ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Artikel  (30)
  • Artikel: DFG Deutsche Nationallizenzen  (30)
  • Springer  (29)
  • Blackwell Publishing, Inc.  (1)
  • American Society of Hematology
  • 2005-2009  (1)
  • 1975-1979  (9)
  • 1970-1974  (11)
  • 1920-1924  (1)
  • 1905-1909  (8)
Sammlung
  • Artikel  (30)
Datenquelle
Erscheinungszeitraum
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Risk analysis 25 (2005), S. 0 
    ISSN: 1539-6924
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Energietechnik
    Notizen: Recent studies demonstrating a concentration dependence of elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suggest that previous estimates of exposure for occupationally exposed cohorts may have underestimated actual exposure, resulting in a potential overestimate of the carcinogenic potency of TCDD in humans based on the mortality data for these cohorts. Using a database on U.S. chemical manufacturing workers potentially exposed to TCDD compiled by the National Institute for Occupational Safety and Health (NIOSH), we evaluated the impact of using a concentration- and age-dependent elimination model (CADM) (Aylward et al., 2005) on estimates of serum lipid area under the curve (AUC) for the NIOSH cohort. These data were used previously by Steenland et al. (2001) in combination with a first-order elimination model with an 8.7-year half-life to estimate cumulative serum lipid concentration (equivalent to AUC) for these workers for use in cancer dose-response assessment. Serum lipid TCDD measurements taken in 1988 for a subset of the cohort were combined with the NIOSH job exposure matrix and work histories to estimate dose rates per unit of exposure score. We evaluated the effect of choices in regression model (regression on untransformed vs. ln-transformed data and inclusion of a nonzero regression intercept) as well as the impact of choices of elimination models and parameters on estimated AUCs for the cohort. Central estimates for dose rate parameters derived from the serum-sampled subcohort were applied with the elimination models to time-specific exposure scores for the entire cohort to generate AUC estimates for all cohort members. Use of the CADM resulted in improved model fits to the serum sampling data compared to the first-order models. Dose rates varied by a factor of 50 among different combinations of elimination model, parameter sets, and regression models. Use of a CADM results in increases of up to five-fold in AUC estimates for the more highly exposed members of the cohort compared to estimates obtained using the first-order model with 8.7-year half-life. This degree of variation in the AUC estimates for this cohort would affect substantially the cancer potency estimates derived from the mortality data from this cohort. Such variability and uncertainty in the reconstructed serum lipid AUC estimates for this cohort, depending on elimination model, parameter set, and regression model, have not been described previously and are critical components in evaluating the dose-response data from the occupationally exposed populations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of environmental contamination and toxicology 10 (1973), S. 225-226 
    ISSN: 1432-0800
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Meteorology and atmospheric physics 26 (1977), S. 39-50 
    ISSN: 1436-5065
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geographie , Physik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Im Dezember 1975 wurden durch eine Fesselballonsonde die vertikalen Temperatur- und Windprofile im Gore River Valley im westlichen Colorado ermittelt. Aus Beobachtungen an einem wolkenlosen Morgen bei einer anfangs starken Inversion im Tal zeigte sich, daß die Inversionsobergrenze stetig um 120 m Std−1. absank und nach ungefähr vier Stunden den Talgrund erreichte. Schwache Talabwinde wehten innerhalb der Inversionsschicht. während stärkere Talaufwinde oberhalb derselben herrschten. Eine Hypothese wird vorgeschlagen, um diese Beobachtungen zu erklären. Die Abkühlung am späten Nachmittag und am Abend, wobei die Bildung einer Inversion einsetzte, deren Schichtdicke in weniger als zwei Stunden 175 m betrug, ist Gegenstand einer gesonderten Untersuchung. Winde innerhalb der Inversionsschicht wurden nicht mehr von den Winden in der freien Atmosphäre beeinflußt und blieben im Laufe der Nacht sehr schwach. Bewölkung während der Erwärmungsperiode an einem Morgen hatte zur Folge, daß das Temperaturprofil sich Isothermie näherte, indem Erwärmung gleichmäßig im ganzen Luftraum des Tales sich fortsetzte.
    Notizen: Summary A tethered balloon sounder was used to collect vertical temperature and wind structure data in the Gore River Valley of Western Colorado during December, 1975. Observations taken on a clear morning in which a deep inversion was initially present in the valley showed that the inversion top descended at a steady rate of ∼120 m hr−1. reaching the valley bottom after approximately 4 hours. Weak down-valley winds were present within the inversion layer while stronger up-valley winds prevailed above. A hypothesis is presented to account for these observations. A case study is presented for afternoon and evening cooling in which a ground-based inversion developed to a depth of 175 m in less than 2 hours. Winds within the inversion became decoupled from the synoptic-scale winds and remained very weak during the night. The effect of cloud cover during a morning heating cycle was to make the temperature soundings approach isothermal while sensible heating continued throughout the valley volume.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Earth, moon and planets 7 (1973), S. 453-474 
    ISSN: 1573-0794
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Chromosoma 29 (1970), S. 462-473 
    ISSN: 1432-0886
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Swarming locusts show three physical criteria, i.e. the phase changes of melanisation of the nymphal stages or hoppers, of the proportions of certain body parts (morphometric ratios), and increased genetic recombination (meiotic chiasma frequencies) in the adult. The control of these changes, initiated by aggregation into swarms, i.e. gregarisation, seems to be vested in a pheromone which is produced by all hoppers in both the solitaria and gregaria phases, also by hoppers of the albino strain. Such a pheromone can be extracted from the locust room air and from the locust, these extracts showing high activity in bioassays, primarily in increased chiasma frequencies but also in hopper colour. The extract in risella oil is more efficient than that in petroleum ether and can be distilled to yield an active distillate. The pheromone is secreted in the faeces of hoppers but not of adults. There is evidence in faeces bioassays that all three physical criteria are affected; the pheromone may be called locustone. It is manufactured or secreted in a specific section of the alimentary canal, i.e. the crop. Reception is not through the antennae but through the stigmata. Preliminary chemical analysis of a risella oil air extract distilled into various other solvents showed the presence of a relatively simple saturated aliphatic chain with a carbonyl function, perhaps a ketone or an ester.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Environmental management 1 (1977), S. 343-348 
    ISSN: 1432-1009
    Schlagwort(e): Flood-plain vegetation ; Land use ; Channelization ; Bank-stabilization ; Flood-plain forest succession
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik
    Notizen: Abstract Changes in vegetation and land use since 1826 were evaluated along the 800 kilometer portion of the Missouri River flood-plain that extends across the State of Missouri using County Land Office Survey records for 1826 and aerial photos for 1937, 1958, and 1972. The combined results show a decline in flood-plain forest coverage from 76% in 1826 to 13% in 1972; cultivated land increased from 18% to 83% during the same time. Uncultivated-unforested areas increased from 6% in 1826 to 27% in 1937, then declined to 1% in 1972; these changes occurred coincident with extensive bank-stabilization and channelization activities initiated in 1912 by the U.S. Army Corps of Engineers. Riverbank stabilization activity since that time may account for the increased rate of decline in flood-plain forests from 0.25% per year between 1826 and 1937 to 1.6% per year between 1937 and 1972. The overall species composition of the 1826 flood-plain forests was found to be most similar to mature forest stands evaluated in 1972; similar frequencies in 1826 and 1972 occurred for hackberry (Celtis occidentalis; 80% in 1826, 83% in 1972), elm (Ulmus spp.; 80% and 83%), and sycamore (Platanus occidentalis; 57% and 50%). Pawpaw (Asimina triloba), found only in mature flood-plain forests in 1972, was recorded along 54% of the 1826 section lines. These combined data indicate (1) that pre-settlement flood-plain forests were extensive and included frequent, mature stands, (2) that in certain areas substantial portions of the flood-plain were in cultivation prior to extensive riverbank stabilization and channelization, and (3) that increased flood-plain forest clearing occurred coincident with increased bank-stabilization activities.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Biochemical genetics 11 (1974), S. 121-139 
    ISSN: 1573-4927
    Schlagwort(e): gene expression ; gene mapping ; lysosomal enzymes ; cell fusion ; gel electrophoresis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Lysosomal acid phosphatase activity in human and mouse cells was separated into multiple zones by starch gel electrophoresis. One of the two major zones in the mouse was apparently extinguished when genetic information from man and the mouse was combined in proliferating man-mouse somatic cell hybrids. The evidence suggested that the absence of the mouse lysosomal acid phosphatase (mAP-1) was influenced by the human genome. The gene coding for human acid phosphatase (hAP-1) was shown to be unlinked to the presumed human component which extinguished the mouse acid phosphatase (mAP-1). The mechanism of “extinction” is postulated to be a modification in the processing of the mouse lysosomal enzyme. A dimeric structure was suggested for acid phosphatase-1 of man, mouse, and rat since a single hybrid enzyme was expressed in man-mouse and mouse-rat somatic cell hybrids.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Biochemical genetics 5 (1971), S. 457-466 
    ISSN: 1573-4927
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Examination of the frequencies of several loci controlling isozymes in three geographically distinct feral populations of mice showed the average animal to be heterozygous at 10.3% of his loci. There was no evidence for interaction between loci, nor any evidence for inbreeding in the populations. Thirty-nine inbred strains, including four newly derived ones, were also characterized for their alleles for as many as 16 polymorphic loci. Among these strains, variability is at least as great as in any single feral population, but probably less than that found among all feral populations of the species.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 156 (1975), S. 475-482 
    ISSN: 1432-0878
    Schlagwort(e): Annulate lamellae ; Spermatocytes ; Grasshoppers ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Intranuclear and cytoplasmic annulate lamellae were studied in grasshopper spermatocytes (Melanoplus) with the electron microscope. Although cytoplasmic annulate lamellae were observed in all three species examined, intranuclear annulate lamellae were found in only one species. The intranuclear annulate lamellae encompass certain nuclear material adjacent to the nuclear envelope forming a vesicle that is extruded into the spermatocyte cytoplasm. In this same species, cytoplasmic annulate lamellae are seen contiguous with granular masses of varying size. These structures were noted as being morphologically indistinguishable from the “yolk nuclei” of dragonfly oocytes (Kessel and Beams, 1969; Kessel, 1973).
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Reviews of physiology, biochemistry and pharmacology 23 (1924), S. 212-273 
    ISSN: 1617-5786
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Zusammenfassung Kurz zusammengefasst sind die wichtigsten, hier niedergelegten Tatsachen folgende: Es wurde eine Methode für die totale Entfernung der Leber bei Hunden ausgebildet, welche frei von den meisten Fehlerquellen ist, die früheren Exstirpationsmethoden des Organs bei Säugetieren anhaften. Es wurde gefunden, dass eine geeignete Einführung von Glukose bei derart operierten Hunden das Leben viele Stunden nach Verlust des gesamten Lebergewebes erhält. Von den vielen an hepatektomierten Tieren gemachten Beobachtungen möchten wir hervorheben, 1. dass die Leber zur Erhaltung des Blutzuckerspiegels absolut wesentlich ist; 2. dass die Leber der wichtigste Faktor, wenn nicht der einzige, bei dem Prozess der Desamidierung und der Harnstoffbildung ist, und 3. dass Bilirubin auch ohne Mitwirkung der Leber gebildet werden kann.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...