fusco, P -- Gargano, F -- Gehrels, N -- Germani, S -- Giglietto, N -- Giordano, F -- Giroletti, M -- Godfrey, G -- Granot, J -- Grenier, I A -- Guiriec, S -- Hadasch, D -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Iyyani, S -- Jogler, T -- Johannesson, G -- Kawano, T -- Knodlseder, J -- Kocevski, D -- Kuss, M -- Lande, J -- Larsson, J -- Larsson, S -- Latronico, L -- Longo, F -- Loparco, F -- Lovellette, M N -- Lubrano, P -- Mayer, M -- Mazziotta, M N -- Michelson, P F -- Mizuno, T -- Monzani, M E -- Moretti, E -- Morselli, A -- Murgia, S -- Nemmen, R -- Nuss, E -- Nymark, T -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orienti, M -- Paneque, D -- Perkins, J S -- Pesce-Rollins, M -- Piron, F -- Pivato, G -- Porter, T A -- Racusin, J L -- Raino, S -- Rando, R -- Razzano, M -- Razzaque, S -- Reimer, A -- Reimer, O -- Ritz, S -- Roth, M -- Ryde, F -- Sartori, A -- Scargle, J D -- Schulz, A -- Sgro, C -- Siskind, E J -- Spandre, G -- Spinelli, P -- Suson, D J -- Tajima, H -- Takahashi, H -- Thayer, J G -- Thayer, J B -- Tibaldo, L -- Tinivella, M -- Torres, D F -- Tosti, G -- Troja, E -- Usher, T L -- Vandenbroucke, J -- Vasileiou, V -- Vianello, G -- Vitale, V -- Werner, M -- Winer, B L -- Wood, K S -- Zhu, S -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):51-4. doi: 10.1126/science.1242302. Epub 2013 Nov 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Space Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24263132" target="_blank"〉PubMed〈/a〉