Publication Date:
2003-09-27
Description:
A survey of the dog genome sequence (6.22 million sequence reads; 1.5x coverage) demonstrates the power of sample sequencing for comparative analysis of mammalian genomes and the generation of species-specific resources. More than 650 million base pairs (〉25%) of dog sequence align uniquely to the human genome, including fragments of putative orthologs for 18,473 of 24,567 annotated human genes. Mutation rates, conserved synteny, repeat content, and phylogeny can be compared among human, mouse, and dog. A variety of polymorphic elements are identified that will be valuable for mapping the genetic basis of diseases and traits in the dog.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirkness, Ewen F -- Bafna, Vineet -- Halpern, Aaron L -- Levy, Samuel -- Remington, Karin -- Rusch, Douglas B -- Delcher, Arthur L -- Pop, Mihai -- Wang, Wei -- Fraser, Claire M -- Venter, J Craig -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1898-903.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Institute for Genomic Research, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512627" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosomes, Mammalian/genetics
;
Computational Biology
;
Conserved Sequence
;
Contig Mapping
;
DNA, Intergenic
;
Dogs/*genetics
;
Genetic Variation
;
*Genome
;
Genome, Human
;
Genomics
;
Humans
;
Long Interspersed Nucleotide Elements
;
Male
;
Mice/genetics
;
Molecular Sequence Data
;
Mutation
;
Phylogeny
;
Physical Chromosome Mapping
;
Polymorphism, Single Nucleotide
;
RNA, Messenger/genetics
;
Repetitive Sequences, Nucleic Acid
;
Sequence Alignment
;
*Sequence Analysis, DNA
;
Short Interspersed Nucleotide Elements
;
Synteny
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
