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  • Articles  (7)
  • Humans  (7)
  • 1990-1994  (4)
  • 1980-1984  (3)
  • 1960-1964
  • 1955-1959
  • 1940-1944
  • Science. 207(4434): 1007-8.  (1)
  • Science. 210(4467): 280-5.  (1)
  • Science. 214(4521): 659-60.  (1)
  • Science. 254(5035): 1202-5.  (1)
  • Science. 256(5058): 799-804.  (1)
  • Science. 257(5071): 738.  (1)
  • Science. 265(5170): 391-4.  (1)
  • 25
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  • Articles  (7)
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  • 1
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    Molecular genetics of epidermolysis bullosa (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-05-18
    Description: Blisters following minor trauma characterize epidermolysis bullosa, a group of hereditary diseases of the skin. In the simplex type, epidermal basal cells are fragile, and mutations of genes encoding keratin intermediate filament proteins underlie that fragility. In the dystrophic types, the causative mutation appears to be in the gene encoding type VII collagen, which is the major component of anchoring fibrils. These recent findings afford solid evidence that at least one function of the cytoskeletal intermediate filament network is the provision of mechanical stability and that anchoring fibrils indeed do anchor the epidermis to the underlying dermis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Epstein, E H Jr -- New York, N.Y. -- Science. 1992 May 8;256(5058):799-804.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, San Francisco, San Francisco General Hospital 94110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1375393" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosomes, Human, Pair 12 ; Chromosomes, Human, Pair 17 ; Cytoskeleton/ultrastructure ; Epidermolysis Bullosa/*genetics/pathology ; Humans ; Keratins/*genetics ; Multigene Family ; Skin/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Myoblast therapy (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Epstein, H F -- Fischman, D A -- Bader, D -- Changeux, J P -- Buckhold, K -- Ordahl, C P -- Hoffman, E -- Kedes, L H -- Konieczny, S -- Leinwand, L A -- New York, N.Y. -- Science. 1992 Aug 7;257(5071):738.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1496388" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Humans ; Male ; Muscles/*transplantation ; Muscular Dystrophies/*surgery ; Transplantation/adverse effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Epidermolysis bullosa simplex: evidence in two families for keratin gene abnormalities (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-02
    Description: Epidermolysis bullosa simplex (EBS) is characterized by skin blistering due to basal keratinocyte fragility. In one family studied, inheritance of EBS is linked to the gene encoding keratin 14, and a thymine to cytosine mutation in exon 6 of keratin 14 has introduced a proline in the middle of an alpha-helical region. In a second family, inheritance of EBS is linked to loci that map near the keratin 5 gene. These data indicate that abnormalities of either of the components of the keratin intermediate filament heterodipolymer can impair the mechanical stability of these epithelial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonifas, J M -- Rothman, A L -- Epstein, E H Jr -- R01-AR28069/AR/NIAMS NIH HHS/ -- R01-AR39953/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Nov 22;254(5035):1202-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Dermatology, San Francisco General Hospital, University of California 94110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1720261" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chromosomes, Human, Pair 12 ; Chromosomes, Human, Pair 17 ; Epidermolysis Bullosa Simplex/*genetics ; Genes ; Genetic Linkage ; Humans ; Keratins/*genetics ; Molecular Sequence Data ; Oligonucleotides/chemistry ; Pedigree ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Potential role of human cytomegalovirus and p53 interaction in coronary restenosis (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-15
    Description: A subset of patients who have undergone coronary angioplasty develop restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38 percent) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Speir, E -- Modali, R -- Huang, E S -- Leon, M B -- Shawl, F -- Finkel, T -- Epstein, S E -- New York, N.Y. -- Science. 1994 Jul 15;265(5170):391-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiology Branch, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8023160" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; *Angioplasty, Balloon ; Antigens, Viral/*metabolism ; Atherectomy, Coronary ; Base Sequence ; Cells, Cultured ; Coronary Disease/*etiology/pathology/therapy ; Coronary Vessels/cytology/metabolism/microbiology ; Cytomegalovirus/*physiology ; Genes, p53 ; Humans ; Immediate-Early Proteins/*metabolism ; Middle Aged ; Molecular Sequence Data ; Muscle, Smooth, Vascular/cytology/metabolism/microbiology ; Recurrence ; Transcriptional Activation ; Transfection ; Tumor Suppressor Protein p53/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    X-linked ichthyosis: increased blood cholesterol sulfate and electrophoretic mobility of low-density lipoprotein (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: Plasma cholesterol sulfate concentration is increased in patients with recessive X-linked ichthyosis, a disease in which steroid sulfatase activity is absent. In these patients, cholesterol sulfate is found primarily in the low-density lipoprotein fraction of plasma, and the electrophoretic mobility of these lipoproteins is greatly increased.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Epstein, E H Jr -- Krauss, R M -- Shackleton, C H -- AM 28069/AM/NIADDK NIH HHS/ -- HL 18574/HL/NHLBI NIH HHS/ -- RR 00719/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):659-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6945674" target="_blank"〉PubMed〈/a〉
    Keywords: Cholesterol Esters/*blood ; Electrophoresis, Agar Gel ; Female ; Genes, Recessive ; Genetic Linkage ; Humans ; Ichthyosis/blood/*genetics ; Lipoproteins, LDL/*blood ; Steryl-Sulfatase ; Sulfatases/deficiency ; Sulfates ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Differential killing of normal and cystic fibrosis fibroblasts by dexamethasone (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, J L -- Epstein, J -- New York, N.Y. -- Science. 1980 Feb 29;207(4434):1007-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352296" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Survival/drug effects ; Cells, Cultured ; Cystic Fibrosis/*drug therapy ; Dexamethasone/*pharmacology ; Ethyl Methanesulfonate/pharmacology ; Humans ; Methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Endoscopy: developments in optical instrumentation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: Optical fibers transmit high-intensity illumination for viewing internal organs and tissue. Remote viewing is obtained by relays of lenses or graded-index-of-refraction rods in rigid endoscopes and by precisely aligned fiber-optic bundles in flexible fiberscopes. Endoscopy is considered for routine examinations, such as in colonoscopy. Lasers are used as surgical tools through endoscopes for cutting and coagulation. They may also be used to provide illumination for the efficient transmission of light through thin optical fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Epstein, M -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):280-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423188" target="_blank"〉PubMed〈/a〉
    Keywords: Colonoscopes ; Colonoscopy/adverse effects ; *Endoscopes ; Fiber Optic Technology/instrumentation ; Humans ; Lasers ; Lighting ; Optical Fibers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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