Publication Date:
2000-08-19
Description:
TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential for its proapoptotic effect. Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, H -- Kolluri, S K -- Gu, J -- Dawson, M I -- Cao, X -- Hobbs, P D -- Lin, B -- Chen, G -- Lu, J -- Lin, F -- Xie, Z -- Fontana, J A -- Reed, J C -- Zhang, X -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1159-64.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947977" target="_blank"〉PubMed〈/a〉
Keywords:
*Apoptosis
;
Cell Fractionation
;
Cell Nucleus/metabolism
;
Cytochrome c Group/*metabolism
;
DNA/metabolism
;
DNA-Binding Proteins/chemistry/genetics/*metabolism
;
Fatty Acids, Unsaturated/pharmacology
;
Genes, Reporter
;
Humans
;
Intracellular Membranes/metabolism/physiology
;
Mitochondria/*metabolism
;
Mutation
;
Nuclear Receptor Subfamily 4, Group A, Member 1
;
Protein Structure, Tertiary
;
Receptors, Cytoplasmic and Nuclear
;
Receptors, Steroid
;
Recombinant Fusion Proteins/metabolism
;
Transcription Factors/chemistry/genetics/*metabolism
;
Transcriptional Activation
;
Transfection
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
