Publication Date:
2018-07-21
Description:
Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a, Published online: 20 July 2018; doi:10.1038/s41467-018-05209-1 Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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