ALBERT

Description: To improve the epigenomic analysis of tissues rich in 5-hydroxymethylcytosine (hmC), we developed a novel protocol called TAB-Methyl-SEQ, which allows for single base resolution profiling of both hmC and 5-methylcytosine by targeted next-generation sequencing. TAB-Methyl-SEQ data were extensively validated by a set of five methodologically different protocols. Importantly, these extensive cross-comparisons revealed that protocols based on Tet1-assisted bisulfite conversion provided more precise hmC values than TrueMethyl-based methods. A total of 109 454 CpG sites were analyzed by TAB-Methyl-SEQ for mC and hmC in 188 genes from 20 different adult human livers. We describe three types of variability of hepatic hmC profiles: (i) sample-specific variability at 40.8% of CpG sites analyzed, where the local hmC values correlate to the global hmC content of livers (measured by LC-MS), (ii) gene-specific variability, where hmC levels in the coding regions positively correlate to expression of the respective gene and (iii) site-specific variability, where prominent hmC peaks span only 1 to 3 neighboring CpG sites. Our data suggest that both the gene- and site-specific components of hmC variability might contribute to the epigenetic control of hepatic genes. The protocol described here should be useful for targeted DNA analysis in a variety of applications.

Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Franklin, C -- Seebacher, F -- Grigg, G C -- Axelsson, M -- New York, N.Y. -- Science. 2000 Sep 8;289(5485):1687-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11001731" target="_blank"〉PubMed〈/a〉

Description: A cornerstone of Einstein's special relativity is Lorentz invariance-the postulate that all observers measure exactly the same speed of light in vacuum, independent of photon-energy. While special relativity assumes that there is no fundamental length-scale associated with such invariance, there is a fundamental scale (the Planck scale, l(Planck) approximately 1.62 x 10(-33) cm or E(Planck) = M(Planck)c(2) approximately 1.22 x 10(19) GeV), at which quantum effects are expected to strongly affect the nature of space-time. There is great interest in the (not yet validated) idea that Lorentz invariance might break near the Planck scale. A key test of such violation of Lorentz invariance is a possible variation of photon speed with energy. Even a tiny variation in photon speed, when accumulated over cosmological light-travel times, may be revealed by observing sharp features in gamma-ray burst (GRB) light-curves. Here we report the detection of emission up to approximately 31 GeV from the distant and short GRB 090510. We find no evidence for the violation of Lorentz invariance, and place a lower limit of 1.2E(Planck) on the scale of a linear energy dependence (or an inverse wavelength dependence), subject to reasonable assumptions about the emission (equivalently we have an upper limit of l(Planck)/1.2 on the length scale of the effect). Our results disfavour quantum-gravity theories in which the quantum nature of space-time on a very small scale linearly alters the speed of light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Asano, K -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Bhat, P N -- Bissaldi, E -- Bloom, E D -- Bonamente, E -- Bonnell, J -- Borgland, A W -- Bouvier, A -- Bregeon, J -- Brez, A -- Briggs, M S -- Brigida, M -- Bruel, P -- Burgess, J M -- Burnett, T H -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cecchi, C -- Celik, O -- Chaplin, V -- Charles, E -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Cominsky, L R -- Connaughton, V -- Conrad, J -- Cutini, S -- Dermer, C D -- de Angelis, A -- de Palma, F -- Digel, S W -- Dingus, B L -- do Couto E Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Finke, J -- Fishman, G -- Focke, W B -- Foschini, L -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Gibby, L -- Giebels, B -- Giglietto, N -- Giordano, F -- Glanzman, T -- Godfrey, G -- Granot, J -- Greiner, J -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Grupe, D -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hoversten, E A -- Hughes, R E -- Johannesson, G -- Johnson, A S -- Johnson, R P -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kawai, N -- Kerr, M -- Kippen, R M -- Knodlseder, J -- Kocevski, D -- Kouveliotou, C -- Kuehn, F -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Madejski, G M -- Makeev, A -- Mazziotta, M N -- McBreen, S -- McEnery, J E -- McGlynn, S -- Meszaros, P -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Moretti, E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohno, M -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Ozaki, M -- Paciesas, W S -- Paneque, D -- Panetta, J H -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Petrosian, V -- Piron, F -- Porter, T A -- Preece, R -- Raino, S -- Ramirez-Ruiz, E -- Rando, R -- Razzano, M -- Razzaque, S -- Reimer, A -- Reimer, O -- Reposeur, T -- Ritz, S -- Rochester, L S -- Rodriguez, A Y -- Roth, M -- Ryde, F -- Sadrozinski, H F-W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Schalk, T L -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Stamatikos, M -- Stecker, F W -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Thayer, J B -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Toma, K -- Torres, D F -- Tosti, G -- Troja, E -- Uchiyama, Y -- Uehara, T -- Usher, T L -- van der Horst, A J -- Vasileiou, V -- Vilchez, N -- Vitale, V -- von Kienlin, A -- Waite, A P -- Wang, P -- Wilson-Hodge, C -- Winer, B L -- Wood, K S -- Wu, X F -- Yamazaki, R -- Ylinen, T -- Ziegler, M -- England -- Nature. 2009 Nov 19;462(7271):331-4. doi: 10.1038/nature08574. Epub 2009 Oct 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, District of Columbia 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19865083" target="_blank"〉PubMed〈/a〉

Description: Pulsars are rapidly rotating, highly magnetized neutron stars emitting radiation across the electromagnetic spectrum. Although there are more than 1800 known radio pulsars, until recently only seven were observed to pulse in gamma rays, and these were all discovered at other wavelengths. The Fermi Large Area Telescope (LAT) makes it possible to pinpoint neutron stars through their gamma-ray pulsations. We report the detection of 16 gamma-ray pulsars in blind frequency searches using the LAT. Most of these pulsars are coincident with previously unidentified gamma-ray sources, and many are associated with supernova remnants. Direct detection of gamma-ray pulsars enables studies of emission mechanisms, population statistics, and the energetics of pulsar wind nebulae and supernova remnants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Anderson, B -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Bignami, G F -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cecchi, C -- Celik, O -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Conrad, J -- Cutini, S -- Dermer, C D -- de Angelis, A -- de Luca, A -- de Palma, F -- Digel, S W -- Dormody, M -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giebels, B -- Giglietto, N -- Giommi, P -- Giordano, F -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guillemot, L -- Guiriec, S -- Gwon, C -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hughes, R E -- Johannesson, G -- Johnson, R P -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kocian, M L -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Madejski, G M -- Makeev, A -- Marelli, M -- Mazziotta, M N -- McConville, W -- McEnery, J E -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Paneque, D -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Pierbattista, M -- Piron, F -- Porter, T A -- Primack, J R -- Raino, S -- Rando, R -- Ray, P S -- Razzano, M -- Rea, N -- Reimer, A -- Reimer, O -- Reposeur, T -- Ritz, S -- Rochester, L S -- Rodriguez, A Y -- Romani, R W -- Ryde, F -- Sadrozinski, H F-W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Starck, J-L -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Tibolla, O -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Van Etten, A -- Vasileiou, V -- Vilchez, N -- Vitale, V -- Waite, A P -- Wang, P -- Watters, K -- Winer, B L -- Wolff, M T -- Wood, K S -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):840-4. doi: 10.1126/science.1175558. Epub 2009 Jul 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574346" target="_blank"〉PubMed〈/a〉

Description: Pulsars are born with subsecond spin periods and slow by electromagnetic braking for several tens of millions of years, when detectable radiation ceases. A second life can occur for neutron stars in binary systems. They can acquire mass and angular momentum from their companions, to be spun up to millisecond periods and begin radiating again. We searched Fermi Large Area Telescope data for pulsations from all known millisecond pulsars (MSPs) outside of globular clusters, using rotation parameters from radio telescopes. Strong gamma-ray pulsations were detected for eight MSPs. The gamma-ray pulse profiles and spectral properties resemble those of young gamma-ray pulsars. The basic emission mechanism seems to be the same for MSPs and young pulsars, with the emission originating in regions far from the neutron star surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Bignami, G F -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Caliandro, G A -- Cameron, R A -- Camilo, F -- Caraveo, P A -- Carlson, P -- Casandjian, J M -- Cecchi, C -- Celik, O -- Charles, E -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cognard, I -- Cohen-Tanugi, J -- Cominsky, L R -- Conrad, J -- Corbet, R -- Cutini, S -- Dermer, C D -- Desvignes, G -- de Angelis, A -- de Luca, A -- de Palma, F -- Digel, S W -- Dormody, M -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Edmonds, Y -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Focke, W B -- Frailis, M -- Freire, P C C -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giebels, B -- Giglietto, N -- Giordano, F -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M H -- Grove, J E -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hobbs, G -- Hughes, R E -- Johannesson, G -- Johnson, A S -- Johnson, R P -- Johnson, T J -- Johnson, W N -- Johnston, S -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kocian, M L -- Kramer, M -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Madejski, G M -- Makeev, A -- Manchester, R N -- Marelli, M -- Mazziotta, M N -- McConville, W -- McEnery, J E -- McLaughlin, M A -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Paneque, D -- Panetta, J H -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Ransom, S M -- Ray, P S -- Razzano, M -- Rea, N -- Reimer, A -- Reimer, O -- Reposeur, T -- Ritz, S -- Rochester, L S -- Rodriguez, A Y -- Romani, R W -- Roth, M -- Ryde, F -- Sadrozinski, H F W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Schalk, T L -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Stappers, B W -- Starck, J L -- Striani, E -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Tanaka, T -- Thayer, J B -- Thayer, J G -- Theureau, G -- Thompson, D J -- Thorsett, S E -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Van Etten, A -- Vasileiou, V -- Venter, C -- Vilchez, N -- Vitale, V -- Waite, A P -- Wallace, E -- Wang, P -- Watters, K -- Webb, N -- Weltevrede, P -- Winer, B L -- Wood, K S -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):848-52. doi: 10.1126/science.1176113.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory,Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574349" target="_blank"〉PubMed〈/a〉

Description: We report the detection of gamma-ray emissions above 200 megaelectron volts at a significance level of 17sigma from the globular cluster 47 Tucanae, using data obtained with the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope. Globular clusters are expected to emit gamma rays because of the large populations of millisecond pulsars that they contain. The spectral shape of 47 Tucanae is consistent with gamma-ray emission from a population of millisecond pulsars. The observed gamma-ray luminosity implies an upper limit of 60 millisecond pulsars present in 47 Tucanae.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cecchi, C -- Celik, O -- Charles, E -- Chaty, S -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Conrad, J -- Cutini, S -- Dermer, C D -- de Palma, F -- Digel, S W -- Dormody, M -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Focke, W B -- Frailis, M -- Fukazawa, Y -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giebels, B -- Giglietto, N -- Giordano, F -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grove, J E -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Horan, D -- Hughes, R E -- Johannesson, G -- Johnson, A S -- Johnson, R P -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kuehn, F -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Makeev, A -- Mazziotta, M N -- McConville, W -- McEnery, J E -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Paneque, D -- Panetta, J H -- Parent, D -- Pelassa, V -- Pepe, M -- Pierbattista, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Razzano, M -- Rea, N -- Reimer, A -- Reimer, O -- Reposeur, T -- Ritz, S -- Rochester, L S -- Rodriguez, A Y -- Romani, R W -- Roth, M -- Ryde, F -- Sadrozinski, H F-W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Sgro, C -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Starck, J-L -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Tanaka, T -- Thayer, J B -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vasileiou, V -- Vilchez, N -- Vitale, V -- Wang, P -- Webb, N -- Winer, B L -- Wood, K S -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):845-8. doi: 10.1126/science.1177023.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679807" target="_blank"〉PubMed〈/a〉

Description: Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. The known distance of the burst enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fermi LAT and Fermi GBM Collaborations -- Abdo, A A -- Ackermann, M -- Arimoto, M -- Asano, K -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Band, D L -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Battelino, M -- Baughman, B M -- Bechtol, K -- Bellardi, F -- Bellazzini, R -- Berenji, B -- Bhat, P N -- Bissaldi, E -- Blandford, R D -- Bloom, E D -- Bogaert, G -- Bogart, J R -- Bonamente, E -- Bonnell, J -- Borgland, A W -- Bouvier, A -- Bregeon, J -- Brez, A -- Briggs, M S -- Brigida, M -- Bruel, P -- Burnett, T H -- Burrows, D -- Busetto, G -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Ceccanti, M -- Cecchi, C -- Celotti, A -- Charles, E -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Cominsky, L R -- Connaughton, V -- Conrad, J -- Costamante, L -- Cutini, S -- Deklotz, M -- Dermer, C D -- de Angelis, A -- de Palma, F -- Digel, S W -- Dingus, B L -- do Couto E Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Edmonds, Y -- Evans, P A -- Fabiani, D -- Farnier, C -- Favuzzi, C -- Finke, J -- Fishman, G -- Focke, W B -- Frailis, M -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giebels, B -- Giglietto, N -- Giommi, P -- Giordano, F -- Glanzman, T -- Godfrey, G -- Goldstein, A -- Granot, J -- Greiner, J -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guillemot, L -- Guiriec, S -- Haller, G -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hernando Morat, J A -- Hoover, A -- Hughes, R E -- Johannesson, G -- Johnson, A S -- Johnson, R P -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kavelaars, A -- Kawai, N -- Kelly, H -- Kennea, J -- Kerr, M -- Kippen, R M -- Knodlseder, J -- Kocevski, D -- Kocian, M L -- Komin, N -- Kouveliotou, C -- Kuehn, F -- Kuss, M -- Lande, J -- Landriu, D -- Larsson, S -- Latronico, L -- Lavalley, C -- Lee, B -- Lee, S-H -- Lemoine-Goumard, M -- Lichti, G G -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Madejski, G M -- Makeev, A -- Marangelli, B -- Mazziotta, M N -- McBreen, S -- McEnery, J E -- McGlynn, S -- Meegan, C -- Meszaros, P -- Meurer, C -- Michelson, P F -- Minuti, M -- Mirizzi, N -- Mitthumsiri, W -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Moretti, E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Nelson, D -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orlando, E -- Ormes, J F -- Ozaki, M -- Paciesas, W S -- Paneque, D -- Panetta, J H -- Parent, D -- Pelassa, V -- Pepe, M -- Perri, M -- Pesce-Rollins, M -- Petrosian, V -- Pinchera, M -- Piron, F -- Porter, T A -- Preece, R -- Raino, S -- Ramirez-Ruiz, E -- Rando, R -- Rapposelli, E -- Razzano, M -- Razzaque, S -- Rea, N -- Reimer, A -- Reimer, O -- Reposeur, T -- Reyes, L C -- Ritz, S -- Rochester, L S -- Rodriguez, A Y -- Roth, M -- Ryde, F -- Sadrozinski, H F-W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Schalk, T L -- Segal, K N -- Sgro, C -- Shimokawabe, T -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Stamatikos, M -- Starck, J-L -- Stecker, F W -- Steinle, H -- Stephens, T E -- Strickman, M S -- Suson, D J -- Tagliaferri, G -- Tajima, H -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Tenze, A -- Thayer, J B -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Turri, M -- Tuvi, S -- Usher, T L -- van der Horst, A J -- Vigiani, L -- Vilchez, N -- Vitale, V -- von Kienlin, A -- Waite, A P -- Williams, D A -- Wilson-Hodge, C -- Winer, B L -- Wood, K S -- Wu, X F -- Yamazaki, R -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2009 Mar 27;323(5922):1688-93. doi: 10.1126/science.1169101. Epub 2009 Feb 19.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19228997" target="_blank"〉PubMed〈/a〉

Description: Gamma-ray burst (GRB) 130427A is one of the most energetic GRBs ever observed. The initial pulse up to 2.5 seconds is possibly the brightest well-isolated pulse observed to date. A fine time resolution spectral analysis shows power-law decays of the peak energy from the onset of the pulse, consistent with models of internal synchrotron shock pulses. However, a strongly correlated power-law behavior is observed between the luminosity and the spectral peak energy that is inconsistent with curvature effects arising in the relativistic outflow. It is difficult for any of the existing models to account for all of the observed spectral and temporal behaviors simultaneously.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preece, R -- Burgess, J Michael -- von Kienlin, A -- Bhat, P N -- Briggs, M S -- Byrne, D -- Chaplin, V -- Cleveland, W -- Collazzi, A C -- Connaughton, V -- Diekmann, A -- Fitzpatrick, G -- Foley, S -- Gibby, M -- Giles, M -- Goldstein, A -- Greiner, J -- Gruber, D -- Jenke, P -- Kippen, R M -- Kouveliotou, C -- McBreen, S -- Meegan, C -- Paciesas, W S -- Pelassa, V -- Tierney, D -- van der Horst, A J -- Wilson-Hodge, C -- Xiong, S -- Younes, G -- Yu, H-F -- Ackermann, M -- Ajello, M -- Axelsson, M -- Baldini, L -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Bellazzini, R -- Bissaldi, E -- Bonamente, E -- Bregeon, J -- Brigida, M -- Bruel, P -- Buehler, R -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Cecchi, C -- Charles, E -- Chekhtman, A -- Chiang, J -- Chiaro, G -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Cominsky, L R -- Conrad, J -- D'Ammando, F -- de Angelis, A -- de Palma, F -- Dermer, C D -- Desiante, R -- Digel, S W -- Di Venere, L -- Drell, P S -- Drlica-Wagner, A -- Favuzzi, C -- Franckowiak, A -- Fukazawa, Y -- Fusco, P -- Gargano, F -- Gehrels, N -- Germani, S -- Giglietto, N -- Giordano, F -- Giroletti, M -- Godfrey, G -- Granot, J -- Grenier, I A -- Guiriec, S -- Hadasch, D -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Iyyani, S -- Jogler, T -- Johannesson, G -- Kawano, T -- Knodlseder, J -- Kocevski, D -- Kuss, M -- Lande, J -- Larsson, J -- Larsson, S -- Latronico, L -- Longo, F -- Loparco, F -- Lovellette, M N -- Lubrano, P -- Mayer, M -- Mazziotta, M N -- Michelson, P F -- Mizuno, T -- Monzani, M E -- Moretti, E -- Morselli, A -- Murgia, S -- Nemmen, R -- Nuss, E -- Nymark, T -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orienti, M -- Paneque, D -- Perkins, J S -- Pesce-Rollins, M -- Piron, F -- Pivato, G -- Porter, T A -- Racusin, J L -- Raino, S -- Rando, R -- Razzano, M -- Razzaque, S -- Reimer, A -- Reimer, O -- Ritz, S -- Roth, M -- Ryde, F -- Sartori, A -- Scargle, J D -- Schulz, A -- Sgro, C -- Siskind, E J -- Spandre, G -- Spinelli, P -- Suson, D J -- Tajima, H -- Takahashi, H -- Thayer, J G -- Thayer, J B -- Tibaldo, L -- Tinivella, M -- Torres, D F -- Tosti, G -- Troja, E -- Usher, T L -- Vandenbroucke, J -- Vasileiou, V -- Vianello, G -- Vitale, V -- Werner, M -- Winer, B L -- Wood, K S -- Zhu, S -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):51-4. doi: 10.1126/science.1242302. Epub 2013 Nov 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Space Science, University of Alabama in Huntsville, Huntsville, AL 35899, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24263132" target="_blank"〉PubMed〈/a〉

Description: Microquasars are accreting black holes or neutron stars in binary systems with associated relativistic jets. Despite their frequent outburst activity, they have never been unambiguously detected emitting high-energy gamma rays. The Fermi Large Area Telescope (LAT) has detected a variable high-energy source coinciding with the position of the x-ray binary and microquasar Cygnus X-3. Its identification with Cygnus X-3 is secured by the detection of its orbital period in gamma rays, as well as the correlation of the LAT flux with radio emission from the relativistic jets of Cygnus X-3. The gamma-ray emission probably originates from within the binary system, opening new areas in which to study the formation of relativistic jets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fermi LAT Collaboration -- Abdo, A A -- Ackermann, M -- Ajello, M -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cecchi, C -- Celik, O -- Chaty, S -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Cominsky, L R -- Conrad, J -- Corbel, S -- Corbet, R -- Dermer, C D -- de Palma, F -- Digel, S W -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dubus, G -- Dumora, D -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Focke, W B -- Fortin, P -- Frailis, M -- Fusco, P -- Gargano, F -- Gehrels, N -- Germani, S -- Giavitto, G -- Giebels, B -- Giglietto, N -- Giordano, F -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hill, A B -- Hjalmarsdotter, L -- Horan, D -- Hughes, R E -- Jackson, M S -- Johannesson, G -- Johnson, A S -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kocian, M L -- Koerding, E -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Madejski, G M -- Makeev, A -- Marchand, L -- Marelli, M -- Max-Moerbeck, W -- Mazziotta, M N -- McColl, N -- McEnery, J E -- Meurer, C -- Michelson, P F -- Migliari, S -- Mitthumsiri, W -- Mizuno, T -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohsugi, T -- Omodei, N -- Ong, R A -- Ormes, J F -- Paneque, D -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Pooley, G -- Porter, T A -- Pottschmidt, K -- Raino, S -- Rando, R -- Ray, P S -- Razzano, M -- Rea, N -- Readhead, A -- Reimer, A -- Reimer, O -- Richards, J L -- Rochester, L S -- Rodriguez, J -- Rodriguez, A Y -- Romani, R W -- Ryde, F -- Sadrozinski, H F-W -- Sander, A -- Saz Parkinson, P M -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spinelli, P -- Starck, J-L -- Stevenson, M -- Strickman, M S -- Suson, D J -- Takahashi, H -- Tanaka, T -- Thayer, J B -- Thompson, D J -- Tibaldo, L -- Tomsick, J A -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vasileiou, V -- Vilchez, N -- Vitale, V -- Waite, A P -- Wang, P -- Wilms, J -- Winer, B L -- Wood, K S -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2009 Dec 11;326(5959):1512-6. doi: 10.1126/science.1182174. Epub .〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965378" target="_blank"〉PubMed〈/a〉

Description: The observations of the exceptionally bright gamma-ray burst (GRB) 130427A by the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the nature of these unique astrophysical sources. GRB 130427A had the largest fluence, highest-energy photon (95 GeV), longest gamma-ray duration (20 hours), and one of the largest isotropic energy releases ever observed from a GRB. Temporal and spectral analyses of GRB 130427A challenge the widely accepted model that the nonthermal high-energy emission in the afterglow phase of GRBs is synchrotron emission radiated by electrons accelerated at an external shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ackermann, M -- Ajello, M -- Asano, K -- Atwood, W B -- Axelsson, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Bechtol, K -- Bellazzini, R -- Bissaldi, E -- Bonamente, E -- Bregeon, J -- Brigida, M -- Bruel, P -- Buehler, R -- Burgess, J Michael -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Cecchi, C -- Chaplin, V -- Charles, E -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Chiaro, G -- Ciprini, S -- Claus, R -- Cleveland, W -- Cohen-Tanugi, J -- Collazzi, A -- Cominsky, L R -- Connaughton, V -- Conrad, J -- Cutini, S -- D'Ammando, F -- de Angelis, A -- DeKlotz, M -- de Palma, F -- Dermer, C D -- Desiante, R -- Diekmann, A -- Di Venere, L -- Drell, P S -- Drlica-Wagner, A -- Favuzzi, C -- Fegan, S J -- Ferrara, E C -- Finke, J -- Fitzpatrick, G -- Focke, W B -- Franckowiak, A -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gehrels, N -- Germani, S -- Gibby, M -- Giglietto, N -- Giles, M -- Giordano, F -- Giroletti, M -- Godfrey, G -- Granot, J -- Grenier, I A -- Grove, J E -- Gruber, D -- Guiriec, S -- Hadasch, D -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Horan, D -- Hughes, R E -- Inoue, Y -- Jogler, T -- Johannesson, G -- Johnson, W N -- Kawano, T -- Knodlseder, J -- Kocevski, D -- Kuss, M -- Lande, J -- Larsson, S -- Latronico, L -- Longo, F -- Loparco, F -- Lovellette, M N -- Lubrano, P -- Mayer, M -- Mazziotta, M N -- McEnery, J E -- Michelson, P F -- Mizuno, T -- Moiseev, A A -- Monzani, M E -- Moretti, E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nemmen, R -- Nuss, E -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orienti, M -- Paneque, D -- Pelassa, V -- Perkins, J S -- Pesce-Rollins, M -- Petrosian, V -- Piron, F -- Pivato, G -- Porter, T A -- Racusin, J L -- Raino, S -- Rando, R -- Razzano, M -- Razzaque, S -- Reimer, A -- Reimer, O -- Ritz, S -- Roth, M -- Ryde, F -- Sartori, A -- Parkinson, P M Saz -- Scargle, J D -- Schulz, A -- Sgro, C -- Siskind, E J -- Sonbas, E -- Spandre, G -- Spinelli, P -- Tajima, H -- Takahashi, H -- Thayer, J G -- Thayer, J B -- Thompson, D J -- Tibaldo, L -- Tinivella, M -- Torres, D F -- Tosti, G -- Troja, E -- Usher, T L -- Vandenbroucke, J -- Vasileiou, V -- Vianello, G -- Vitale, V -- Winer, B L -- Wood, K S -- Yamazaki, R -- Younes, G -- Yu, H-F -- Zhu, S J -- Bhat, P N -- Briggs, M S -- Byrne, D -- Foley, S -- Goldstein, A -- Jenke, P -- Kippen, R M -- Kouveliotou, C -- McBreen, S -- Meegan, C -- Paciesas, W S -- Preece, R -- Rau, A -- Tierney, D -- van der Horst, A J -- von Kienlin, A -- Wilson-Hodge, C -- Xiong, S -- Cusumano, G -- La Parola, V -- Cummings, J R -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):42-7. doi: 10.1126/science.1242353. Epub 2013 Nov 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24263133" target="_blank"〉PubMed〈/a〉