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  • 1
    Unbekannt
    Berlin, Heidelberg : Springer
    Schlagwort(e): Biochemistry ; Toxicology
    ISBN: 9783540331209
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Unbekannt
    Berlin, Heidelberg : Springer
    Schlagwort(e): Biochemistry ; Chemistry, Organic ; Medicine ; Toxicology
    ISBN: 9783540797296
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Unbekannt
    New York, NY : Springer
    Schlagwort(e): Chemistry, Organic ; Food science
    ISBN: 9780387740874
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Unbekannt
    Boston, MA : Springer
    Schlagwort(e): Chemistry ; Food science
    ISBN: 9780387249803
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Unbekannt
    Boston, MA : Springer
    Schlagwort(e): Chemistry ; Food science ; Immunology
    ISBN: 9780387283913
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Unbekannt
    Berlin, Heidelberg : Springer
    Schlagwort(e): Biochemistry ; Chemistry, Organic ; Medicine ; Toxicology
    ISBN: 9783540742296
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Schlagwort(e): Life sciences ; Science ; Urban planning ; City planning ; Urban ecology (Biology) ; System theory ; International environmental law ; Sustainable development ; Life Sciences ; Urban Ecology ; Urbanism ; Sustainable Development ; Complex Systems ; Science, general ; International Environmental Law
    Beschreibung / Inhaltsverzeichnis: 1. A global outlook on urbanization --- 2. History of urbanization and the missing ecology --- 3. Urbanization and global trends in biodiversity and ecosystem services --- 4. Regional assessment of Asia.- 5. Sub-regional assessment of China: Urbanization in biodiversity hotspots --- 6. Sub-regional assessment of India --- 7. Local assessment of Bangalore.- 8. Local assessment of Tokyo --- 9. Local assessment of Shanghai --- 10. Patterns and trends in urban biodiversity and landscape design --- 11. Urban ecosystem services.- 12. Shrinking cities, biodiversity and ecosystem services --- 13. Regional assessments of Europe --- 14. Regional assessment of North America --- 15. Regional assessment of Oceania --- 16. Local assessment of Istanbul: Biodiversity and ecosystem services --- 17. Local assessment of Stockholm --- 18. Local assessment of Chicago --- 19. Local assessment of New York City.-20. Local assessment of Melbourne --- 21. A synthesis of global urbanization projections --- 22. Urbanization forecasts, effects on land use, biodiversity, and ecosystem services --- 23. Regional assessment of Africa --- 24. Local assessment of Cape Town.- 25. Climate change and urban biodiversity vulnerability --- 26. Feeding cities --- 27. Urban governance of biodiversity and ecosystem services --- 28. Regional assessment of Latin America --- 29. Local assessment of Rio de Janeiro.- 30. Urban landscapes as learning arenas for biodiversity and ecosystem services management --- 31. Restoration ecology in an urbanizing world --- 32. Indicators for management of urban biodiversity and ecosystem services --- 33. Stewardship of the Biosphere in the Urban Era
    Seiten: Online-Ressource (XXVIII, 755 pages) , 150 illustrations, 23 illustrations in color
    ISBN: 9789400770881
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Unbekannt
    Tokyo : Springer
    Schlagwort(e): Life sciences ; Cell biology ; Developmental biology ; Plant science ; Botany ; Life Sciences ; Developmental Biology ; Plant Sciences ; Cell Biology
    Beschreibung / Inhaltsverzeichnis: Part 1 Sperm Attraction, Activation and Acrosome Reaction --- 1 Sperm Chemotaxis: The First Authentication Events Between Conspecific Gametes Prior to Fertilization (Manabu Yoshida) --- 2 Respiratory CO2 Mediates Sperm Chemotaxis in Squids (Noritaka Hirohashi) --- 3 Specific Mechanism of Sperm Storage in Avian Oviducts (Tomohiro Sasanami) --- 4 Allurin: Exploring the Activity of a Frog Sperm Chemoattractant in Mammals (Douglas E. Chandler) --- 5 Structure, Function and Phylogenetic Consideration of Calaxin (Kazuo Inaba) --- 6 Cl- Channels and Transporters in Sperm Physiology (Alberto Darszon) --- 7 Equatorin-related Subcellular and Molecular Events During Sperm Priming for Fertilization in Mice (Kiyotaka Toshimori) --- 8 Acrosome Reaction-mediated Motility Initiation that is Critical for the Internal Fertilization of Urodele Amphibians (Akihiko Watanabe) --- 9 Analysis of the Mechanism that Brings Protein Disulfide Isomerase-P5 to Inhibit Oxidative Refolding of Lysozyme (Miho Miyakawa) --- Part 2 Gametogenesis, Gamete Recognition, Activation, and Evolution --- 10 Effect of Relaxin-like Gonad-Stimulating Substance (GSS) on Gamete Shedding and 1-Methyladenine Production in Starfish Ovaries (Masatoshi Mita) --- 11 Incapacity of 1-Methyladenine Production to Relaxin-like Gonad-Stimulating Substance (GSS) in Ca2+-free Seawater-treated Starfish Ovarian Follicle Cells (Masatoshi Mita) --- 12 Novel Isoform of Vitellogenin Expressed in Eggs is a Binding Partner of the Sperm Proteases, HrProacrosin and HrSermosin, in the Ascidian Halocynthia roretzi (Hitoshi Sawada) --- 13 Actin Cytoskeleton and Fertilization in Starfish Eggs (Luigia Santella) --- 14 Focused Proteomics on Egg Membrane Microdomains to Elucidate the Cellular and Molecular Mechanisms of Fertilization in the African Clawed Frog Xenopus laevis (Ken-ichi Sato) --- 15 Egg Activation in Polyspermy: Its Molecular Mechanisms and Evolution in Vertebrates (Yasuhiro Iwao ) --- 16 ATP Imaging in Xenopus laevis Oocyte (Takashi Ijiri) --- 17 Mitochondrial Activation and Nitric Oxide (NO) Release at Fertilization in Echinoderm Eggs (Tatsuma Mohri) --- 18 Functional Roles of Spe Genes in the Male Germline During Reproduction of Caenorhabditis elegans (Hitoshi Nishimura) --- 19 Origin of Female/Male Gender as Deduced by the Mating Type Loci of the Colonial Volvocalean Greens (Hisayoshi Nozaki) --- Part 3 Allorecognition in Male–Female Interaction --- 20 Allorecognition and Lysin Systems During Ascidian Fertilization (Hitoshi Sawada) --- 21 Self-incompatibility in the Brassicaceae (Megumi Iwano) --- 22 Signalling Events in Pollen Acceptance or Rejection in the Arabidopsis Species (Daphne R. Goring) --- 23 Papaver rhoeas S-Determinants and the Signaling Networks they Trigger (Vernonica E. Franklin-Tong ) --- 24 S-RNase-based Self-incompatibility in Petunia: A Complex Non-self Recognition System Between Pollen and Pistil (Teh-hui Kao) --- 25 Self-incompatibility System of Ipomoea trifida, a Wild-type Sweet Potato (Tohru Tsuchiya) --- Part 4 Male–Female Interaction and Gamete Fusion --- 26 Profiling the GCS1-based Gamete Fusion Mechanism (Toshiyuki Mori) --- 27 Fertilization Mechanisms of the Rodent Malarial Parasite Plasmodium berghei (Makoto Hirai) --- 28 Sexual Reproduction of a Unicellular Charophycean Alga, Closterium peracerosum-strogosum-littorale Complex (Hiroyuki Sekimoto) --- 29 Fertilization of Brown Algae: Flagellar Function in Phototaxis and Chemotaxis (Taizo Motomura ) --- 30 Gene and Protein Expression Profiles in Rice Gametes and Zygotes: A Cue for Understanding the Mechanisms of Gametic and Early Zygotic Development in Angiosperms (Takashi Okamoto) --- 31 Role of CD9 in Sperm-Egg Fusion and Virus-induced Cell Fusion in Mammals (Kenji Miyado) --- 32 The Mechanism of Sperm-Egg Fusion in Mouse and the Involvement of IZUMO1 (Naokazu Inoue) --- 33 A ZP2 Cleavage Model of Gamete Recognition and the Post-fertilization Block to Polyspermy (Jurrien Dean) --- 34 Involvement of Carbohydrate Residues of the Zona Pellucida in In Vitro Sperm Recognition in Pigs and Cattle (Naoto Yonezawa) --- Part 5 Organella, Proteolysis, and New Techniques --- 35 The Role of Peroxisomes in Plant Reproductive Processes (Shoji Mano) --- 36 Regulation of Vacuole-mediated Programmed Cell Death During Innate Immunity and Reproductive Development in Plants (Tomoko Koyano) --- 37 Sperm Proteasomes as a Putative Egg Coat Lysin in Mammals (Peter Sutovsky) --- 38 Germline Transformation in the Ascidian Ciona intestinalis (Yasunori Sasakura) --- BM Index.  
    Seiten: Online-Ressource (XII, 480 pages) , 127 illustrations, 102 illustrations in color
    ISBN: 9784431545897
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Schlagwort(e): medical geology
    Beschreibung / Inhaltsverzeichnis: All living organisms are composed of major, minor, and trace elements, given by nature and supplied by geology. Medical geology is a rapidly growing discipline dealing with the influence of natural geological and environmental risk factors on the distribution of health problems in humans and animals. As a multi-disciplinary scientific field, medical geology has the potential of helping medical and public health communities all over the world in the pursuit of solutions to a wide range of environmental and naturally induced health issues. The natural environment can impact health in a variety of ways. The composition of rocks and minerals are imprinted on the air that we breathe, the water that we drink, and the food that we eat. For many people this transference of minerals and the trace elements they contain is beneficial as it is the primary source of nutrients (such as calcium, iron, magnesium, potassium, and about a dozen other elements) that are essential for a healthy life. However, sometimes the local geology can cause significant health problems because there is an insufficient amount of an essential element or an excess of a potentially toxic element (such as arsenic, mercury, lead, fluorine, etc.), or a harmful substance such as methane gas, dust-sized particles of asbestos, quartz or pyrite, or certain naturally occurring organic compounds. Current and future medical geology concerns include: dangerous levels of arsenic in drinking water in dozens of countries including the USA; mercury emissions from coal combustion and its bioaccumulation in the environment; the impacts of mercury and lead mobilizations in regions were artisanal gold mining is conducted; the residual health impacts of geologic processes such as volcanic emissions, earthquakes, tsunamis, hurricanes, and geogenic dust; exposure to fibrous minerals such as asbestos and erionite; and the health impacts of global climate change. Billions of people, most in developing countries, are afflicted by these and other environmental health issues that can be avoided, prevented, mitigated or minimized through research and educational outreach. This Special Issue of Geosciences discusses recent advances in medical geology, providing examples from research conducted all over the world. Among the topics to be discussed are: - Health effects from trace elements, metals and metalloids - Regional and global impacts of natural dust (including the study of nanoparticles) - Chemical and environmental pathology of diseases associated with natural environment - Novel analytical approaches to the study of natural geochemical and environmental agents - Research on beneficial health aspects of natural geological materials - Risk management, risk communication and risk mitigation on medical geology - Remote sensing and GIS applications on medical geology - Epidemiology and public health studies on medical geology - Climate change and medical geology - Clinical and toxicological research on biomarkers of exposure - Veterinary medical geology - Biosurveillance and biomonitoring studies on medical geology
    Seiten: Online-Ressource (XIV, 238 Seiten)
    Ausgabe: Printed Edition of the Special Issue Published in Geosciences
    ISBN: 9783038421986
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Schlagwort(e): Life sciences ; Ecology ; Wildlife ; Fish ; Life Sciences ; Fish & Wildlife Biology & Management ; Ecology ; Environmental Monitoring/Analysis
    Beschreibung / Inhaltsverzeichnis: 1 Introduction: Overview of Our Research on Impacts of the Fukushima Dai-ichi Nuclear Power Plant Accident on Fish and Fishing Grounds --- Part I Seawater and Plankton --- 2 134Cs and 137Cs in the Seawater Around Japan and in the North Pacific --- 3 Temporal Changes in 137Cs Concentration in Zooplankton and Seawater off the Joban–Sanriku Coast, and in Sendai Bay, After the Fukushima Dai-ichi Nuclear Accident --- Part II Sediments and Benthos --- 4 Three-Dimensional Distribution of Radiocesium in Sea Sediment Derived from the Fukushima Dai-ichi Nuclear Power Plant --- 5 Radiocesium Concentrations in the Organic Fraction of Sea Sediments --- 6 Bottom Turbidity, Boundary Layer Dynamics, and Associated Transport of Suspended Particulate Materials off the Fukushima Coast --- 7 Investigation of Radiocesium Translation from Contaminated Sediment to Benthic Organisms --- Part III Marine Fish --- 8 Detection of 131I, 134Cs, and 137Cs Released into the Atmosphere from FNPP in Small Epipelagic Fishes, Japanese Sardine and Japanese Anchovy, off the Kanto Area, Japan --- 9 Radiocesium Concentration of Small Epipelagic Fishes (Sardine and Japanese Anchovy) off the Kashima-Boso Area --- 10 Why Do the Radionuclide Concentrations of Pacific Cod Depend on the Body Size? --- 11 Radiocesium Contamination Histories of Japanese Flounder (Paralichthys olivaceus) After the 2011 Fukushima Nuclear Power Plant Accident --- Part IV Mechanisms of Severe Contamination in Fish --- 12 Evaluating the Probability of Catching Fat Greenlings (Hexagrammos otakii) Highly Contaminated with Radiocesium off the Coast of Fukushima --- 13 Analysis of the Contamination Process of the Extremely Contaminated Fat Greenling by Fukushima-Derived Radioactive Material --- 14 Contamination Levels of Radioactive Cesium in Fat Greenling Caught at the Main Port of the Fukushima Dai-ichi Nuclear Power Plant --- Part V Freshwater Systems --- 15 Comparison of Radioactive Cesium Contamination of Lake Water, Bottom Sediment, Plankton, and Freshwater Fish Among Lakes of Fukushima Prefecture, Japan, After the Fukushima Fallout --- 16 Radiocesium Concentrations and Body Size of Freshwater Fish in Lake Hayama 1 Year After the Fukushima Dai-Ichi Nuclear Power Plant Accident --- 17 Spatiotemporal Monitoring of 134Cs and 137Cs in Ayu, Plecoglossus altivelis, a Microalgae-Grazing Fish, and in Their Freshwater Habitats in Fukushima --- 18 Radiocesium Concentrations in the Muscle and Eggs of Salmonids from Lake Chuzenji, Japan, After the Fukushima Fallout --- 19 Assessment of Radiocesium Accumulation by Hatchery-Reared Salmonids After the Fukushima Nuclear Accident
    Seiten: Online-Ressource (XI, 238 pages) , 103 illustrations, 37 illustrations in color
    ISBN: 9784431555377
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Schlagwort(e): Life sciences ; Management ; Industrial management ; Geography ; Agriculture ; Agricultural economics ; Life Sciences ; Agriculture ; Agricultural Economics ; Geography, general ; Innovation/Technology Management
    Beschreibung / Inhaltsverzeichnis: Foreword --- 1. Innovation for Marginalized Smallholder Farmers and Development: an Overview and Implications for Policy and Research --- Part 1 Innovation for the Rural Poor: Theory, Trends and Impacts --- 2. Institutional and technological innovations in polycentric systems –pathways for escaping marginality --- 3. Innovations for Food and Nutrition Security: Impacts and Trends --- 4. Psychology of Innovation: Innovating human psychology? --- 5. An optimization model for technology adoption of marginalized smallholders --- Part 2 Diversification of Agricultural Production and Income --- 6. The BRAC Approach to Small Farmers' Innovations --- 7. Agricultural Research and Extension Linkages in Amhara Region, Ethiopia --- 8. Transaction costs on the Ethiopian formal seed market and innovations for encouraging private sector investments --- 9. Agricultural Service Delivery Through Mobile Phone: Local innovations and Technological Opportunities in Kenya --- 10. Identification and Acceleration of Farmer Innovativeness in Upper East Ghana --- 11. Gender, social equity and innovations in smallholder farming systems: pitfalls and pathways --- 12. Assessing the Sustainability of Agricultural Technology Options for Poor Rural Farmers --- 13. Land Degradation and Sustainable Land Management Innovations in Central Asia --- 14. Biomass-based value web. A Novel Perspective for Emergng Bioeconomies in Sub-Saharan Africa --- Part 3 Sustainable Intensification of Agriculture --- 15. Adoption of Stress-tolerant Rice Varieties in Bangladesh --- 16. More than cereal based cropping innovations for improving food and livelihood security of poor small holders in marginal areas of Bangladesh --- 17. Integrated Rice-fish Farming System in Bangladesh: An Ex-Ante Value Chain Evaluation Framework --- 18. Technologies for Maize, Wheat, Rice and Pulses in Marginal Districts of Odisha and Bihar --- 19. Technological Innovations for Smallholder Farmers in Ghana --- 20. Potential impacts of yield increasing crop technologies on poverty reduction in two districts of Ethiopia
    Seiten: Online-Ressource (XV, 435 pages) , 80 illustrations, 50 illustrations in color
    ISBN: 9783319257181
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Applied ecology ; Biodiversity ; Ecosystems ; Conservation biology ; Ecology ; Community psychology ; Environmental psychology ; Life Sciences ; Applied Ecology ; Biodiversity ; Conservation Biology/Ecology ; Ecosystems ; Community and Environmental Psychology
    Beschreibung / Inhaltsverzeichnis: 1. The Biodiversity Data Impediment to a Sustainable World (Working in a Networked World) --- 2. Essential Biodiversity Variables --- 3. Stratification and Terrestrial Ecosystem Observations --- 4. Ecosystem Services --- 5. Species Observations --- 6. Monitoring Changes in Genetic Diversity --- 7. Marine and Coastal Systems --- 8. Biodiversity Observations for Freshwater Ecosystems --- 9. Remote Sensing for Biodiversity --- 10. Involving Citizen Scientists in Biodiversity Observation --- 11. Biodiversity Modelling --- 12. Cyber-Architecture --- 13. Using Data for Decision-Making: From Observations To Indicators and Other Policy Tools --- 14. Capacity Building in Biodiversity Monitoring – Case Studies
    Seiten: Online-Ressource (XII, 326 pages) , 34 illustrations, 27 illustrations in color
    ISBN: 9783319272887
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Schlagwort(e): Life sciences ; Agriculture ; Climate change ; Environmental management ; Soil science ; Soil conservation ; Air pollution ; Life Sciences ; Agriculture ; Climate Change ; Atmospheric Protection/Air Quality Control/Air Pollution ; Soil Science & Conservation ; Environmental Management
    Beschreibung / Inhaltsverzeichnis: Chapter 1 Introduction to the SAMPLES Approach --- Chapter 2 Targeting Landscapes to Identify Mitigation Options --- Chapter 3 Determining Greenhouse Gas Emissions and Removals Associated with Land Use and Land Cover Change --- Chapter 4 Quantifying Greenhouse Gas Emissions from Managed and Natural Soils --- Chapter 5 A Comparison of Methodologies for Measuring Methane Emissions from Ruminants --- Chapter 6 Quantifying Tree Biomass Carbon Stocks and Fluxes in Agricultural Landscapes --- Chapter 7 Methods for Smallholder Quantification of Soil Carbon Stocks and Stock Changes --- Chapter 8 Yield Estimation of Food and Non-Food Crops in Smallholder Production Systems --- Chapter 9 Scaling Point and Plot Measurements of Greenhouse Gas Fluxes, Balances and Intensities to Whole Farms and Landscapes --- Chapter 10 Methods for Environment-Productivity Trade-off Analysis in Agricultural Systems
    Seiten: Online-Ressource (XV, 203 pages) , 33 illustrations, 27 illustrations in color
    ISBN: 9783319297941
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Unbekannt
    Cham : Springer
    Schlagwort(e): Medicine ; Human genetics ; Ethics ; Medical ethics ; Biomedicine ; Human Genetics ; Theory of Medicine/Bioethics ; Ethics
    Beschreibung / Inhaltsverzeichnis: This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved
    Seiten: Online-Ressource (XV, 267 pages)
    ISBN: 9783319184289
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Schlagwort(e): Life sciences ; Agriculture ; Plant biochemistry ; Plant genetics ; Life Sciences ; Plant Genetics & Genomics ; Agriculture ; Plant Biochemistry
    Beschreibung / Inhaltsverzeichnis: Part I Wheat Genetics: Past, Present, and Future --- 1 Prof. H. Kihara’s genome concept and advancements in wheat cytogenetics in his school --- 2 How a gene from Japan revolutionized the world of wheat: CIMMYT’s quest for combining genes to mitigate threats to global food security --- Part II Germplasm and Genetic Diversity --- 3 Genetic resources of Triticum --- 4 Development of core set of wheat (Triticum spp.) germplasm conserved in the National Genebank in India --- 5 Transfer to wheat of potentially new stem rust resistance genes from Aegilops speltoides --- 6 Genetic variation and its geographical distribution in Aegilops caudata L.: morphology, hybrid sterility and gametocidal genes --- Part III Cytogenetics and Allopolyploid Evolution --- 7 Wheat chromosome analysis --- 8 New aneuploids of common wheat --- 9 Chromosomal changes over the course of polyploid wheat evolution and domestication --- Part IV Toward Whole Genome Sequencing --- 10 Comprehensive functional analyses of expressed sequence tags in common wheat --- 11 Development of the BAC physical maps of wheat chromosome 6B for its genomic sequencing --- Part V Structural and Functional Genomics --- 12 Sequencing of wheat chromosome 6B: toward functional genomics --- 13 Genetic mechanisms of vernalization requirement duration in winter wheat cultivars --- 14 Building ultra-dense genetic maps in the presence of genotyping errors and missing data --- Part VI Functional Gene Analysis and Molecular Tools --- 15 Exploiting comparative biology and genomics to understand a trait in wheat, Ph1 --- 16 The specific features of anthocyanin biosynthesis regulation in wheat --- 17 Association of wheat miRNAs with hybrid incompatibility in interspecific crosses of Triticum and Aegilops --- 18 High efficiency wheat transformation mediated by Agrobacterium tumefaciens --- 19 extra early-flowering (exe) mutants in einkorn wheat generated by heavy-ion beam irradiation --- Part VII Biotic Stress Response --- 20 Stem rust resistance - two approaches --- 21 Germplasm enhancement for resistance to Pyrenophora tritici-repentis in wheat --- 22 Next Generation Sequencing enabled genetics in hexaploid wheat --- Part VIII Abiotic Stress Response --- 23 Genomics approaches to dissect the genetic basis of drought resistance in durum wheat --- 24 Hybrid breeding in wheat --- 25 Broadening the genetic diversity of common and durum wheat for abiotic stress tolerance breeding --- 26 Early maturity in wheat for adaptation to high temperature stress --- 27 Gene expression profiles involved in development of freezing tolerance in common wheat --- Part IX Improvement of Grain Quality --- 28 Coping with wheat quality in a changing environment - Proteomics evidence for stress caused by environmental changes --- 29 Starch modification: a model for wheat MAS breeding --- 30 Quality characteristics of soft kernel durum - a new cereal crop --- 31 Proposal of international gluten research group --- 32 Enlargement of the genetic diversity for grain quality in bread wheat through alien introgression --- 33 Complex G x E interactions and QTL clusters govern end-use quality traits in hexaploid wheat --- 34 A consistent QTL for flour yield on chromosome 3B in the soft winter wheat variety, Kitahonami --- Part X Marker-Assisted Breeding --- 35 Recent improvements in Japanese wheat varieties --- 36 Determining the order of resistance genes Qsng-3BS, Fhb1 and Sr2 and combining them in coupling on wheat chromosome 3BS --- 37 Meta-analysis of resistance to Fusarium head blight in tetraploid wheat – implications for durum wheat breeding --- 38 Interest of a multiparental and outcrossing wheat population for fine mapping --- 39 The effect of Earliness per se (Eps) genes on flowering time in bread wheat --- Part XI Toward Sustainable Wheat Production --- 40 Recapitulating the OECD-CRP session (sponsored by the OECD’s Co-operative Research Program on Biological Resource Management for Sustainable Agricultural Systems --- 41 Exploring genetic resources to increase adaptation of wheat to climate change --- 42 Genomic approaches towards durable fungal disease resistance in wheat --- 43 Review and new progress in wheat wide hybridization for improving the resistance to biotic and abiotic stresses --- 44 Global crop improvement networks to bridge technology gaps --- 45 Genomic selection in plants: empirical results and implications for wheat breeding --- 46 Dietary fibre: wheat genes for enhanced human health --- BM Appendix I: Program --- Appendix II: Poster Presentation List --- Appendix III: Committees
    Seiten: Online-Ressource (XVI, 445 pages)
    ISBN: 9784431556756
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    Schlagwort(e): Life sciences ; Nucleic acids ; Plant breeding ; Biology ; Technique ; Life Sciences ; Plant Breeding/Biotechnology ; Biological Techniques ; Nucleic Acid Chemistry
    Beschreibung / Inhaltsverzeichnis: Introduction --- Health and Safety Considerations --- Sample Collection and Storage --- Low-Cost DNA Extraction --- PCR Amplification for Low-Cost Mutation Discovery --- Enzymatic Mismatch Cleavage and Agarose Gel Evaluation of Samples --- Alternative Enzymology for Mismatch Cleavage for TILLING and Ecotilling: Extraction of Enzymes form Common Weedy Plants --- Example Data --- Conclusions.  
    Seiten: Online-Ressource (X, 35 pages) , 9 illustrations, 3 illustrations in color
    ISBN: 9783319162591
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 17
    Schlagwort(e): Life sciences ; Genetic engineering ; Agriculture ; Plant physiology ; Plant breeding ; Life Sciences ; Plant Breeding/Biotechnology ; Agriculture ; Genetic Engineering ; Plant Physiology
    Beschreibung / Inhaltsverzeichnis: Introduction --- Objectives --- Protocol for measuring soil salinity --- Protocol for screening for salt tolerance in rice --- Protocol for screening for salt tolerance in barley and wheat.  
    Seiten: Online-Ressource (X, 37 pages) , 7 illustrations, 6 illustrations in color
    ISBN: 9783319265902
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 18
    Schlagwort(e): Biomedical engineering ; Sports medicine ; Biomedical Engineering/Biotechnology ; Sports Medicine ; Biomedical Engineering
    Beschreibung / Inhaltsverzeichnis: Retention Requirements for Alpine Ski Bindings --- Helmet Use and Self-Reported Risk Taking in Skiing and Snowboarding --- Evaluating the Performance of Helmet Linings Incorporating Fluid Channels --- Polarizing Filters in Ski Sports --- Emergency Release for Winter Sports Equipment --- Analyzing the Riding Behavior of Recreational Skiers and Snowboarders --- Reaction Times of Skiers and Snowboarders --- Gender-Specific Effects of Smoking and Alcohol Consumption on the Risk of Falling in Downhill Skiers --- Hydration Packs Modify Professional Skiers Hydration Levels in All Day Skiing: A Randomized Controlled Trial --- Are ACL Injuries Related to Perceived Fatigue in Female Skiers? --- Aging Trends in Alpine Skiing --- Skiing and Boarding Injuries on Norwegian Slopes during Two Winter Seasons --- Skiing and Snowboarding Injuries in the Czech Republic in Winter Seasons 2003–2008 --- Relative Motion of ACL Insertion Points In Vivo: A Case Study, Including Skiing Maneuvers --- Jumper Kinematics on Terrain Park Jumps: Relationship between Takeoff Speed and Distance Traveled --- Reaction Forces and Moments in Carved Turns
    Seiten: Online-Ressource (X, 206 pages) , 61 illustrations, 39 illustrations in color
    ISBN: 9783319527550
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
    Schlagwort(e): Life sciences ; Animal ecology ; Community ecology, Biotic ; Environmental monitoring ; Life Sciences ; Animal Ecology ; Community & Population Ecology ; Monitoring/Environmental Analysis
    Beschreibung / Inhaltsverzeichnis: FOREWORD --- 2. GENERAL INTRODUCTION --- 2.1. Background analysis --- 2.2. Migratory Birds and HPAI --- 2.3. Using SIA to understand the dissemination of HPAI – The way ahead! --- 3. ANIMAL MIGRATION TRACKING METHODS --- 3.1. Extrinsic Markers --- 3.2. Intrinsic Markers --- 3.3. The Stable Isotopes of Water on a Spatial Scale --- 3.4. Deriving isoscapes in the absence of GNIP data --- 3.5. Use of Stable Isotopes in Migration Studies --- 3.6. Approaches for Determining Migratory Connectivity --- 4. PRACTICAL CONSIDERATIONS --- 4.1. Sample Collection and Tissue Preparation --- 4.2. Other Stable Isotopes for Migration Research --- 5. REFERENCES
    Seiten: Online-Ressource (XII, 49 pages) , 15 illustrations, 4 illustrations in color
    ISBN: 9783319282985
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Aquatic ecology ; Life Sciences ; Freshwater & Marine Ecology
    Beschreibung / Inhaltsverzeichnis: Foreword --- Preface --- Part 1 A brief history of marine litter research --- Part 2 Abiotic aspects of marine litter pollution --- Global distribution, composition and abundance of marine litter --- Persistence of plastic litter in the oceans --- Part 3 Biological implications of marine litter --- Deleterious effects of litter on marine life --- The complex mixture, fate and toxicity of chemicals associated with plastic debris in the marine environment --- Marine litter as habitat and dispersal vector --- Part 4 Micro plastics --- Micro plastics in the marine environment: sources, consequences and solutions --- Methodology used for the detection and identification of micro plastics – a critical appraisal --- Sources and pathways of micro plastics to habitats --- Micro plastics in the marine environment: distribution, interactions and effects --- Modeling the role of micro plastics in bioaccumulation of organic chemicals to marine aquatic organisms. A critical review --- Nano plastics in the aquatic environment. Critical review --- Part 5 Socio-economic implications of marine anthropogenic litter --- Micro and nano-plastics and human health --- The economics of marine litter --- Regulation and management of marine litter --- Marine litter and the contribution of citizen science
    Seiten: Online-Ressource (XVIII, 447 pages) , 68 illustrations, 35 illustrations in color
    ISBN: 9783319165103
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 21
    Schlagwort(e): Toxicology ; Medicine ; Human physiology ; Immunology ; Cytology ; Pharmacology/Toxicology ; Molecular Medicine ; Human Physiology ; Immunology ; Cell Biology
    Beschreibung / Inhaltsverzeichnis: Preface --- Part 1. Physiology of HDL --- Part 2. Pathology of HDL --- Part 3. Possible Indications and Target Mechanisms of HDL Therapy --- Part 4. Treatments for Dyslipidemias and Dysfunction of HDL
    Seiten: Online-Ressource (XIII, 694 pages) , 40 illustrations, 37 illustrations in color
    ISBN: 9783319096650
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 22
    Unbekannt
    Cham : Springer
    Schlagwort(e): Medicine ; Human physiology ; Neurosciences ; Endocrinology ; Cell biology ; Biomedicine ; Human Physiology ; Endocrinology ; Cell Biology ; Neurosciences
    Beschreibung / Inhaltsverzeichnis: The Epigenetic And Metabolic Language Of the Circadian Clock --- Molecular Architecture of the Circadian Clock in Mammals --- Circadian Mechanisms in Bioenergetics and Cell Metabolism --- Control of metabolism by central and peripheral clocks in Drosophila --- Circadian post-transcriptional control of metabolism --- Redox and Metabolic Oscillations in the Clockwork --- Rev-erbs: Integrating Metabolism Around the Clock --- Control of sleep-wake cycles in Drosophila --- Circadian metabolomics: insights for biology and medicine --- Rhythms within rhythms: the importance of oscillations for glucocorticoid hormones --- The genetics of autism spectrum disorders.
    Seiten: Online-Ressource (XIII, 132 pages) , 28 illustrations, 26 illustrations in color
    ISBN: 9783319270692
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 23
    Schlagwort(e): Life sciences ; Genetic engineering ; Agriculture ; Plant genetics ; Plant breeding ; Life Sciences ; Plant Breeding/Biotechnology ; Agriculture ; Genetic Engineering ; Plant Genetics & Genomics
    Beschreibung / Inhaltsverzeichnis: Mutagenesis for Crop Breeding and Functional Genomics --- Chemical and Physical Mutagenesis in Jatropha curcas --- Chemical Mutagenesis and Chimera Dissolution in Vegetatively Propagated Banana --- Mutation Induction Using Gamma Irradiation and Embryogenic Cell Suspensions in Plantain (Musa spp.) --- Optimization of Somatic Embryogenesis in Cassava --- Creation of a TILLING Population in Barley after Chemical Mutagenesis with Sodium Azide and MNU --- Site-Directed Mutagenesis in Barley by Expression of TALE Nuclease in Embryogenic Pollen --- Doubled Haploidy as a Tool for Chimera Dissolution of TALEN-Induced Mutations in Barley --- Field Evaluation of Mutagenized Rice Material --- Root Phenotyping Pipeline for Cereal Plants --- Breeding New Aromatic Rice with High Iron using Gamma Radiation and Hybridization --- Utilizing NIRS for Qualitative and Non-Destructive Identification of Seed Mutants in Large Populations --- Protocols for Proteome Analyses of Jatropha curcas --- Low-Cost Methods for DNA Extraction and Quantification --- A Protocol for Benchtop Extraction of Single-Strand-Specific Nucleases for Mutation Discovery --- A Protocol for Validation of Doubled Haploid Plants by Enzymatic Mismatch Cleavage --- Bioinformatics-Based Assessment of the Relevance of Candidate Genes for Mutation Discovery --- Mutation Detection by Analysis of DNA Heteroduplexes in TILLING Populations of Diploid Species --- Determining Mutation Density using Restriction Enzyme Sequence Comparative Analysis (RESCAN) --- Next-Generation Sequencing for Targeted Discovery of Rare Mutations in Rice
    Seiten: Online-Ressource (XX, 340 pages) , 76 illustrations, 69 illustrations in color
    ISBN: 9783319450216
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 24
    Schlagwort(e): Medicine ; Public health ; Medical research ; Quality of life ; Biomedicine ; Biomedicine general ; Public Health ; Quality of Life Research
    Beschreibung / Inhaltsverzeichnis: Preface.- Data and Methods.- Population Norms for the EQ-5D --- Cross-Country Analysis of EQ-5D Data --- Socio-demographic Indicators based on EQ-5D --- Annex 1 --- Annex 2
    Seiten: Online-Ressource (XV, 196 pages) , 14 illustrations, 9 illustrations in color
    ISBN: 9789400775961
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 25
    Schlagwort(e): Medicine ; Public health ; Medical research ; Quality of life ; Biomedicine ; Biomedicine general ; Public Health ; Quality of Life Research
    Beschreibung / Inhaltsverzeichnis: Preface.- Data and Methods.- Population Norms for the EQ-5D --- Cross-Country Analysis of EQ-5D Data --- Socio-demographic Indicators based on EQ-5D --- Annex 1 --- Annex 2
    Seiten: Online-Ressource (XV, 196 pages) , 14 illustrations, 9 illustrations in color
    ISBN: 9789400775961
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Aquatic ecology ; Life Sciences ; Freshwater & Marine Ecology
    Beschreibung / Inhaltsverzeichnis: Foreword --- Preface --- Part 1 A brief history of marine litter research --- Part 2 Abiotic aspects of marine litter pollution --- Global distribution, composition and abundance of marine litter --- Persistence of plastic litter in the oceans --- Part 3 Biological implications of marine litter --- Deleterious effects of litter on marine life --- The complex mixture, fate and toxicity of chemicals associated with plastic debris in the marine environment --- Marine litter as habitat and dispersal vector --- Part 4 Micro plastics --- Micro plastics in the marine environment: sources, consequences and solutions --- Methodology used for the detection and identification of micro plastics – a critical appraisal --- Sources and pathways of micro plastics to habitats --- Micro plastics in the marine environment: distribution, interactions and effects --- Modeling the role of micro plastics in bioaccumulation of organic chemicals to marine aquatic organisms. A critical review --- Nano plastics in the aquatic environment. Critical review --- Part 5 Socio-economic implications of marine anthropogenic litter --- Micro and nano-plastics and human health --- The economics of marine litter --- Regulation and management of marine litter --- Marine litter and the contribution of citizen science
    Seiten: Online-Ressource (XVIII, 447 pages) , 68 illustrations, 35 illustrations in color
    ISBN: 9783319165103
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
    Schlagwort(e): Life sciences ; Food ; Biotechnology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Food Science ; Environmental Science and Engineering
    Beschreibung / Inhaltsverzeichnis: Part I : Agro-Food Systems --- Food Security in the Southern Mediterranean/North Africa --- Sustainability in cereal crop production in Mediterranean environments --- Innovative crop productions for healthy foods: the case of Chia --- The hidden costs of livestock environmental sustainability: the case of Podolian cattle --- Feeding, nutrition and sustainability in dairy enterprises: the case of Mediterranean buffaloes (bubalus bubalis) --- Sustainability of sheep and goat production systems --- The role of local sheep and goat breeds and their products as a tool for sustainability and safeguard of the Mediterranean environment --- Innovative use of jenny milk from sustainable rearing --- Sustainable agricultural practices in disease defence of traditional crops in Southern Italy: the case study of tomato cherry protected by Trichoderma harzianum T-22 against Cucumber mosaic virus --- Development of integrated disease control measures for the valorisation of traditional crops in Southern Italy: the case study of "Fagiolo di Sarconi" --- Fostering sustainable climate change adaptations: a case study of the Turkish Cypriot Community’s adoption of pomegranate farming --- The role of women in the sustainability of the wine industry through the analysis of case studies --- Part II : Natural Resource Systems and Environment --- The effects of climate change on the multifunctional role of Basilicata’s forests: the effects induced on yield and CO2 absorption --- Wildlife agriculture interactions, spatial analysis and trade-off between environmental sustainability and risk of economic damage --- The sustainability of non-renewable resources use at regional level: a case study on allocation of oil royalties --- Land use sector involvement in mitigation policies across carbon markets --- Evaluating the role of soil variability on potential groundwater pollution and recharge in a Mediterranean agricultural watershed --- Grazing and biodiversity conservation: highlights on a Nature 2000 network site --- Evaluation of native grasses for sustainable turfgrass in the bioclimatic Mediterranean Region.-Biodiversity of hypogeous fungi in Basilicata --- Part III: New technologies --- New technologies for the sustainable management and planning of rural land and environment --- Processing plants and technologies for a sustainable Mediterranean food chain --- Geophysical techniques for plant, soil and root research related to Satellite technologies to support the sustainability of agricultural production --- Electrolyzed water in the food industry as supporting of environmental sustainability
    Seiten: Online-Ressource (XXVIII, 397 pages) , 80 illustrations, 48 illustrations in color
    ISBN: 9783319163574
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 28
    Schlagwort(e): Life sciences ; Biodiversity ; Nature conservation ; Life Sciences ; Biodiversity ; Nature Conservation ; Plant Systematics/Taxonomy/Biogeography ; Animal Systematics/Taxonomy/Biogeography
    Beschreibung / Inhaltsverzeichnis: Phylogenetics and conservation biology: drawing a path into the diversity of life --- The value of phylogenetic diversity --- The PD phylogenetic diversity framework: linking evolutionary history to feature diversity for biodiversity conservation --- Reconsidering the loss of evolutionary history: how does non-random extinction prune the tree-of-life?- Phylogenetics and conservation in New Zealand: the long and the short of it --- What is the meaning of extreme phylogenetic diversity? The case of phylogenetic relict species --- Using phylogenetic dissimilarities among sites for biodiversity assessments and conservation --- Phylogenetic diversity measures and their decomposition: a framework based on hill numbers --- Split diversity: measuring and optimizing biodiversity using phylogenetic split networks --- The rarefaction of phylogenetic diversity: formulation, extension and application --- Support in area prioritization using phylogenetic information --- Assessing hotspots of evolutionary history with data from multiple phylogenies: an analysis of endemic clades from New Caledonia --- Representing hotspots of evolutionary history in systematic conservation planning for European mammals --- Priorities for conservation of the evolutionary history of amphibians in the cerrado --- Global spatial analyses of phylogenetic conservation priorities for aquatic mammals --- Metapopulation capacity meets evolutionary distinctness: spatial fragmentation complements phylogenetic rarity in prioritization. - Patterns of species, phylogenetic and mimicry diversity of clearwing butterflies in the Neotropics --- Conservation of phylogenetic diversity in Madagascar’s largest endemic plant family, Sarcolaenaceae --- The future of phylogenetic systematics in conservation biology: linking biodiversity and society
    Seiten: Online-Ressource (XVII, 390 pages) , 79 illustrations
    ISBN: 9783319224619
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 29
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Ecosystems ; Sustainable development ; Natural resources ; Agricultural economics ; Life Sciences ; Ecosystems ; Sustainable Development ; Agricultural Economics ; Natural Resource and Energy Economics ; Natural Resources
    Beschreibung / Inhaltsverzeichnis: 1. Introduction --- Part I: Bioeconomy Concepts and Research Methods --- Chapter 2: Context --- Chapter 3: Bioeconomy concepts --- Chapter 4: Core principles --- Chapter 4: Inter- and Transdisciplinarity in the Bioeconomy --- Part II: Knowledge Base for Biobased Value Chains --- Chapter 5:Biobased Resources and Value Chains --- Chapter 6: Primary Production --- Chapter 7: Processing of Biobased Resources --- Chapter 8: Markets, Sustainability management and Entrepreneurship.- Part III: Transition to a Sustainable Bioeconomy --- Chapter9:  Modelling and Tools Supporting the Transition to a Bioeconomy --- Chapter 10: Environmental Economics, the Bioeconomy and the Role of Government --- Chapter 11: Economic Growth, Development, and Innovation – The Transformation towards a Knowledge-based Bioeconomy --- Chapter 12: The Bioeconomist
    Seiten: Online-Ressource (VI, 354 pages) , 165 illustrations, 139 illustrations in color
    ISBN: 9783319681528
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 30
    Unbekannt
    Rijeka : InTech
    Schlagwort(e): aerospace ; microgravity ; space ethics ; aviation medicine
    Beschreibung / Inhaltsverzeichnis: 1. Reimagining Icarus: Ethics, Law and Policy Considerations for Commercial Human Spaceflight / By Sara M. Langston --- 2. Basic Methodology for Space Ethics / By Tony Milligan --- 3. From the Individual to the Cultural Space Group / By Carole Tafforin --- 4. Acute and Chronic Effects of Hypobaric Exposure upon the Brain / By Paul Sherman and John Sladky --- 5. Spaceflight Induced Changes in the Central Nervous System / By Alex P. Michael --- 6. The Effect of Gravity on the Nervous System / By Florian P.M. Kohn, Claudia Koch and Ramona Ritzmann --- 7. Spaceflight: Immune Effects and Nutritional Countermeasure / By Anil D Kulkarni, Marie-Francoise Doursout, Asmita Kulkarni, Alamelu Sundaresan, Takehito Miura, Koji Wakame and Hajime Fujii --- 8. Countermeasure Development for Lumbopelvic Deconditioning in Space / By Andrew Winnard, Dorothee Debuse and Nick Caplan --- 9. Tumor Cells in Microgravity / By Jun Chen --- 10. Plants in Space / By Bratislav Stankovic --- 11. Approaches to Assess the Suitability of Zooplankton for Bioregenerative Life Support Systems / By Miriam Knie, Bernard Wolfschoon Ribeiro, Jessica Fischer, Burkhard Schmitz, Kay Van Damme, Ruth Hemmersbach, Donat-P. Häder and Christian Laforsch --- 12. Are We Alone? The Search for Life on Mars and Other Planetary Bodies / By Stephanie A. Smith, Andrzej Paszczynski and Susan E. Childers --- 13. Exploring the Stratosphere: What We Missed by Shooting for the Moon / By Laura Galdamez --- 14. The Mortality of Space Explorers / By Robert J. Reynolds and Steven M. Day
    ISBN: 9781789232219
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 31
    Unbekannt
    Rijeka : InTech
    Schlagwort(e): fractal geometry ; fractal analysis ; fractals ; application ; medicine ; social sciences
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Fractal Analysis of Cardiovascular Signals Empowering the Bioengineering Knowledge by Ricardo L. Armentano, Walter Legnani and Leandro J. Cymberknop --- Chapter 2: Complex Systems with Self-Elimination of Dissipation with Implication in Bio-Structural Behavior Via Nondifferentiability by Maricel Agop, Decebal Vasincu, Daniel Timofte, Elena Simona Bacaita, Andrei Agop and Stefan Andrei Irimiciuc --- Chapter 3: The Fractal Analysis of the Images and Signals in Medical Diagnostics by Tayurskii Dmitrii Albertovich and Rusanova Inna Aleksandrovna --- Chapter 4: Polyadic Cantor Fractals: Characterization, Generation, and Application as Ultrasonic Lenses by Sergio Castiñeira-Ibañez, Daniel Tarrazó-Serrano, José Miguel Fuster, Pilar Candelas and Constanza Rubio --- Chapter 5: Fractal to Non-Fractal Morphological Transitions in Stochastic Growth Processes by José Roberto Nicolás-Carlock, Víctor Dossetti and José Luis Carrillo- Estrada --- Chapter 6: The Altepetl: Fractal Modeling of a Pre-Hispanic Human Agency by Fernando López Aguilar --- Chapter 7: Fractal Analysis Based on Hierarchical Scaling in Complex Systems by Yanguang Chen --- Chapter 8: Characterization of Cultural Traits by Means of Fractal Analysis by Sabrina Farías-Pelayo --- Chapter 9: On Self-Affine and Self-Similar Graphs of Fractal Interpolation Functions Generated from Iterated Function Systems by Sean Dillon and Vasileios Drakopoulos --- Chapter 10: Pair-Pair Angular Correlation Function by Filipe Leoncio Braga and Alexandre Barbosa de Souza
    Seiten: Online-Ressource (224 Seiten)
    ISBN: 9789535132141
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 32
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Virology ; Animal ecology ; Aquatic ecology ; Conservation biology ; Ecology ; Wildlife ; Fish ; Environmental health ; Life Sciences ; Animal Ecology ; Environmental Health ; Fish & Wildlife Biology & Management ; Virology ; Freshwater & Marine Ecology ; Conservation Biology/Ecology
    Beschreibung / Inhaltsverzeichnis: Introduction --- Distribution and Phylogeny of Ranaviruses --- Host-pathogen Ecology and Evolution --- Molecular Biology of Ranaviruses --- Immune Evasion and Host Immunity --- Pathology and Diagnostics --- Design and Analysis of Ranavirus Studies --- Global Ranavirus Consortium
    Seiten: Online-Ressource (X, 246 pages) , 25 illustrations, 21 illustrations in color
    ISBN: 9783319137551
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 33
    Schlagwort(e): Life sciences ; Human physiology ; Food ; Biotechnology ; Microbiology ; Life Sciences ; Food Microbiology ; Food Science ; Human Physiology
    Beschreibung / Inhaltsverzeichnis: Introduction --- Gastrointestinal digestion models, general introduction --- Static digestion models general introduction --- InfoGest consensus method --- Approaches to static digestion models --- Dynamic digestion models general introduction --- The TNO gastro-Intestinal Model (TIM) --- Dynamic Gastric Model (DGM) --- Human Gastric Simulator (Riddet model) --- The DIDGI® System --- General introduction to cells, cell lines and cell culture --- Epithelial cell models; General introduction --- Caco-2 cell line --- HT29 cell line --- The IPEC-J2 cell line --- Co-cultivation of Caco-2 and HT-29MT --- Innate and adaptive immune cells; General introduction --- THP-1 and U937 cells --- Peripheral blood mononuclear cells --- PBMC-derived T cells --- Dendritic Cells --- Co-culture Caco-2/ immune cells --- Enteroendocrine Cell Models: General introduction --- STC-1 cells --- NCI-H716 cells --- Murine GLUTag cells --- In vitro intestinal tissue models: General introduction --- Intestinal crypt organoids as experimental models --- Porcine ex vivo intestinal segment model --- Ussing chamber --- In vitro fermentation models: General Introduction --- One compartment fermentation model --- The TNO in vitro model of the colon - TIM-2 --- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME® --- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
    Seiten: Online-Ressource (XVII, 338 pages) , 57 illustrations, 35 illustrations in color
    ISBN: 9783319161044
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
    Schlagwort(e): Life sciences ; Developmental biology ; Evolutionary biology ; Animal genetics ; Entomology ; Biomathematics ; Life Sciences ; Animal Genetics and Genomics ; Evolutionary Biology ; Mathematical and Computational Biology ; Developmental Biology ; Entomology
    Beschreibung / Inhaltsverzeichnis: Foreword --- Preface --- Contributors --- Part I. The Nympalid Groundplan (NGP) and Diversification --- Chapter1:The common developmental origin of eyespots and parafocal elements;And a new model-mechanism for color pattern formation --- Chapter2:Exploring color pattern diversification in early lineages of Satyrinae (Nymphalidae) --- Chapter3:Camouflage variation on a theme of the Nymphalid Ground Plan --- Chapter4:Morphological evolution repeatedly caused by mutations in signaling ligand genes --- Part II. Eyespots and Evolution --- Chapter5:Physiology and evolution of wing pattern plasticity in Bicyclus butterflies: a critical review ofthe literature --- Chapter6:Spatial variation in boundary conditions can govern selection and location of eyespots inbutterfly wings --- Chapter7:Self-Similarity, Distortion Waves, and the Essence of Morphogenesis: A Generalized View ofColor Pattern Formation in Butterfly Wings --- Part III. Developmental Genetics --- Chapter8:A practical guide to CRISPR/Cas9 genome editing in Lepidoptera --- Chapter9:What can we learn about adaptation from the wing pattern genetics of Heliconiusbutterflies? --- Chapter10:Molecular mechanism and evolutionary process underlying female-limited Batesian mimicry in Papilio polytes --- Part IV. Ecological Aspects and Adaptation --- Chapter11:Chemical Ecology of Poisonous Butterflies: Model or Mimic?— A Paradox of Sexual Dimorphisms in Müllerian Mimicry --- Chapter12:A model for population dynamics of the mimetic butterfly Papilio polytesin Sakishima Islands, Japan (II) --- Chapter13:Evolutionary trends in phenotypic elements of seasonal forms of the tribe Junoniini(Lepidoptera: Nymphalidae) --- Chapter14:Estimating the mating success of male butterflies in the field.-Part V. Color Patterns of Larva and Other Insects --- Chapter15:Molecular Mechanisms of Larval Color Pattern Switch in the Swallowtail Butterfly --- Chapter16:Drosophila guttifera as a model system for elucidating color pattern formation --- Chapter17:Molecular mechanisms underlying color vision and color formation in dragonflies
    Seiten: Online-Ressource (XII, 321 pages) , 103 illustrations, 89 illustrations in color
    ISBN: 9789811049569
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 35
    Unbekannt
    Cham : Springer
    Schlagwort(e): Medicine ; Human genetics ; Neurosciences ; Biomedical engineering ; Biomedicine ; Human Genetics ; Neurosciences ; Biomedical Engineering/Biotechnology
    Beschreibung / Inhaltsverzeichnis: Introduction --- In vitro modeling of complex neurological diseases --- Aquatic model organisms in neurosciences : the genome editing revolution --- Genome-wide genetic screening in the mammalian CNS --- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish --- Dissecting the role of synaptic proteins with CRISPR --- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer --- Neuroscience research using non-human primate models and genome editing --- Multiscale genome engineering: Genome-wide screens and targeted approaches --- Using Genome Engineering to Understand Huntington’s Disease --- Therapeutic gene editing in muscles and muscle stem cells
    Seiten: Online-Ressource (XI, 123 pages) , 16 illustrations in color
    ISBN: 9783319601922
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 36
    Unbekannt
    Tokyo : Springer
    Schlagwort(e): Life sciences ; Cell biology ; Developmental biology ; Plant science ; Botany ; Life Sciences ; Developmental Biology ; Plant Sciences ; Cell Biology
    Beschreibung / Inhaltsverzeichnis: Part 1 Sperm Attraction, Activation and Acrosome Reaction --- 1 Sperm Chemotaxis: The First Authentication Events Between Conspecific Gametes Prior to Fertilization (Manabu Yoshida) --- 2 Respiratory CO2 Mediates Sperm Chemotaxis in Squids (Noritaka Hirohashi) --- 3 Specific Mechanism of Sperm Storage in Avian Oviducts (Tomohiro Sasanami) --- 4 Allurin: Exploring the Activity of a Frog Sperm Chemoattractant in Mammals (Douglas E. Chandler) --- 5 Structure, Function and Phylogenetic Consideration of Calaxin (Kazuo Inaba) --- 6 Cl- Channels and Transporters in Sperm Physiology (Alberto Darszon) --- 7 Equatorin-related Subcellular and Molecular Events During Sperm Priming for Fertilization in Mice (Kiyotaka Toshimori) --- 8 Acrosome Reaction-mediated Motility Initiation that is Critical for the Internal Fertilization of Urodele Amphibians (Akihiko Watanabe) --- 9 Analysis of the Mechanism that Brings Protein Disulfide Isomerase-P5 to Inhibit Oxidative Refolding of Lysozyme (Miho Miyakawa) --- Part 2 Gametogenesis, Gamete Recognition, Activation, and Evolution --- 10 Effect of Relaxin-like Gonad-Stimulating Substance (GSS) on Gamete Shedding and 1-Methyladenine Production in Starfish Ovaries (Masatoshi Mita) --- 11 Incapacity of 1-Methyladenine Production to Relaxin-like Gonad-Stimulating Substance (GSS) in Ca2+-free Seawater-treated Starfish Ovarian Follicle Cells (Masatoshi Mita) --- 12 Novel Isoform of Vitellogenin Expressed in Eggs is a Binding Partner of the Sperm Proteases, HrProacrosin and HrSermosin, in the Ascidian Halocynthia roretzi (Hitoshi Sawada) --- 13 Actin Cytoskeleton and Fertilization in Starfish Eggs (Luigia Santella) --- 14 Focused Proteomics on Egg Membrane Microdomains to Elucidate the Cellular and Molecular Mechanisms of Fertilization in the African Clawed Frog Xenopus laevis (Ken-ichi Sato) --- 15 Egg Activation in Polyspermy: Its Molecular Mechanisms and Evolution in Vertebrates (Yasuhiro Iwao ) --- 16 ATP Imaging in Xenopus laevis Oocyte (Takashi Ijiri) --- 17 Mitochondrial Activation and Nitric Oxide (NO) Release at Fertilization in Echinoderm Eggs (Tatsuma Mohri) --- 18 Functional Roles of Spe Genes in the Male Germline During Reproduction of Caenorhabditis elegans (Hitoshi Nishimura) --- 19 Origin of Female/Male Gender as Deduced by the Mating Type Loci of the Colonial Volvocalean Greens (Hisayoshi Nozaki) --- Part 3 Allorecognition in Male–Female Interaction --- 20 Allorecognition and Lysin Systems During Ascidian Fertilization (Hitoshi Sawada) --- 21 Self-incompatibility in the Brassicaceae (Megumi Iwano) --- 22 Signalling Events in Pollen Acceptance or Rejection in the Arabidopsis Species (Daphne R. Goring) --- 23 Papaver rhoeas S-Determinants and the Signaling Networks they Trigger (Vernonica E. Franklin-Tong ) --- 24 S-RNase-based Self-incompatibility in Petunia: A Complex Non-self Recognition System Between Pollen and Pistil (Teh-hui Kao) --- 25 Self-incompatibility System of Ipomoea trifida, a Wild-type Sweet Potato (Tohru Tsuchiya) --- Part 4 Male–Female Interaction and Gamete Fusion --- 26 Profiling the GCS1-based Gamete Fusion Mechanism (Toshiyuki Mori) --- 27 Fertilization Mechanisms of the Rodent Malarial Parasite Plasmodium berghei (Makoto Hirai) --- 28 Sexual Reproduction of a Unicellular Charophycean Alga, Closterium peracerosum-strogosum-littorale Complex (Hiroyuki Sekimoto) --- 29 Fertilization of Brown Algae: Flagellar Function in Phototaxis and Chemotaxis (Taizo Motomura ) --- 30 Gene and Protein Expression Profiles in Rice Gametes and Zygotes: A Cue for Understanding the Mechanisms of Gametic and Early Zygotic Development in Angiosperms (Takashi Okamoto) --- 31 Role of CD9 in Sperm-Egg Fusion and Virus-induced Cell Fusion in Mammals (Kenji Miyado) --- 32 The Mechanism of Sperm-Egg Fusion in Mouse and the Involvement of IZUMO1 (Naokazu Inoue) --- 33 A ZP2 Cleavage Model of Gamete Recognition and the Post-fertilization Block to Polyspermy (Jurrien Dean) --- 34 Involvement of Carbohydrate Residues of the Zona Pellucida in In Vitro Sperm Recognition in Pigs and Cattle (Naoto Yonezawa) --- Part 5 Organella, Proteolysis, and New Techniques --- 35 The Role of Peroxisomes in Plant Reproductive Processes (Shoji Mano) --- 36 Regulation of Vacuole-mediated Programmed Cell Death During Innate Immunity and Reproductive Development in Plants (Tomoko Koyano) --- 37 Sperm Proteasomes as a Putative Egg Coat Lysin in Mammals (Peter Sutovsky) --- 38 Germline Transformation in the Ascidian Ciona intestinalis (Yasunori Sasakura) --- BM Index.  
    Seiten: Online-Ressource (XII, 480 pages) , 127 illustrations, 102 illustrations in color
    ISBN: 9784431545897
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    Schlagwort(e): Life sciences ; Science ; Urban planning ; City planning ; Urban ecology (Biology) ; System theory ; International environmental law ; Sustainable development ; Life Sciences ; Urban Ecology ; Urbanism ; Sustainable Development ; Complex Systems ; Science, general ; International Environmental Law
    Beschreibung / Inhaltsverzeichnis: 1. A global outlook on urbanization --- 2. History of urbanization and the missing ecology --- 3. Urbanization and global trends in biodiversity and ecosystem services --- 4. Regional assessment of Asia.- 5. Sub-regional assessment of China: Urbanization in biodiversity hotspots --- 6. Sub-regional assessment of India --- 7. Local assessment of Bangalore.- 8. Local assessment of Tokyo --- 9. Local assessment of Shanghai --- 10. Patterns and trends in urban biodiversity and landscape design --- 11. Urban ecosystem services.- 12. Shrinking cities, biodiversity and ecosystem services --- 13. Regional assessments of Europe --- 14. Regional assessment of North America --- 15. Regional assessment of Oceania --- 16. Local assessment of Istanbul: Biodiversity and ecosystem services --- 17. Local assessment of Stockholm --- 18. Local assessment of Chicago --- 19. Local assessment of New York City.-20. Local assessment of Melbourne --- 21. A synthesis of global urbanization projections --- 22. Urbanization forecasts, effects on land use, biodiversity, and ecosystem services --- 23. Regional assessment of Africa --- 24. Local assessment of Cape Town.- 25. Climate change and urban biodiversity vulnerability --- 26. Feeding cities --- 27. Urban governance of biodiversity and ecosystem services --- 28. Regional assessment of Latin America --- 29. Local assessment of Rio de Janeiro.- 30. Urban landscapes as learning arenas for biodiversity and ecosystem services management --- 31. Restoration ecology in an urbanizing world --- 32. Indicators for management of urban biodiversity and ecosystem services --- 33. Stewardship of the Biosphere in the Urban Era
    Seiten: Online-Ressource (XXVIII, 755 pages) , 150 illustrations, 23 illustrations in color
    ISBN: 9789400770881
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 38
    Schlagwort(e): Life sciences ; Biodiversity ; Nature conservation ; Life Sciences ; Biodiversity ; Nature Conservation ; Plant Systematics/Taxonomy/Biogeography ; Animal Systematics/Taxonomy/Biogeography
    Beschreibung / Inhaltsverzeichnis: Phylogenetics and conservation biology: drawing a path into the diversity of life --- The value of phylogenetic diversity --- The PD phylogenetic diversity framework: linking evolutionary history to feature diversity for biodiversity conservation --- Reconsidering the loss of evolutionary history: how does non-random extinction prune the tree-of-life?- Phylogenetics and conservation in New Zealand: the long and the short of it --- What is the meaning of extreme phylogenetic diversity? The case of phylogenetic relict species --- Using phylogenetic dissimilarities among sites for biodiversity assessments and conservation --- Phylogenetic diversity measures and their decomposition: a framework based on hill numbers --- Split diversity: measuring and optimizing biodiversity using phylogenetic split networks --- The rarefaction of phylogenetic diversity: formulation, extension and application --- Support in area prioritization using phylogenetic information --- Assessing hotspots of evolutionary history with data from multiple phylogenies: an analysis of endemic clades from New Caledonia --- Representing hotspots of evolutionary history in systematic conservation planning for European mammals --- Priorities for conservation of the evolutionary history of amphibians in the cerrado --- Global spatial analyses of phylogenetic conservation priorities for aquatic mammals --- Metapopulation capacity meets evolutionary distinctness: spatial fragmentation complements phylogenetic rarity in prioritization. - Patterns of species, phylogenetic and mimicry diversity of clearwing butterflies in the Neotropics --- Conservation of phylogenetic diversity in Madagascar’s largest endemic plant family, Sarcolaenaceae --- The future of phylogenetic systematics in conservation biology: linking biodiversity and society
    Seiten: Online-Ressource (XVII, 390 pages) , 79 illustrations
    ISBN: 9783319224619
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 39
    Schlagwort(e): Medicine ; Proteins ; Biology ; Technique ; Biomedicine ; Biomedicine general ; Protein Science ; Protein-Ligand Interactions ; Biological Techniques
    Beschreibung / Inhaltsverzeichnis: Supramolecular Protein Ligands – Unexplored Teritory Of Potential Pharmacological Activity --- Supramolecular Congo Red As Specific Ligand Of Antibodies Engaged In Immune Complex --- Protein Conditioning For Binding Congo Red And Other Supramolecular Ligands --- Metal Ions Introduced To Proteins By Supramolecular Ligands --- Possible Mechanism Of Amyloidogenesis Of V Domains --- Supramolecular Structures As Carrier Systems Enabling The Use Of Metal Ions In Antibacterial Therapy --- Congo Red Interactions With Single-Walled Carbon Nanotubes
    Seiten: Online-Ressource (XII, 136 pages) , 98 illustrations, 44 illustrations in color
    ISBN: 9783319656397
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Schlagwort(e): Life sciences ; Food ; Biotechnology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Food Science ; Environmental Science and Engineering
    Beschreibung / Inhaltsverzeichnis: Part I : Agro-Food Systems --- Food Security in the Southern Mediterranean/North Africa --- Sustainability in cereal crop production in Mediterranean environments --- Innovative crop productions for healthy foods: the case of Chia --- The hidden costs of livestock environmental sustainability: the case of Podolian cattle --- Feeding, nutrition and sustainability in dairy enterprises: the case of Mediterranean buffaloes (bubalus bubalis) --- Sustainability of sheep and goat production systems --- The role of local sheep and goat breeds and their products as a tool for sustainability and safeguard of the Mediterranean environment --- Innovative use of jenny milk from sustainable rearing --- Sustainable agricultural practices in disease defence of traditional crops in Southern Italy: the case study of tomato cherry protected by Trichoderma harzianum T-22 against Cucumber mosaic virus --- Development of integrated disease control measures for the valorisation of traditional crops in Southern Italy: the case study of "Fagiolo di Sarconi" --- Fostering sustainable climate change adaptations: a case study of the Turkish Cypriot Community’s adoption of pomegranate farming --- The role of women in the sustainability of the wine industry through the analysis of case studies --- Part II : Natural Resource Systems and Environment --- The effects of climate change on the multifunctional role of Basilicata’s forests: the effects induced on yield and CO2 absorption --- Wildlife agriculture interactions, spatial analysis and trade-off between environmental sustainability and risk of economic damage --- The sustainability of non-renewable resources use at regional level: a case study on allocation of oil royalties --- Land use sector involvement in mitigation policies across carbon markets --- Evaluating the role of soil variability on potential groundwater pollution and recharge in a Mediterranean agricultural watershed --- Grazing and biodiversity conservation: highlights on a Nature 2000 network site --- Evaluation of native grasses for sustainable turfgrass in the bioclimatic Mediterranean Region.-Biodiversity of hypogeous fungi in Basilicata --- Part III: New technologies --- New technologies for the sustainable management and planning of rural land and environment --- Processing plants and technologies for a sustainable Mediterranean food chain --- Geophysical techniques for plant, soil and root research related to Satellite technologies to support the sustainability of agricultural production --- Electrolyzed water in the food industry as supporting of environmental sustainability
    Seiten: Online-Ressource (XXVIII, 397 pages) , 80 illustrations, 48 illustrations in color
    ISBN: 9783319163574
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 41
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Ecosystems ; Sustainable development ; Natural resources ; Agricultural economics ; Life Sciences ; Ecosystems ; Sustainable Development ; Agricultural Economics ; Natural Resource and Energy Economics ; Natural Resources
    Beschreibung / Inhaltsverzeichnis: 1. Introduction --- Part I: Bioeconomy Concepts and Research Methods --- Chapter 2: Context --- Chapter 3: Bioeconomy concepts --- Chapter 4: Core principles --- Chapter 4: Inter- and Transdisciplinarity in the Bioeconomy --- Part II: Knowledge Base for Biobased Value Chains --- Chapter 5:Biobased Resources and Value Chains --- Chapter 6: Primary Production --- Chapter 7: Processing of Biobased Resources --- Chapter 8: Markets, Sustainability management and Entrepreneurship.- Part III: Transition to a Sustainable Bioeconomy --- Chapter9:  Modelling and Tools Supporting the Transition to a Bioeconomy --- Chapter 10: Environmental Economics, the Bioeconomy and the Role of Government --- Chapter 11: Economic Growth, Development, and Innovation – The Transformation towards a Knowledge-based Bioeconomy --- Chapter 12: The Bioeconomist
    Seiten: Online-Ressource (VI, 354 pages) , 165 illustrations, 139 illustrations in color
    ISBN: 9783319681528
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Unbekannt
    Cham : Springer
    Schlagwort(e): Medicine ; Molecular biology ; Health promotion ; Cardiology ; Diabetes ; Endocrinology ; Metabolic diseases ; Biomedicine ; Molecular Medicine ; Health Promotion and Disease Prevention ; Endocrinology ; Cardiology ; Diabetes ; Metabolic Diseases
    Beschreibung / Inhaltsverzeichnis: Introduction --- Human brown adipose tissue plasticity: hormonal and environmental manipulation --- The energy sensor AMPK: Adaptations to exercise, nutritional and hormonal signals --- Plasma steroids and cardiorespiratory fitness response to regular exercise --- Sending the signal: Muscle glycogen availability as a regulator of training adaptation --- Optimized engagement of macrophages and satellite cells in the repair and regeneration of exercised muscle --- Skeletal muscle microRNAs: Roles in differentiation, disease and exercise --- Tryptophan-kynurenine metabolites in exercise and mental health --- FNDC5/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain
    Seiten: Online-Ressource (X, 102 pages)
    ISBN: 9783319727905
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
    Schlagwort(e): Life sciences ; Agriculture ; Plant science ; Botany ; Sustainable development ; Life Sciences ; Agriculture ; Plant Sciences ; Sustainable Development
    Beschreibung / Inhaltsverzeichnis: Part 1. Introduction of Sago Resources- Chapter 1: Status and Outlook of Global Food Security and the Role of Under-Utilized Food Resource: Sago Palm (Hiroyuki Konuma) --- Chapter 2: Growing Area of Sago Palm and Its Environment (M. H. Bintoro) --- Chapter 3: Life and Livelihood in Sago Growing Area (Yukio Toyoda) --- Part 2. Diversity of Sago Resource in Asia and Pacific --- Chapter 4: Genetic Variation, Agronomic Features of Sago Palm in Asia and Pacific (Hiroshi Ehara) --- Chapter 5: Genetic Diversity of Sago Palm Resources in Indonesia (Barahima Abbas) --- Part 3. Sago Industry Contributes for Food Security and Rural Development in Core Producing Countries --- Chapter 6: An Overview of Sago Industry Development from 20th c. to 21st c. (Jong Foh Shoon) --- Chapter 7: Suitability of Peat Swamp Areas for Commercial Production of Sago Crop - Sarawak Experience (Roland Yong Chiew Ming) --- Chapter 8: Feasibility of Small Scale Sago Industries on Small Island in East Indonesia (Wardis Girsang) --- Chapter 9: Addressing Food Insecurity through Food Safety and Cropping of Sago in Papua New Guinea (Aisak G Pue) --- Chapter 10: Conservation and Sustainable Utilization of the Fiji Sago Palm (Dick Watling) --- Part 4. Agricultural Botany of Sago Palm --- Chapter 11: Matter Production as A Basis of Starch Production in Sago Palm (Yoshinori Yamamoto) --- Chapter 12: Morphogenesis of Sago Palm (Satoshi Nakamura) --- Chapter 13: Morphological and Anatomical Characteristics of Sago Palm Starch (Yoji Nitta) --- Part 5. Growth Environment --- Chapter 14: Soil Environment in Sago Palm Forest (Masanori Okazaki) --- Chapter 15: Interaction between Microbes Activities and Sago Palm Growth (Koki Toyoda) --- Part 6. Starch Production and Utilization --- Chapter 16: Study on the Transformation in Extraction and Consumption Processes of Sago Starch in a Traditional Society of Indonesia (Yoshihiko Nishimura) --- Chapter 17: Improvement of Sago Processing Machine (Darma) --- Chapter 18: The Structure and Characteristics of Sago Starch (Masanori Okazaki) --- Chapter 19: Recovery of Starch from Sago Pith Waste and Waste Water Treatment (Budi Santoso) --- Chapter 20: Acid modification of sago starch and its fiber for industrial application (Titi Candra Sunarti) --- Part 6. New Carbohydrate Resources --- Chapter 21: Starch Properties and Uses as food for Human Health and Welfare (Kazuko Hirao) --- Chapter 21: Production, Purification and Health Benefits of Sago Sugar (Kazuko Hirao) --- Chapter 22: Production, Purification and Health Benefits of Sago Sugar (Kopli Bujang) --- Chapter 23: New Sago Starch Resources and Its Properties from Starch Pith Waste and Pacific Sago Palms (Takashi Mishima) --- Part 8. Conclusion --- Chapter 24: Outcomes and Recommendations from the 12th International Sago Symposium (Yoshinori Yamamoto)
    Seiten: Online-Ressource (XIII, 330 pages) , 106 illustrations, 71 illustrations in color
    ISBN: 9789811052699
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 44
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Hydrology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Hydrology/Water Resources ; Environmental Science and Engineering
    Beschreibung / Inhaltsverzeichnis: Foreword --- Summary --- 2. In-Situ Destructive Sampling --- 2.1 The Concept of Representivity --- 2.2 Plant Sampling Pattern and Design --- 2.3 Biomass Water Equivalent --- 2.4 Conclusions --- 3. Remote Sensing via Satellite Imagery Analysis --- 3.1 Photo-Reflective Properties of Plants --- 3.2 Satellite Image Analysis --- 3.3 Conclusions --- 4. Estimate of Biomass Water Equivalent via the Cosmic Ray Neutron Sensor --- 4.1 The role of Biomass in the CRNS Calibration --- 4.2 Relationship between Neutrons and Crop Biomass --- 4.3 Dire4ct Relationship between Neutrons and Biomass --- 4.4 Conclusions
    Seiten: Online-Ressource (X, 33 pages) , 18 illustrations, 14 illustrations in color
    ISBN: 9783319695396
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
    Schlagwort(e): Medicine ; Neurosciences ; Pharmacology ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Pharmacology/Toxicology
    Beschreibung / Inhaltsverzeichnis: 1.Overview --- 2.In vivo imaging of nicotinic acetylcholine receptors in the central nervous system --- 3.A new aspect of cholinergic transmission in the central nervous system --- 4.Nicotinic acetylcholine receptor signaling: roles in neuroprotection --- 5.Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection --- 6.Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans --- 7.Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders --- 8.Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer’s and Parkinson’s diseases --- 9.SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors --- 10.Removal of blood amyloid as a therapeutic strategy for Alzheimer’s disease: the influence of smoking and nicotine
    Seiten: Online-Ressource (X, 191 pages) , 62 illustrations, 20 illustrations in color
    ISBN: 9789811084881
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 46
    Schlagwort(e): Life sciences ; Ecosystems ; Aquatic ecology ; Conservation biology ; Ecology ; Nature conservation ; Marine sciences ; Freshwater ; Life Sciences ; Freshwater & Marine Ecology ; Ecosystems ; Conservation Biology/Ecology ; Nature Conservation ; Marine & Freshwater Sciences
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Challenges in Riverine Ecosystem Management --- Part I Human Impacts, Mitigation and Restoration --- Chapter 2. Historic Milestones of Human River Uses and Ecological Impacts --- Chapter 3. River Morphology, Channelization, and Habitat Restoration --- Chapter 4. River Hydrology, Flow Alteration, and Environmental Flow --- Chapter 5. Hydropeaking Impacts and Mitigation --- Chapter 6. Dams: Ecological Impacts and Management --- Chapter 7. Aquatic Habitat Modeling in Running Waters --- Chapter 8. The Role of Sediment and Sediment Dynamics in the Aquatic Environment --- Chapter 9. River Connectivity, Habitat Fragmentation and Related Restoration Meas --- Chapter 10. Phosphorus and Nitrogen Dynamics in Riverine Systems: Human Impacts and Management Options --- Chapter 11. Climate Change Impacts in Riverine Ecosystems --- Chapter 12. Ecotoxicology --- Chapter 13. Land Use --- Chapter 14. Recreational Fisheries – The Need for Sustainability in Fisheries Management of Alpine Rivers --- Part II Management, Methodologies, Governance --- Chapter 15. Restoration in Integrated River Basin Management --- Chapter 16.Adaptive Management of Riverine Socio-ecological Systems --- Chapter 17. Legislative Framework for River Ecosystem Management on International and European Level --- Chapter 18. Ensuring Long-Term Cooperation Over Transboundary Water Resources Through Joint River Basin Management --- Chapter 19. Biomonitoring and Bioassessment --- Chapter 20. Biodiversity and Freshwater Information Systems --- Chapter 21. Ecosystem Services in River Landscapes --- Chapter 22. Public Participation and Environmental Education --- Chapter 23. NGOs in Freshwater Resource Management --- Part III Case Studies --- Chapter 24. Danube Under Pressure: Hydropower Rules the Fish --- Chapter 25. Danube Floodplain Lobau --- Chapter 26. Danube Sturgeons: Past and Future --- Chapter 27. Healthy Fisheries Sustain Society and Ecology in Burkina Faso --- Chapter 28. The Tisza River: Managing a Lowland River in the Carpathian Basin --- Part IV Summary --- Chapter 29. Landmarks, Advances and Future Challenges in Riverine Ecosystem Management
    Seiten: Online-Ressource (VII, 571 pages) , 123 illustrations, 82 illustrations in color
    ISBN: 9783319732503
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 47
    Unbekannt
    Cham : Springer
    Schlagwort(e): Medicine ; Neurosciences ; Neurology ; Psychiatry ; Biomedicine ; Neurosciences ; Neurology ; Psychiatry
    Beschreibung / Inhaltsverzeichnis: Hippocampal mechanisms for the segmentation of space by goals and boundaries --- Cortical Evolution: Introduction to the Reptilian Cortex --- Flow of information underlying a tactile decision in mice --- The Visual Brain: Computing through Multiscale Complexity --- Grid cells and spatial maps in entorhinal cortex and hippocampus --- The striatum and decision-making based on value --- Decoding the dynamics of conscious perception: The temporal generalization method --- Sleep and synaptic down-selection --- Federating and integrating what we know about the brain at all scales - a challenge for the future. Computer science meets the clinical neurosciences
    Seiten: Online-Ressource (XIII, 172 pages) , 33 illustrations, 30 illustrations in color
    ISBN: 9783319288024
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 48
    Schlagwort(e): Life sciences ; Human physiology ; Food ; Biotechnology ; Microbiology ; Life Sciences ; Food Microbiology ; Food Science ; Human Physiology
    Beschreibung / Inhaltsverzeichnis: Introduction --- Gastrointestinal digestion models, general introduction --- Static digestion models general introduction --- InfoGest consensus method --- Approaches to static digestion models --- Dynamic digestion models general introduction --- The TNO gastro-Intestinal Model (TIM) --- Dynamic Gastric Model (DGM) --- Human Gastric Simulator (Riddet model) --- The DIDGI® System --- General introduction to cells, cell lines and cell culture --- Epithelial cell models; General introduction --- Caco-2 cell line --- HT29 cell line --- The IPEC-J2 cell line --- Co-cultivation of Caco-2 and HT-29MT --- Innate and adaptive immune cells; General introduction --- THP-1 and U937 cells --- Peripheral blood mononuclear cells --- PBMC-derived T cells --- Dendritic Cells --- Co-culture Caco-2/ immune cells --- Enteroendocrine Cell Models: General introduction --- STC-1 cells --- NCI-H716 cells --- Murine GLUTag cells --- In vitro intestinal tissue models: General introduction --- Intestinal crypt organoids as experimental models --- Porcine ex vivo intestinal segment model --- Ussing chamber --- In vitro fermentation models: General Introduction --- One compartment fermentation model --- The TNO in vitro model of the colon - TIM-2 --- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME® --- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
    Seiten: Online-Ressource (XVII, 338 pages) , 57 illustrations, 35 illustrations in color
    ISBN: 9783319161044
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 49
    Schlagwort(e): Life sciences ; Hydrology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Hydrology/Water Resources ; Environmental Science and Engineering
    Beschreibung / Inhaltsverzeichnis: Foreword --- Summary --- 2. In-Situ Destructive Sampling --- 2.1 The Concept of Representivity --- 2.2 Plant Sampling Pattern and Design --- 2.3 Biomass Water Equivalent --- 2.4 Conclusions --- 3. Remote Sensing via Satellite Imagery Analysis --- 3.1 Photo-Reflective Properties of Plants --- 3.2 Satellite Image Analysis --- 3.3 Conclusions --- 4. Estimate of Biomass Water Equivalent via the Cosmic Ray Neutron Sensor --- 4.1 The role of Biomass in the CRNS Calibration --- 4.2 Relationship between Neutrons and Crop Biomass --- 4.3 Dire4ct Relationship between Neutrons and Biomass --- 4.4 Conclusions
    Seiten: Online-Ressource (X, 33 pages) , 18 illustrations, 14 illustrations in color
    ISBN: 9783319695396
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 50
    Schlagwort(e): Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology
    Beschreibung / Inhaltsverzeichnis: Parcellations and connectivity patterns in human and macaque cerebral cortex --- Nanoconnectomics --- Inhibitory cell cypes, circuits and receptive fields in mouse visual cortex --- Form meets function in the brain: observing the activity and structure of specific neural connections --- The network for intracortical communication in mouse visual cortex --- The brain in space --- In-vivo connectivity in monkeys --- Connectome networks: from cells to systems --- Intra- and Inter-hemispheric connectivity supporting hemispheric specialization --- Genetics of the connectome and the ENIGMA project
    Seiten: Online-Ressource (X, 166 pages) , 32 illustrations, 28 illustrations in color
    ISBN: 9783319277776
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 51
    Schlagwort(e): Life sciences ; Climate change ; Animal ecology ; Conservation biology ; Ecology ; Vertebrates ; Life Sciences ; Conservation Biology/Ecology ; Vertebrates ; Animal Ecology ; Climate Change/Climate Change Impacts
    Beschreibung / Inhaltsverzeichnis: Bats in the Anthropocene --- Urbanisation and its effects on bats – a global meta-analysis --- Bats and roads --- Responses of tropical bats to habitat fragmentation, logging, and deforestation --- Insectivorous bats and silviculture: balancing timber production and bat conservation --- Bats in the anthropogenic matrix: Challenges and opportunities for the conservation of Chiroptera and their ecosystem services in agricultural landscapes --- Dark matters: the effects of artificial lighting on bats --- Bats and water: anthropogenic alterations threaten global bat populations --- White-nose syndrome in bats --- Zoonotic viruses and conservation of bats --- Impacts of Wind Energy Development on Bats: a Global Perspective --- Exploitation of Bats for Bushmeat and Medicine --- The conflict between pteropodid bats and fruit growers: species, legislation and mitigation --- Bats and buildings: The conservation of synanthropic bats --- Conservation ecology of cave bats --- The roles of taxonomy and systematics in bat conservation --- Networking networks for global bat conservation --- Cute, Creepy, or Crispy – how values, attitudes and norms shape human behavior toward bats. 
    Seiten: Online-Ressource (IX, 606 pages) , 77 illustrations, 52 illustrations in color
    ISBN: 9783319252209
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 52
    Schlagwort(e): Medicine ; Neurosciences ; Otorhinolaryngology ; Biomedicine ; Neurosciences ; Otorhinolaryngology
    Beschreibung / Inhaltsverzeichnis: The International Symposium on Hearing is a prestigious,triennial gathering where world-class scientists present and discuss the most recent advances in the field of human and animal hearing research. The 2015 edition will particularly focus on integrative approaches linking physiological, psychophysical and cognitive aspects of normal and impaired hearing. Like previous editions, the proceedings will contain about 50 chapters ranging from basic to applied research, and of interest to neuroscientists, psychologists, audiologists, engineers, otolaryngologists, and artificial intelligent researchers
    Seiten: Online-Ressource (XXIX, 484 pages) , 138 illustrations, 92 illustrations in color
    ISBN: 9783319254746
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 53
    Schlagwort(e): Life sciences ; Management ; Industrial management ; Geography ; Agriculture ; Agricultural economics ; Life Sciences ; Agriculture ; Agricultural Economics ; Geography, general ; Innovation/Technology Management
    Beschreibung / Inhaltsverzeichnis: Foreword --- 1. Innovation for Marginalized Smallholder Farmers and Development: an Overview and Implications for Policy and Research --- Part 1 Innovation for the Rural Poor: Theory, Trends and Impacts --- 2. Institutional and technological innovations in polycentric systems –pathways for escaping marginality --- 3. Innovations for Food and Nutrition Security: Impacts and Trends --- 4. Psychology of Innovation: Innovating human psychology? --- 5. An optimization model for technology adoption of marginalized smallholders --- Part 2 Diversification of Agricultural Production and Income --- 6. The BRAC Approach to Small Farmers' Innovations --- 7. Agricultural Research and Extension Linkages in Amhara Region, Ethiopia --- 8. Transaction costs on the Ethiopian formal seed market and innovations for encouraging private sector investments --- 9. Agricultural Service Delivery Through Mobile Phone: Local innovations and Technological Opportunities in Kenya --- 10. Identification and Acceleration of Farmer Innovativeness in Upper East Ghana --- 11. Gender, social equity and innovations in smallholder farming systems: pitfalls and pathways --- 12. Assessing the Sustainability of Agricultural Technology Options for Poor Rural Farmers --- 13. Land Degradation and Sustainable Land Management Innovations in Central Asia --- 14. Biomass-based value web. A Novel Perspective for Emergng Bioeconomies in Sub-Saharan Africa --- Part 3 Sustainable Intensification of Agriculture --- 15. Adoption of Stress-tolerant Rice Varieties in Bangladesh --- 16. More than cereal based cropping innovations for improving food and livelihood security of poor small holders in marginal areas of Bangladesh --- 17. Integrated Rice-fish Farming System in Bangladesh: An Ex-Ante Value Chain Evaluation Framework --- 18. Technologies for Maize, Wheat, Rice and Pulses in Marginal Districts of Odisha and Bihar --- 19. Technological Innovations for Smallholder Farmers in Ghana --- 20. Potential impacts of yield increasing crop technologies on poverty reduction in two districts of Ethiopia
    Seiten: Online-Ressource (XV, 435 pages) , 80 illustrations, 50 illustrations in color
    ISBN: 9783319257181
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 54
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Applied ecology ; Biodiversity ; Ecosystems ; Conservation biology ; Ecology ; Community psychology ; Environmental psychology ; Life Sciences ; Applied Ecology ; Biodiversity ; Conservation Biology/Ecology ; Ecosystems ; Community and Environmental Psychology
    Beschreibung / Inhaltsverzeichnis: 1. The Biodiversity Data Impediment to a Sustainable World (Working in a Networked World) --- 2. Essential Biodiversity Variables --- 3. Stratification and Terrestrial Ecosystem Observations --- 4. Ecosystem Services --- 5. Species Observations --- 6. Monitoring Changes in Genetic Diversity --- 7. Marine and Coastal Systems --- 8. Biodiversity Observations for Freshwater Ecosystems --- 9. Remote Sensing for Biodiversity --- 10. Involving Citizen Scientists in Biodiversity Observation --- 11. Biodiversity Modelling --- 12. Cyber-Architecture --- 13. Using Data for Decision-Making: From Observations To Indicators and Other Policy Tools --- 14. Capacity Building in Biodiversity Monitoring – Case Studies
    Seiten: Online-Ressource (XII, 326 pages) , 34 illustrations, 27 illustrations in color
    ISBN: 9783319272887
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 55
    Unbekannt
    Cham : Springer
    Schlagwort(e): Medicine ; Neurosciences ; Endocrinology ; Biomedicine ; Neurosciences ; Endocrinology
    Beschreibung / Inhaltsverzeichnis: A brief overview of techniques for modulating neuroendocrine and other neural systems --- Basics of stem cell biology as applied to the brain --- Human pluripotent-derived lineages for repairing hypopituitarism --- Recapitulating hypothalamus and pituitary development using ES/iPS cells --- Regulation of body weight and metabolism by tanycyte-derived neurogenesis in young adult mice --- Genetic dissection of the neuroendocrine and behavioral responses to stressful challenges --- Pituitary stem cells: quest for hidden functions --- Pituitary stem cells during normal physiology and disease --- Epigenetic mechanisms of pituitary cell fate specification --- Advances in stem cells biology: new approaches to understand depression --- Perspective on stem cells in developmental biology, with special reference to neuroendocrine systems.
    Seiten: Online-Ressource (XII, 156 pages) , 16 illustrations in color
    ISBN: 9783319416038
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 56
    Unbekannt
    Cham : Springer
    Schlagwort(e): Life sciences ; Forest products ; Plant anatomy ; Plant development ; Plant physiology ; Life Sciences ; Plant Anatomy/Development ; Plant Physiology ; Plant Systematics/Taxonomy/Biogeography ; Wood Science & Technology
    Beschreibung / Inhaltsverzeichnis: Introduction --- Preparation techniques - Making anatomical structures visible --- Morphology of the plant body --- Cellular composition of the plant bodies --- Structure of cell walls and cell contents --- Primary, secondary and tertiary meristem --- Stem anatomical structures of major taxonomic units --- Evolution of stems --- Anatomical adaptions to permanent changed environmental conditions --- Anatomical adaptions to temporarily changed environmental conditions --- Coexistence of algae, fungi and vascular plants --- Wood decay --- Fossilization, permineralization, coalification, carbonization and wetwood conservation --- Technically altered wood products
    Seiten: Online-Ressource (VII, 207 pages)
    ISBN: 9783319735245
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 57
    Schlagwort(e): Life sciences ; Agriculture ; Plant breeding ; Life Sciences ; Plant Breeding/Biotechnology ; Agriculture
    Beschreibung / Inhaltsverzeichnis: General Introduction --- Screening Protocols for Heat Tolerance in Rice at the Seedling and Reproductive Stages --- Validation of Screening Protocols for Heat Tolerance in Rice --- Conclusion --- References
    Seiten: Online-Ressource (XII, 39 pages) , 16 illustrations, 10 illustrations in color
    ISBN: 9783319773384
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 58
    Schlagwort(e): Life sciences ; Agriculture ; Climate change ; Environmental management ; Soil science ; Soil conservation ; Air pollution ; Life Sciences ; Agriculture ; Climate Change ; Atmospheric Protection/Air Quality Control/Air Pollution ; Soil Science & Conservation ; Environmental Management
    Beschreibung / Inhaltsverzeichnis: Chapter 1 Introduction to the SAMPLES Approach --- Chapter 2 Targeting Landscapes to Identify Mitigation Options --- Chapter 3 Determining Greenhouse Gas Emissions and Removals Associated with Land Use and Land Cover Change --- Chapter 4 Quantifying Greenhouse Gas Emissions from Managed and Natural Soils --- Chapter 5 A Comparison of Methodologies for Measuring Methane Emissions from Ruminants --- Chapter 6 Quantifying Tree Biomass Carbon Stocks and Fluxes in Agricultural Landscapes --- Chapter 7 Methods for Smallholder Quantification of Soil Carbon Stocks and Stock Changes --- Chapter 8 Yield Estimation of Food and Non-Food Crops in Smallholder Production Systems --- Chapter 9 Scaling Point and Plot Measurements of Greenhouse Gas Fluxes, Balances and Intensities to Whole Farms and Landscapes --- Chapter 10 Methods for Environment-Productivity Trade-off Analysis in Agricultural Systems
    Seiten: Online-Ressource (XV, 203 pages) , 33 illustrations, 27 illustrations in color
    ISBN: 9783319297941
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 59
    Schlagwort(e): Life sciences ; Ecology ; Wildlife ; Fish ; Life Sciences ; Fish & Wildlife Biology & Management ; Ecology ; Environmental Monitoring/Analysis
    Beschreibung / Inhaltsverzeichnis: 1 Introduction: Overview of Our Research on Impacts of the Fukushima Dai-ichi Nuclear Power Plant Accident on Fish and Fishing Grounds --- Part I Seawater and Plankton --- 2 134Cs and 137Cs in the Seawater Around Japan and in the North Pacific --- 3 Temporal Changes in 137Cs Concentration in Zooplankton and Seawater off the Joban–Sanriku Coast, and in Sendai Bay, After the Fukushima Dai-ichi Nuclear Accident --- Part II Sediments and Benthos --- 4 Three-Dimensional Distribution of Radiocesium in Sea Sediment Derived from the Fukushima Dai-ichi Nuclear Power Plant --- 5 Radiocesium Concentrations in the Organic Fraction of Sea Sediments --- 6 Bottom Turbidity, Boundary Layer Dynamics, and Associated Transport of Suspended Particulate Materials off the Fukushima Coast --- 7 Investigation of Radiocesium Translation from Contaminated Sediment to Benthic Organisms --- Part III Marine Fish --- 8 Detection of 131I, 134Cs, and 137Cs Released into the Atmosphere from FNPP in Small Epipelagic Fishes, Japanese Sardine and Japanese Anchovy, off the Kanto Area, Japan --- 9 Radiocesium Concentration of Small Epipelagic Fishes (Sardine and Japanese Anchovy) off the Kashima-Boso Area --- 10 Why Do the Radionuclide Concentrations of Pacific Cod Depend on the Body Size? --- 11 Radiocesium Contamination Histories of Japanese Flounder (Paralichthys olivaceus) After the 2011 Fukushima Nuclear Power Plant Accident --- Part IV Mechanisms of Severe Contamination in Fish --- 12 Evaluating the Probability of Catching Fat Greenlings (Hexagrammos otakii) Highly Contaminated with Radiocesium off the Coast of Fukushima --- 13 Analysis of the Contamination Process of the Extremely Contaminated Fat Greenling by Fukushima-Derived Radioactive Material --- 14 Contamination Levels of Radioactive Cesium in Fat Greenling Caught at the Main Port of the Fukushima Dai-ichi Nuclear Power Plant --- Part V Freshwater Systems --- 15 Comparison of Radioactive Cesium Contamination of Lake Water, Bottom Sediment, Plankton, and Freshwater Fish Among Lakes of Fukushima Prefecture, Japan, After the Fukushima Fallout --- 16 Radiocesium Concentrations and Body Size of Freshwater Fish in Lake Hayama 1 Year After the Fukushima Dai-Ichi Nuclear Power Plant Accident --- 17 Spatiotemporal Monitoring of 134Cs and 137Cs in Ayu, Plecoglossus altivelis, a Microalgae-Grazing Fish, and in Their Freshwater Habitats in Fukushima --- 18 Radiocesium Concentrations in the Muscle and Eggs of Salmonids from Lake Chuzenji, Japan, After the Fukushima Fallout --- 19 Assessment of Radiocesium Accumulation by Hatchery-Reared Salmonids After the Fukushima Nuclear Accident
    Seiten: Online-Ressource (XI, 238 pages) , 103 illustrations, 37 illustrations in color
    ISBN: 9784431555377
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 60
    Schlagwort(e): Medicine ; Immunology ; Molecular biology ; Cell biology ; Biomedicine ; Molecular Medicine ; Immunology ; Cell Biology
    Beschreibung / Inhaltsverzeichnis: Part I Basic Research for Innovative Medicine --- 1. Diverting Glycolysis to Combat Oxidative Stress --- 2. Metabolic Regulation by Nuclear Receptors --- 3. Fighting Fire with Fire in Cancer --- 4. Linear Polyubiquitination: a Crucial Regulator of NF-kB Activation --- 5. VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders --- 6. Roles of E-cadherin in hepatocarcinogenesis --- 7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors --- 8. Inhibitory immunoreceptors on mast cells in allergy and inflammation --- 9. Doxycycline-inducible Autoimmune Blistering Skin Disease Model --- 10. T-cell Senescence and Autoimmunity --- Part II Translational Research for Innovative Medicine --- 11. IL-6: A new era for the treatment of autoimmune inflammatory diseases --- 12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies --- 13. Multifaceted translational approach of major mental illness --- 14. Translational research of leptin in lipodystrophy and its related diseases --- 15. Translational research of the activation of the C-type natriuretic peptide (CNP)-guanylyl cyclase-B pathway for skeletal dysplasia --- 16. Clarity and Challenges in Tissue Fibrosis --- 17. TRP Channels: Their Function and Potentiality as Drug Targets --- 18. Autophagic Cell Death and Cancer Chemotherapeutics --- 19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis --- 20. RNA activation --- Part III New Technology for Innovative Medicine --- 21. Cardiac Reprogramming for Heart Repair --- 22. Development of a new in vivo optical probe for biological diagnosis and therapy --- 23. Introduction of mesenchymal stem cells for liver surgery (hepatectomy and transplantation) --- 24. Synaptic and axonal plasticity induction in the human cerebral cortex --- 25. TIM-3 is a novel therapeutic target for eradicating acute myelogenous leukemia stem cells --- 26. TGF-beta LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis --- 27. Cell-based regenerative therapy for liver disease
    Seiten: Online-Ressource (IX, 339 pages)
    ISBN: 9784431556510
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 61
    Unbekannt
    Basel, Beijing, Wuhan : MDPI
    Schlagwort(e): aerosol optical depth ; climate variability and health ; earth observation ; environmental health ; environmental remote sensing ; exposure to air pollutant ; geospatial technology ; health GIS ; landscape epidemiology ; public health ; public health tracking ; remote sensing ; spatial surveillance ; spatial epidemiology ; tele-epidemiology
    Beschreibung / Inhaltsverzeichnis: Editorial - Remote Sensing and Geospatial Technologies in Public Health / ISPRS Int. J. Geo-Inf. 2018, 7(8), 303; https://doi.org/10.3390/ijgi7080303 --- CALPUFF and CAFOs: Air Pollution Modeling and Environmental Justice Analysis in the North Carolina Hog Industry / ISPRS Int. J. Geo-Inf. 2015, 4(1), 150-171; https://doi.org/10.3390/ijgi4010150 --- Analyzing the Correlation between Deer Habitat and the Component of the Risk for Lyme Disease in Eastern Ontario, Canada: A GIS-Based Approach / ISPRS Int. J. Geo-Inf. 2015, 4(1), 105-123; https://doi.org/10.3390/ijgi4010105 --- Geospatial Technology: A Tool to Aid in the Elimination of Malaria in Bangladesh / ISPRS Int. J. Geo-Inf. 2015, 4(1), 47-58; https://doi.org/10.3390/ijgi4010047 --- Examining Personal Air Pollution Exposure, Intake, and Health Danger Zone Using Time Geography and 3D Geovisualization / ISPRS Int. J. Geo-Inf. 2015, 4(1), 32-46; https://doi.org/10.3390/ijgi4010032 --- Use of the NASA Giovanni Data System for Geospatial Public Health Research: Example of Weather-Influenza Connection / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1372-1386; https://doi.org/10.3390/ijgi3041372 --- Mapping Entomological Dengue Risk Levels in Martinique Using High-Resolution Remote-Sensing Environmental Data / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1352-1371; https://doi.org/10.3390/ijgi3041352 --- Improving Inland Water Quality Monitoring through Remote Sensing Techniques / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1234-1255; https://doi.org/10.3390/ijgi3041234 --- Impacts of Scale on Geographic Analysis of Health Data: An Example of Obesity Prevalence / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1198-1210; https://doi.org/10.3390/ijgi3041198 --- Geographical Variation of Incidence of Chronic Obstructive Pulmonary Disease in Manitoba, Canada / ISPRS Int. J. Geo-Inf. 2014, 3(3), 1039-1057; https://doi.org/10.3390/ijgi3031039 --- Holistics 3.0 for Health / ISPRS Int. J. Geo-Inf. 2014, 3(3), 1023-1038; https://doi.org/10.3390/ijgi3031023 --- Dasymetric Mapping and Spatial Modeling of Mosquito Vector Exposure, Chesapeake, Virginia, USA / ISPRS Int. J. Geo-Inf. 2014, 3(3), 891-913; https://doi.org/10.3390/ijgi3030891 --- Modeling Properties of Influenza-Like Illness Peak Events with Crossing Theory / ISPRS Int. J. Geo-Inf. 2014, 3(2), 764-780; https://doi.org/10.3390/ijgi3020764 --- Correlating Remote Sensing Data with the Abundance of Pupae of the Dengue Virus Mosquito Vector, Aedes aegypti, in Central Mexico / ISPRS Int. J. Geo-Inf. 2014, 3(2), 732-749; https://doi.org/10.3390/ijgi3020732 --- Canadian Forest Fires and the Effects of Long-Range Transboundary Air Pollution on Hospitalizations among the Elderly / ISPRS Int. J. Geo-Inf. 2014, 3(2), 713-731; https://doi.org/10.3390/ijgi3020713 --- Nexus of Health and Development: Modelling Crude Birth Rate and Maternal Mortality Ratio Using Nighttime Satellite Images / ISPRS Int. J. Geo-Inf. 2014, 3(2), 693-712; https://doi.org/10.3390/ijgi3020693
    Seiten: Online-Ressource (244 Seiten) , Illustrationen, Diagramme
    Ausgabe: Printed Edition of the Special Issue Published in ISPRS International Journal of Geo-Information
    ISBN: 9783038971733
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 62
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 24 (2004), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 63
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 24 (2004), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The effects of the immunosuppressants, tacrolimus (FK506) and cyclosporin A (CsA), on catecholamine (CA) release were examined in cultured bovine adrenal chromaffin cells. 2 In intact cells, FK506 (1–30 μm) inhibited CA release stimulated by acetylcholine (ACh; 100 μm), 1,1-dimethyl-4-phenyl-piperazinium (DMPP, 10 μm) or high K+ (40 mm). CsA (1–30 μm) had a little inhibitory effect on the ACh- or DMPP-stimulated CA release, whereas it enhanced the high K+-stimulated CA release. 3 In β-escin-permeabilized cells, FK506 inhibited CA release stimulated by Ca2+ (1 and 10 μm) in the presence and absence of MgATP (2 mm). CsA induced CA release under Ca2+-free condition and enhanced the Ca2+-stimulated CA release in the presence and absence of MgATP. 4 It is known that the Ca2+-dependent exocytosis involves at least two distinct steps, ATP-requiring priming stage and ATP-independent fusion step in adrenal chromaffin cells. Therefore, it is suggested that FK506 inhibits the Ca2+-dependent exocytosis probably at the fusion step whereas CsA induces CA release from bovine adrenal chromaffin cells.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 64
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Prolonged bed rest or exposure to microgravity may cause several alterations in autonomic nervous system response (ANSR). 2 Hindlimb unloading (HU) rats were used as an animal model of simulated microgravity to investigate ANSR changes. The experiments were carried out to investigate the effects of simulated microgravity on the autonomic nervous response of the perfused mesenteric vascular bed (MVB), vas deferens and the colon and duodenum from 2-week HU rats. 3 In MVB preparations of HU rats, the frequency-dependent increases in perfusion pressure with perivascular nerve stimulation (PNS; 8–40 Hz) were inhibited, whereas the noradrenaline (NA) concentration-dependent (1–100 μm) perfusion pressure increases were potentiated. The latter most probably reflected up-regulation of α-adrenergic receptor function. Relaxant responses of NA-precontracted MVB to PNS (4–30 Hz) or isoprenaline were not different between control and HU preparations, while vasodilation induced by the endothelial agonist ACh was reduced. 4 Transmural stimulation (2–40 Hz) induced frequency-dependent twitches of the vas deferens which were reduced in vas deferens of HU rats, while the sensitivity to NA-induced contraction was significantly increased. 5 In the gastroenteric system of HU rat, direct contractile responses to carbachol or tachykinin as well as relaxant or contractile responses to nervous stimulation appeared unchanged both in the proximal colon rings and in duodenal longitudinal strips. 6 In conclusion, HU treatment affects peripheral tissues in which the main contractile mediators are the adrenergic ones such as resistance vessels and vas deferens, probably by reducing the release of neuromediator. This study validates NA signalling impairment as a widespread process in microgravity, which may most dramatically result in the clinical phenotype of orthostatic intolerance.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 65
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 This double-blind, cross-over, placebo-controlled study on six healthy male volunteers was designed to evaluate the effects of α2-adrenoceptor antagonism on cardiac parasympathetic regulation. 2 The subjects received atipamezole intravenously as a three-step infusion, which aimed at steady-state serum concentrations of 10, 30 and 90 ng ml−1 at 50-min intervals. 3 Drug effects were assessed with repeated recordings of blood pressure and electrocardiogram, in which the high-frequency (0.15–0.40 Hz) R-R interval variation is supposed to reflect cardiac parasympathetic efferent neuronal activity. 4 At the end of the three steps of the infusion, the mean (±SD) concentrations of atipamezole were 10.5 (3.9), 26.8 (5.6) and 81.3 (21.1) ng ml−1. 5 Within this concentration range, atipamezole appeared to reduce slightly the high-frequency R-R interval fluctuations, indicating a minor vagolytic effect in the heart. 6 Atipamezole increased systolic and diastolic arterial pressure, on average by 20 and 14 mmHg (maxima at the second step of the infusion), which evidently reflects an overall sympathetic augmentation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 66
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 67
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Our previous report showed that in acute cholestasis, the subsensitivity to morphine inhibitory effect on electrical-stimulated contractions develops significantly faster in guinea-pig ileum (GPI) and in mouse vas deferens (MVD) (45.2 and 29.9 times, respectively) compared with non-cholestatic subjects. 2 The possible contribution of α2-adrenoceptor and nitric oxide (NO) pathways on the development of tolerance was assessed in GPI and MVD of cholestatic subjects. 3 Daily administration of naltrexone (20 mg kg−1), yohimbine (5 mg kg−1), and Nω-nitro-l-arginine methyl ester (l-NAME) (3 mg kg−1) to cholestatic animals significantly (P-value 〈 0.05) inhibited the process of subsensitivity in all groups. 4 Consistent with the literature, it was concluded that both the α2-adrenergic system and NO have close interaction with the opioid system and may underlie some of the mechanisms involved in the subsensitivity development to opioids in acute cholestatic states.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 68
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 We examined the role of the NO/cyclic GMP (cyclic GMP) pathway in nitric oxide (NO)- and vasoactive intestinal peptide (VIP)-induced relaxation of feline lower oesophageal sphincter (LES). Furthermore, it was studied whether methylene blue, LY83583 and ODQ, which are soluble guanylate cyclase (sGC) inhibitors, could inhibit NO-induced relaxation.2 The nitric oxide synthase (NOS) inhibitor, N-nitro-l-arginine (l-NNA) had no effect in sodium nitropruside (SNP)-induced relaxation, but 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1)-induced relaxation was decreased by the pretreatment of l-NNA, which showed that SIN-1, not SNP, could activate NOS to cause relaxation. Methylene blue and LY83583 did not inhibit the relaxation by SNP and SIN-1. However, the more specific sGC inhibitor ODQ blocked the relaxation induced by NO donors.3 To identify the relationship of NOS, sGC and adenylate cyclase in VIP-induced relaxation, tissue were pretreated with l-NNA and ODQ and SQ22536. These inhibitors produced significant inhibition of this response to VIP. The adenylyl cyclase inhibitor SQ 22536 also inhibited relaxation by VIP.4 In conclusion, our data showed that SNP- and SIN-1-induced relaxation was mediated by sGC. Of sGC inhibitors, methylene blue and LY83583 were not adequate for the examination of NO donor-induced feline LES smooth muscle relaxation. VIP also caused relaxation by the pathway involving NO and cGMP and cAMP.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 69
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The vasoconstrictor response to periarterial nerve electrical stimulation (PNS) and neurotransmission by ATP are discussed and illustrated, using canine isolated and perfused splenic arterial preparations. 2 The conditions for appearance of dominant purinergic constrictor response to PNS are discussed. 3 Modulation of the purinergic vasoconstrictor responses to PNS by several kinds of presynaptic receptor agonists and antagonists is reviewed. 4 Influences of purinergic responses to PNS by guanethidine, reserpine, tetrodotoxin (TTX) or ω-conotoxin GVIA (ωCTX) are also reviewed. 5 Effects of imipramine and removal of the endothelium are discussed. 6 Evidence is presented for selective inhibition of purinergic responses to PNS by an adequate cold storage of the vessel. 7 The roles of ATP released by PNS in isolated canine splenic arteries are proposed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 70
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The aim of the present study was to investigate the role of several possible neurotransmitters in mediating non-adrenergic, non-cholinergic (NANC) relaxation, and the effects of phosphodiesterase (PDE) III and V inhibitors on adrenergic and NANC relaxation in branch pulmonary artery (PA) of guinea-pig. 2 Under the NANC conditions, electrical field stimulation (EFS, 60 V, 0.2 ms, 20 Hz) induced a tetrodotoxin-sensitive relaxation of the histamine-precontracted PA rings. The nitric oxide (NO) synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME, 10−4 m) and the guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 10−5 m) partially inhibited the EFS-induced relaxation. The inhibitory effect of l-NAME was reversed completely by l-arginine (10−3 m), but not d-arginine (10−3 m). 3 This NANC relaxation was attenuated by 8-phenyltheophylline (10−5 m), a P1-purinoceptor antagonist. 4 The NANC response was potentiated by 10−6 m zaprinast, a type V PDE inhibitor, but was unaffected by 3 × 10−6 m milrinone, a type III PDE inhibitor. 5 Sodium nitroprusside (SNP) caused a concentration-dependent vasodilator effect which was potentiated by zaprinast, but unaffected by milrinone. Moreover, the effect of combination of zaprinast with milrinone was not significantly different from that observed with zaprinast alone. 6 Isoprenaline produced a concentration-dependent vasodilatation in branch PA of guinea-pig which was potentiated by both zaprinast and milrinone, the efficacy of milrinone being greater than zaprinast. 7 These results suggest that both nitrergic and purinergic pathways are involved in mediating the NANC relaxation in branch PA of guinea-pig. The combination of PDE III or V inhibitors with vasorelaxant drugs may be a hopeful approach for the treatment of pulmonary hypertension.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 71
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The aim of this study was to characterize the histamine receptor type mediating relaxation of the vascular bed of the nasal mucosa from the guinea-pig, and to determine the role of cyclo-oxygenase products and nitric oxide in this relaxant response to histamine. These studies were performed in isolated nasal mucosae examined in vitro to obtain potencies of histamine receptor-type selective agonists in causing vasorelaxation and to determine affinities of histamine receptor antagonists for inhibiting histamine-induced relaxation. 2 After contraction of nasal mucosae with noradrenaline, histamine caused a maximal relaxation response that was 75 ± 6% of the contraction caused by noradrenaline with a mean EC50 value of 4.3 ± 0.5 μm. Neither dimaprit (H2-receptor selective) nor R-α-methylhistamine (H3-receptor selective) caused significant relaxation of nasal mucosae. In contrast, betahistine (H1-receptor selective) caused an 81 ± 7% relaxation of noradrenaline-induced tone with an EC50 value of 15 ± 1 μm. 3 pA2 experiments were performed to obtain KB values of chlorpheniramine (H1-receptor selective) and diphenhydramine (H1-receptor selective) for blocking histamine-stimulated relaxation of nasal mucosae. KB values for chlorpheniramine (0.87 nm) and diphenhydramine (7.4 nm) were consistent with their interaction at the H1-receptor type. Additionally, neither 10 μm cimetidine (H2-receptor selective) nor 1 μm thioperamide (H3-receptor selective) had any effect on the relaxation curve for histamine. 4 In the presence of 10 μm indomethacin (cyclo-oxygenase inhibitor), histamine caused a maximal relaxation response of 73 ± 5% of the noradrenaline-induced tone with an EC50 value of 2.9 ± 0.2 μm, which was not different from control values (EC50 = 5.0 ± 0.4 μm; maximal relaxation = 71 ± 6%). In contrast, 200 μm NG-nitro-l-arginine (nitric oxide synthase inhibitor) completely inhibited histamine-induced relaxation of nasal mucosae. 5 In conclusion, data from the present study suggest only the H1-receptor type mediates relaxation of nasal mucosal blood vessels to histamine, and histamine-induced relaxation of nasal mucosae is entirely dependent on nitric oxide production.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 72
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 This study was aimed at evaluating the effect of rutin and harmaline (1-methyl-7-methoxy-3,4-dihydro-β-carboline) on the development of the surgically induced reflux oesophagitis, on gastric secretion, lipid peroxidation, polymorphonucleocytes (PMNs) accumulation, superoxide and hydroxyl radical production in PMNs, cytokine [interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α)] production in blood and [Ca2+]i mobilization in PMNs. 2 Rutin and harmaline significantly prevented the development of reflux oesophagitis and gastric secretion. Treatments of oesophagitis rats with rutin and harmaline inhibited lipid peroxidation, and myeloperoxidase (MPO) in the oesophagus in comparison with untreated rats. 3 Superoxide anion and hydrogen peroxide production in 1 μm formylmethionylleucylphenylalanine (fMLP)- or 0.1 μg ml−1N-phorbol 12-myristate 13-acetate (PMA)-activated PMNs was inhibited by rutin and harmaline in a dose-dependent fashion. Rutin and harmaline effectively scavenged the hydroxyl radical and hydrogen peroxide. Treatments of oesophagitis rats with rutin and harmaline inhibited IL-1β production in the oesophagus in comparison with untreated rats, but TNF-α production was not affected by rutin and harmaline. The fMLP-induced elevation of [Ca2+]i was inhibited by rutin. 4 The results of this study suggest that rutin and harmaline may have beneficial protective effects against reflux oesophagitis by the inhibition of gastric acid secretion, oxidative stress, inflammatory cytokine production (i.e. IL-1β), and intracellular calcium mobilization in PMNs in rats.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 73
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Although monumental efforts have been made to define the action sites of cough, the importance of neurotransmitter systems in the cough reflex has received limited attention. We studied the roles for four major neurotransmitters [acetylcholine, histamine, serotonin (5-hydroxytryptamine, 5-HT) and dopamine] in the modulation of the cough reflex. 2 Atropine (muscarinic cholinergic blocking agent), pyrilamine maleate (PM, histamine H1 blocker), cimetidine (histamine H2 blocker), 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, specific 5-HT1A receptor agonist) and SCH-23390 (selective dopamine D1 receptor antagonist) were examined on the cough response to inhaled capsaicin in conscious guinea-pigs. 3 All the drugs significantly decreased the number of capsaicin-induced coughs in a dose-dependent manner. To compare the sensitivity of these drugs on cough response, we calculated the effective doses for 50% inhibition of cough (ED50) when the animals were exposed to 3 × 10−4 m capsaicin. The ED50 values were 0.03 μm kg−1 for atropine, 0.2 μm kg−1 for 8-OH-DPAT, 6.2 μm kg−1 for SCH-23390, 8.5 μm kg−1 for PM and 13.9 μm kg−1 for cimetidine. 4 These findings indicated that all these four neurotransmitters may be involved in the regulation of the cough reflex. Multiple changes of these neurotransmitters in disorders of the central nervous system might synergically affect the cough reflex.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 74
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 We have investigated the actions of the α1D-adrenoceptor selective antagonist BMY 7378 in comparison with yohimbine at α1- and α2-adrenoceptors. 2 In rat aorta (α1D-adrenoceptor), BMY 7378 (pA2 of 8.67) was about 100 times more potent than yohimbine (pA2 of 6.62) at antagonizing the contractile response to noradrenaline. 3 In human saphenous vein (α2C-adrenoceptor), BMY 7378 (pA2 of 6.48) was approximately 10 times less potent than yohimbine (pA2 of 7.56) at antagonizing the contractile response to noradrenaline. 4 In prostatic portions of rat vas deferens, BMY 7378 (10 μm) did not significantly affect the concentration-dependent inhibition of single pulse nerve stimulation-evoked contractions by xylazine (an action at prejunctional α2D-adrenoceptors). 5 In ligand-binding studies, BMY 7378 showed 10-fold selectivity for α2C-adrenoceptors (pKi of 6.54) over other α2-adrenoceptors. 6 It is concluded that BMY 7378, in addition to α1D-adrenoceptor selectivity in terms of α1-adrenoceptors, shows selectivity for α2C-adrenoceptors in terms of α2-adrenoceptors.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 75
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 To investigate anti-inflammatory activity of organic germanium, we measured the effect of germanium-concentrated yeast on arachidonic acid release, prostaglandin E2 (PGE2) production, histamine release, and intracellular H2O2 or hydroperoxide generation in RBL 2H3 cells, and carrageenan-induced paw oedema in rats. 2 Germanium-concentrated yeast dose-dependently inhibited carrageenan-induced paw oedema, suggesting that germanium-concentrated yeast has anti-inflammatory activity in acute inflammation. 3 Germanium-concentrated yeast significantly inhibited melittin-induced arachidonic acid release and PGE2 production in RBL 2H3 cells. 4 Germanium-concentrated yeast did not affect melittin-induced histamine release and silica-induced intracellular H2O2 or hydroperoxide generation in RBL 2H3 cells. 5 These results suggest that anti-inflammatory activity of germanium-concentrated yeast appears partly to be related to the inhibition of arachidonic acid release and PGE2 production in RBL 2H3 cells.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 76
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The pressor action of noradrenaline and its blockade by selective α1-adrenoceptor antagonists in the pithed mouse were evaluated. 2 Chloroethylclonidine (α1B/D-adrenoceptor alkylating agent) or BMY 7378 (α1D-adrenoceptor antagonist), both at 1 mg kg−1, did not block the increase in blood pressure induced by noradrenaline. 3 5-Methylurapidil (α1A-adrenoceptor antagonist), at 0.1 mg kg−1, displaced the dose–response curve approximately six-fold to the right. 4 The results support the idea that the pithed mouse vasculature express α1A-adrenoceptors and suggest that it is a good model to study the roles of α1-adrenoceptors in gene knockout or overexpression.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 77
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The aim of this paper was to determine the different signalling cascades involved in contraction of the rat urinary bladder detrusor muscle mediated via muscarinic acetylcholine receptors (muscarinic AChR). Contractile responses, phosphoinositides (IPs) accumulation, nitric oxide synthase (NOS) activity and cyclic GMP (cGMP) production were measured to determine the reactions associated with the effect of cholinergic agonist carbachol. The specific muscarinic AChR subtype antagonists and different inhibitors of the enzymatic pathways involved in muscarinic receptor-dependent activation of NOS and cGMP were tested. 2 Carbachol stimulation of M3 and M4 muscarinic AChR increased contractility, IPs accumulation, NOS activity and cGMP production. All of these effects were selectively blunted by 4-DAMP and tropicamide, M3 and M4 antagonists respectively. 3 The inhibitors of phospholipase C (PLC), calcium/calmodulin (CaM), neuronal NOS (nNOS) and soluble guanylate cyclase, but not of protein kinase C and endothelial NOS (eNOS), inhibited the carbachol action on detrusor contractility. These inhibitors also attenuated the muscarinic receptor-dependent increase in cGMP and activation of NOS. 4 In addition, sodium nitroprusside and 8-bromo-cGMP, induced negative relaxant effect. 5 The results obtained suggest that carbachol activation of M3 and M4 muscarinic AChRs, exerts a contractile effect on rat detrusor that is accompanied by an increased production of cGMP and nNOS activity. The mechanism appears to occur secondarily to stimulation of IPs turnover via PLC activation. This in turn, triggers cascade reactions involving CaM, leading to activation of nNOS and soluble guanylate cyclase. They, in turn, exert a modulator inhibitory cGMP-mediated mechanism limiting the effect of muscarinic AChR stimulation of the bladder.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 78
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The objective was to investigate a possible contribution of a nerve-derived hyperpolarizing factor to the differences between non-adrenergic non-cholinergic (NANC) nerve-mediated relaxations in different states of active tone in the rat gastric fundus. 2 NANC relaxations induced by electrical field stimulation (ES: 0.1, 0.5 and 1 Hz; 25 V; 1 ms; 10 s) in 40% contracted strips (S40) were greater when compared with those in 80% contracted strips (S80). 3 ES-induced relaxations were effectively attenuated by Nω-nitro-l-arginine (l-NNA; 100 μm) in S40 and S80. Percentage reduction of the responses obtained in the presence of l-NNA in S40 group was less than that of S80. 4 In S40 group, nifedipine (0.5–1 μm) and verapamil (0.5–1 μm) inhibited the responses to 0.1 and 0.5 Hz. Nifedipine (1 μm) and verapamil (0.5 μm) caused no change in the responses to ES in S80. 5 In S40, when l-NNA (100 μm) and nifedipine or verapamil, either in 1 μm concentration, were administered together, the inhibition on the electrical relaxations were more than that of each drug alone. 6 In conclusion, NANC nerve-mediated relaxations are increased when studied in an active state of 40%, and a factor, sensitive to nifedipine seems to be responsible for this distinction.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 79
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Experiments were carried out to characterize the possible adrenergic properties of the 5-HT1A antagonists WAY 100635 and MM-77 using the mouse isolated vasa deferentia preparation. 2 When vasa deferentia were preincubated for 10 min in the presence of MM-77 (10−8–10−6 m) or WAY100635 (10−8–7 × 10−7 m), a concentration-dependent inhibition of the contractile response to submaximal electrical field stimulation (10 Hz, 50 V, 50 ms) was observed with pIC50 values of 7.05 ± 0.01 and 6.85 ± 0.1 respectively. 3 MM-77 (10−8–10−6 m) antagonized the contractile responses of the vasa deferentia to phenylephrine (PE) (10−6–10−3 m) in a concentration-dependent manner. Schild plots of these data were linear and yielded a mean ρA2 value of 6.81 ± 0.084. The mean slope was 1.42 ± 0.22. 4 WAY100635 (10−8–10−6 m) antagonized the contractile responses of the vasa deferentia to PE (10−6–10−3 m) in a concentration-dependent manner. Schild plots of these data were linear and yielded a mean ρA2 value of 7.05 ± 0.08. The mean slope was 0.97 ± 0.1. 5 The results suggest that while WAY100635 acts as a competitive antagonist at α1-adrenoceptors, MM-77 displays non-competitive antagonist characteristics at this receptor subtype. 6 These results may have important implications for the use of these compounds as 5-HT1A receptor antagonists in in vivo studies.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 80
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The aim of the present study was to examine the modulator influence of muscarinic M2 receptors on responses of rat urinary bladder detrusor muscle evoked by endogenous stimuli, i.e. by stimulation of the bladder innervation. 2 Responses were evoked by electrical field stimulation (EFS; 2–20 Hz, 0.8 ms, 60 V) of isolated strip preparations mounted in organ baths. The tension of the muscle strips was recorded digitally. EFS was performed by applying stimulation with either a short duration (5 s) or a longer duration (to reach peak response; approximately 20 s). 3 Effects of muscarinic receptor antagonists (muscarinic M1/M3 receptor selective: 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP); muscarinic M2 receptor selective: methoctramine), a β-adrenergic antagonist (propranolol) and an adenosine receptor antagonist (8-p-sulfophenyltheophylline) were assessed on contractile activity and on poststimulatory relaxations. 4 Low concentrations of methoctramine (10−8 m) reduced or tended to reduce the EFS-induced contraction, e.g. at 2 Hz by 12% while methoctramine at 10−7 m had no significant effect. In addition, in the presence of 4-DAMP (10−9 m), which tended to inhibit contractions at all frequencies (2–20 Hz; −17 to −25%), methoctramine at 10−8 and 10−7 m induced a further reduction of the contractile responses (−5 to −10%; 2–20 Hz). 5 The β-adrenergic receptor antagonist propranolol (10−6 m) and the adenosine receptor antagonist 8-p-sulfophenyltheophylline (10−6 m) both increased contractile responses by 9–21% (2–10 Hz, long duration; P 〈 0.05–0.001) as a consequence of antagonizing relaxatory stimuli. Neither antagonist affected the contractile responses to EFS with the short duration stimulation. Poststimulatory relaxations were reduced by 30–60% (P 〈 0.05) by propranolol and by 40–60% (P 〈 0.001) by 8-p-sulfophenyltheophylline, but for 8-p-sulfophenyltheophylline only after stimulation with the short duration. 6 In the presence of methoctramine (10−7 m), the 8-p-sulfophenyltheophylline-induced increases of the contractile response to long duration EFS were significantly enhanced at 10 Hz (+12 ± 4%; P 〈 0.05), whereas no such enhancement of the propranolol inhibitory effect occurred in the presence of methoctramine. However, poststimulatory β-adrenoceptor-evoked relaxations after short duration EFS were increased by about 35% in the presence of methoctramine, but not those after long duration. 7 Thus, muscarinic M2 receptor activation inhibits adenosine receptor- and β-adrenoceptor-evoked relaxations of the rat detrusor muscle. The inhibition occurs via a transient postjunctional mechanism that mainly affects responses with a short latency.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 81
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 To clarify the effects of doxapram on the baroreflex, we recorded carotid sinus nerve (CSN) activity in isolated and perfused carotid artery bifurcations of rabbits. 2 The CSN activity due to chemoreceptor stimulation was blocked by resection of the nerve branches from the carotid body. After the resection, the CSN activity was correlated to increase of carotid sinus (CS) pressure. 3 Administration of doxapram reduced the CSN activity originating from baroreceptors. The effect of doxapram on baroreceptors was dose dependent and reversible. 4 It is unlikely that doxapram altered CS wall mechanics because CS pressure did not change in the presence of the drug. 5 We conclude that doxapram acts on the cardiovascular system in part by inhibiting the negative feedback loop that originates in CS baroreceptors.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 82
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Cardiac glycosides have been used for centuries as therapeutic agents for the treatment of heart diaseases. In patients with heart failure, digoxin and the other glycosides exert their positive inotropic effect by inhibiting Na+–K+-ATPase, thereby increasing intracellular sodium, which, in turn, inhibits the Na+/Ca2+ exchanger and increases intracellular calcium levels. As the therapeutic index of digitalis is narrow, arrhythmias are common problems in clinical practice. The mechanisms and mediators of these arrhythmias, however, are not completely understood. 2 The involvement of the sympathetic and parasympathetic nervous system in digitalis cardiac toxicity is reviewed. 3 Receptors, channels, exchange systems or other cellular components involved in digitalis-induced cardiotoxicity are also reviewed. 4 Possible mediators of digitalis-induced cardiac toxicity are discussed. 5 Management of digitalis toxicity in patients is summarized. 6 The determination of the possible mediators of digitalis-induced cardiac toxicity will enhance our knowledge and lead to the development of new therapeutic strategies to treat these lethal arrhythmias.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 83
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Microinjection of peptide YY (PYY) (0.23–2.3 nmol) into the posterior hypothalamic nucleus (PHN) of conscious rats evokes a dose-dependent pressor response and a bradycardia. 2 The increase in mean arterial pressure evoked by 2.3 nmol of PYY was not blocked by intravenous pretreatment with: (i) the nicotinic ganglionic receptor antagonist pentolinium (PENT, 10 mg kg−1) alone, or in combination with the muscarinic receptor antagonist methylatropine (MeATR, 1 mg kg−1); (ii) the α1-adrenoceptor antagonist prazosin (PRAZ, 0.2 mg kg−1); (iii) the V1-vasopressin receptor antagonist [d(CH2)5Tyr(Me)]AVP (AVPX, 20 μg kg−1); (iv) the combination of AVPX, PENT and MeATR; (v) the combination of PRAZ, AVPX, PENT, MeATR, and the α2-adrenoceptor antagonist yohimbine (0.3 mg kg−1); or (vi) the angiotensin II type 1 receptor antagonist ZD 7155 (1 mg kg−1). 3 Adrenal demedullation inhibited the PYY-evoked responses of drug-naïve rats, and rats pretreated with the combination of PENT, MeATR and AVPX. 4 Transection of the splanchnic nerve innervating the adrenal medullae attenuated the bradycardia, as did ZD 7155, but not the PYY-evoked pressor response. 5 Systemic pretreatment of rats with the neuropeptide Y1 receptor antagonist BIBP 3226 (1 mg kg−1) blocked the PYY-evoked cardiovascular changes, but not those evoked by microinjection of carbachol (5.5 nmol) into the PHN. 6 These results suggest that the cardiovascular changes evoked from the PHN by PYY requires the presence of the adrenal medullae, which are stimulated by: (i) a hormone to release an NPY-like substance that evokes the pressor response, and (ii) the splanchnic nerve to evoke the release of a substance that results in the bradycardia.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 84
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 85
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 We examined whether extremely low frequency electromagnetic fields (ELF-EMF) affect the basal level of cardiovascular parameters and influence of drugs acting on the sympathetic nervous system. 2 Male rats were exposed to sham control and EMF (60 Hz, 20 G) for 1 (MF-1) or 5 days (MF-5). We evaluated the alterations of blood pressure (BP), pulse pressure (PP), heart rate (HR), and the PR interval, QRS interval and QT interval on the electrocardiogram and dysrhythmic ratio in basal level and dysrhythmia induced by β-adrenoceptor agonists. 3 In terms of the basal levels, there were no statistically significant differences among control, MF-1 and MF-5 in PR interval, QRS interval, mean BP, HR and PP. However, the QT interval, representing ventricular repolarization, was significantly reduced by MF-1 (P 〈 0.05). 4 (−)-Dobutamine (β1-adrenoceptor-selective agonist)-induced tachycardia was significantly suppressed by ELF-EMF exposure in MF-1 for the increase in HR (ΔHR), the decrease in QRS interval (ΔQRS) and the decrease in QT (ΔQT) interval. Adrenaline (nonselective β-receptor agonist)-induced dysrhythmia was also significantly suppressed by ELF-EMF in MF-1 for the number of missing beats, the dysrhythmic ratio, and the increase in BP and PP. 5 These results indicated that 1-day exposure to ELF-EMF (60 Hz, 20 G) could suppress the increase in HR by affecting ventricular repolarization and may have a down-regulatory effect on responses of the cardiovascular system induced by sympathetic agonists.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 86
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 25 (2005), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Cyclic AMP formation has consistently been reported to be desensitized in various tissues including heart of animal models of end-stage renal failure (ESRF). In contrast, reports on desensitization of cAMP formation in ESRF patients remain contradictory. Whether this discrepancy results from a difference between human ESRF and its animal models or from the use of circulating blood cells in the human and various solid tissues in the animal studies, remains unclear. Therefore, we performed three studies with heart and platelets of ESRF patients undergoing haemodialysis or continuous ambulatory peritoneal dialysis and age- and gender-matched controls with normal renal function (n = 11–13 each). 2 In platelets from haemodialysis patients adenylyl cyclase activity in response to receptor-dependent and -independent agonists was reduced by ≈30%, and this could be explained by an alteration at the level of adenylyl cyclase itself. However, no such desensitization was seen in platelets from peritoneal dialysis patients. 3 In hearts from ESRF patients undergoing haemodialysis, β-adrenoceptor density and subtype distribution, cAMP formation in response to the β-adrenoceptor agonist isoprenaline or various receptor-independent stimuli, were very similar to those in control patients but activity of G-protein-coupled receptor kinase was increased by ≈20%. 4 We conclude that conflicting reports on the desensitization of cAMP formation between ESRF patients and ESRF animal models are not explained by the use of solid tissues in animal studies vs. circulating blood cells in patient studies. Rather desensitization of cAMP formation seems to be a less consistent feature of human ESRF than of its animal models.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 87
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 24 (2004), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 We have compared vasoconstriction responses in isolated mesenteric small arteries from mice and rats as elicited by KCl, noradrenaline and the lysosphingolipids sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC). 2 Contractile responses to KCl and noradrenaline, but not those of S1P or SPC, were significantly related to vessel diameter in both species. 3 When comparing vessels of similar diameter, contractile responses for KCl and the three agonists were much smaller in mice than in rats, e.g. 8.3 ± 0.4 vs. 14.7 ± 0.7 mn for noradrenaline. 4 Based upon the antagonist rank order of potency of prazosin (pKB 8.80) 〉 B8805-033 (pKB 7.89) 〉 yohimbine (pKB 6.18) ≈ BMY 7378 (pA2 6.03), noradrenaline responses in mice were mediated solely via α1A-adrenoceptors, similar to what repeatedly has been shown in rats. 5 The S1P3 receptor antagonist suramin (100 μm) significantly inhibited responses to S1P and SPC in rats but not in mice, and did not affect noradrenaline responses in either species. 6 We conclude that for any given diameter, mouse mesenteric arteries develop less contraction in response to various stimuli. Noradrenaline acts via α1A-adrenoceptors in both species. Responses to S1P and SPC differ between both species with regard to suramin-sensitivity indicating involvement of different receptor subtypes for lysosphingolipids in both species.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 88
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 24 (2004), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 A fructose (Fru)-enriched diet induces a mild increase in blood pressure associated with hyperglycaemia, hypertriglyceridaemia, and insulin resistance, resembling the human ‘syndrome X’, being an useful model to study hypertension and type 2 diabetes. 2 A sustained elevation of blood pressure is associated with cardiovascular structural modifications such as left ventricular hypertrophy and increased wall thickness:lumen diameter ratio in blood vessels. 3 Prostanoids (PR), metabolites of arachidonic acid through the cyclooxygenase pathway, include vasoactive substances synthesized and released by the vessel walls. 4 The aim of the present study was to analyse, in Fru-treated rats: (i) the morphology of mesenteric vessels and; (ii) the PR production in aorta and mesenteric vessels, in order to assess whether these parameters are related with the haemodynamic alterations observed in this experimental model. 5 Blood pressure, glycaemia and triglyceridaemia, were significantly elevated in both (4 and 22 weeks) Fru-treated groups. Meanwhile body and heart weight as well as insulinaemia were similar between experimental animals and controls. 6 The mesenteric vessels of Fru-treated rats (22 weeks) showed an increased thickness and area of the media when compared with the controls; meanwhile, the lumen diameter was similar in both groups. 7 The Fru treatment for 4 weeks did not modify PR production in aorta, whereas in the mesenteric bed it diminished prostaglandin (PG) E2 release significantly compared with the controls. However, in the group treated for 22 weeks, Fru reduced PGI2 production in the aorta, as assessed by 6-keto-PGF1α measurements. Meanwhile, in the mesenteric bed, the chronic Fru treatment decreased PGE2 release but, rather surprisingly, increased the output of PGI2 when compared with its corresponding controls. 8 In conclusion, the present study shows the existence of an alteration in the morphology of mesenteric vessels in Fru-treated rats, which could be related to an increase in peripheral resistance and the consequent mild hypertension observed in this model. However, a diminished release of vasodilator PRs, such as PGE2 in mesenteric vessels at 4 and 22 weeks and PGI2 in aorta at 22 weeks could further impair the vessel response. The increase in PGI2 observed in the chronic group in mesenteric vessels could be attributed to a compensatory mechanism.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 89
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 24 (2004), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Electrical field stimulation (EFS) (0.5 ms in train of 2–32 Hz for 300 ms) in smooth muscle of pigeon oesophagus, in the presence of atropine (1 μm) and guanethidine (1 μm), elicited an inhibitory response consisting of a transient hyperpolarization (inhibitory junction potential, IJP) associated with muscle relaxation. 2 Sodium nitroprusside (SNP, 100 μm) induced hyperpolarization correlated to mechanical relaxation. 3 The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine (from 0.1 to 100 μm) caused a concentration-dependent reduction of electromechanical response to EFS indicating a role for NO in this response. 4 Apamin (1 μm) reduced both IJP and relaxation to EFS but was without effect on the response to SNP indicating a role for purines, which are also blocked by apamin. 5 Adenosine, AMP, ADP and ATP (all from 1 μm to 1 mm) application caused transient hyperpolarization and muscular relaxation with the following order of potency: adenosine 〉 AMP 〉 ADP 〉 ATP. 6 Inhibitory responses evoked by purines are TTX (1 μm) insensitive but they were inhibited by apamin. This indicates that a purine component for the non-adrenergic non-cholinergic (NANC) response exists but the purine receptor site is not located on the neurone. 7 Overall these results suggest that NANC inhibitory response elicited by EFS presents two different components apamin-sensitive, probably purines-mediated and apamin-insensitive probably NO-mediated as apamin only partially block the response to EFS.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 24 (2004), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Sibenadet (Viozan®), a dual dopamine D2/β2-adrenoceptor agonist, suppresses histamine-induced tachypnoea in the dog by activating dopamine D2 receptors. We here compare the effects of sibenadet and formoterol, a selective β2-adrenoceptor agonist, on histamine-induced tachypnoea in the rhesus monkey. 2 Anaesthetized, spontaneously breathing, rhesus monkeys were set up for measuring airways resistance, respiratory rate, blood pressure and heart rate. 3 Both sibenadet and formoterol administered by aerosol, induced inhibition of the bronchoconstrictor response to aerosolized methacholine accompanied by tachycardia. Sibenadet, but not formoterol, also reduced blood pressure. 4 Administration of histamine by inhalation induced tachypnoea which was accompanied by bronchoconstriction. Tachypnoea to histamine was suppressed by both sibenadet and formoterol at doses which manifest anti-bronchoconstrictor activity. These effects and the accompanying tachycardia but not the hypotension induced by sibenadet were abolished by pretreatment with propranolol. 5 The dopamine D2 receptor agonist, quinagolide, did not suppress tachypnoea to histamine despite inducing a fall in blood pressure indicating activation of dopamine D2 receptors. 6 Thus, both sibenadet and formoterol suppress histamine-evoked tachypnoea in the rhesus monkey. The effect arises exclusively through activation of β2-adrenoceptors and probably reflects the anti-bronchoconstrictor effects of these agents. The results reveal a fundamental difference in the role of dopamine receptors in the airways of dog and rhesus monkey.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The present survey is dealing with the interactions between the renin–angiotensin–aldosterone system (RAAS) and the sympathetic nervous system (SNS) in various organs and tissues, with an emphasis on the angiotensin AT-receptors located at the sympathetic nerve endings. 2 Angiotensin II, the main effector of the RAAS is known to stimulate sympathetic nerve traffic and its sequelae in numerous organs and tissues, such as the central nervous system, the adrenal medulla, the sympathetic ganglia and the sympathetic nerve endings. These stimulatory effects are mediated by AT1-receptors and counteracted by AT1-receptor antagonists. 3 Sympatho-inhibition at the level of the sympathetic nerve ending appears to be a class effect of the AT1-receptor blockers, mediated by presynaptic AT1-receptors. With respect to the ratio pre-/postsynaptic AT1-receptor antagonism important quantitative differences between the various compounds were found. 4 Both the pre- and postjunctional receptors at the sympathetic nerve endings belong to the AT1-receptor population. However, the presynaptic receptors belong to the AT1B-subtype, whereas the postjunctional receptors probably belong to a different AT1-receptor subpopulation. 5 Sympatho-inhibition is a class effect of the AT1-receptor antagonists. In conditions in which the SNS plays a pathophysiological role, such as hypertension and congestive heart failure, this property may well be of therapeutic relevance.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The psychostimulant constituent of khat leaves, S-(−)-cathinone, was examined for vascular activity on the coronary vasculature of guinea-pig-isolated perfused hearts and aortic ring preparations. 2 Cathinone caused coronary vasoconstriction, negative inotropy and negative chronotropy in isolated hearts. The major metabolite of cathinone after its ingestion, 1R.2S-(−)-norephedrine (norephedrine), also caused coronary vasoconstriction comparable with that by cathinone. Norephedrine, however, had no effect on force or rate of cardiac contractions. 3 Cocaine (10 μm) potentiated the coronary vasoconstriction and positive inotropy by noradrenaline indicating inhibition of neuronal uptake. The vasoconstriction and negative inotropy by cathinone, however, were not affected, indicating that its action was not via release of noradrenaline from sympathetic neurones. 4 The α1-adrenoceptor antagonist, prazosin, blocked the vasoconstriction by noradrenaline, but not that produced by cathinone in the presence of cocaine. This indicates that the coronary vasoconstriction by cathinone was not due to an action on α1-adrenoceptors either directly or indirectly through noradrenaline release. 5 Three repeated doses of cathinone displayed the same coronary vasoconstrictor responses, indicating a lack of tachyphylaxis and therefore confirming that the response was unlikely to be due to indirect sympathomimetic activity through release of noradrenaline. 6 In guinea-pig aortic rings, the order of vasoconstrictor activity was: noradrenaline 〉 norephedrine 〉 cathinone, with each causing approximately equivalent maximum responses. The time to reach plateau contractions was shortest for noradrenaline (5.1 ± 0.5 min), then norephedrine (9.3 ± 1.5 min) and cathinone the longest (25.4 ± 3.2 min, 335 μm dose). 7 These results indicate that cathinone has vasoconstrictor activity which is not due to indirect or direct sympathomimetic activity. The precise mechanism for this vasoconstriction remains to be determined. The coronary vasoconstriction may explain the increased incidence of myocardial infarction in khat chewers, which may arise from coronary vasospasm.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 A variety of prostanoids were examined for their ability to alter the periarterial nerve stimulation-induced release of noradrenaline (NA) and neuropeptide Y immunoreactive compounds (NPY-ir) from the perfused mesenteric arterial bed of the rat. 2 Periarterial nerve stimulation (16 Hz) increased the overflow of NA, NPY-ir and perfusion pressure. 3 The prostacyclin (PGI2) analogues, carbaPGI2 and cicaprost both produced a concentration-dependent attenuation of the nerve stimulation-induced increase in NA, NPY-ir overflow and perfusion pressure. 4 The prostaglandin (PG) analogue PGE2 attenuated the evoked increase in NPY-ir overflow as well as a modest decrease in NA. 5 PGE1, sulprostone and iloprost attenuated the nerve stimulation-induced increase in NA overflow but not NPY-ir. 6 Neither PGF2α nor the thromboxane A2 analogue U46619 altered the evoked increase in NA or NPY-ir overflow. 7 The results support the view that sympathetic co-transmitter release can be differentially modulated by paracrine/autocrine mediators at sympathetic neuroeffector junctions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Experiments were undertaken to determine if the imidazoline/α2-adrenoceptor agonist, rilmenidine, would produce mydriasis in cats and, if so, to delineate its site of action and determine if this effect is mediated by imidazoline receptors or α2-adrenoceptors. 2 Rilmenidine produced dose-related pupillary dilator responses in pentobarbital anaesthetized cats that were independent of sympathetic innervation to the iris but were dependent upon intact parasympathetic neuronal tone. The ED50 for rilmenidine-induced pupillary dilation was approximately 200 μg kg−1, i.v., and was sustained for at least 1 h. 3 The highly selective α2-adrenoceptor antagonist, RS-79948, administered either before or after rilmenidine, antagonized rilmenidine-induced mydriasis. Neuronally induced reflex inhibition of parasympathetic nerve activity was also inhibited by administration of RS-79948. 4 These results suggest that rilmenidine acts like clonidine to produce pupillary dilation by inhibition of parasympathetic tone to the iris sphincter and that this central nervous system parasympatho-inhibition is mediated by α2-adrenoceptors, rather than imidazoline receptors.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Increasing evidence indicates the occurrence of functional interconnections between immune and nervous systems, although data available on the mechanisms of this bi-directional cross-talking are frequently incomplete and not always focussed on their relevance for neuroimmune modulation.
2 Primary (bone marrow and thymus) and secondary (spleen and lymph nodes) lymphoid organs are supplied with an autonomic (mainly sympathetic) efferent innervation and with an afferent sensory innervation. Anatomical studies have revealed origin, pattern of distribution and targets of nerve fibre populations supplying lymphoid organs.
3 Classic (catecholamines and acetylcholine) and peptide transmitters of neural and non-neural origin are released in the lymphoid microenvironment and contribute to neuroimmune modulation. Neuropeptide Y, substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide represent the neuropeptides most involved in neuroimmune modulation.
4 Immune cells and immune organs express specific receptors for (neuro)transmitters. These receptors have been shown to respond in vivo and/or in vitro to the neural substances and their manipulation can alter immune responses. Changes in immune function can also influence the distribution of nerves and the expression of neural receptors in lymphoid organs.
5 Data on different populations of nerve fibres supplying immune organs and their role in providing a link between nervous and immune systems are reviewed. Anatomical connections between nervous and immune systems represent the structural support of the complex network of immune responses. A detailed knowledge of interactions between nervous and immune systems may represent an important basis for the development of strategies for treating pathologies in which altered neuroimmune cross-talking may be involved.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 Calcium/calmodulin-dependent protein kinase II (CaMKII) has an important function in mediating insulin release but its role in the development of diabetes-induced cardiovascular complications is not known. 2 We investigated the ability of a chronic administration of KN-93 (5 mg kg−1alt diem for 4 weeks), an inhibitor of CaMKII, to modulate the altered vasoreactivity of the perfused mesenteric bed to common vasoconstrictors and vasodilators in streptozotocin (STZ)-induced diabetes. 3 The vasoconstrictor responses induced by noradrenaline (NE), endothelin-1 (ET-1), and angiotensin II (Ang II), were significantly increased whereas, vasodilator responses to carbachol and histamine were significantly reduced in the perfused mesenteric bed of the STZ-diabetic rats as compared with non-diabetic controls. 4 Inhibition of CaMKII by KN-93 treatment did not affect blood glucose levels but produced a significant normalization of the altered agonist-induced vasoconstrictor and vasodilator responses. KN-93 did not affect agonist-induced responses in control animals. In addition, KN-93 significantly reduced weight loss in diabetic rats. 5 The present data suggest that CaMKII is an essential mediator in the development of diabetic vascular dysfunction and may also play an important role in signalling pathways leading to weight loss during diabetes.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 There is good evidence that β-blockers improve ventricular function, disease progression and survival in patients with left ventricular systolic dysfunction. The aim of this study was to determine the effects of atenolol therapy on the sympathetic nervous system at rest and after ergometric exercise, on left ventricular function and on baseline plasma atrial natriuretic factor (ANF) in ambulatory patients with chronic heart failure (CHF). 2 Twenty-two patients [left ventricular ejection fraction (LVEF) 〈36%; New York Heart Association II–III] were studied before atenolol treatment. Because of cardiac events (new Hospital admission or death) only 13 patients completed 1 year of treatment. Baseline noradrenaline (NE) concentrations were similar in patients and controls while ANF was higher in patients than in controls (328 ± 35 pg ml−1vs. 37 ± 3 pg ml−1; P 〈 0.01). 3 Patients with events showed higher NE (540 ± 87 pg ml−1vs. 303 ± 44 pg ml−1; P 〈 0.01) and ANF (460 ± 70 pg ml−1vs. 291 ± 44 pg ml−1; P 〈 0.03) at rest; and greater NE response to exercise (2.003 ± 525 pg ml−1vs. 694 ± 121 pg ml−1; P 〈 0.005). Atenolol treatment improved LVEF (19.5 ± 1.9%vs. 33 ± 3.9%; P 〈 0.001), increased exercise tolerance (9 ± 3.2 min vs. 17 ± 4.8 min; P 〈 0.001) and decreased plasma ANF (292 ± 42 pg ml−1vs. 133 ± 35 pg ml−1; P 〈 0.01). 4 Reduced basal dihydroxyphenylglycol (DHPG)/NE ratio (3.4 ± 0.46 vs. 4.3 ± 0.35; P 〈 0.01) was observed in patients compared with healthy volunteers. Atenolol increased DHPG plasma levels (1.398 ± 129 pg ml−1vs. 913 ± 86 pg ml−1; P 〈 0.005) but the DHPG/NE ratio during exercise was not modified after treatment, suggesting that re-uptake of released NE is not changed by β-blocker treatment. 5 In conclusion, the fact that atenolol treatment improves ventricular dysfunction and clinical status without changing plasma NE levels in CHF patients, suggests that plasma NE is a poor surrogate measurement for cardiac sympathetic activity in this pathology. In addition, decrease in plasma ANF produced by atenolol treatment may reflect the improvement of ventricular function.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Notizen: 1 The aim of the study was to investigate the role of the α1D-adrenoceptor in α1-adrenoceptor-induced contraction of human prostate by means of protection experiments. 2 Responses of human prostate strips to noradrenaline were recorded, along with responses of rat aorta and vas deferens, tissues possessing predominantly α1D- and α1A-adrenoceptors respectively, for comparison. α1-adrenoceptors were then inactivated by incubation with the irreversible antagonist phenoxybenzamine. In some tissues α1A- or α1D-adrenoceptors were ‘protected’ from inactivation by incubation in the presence of the selective α1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline. 3 Phenoxybenzamine reduced the maximum noradrenaline-induced response and the potency of noradrenaline in all tissues. In rat vas deferens and human prostate, 5-methylurapidil protected α1A-adrenoceptors in a concentration–dependent manner. In rat aorta, 10 nm BMY 7378 almost fully protected α1D-adrenoceptors. However, concentrations of BMY 7378 up to 30-fold higher failed to protect receptors in the human prostate. 4 These results suggest that in human prostate functional α1D-adrenoceptors do not contribute to noradrenaline-induced contractile responses.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    ISSN: 1474-8673
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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