Publication Date:
1978-07-14
Description:
As the pluripotent cells of early embryos differentiate, each progressively loses the potency to develop into several phenotypes. Ultimately, each cell becomes irreversibly restricted to the expression of a single phenotype. Although in many instances details regarding those restriction events are well known, there is little information concerning the nature of the gene transcription changes involved. A model that accounts for the diminution of developmental potential as resulting from progressive, irreversible repression of previously active genes is presented. A scheme of progressive gene repression, rather than selective gene activation, is most consistent with observations from experimental embryology as well as from more recent biochemical experimentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caplan, A I -- Ordahl, C P -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):120-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351805" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blastocyst/physiology
;
*Cell Differentiation
;
Cell Nucleus/physiology
;
Cytoplasm/physiology
;
Environment
;
Enzyme Repression
;
Extremities/physiology
;
*Genes
;
*Models, Biological
;
*Morphogenesis
;
Phenotype
;
Regeneration
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink