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  • Books  (73)
  • Articles  (3,756,880)
  • Medicine  (3,507,094)
  • Technology  (266,498)
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  • Books  (73)
  • Journals  (2,899)
  • Articles  (3,756,880)
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  • 1
    Unknown
    Berlin, Heidelberg : Springer
    Keywords: Biochemistry ; Toxicology
    ISBN: 9783540331209
    Language: English
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  • 2
    Unknown
    Berlin, Heidelberg : Springer
    Keywords: Biochemistry ; Chemistry, Organic ; Medicine ; Toxicology
    ISBN: 9783540797296
    Language: English
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  • 3
    Unknown
    New York, NY : Springer
    Keywords: Chemistry, Organic ; Food science
    ISBN: 9780387740874
    Language: English
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  • 4
    Unknown
    Boston, MA : Springer
    Keywords: Chemistry ; Food science
    ISBN: 9780387249803
    Language: English
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  • 5
    Keywords: Chemistry ; Food science ; Immunology
    ISBN: 9780387283913
    Language: English
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  • 6
    Unknown
    Berlin, Heidelberg : Springer
    Keywords: Biochemistry ; Chemistry, Organic ; Medicine ; Toxicology
    ISBN: 9783540742296
    Language: English
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  • 7
    Keywords: Life sciences ; Science ; Urban planning ; City planning ; Urban ecology (Biology) ; System theory ; International environmental law ; Sustainable development ; Life Sciences ; Urban Ecology ; Urbanism ; Sustainable Development ; Complex Systems ; Science, general ; International Environmental Law
    Description / Table of Contents: 1. A global outlook on urbanization --- 2. History of urbanization and the missing ecology --- 3. Urbanization and global trends in biodiversity and ecosystem services --- 4. Regional assessment of Asia.- 5. Sub-regional assessment of China: Urbanization in biodiversity hotspots --- 6. Sub-regional assessment of India --- 7. Local assessment of Bangalore.- 8. Local assessment of Tokyo --- 9. Local assessment of Shanghai --- 10. Patterns and trends in urban biodiversity and landscape design --- 11. Urban ecosystem services.- 12. Shrinking cities, biodiversity and ecosystem services --- 13. Regional assessments of Europe --- 14. Regional assessment of North America --- 15. Regional assessment of Oceania --- 16. Local assessment of Istanbul: Biodiversity and ecosystem services --- 17. Local assessment of Stockholm --- 18. Local assessment of Chicago --- 19. Local assessment of New York City.-20. Local assessment of Melbourne --- 21. A synthesis of global urbanization projections --- 22. Urbanization forecasts, effects on land use, biodiversity, and ecosystem services --- 23. Regional assessment of Africa --- 24. Local assessment of Cape Town.- 25. Climate change and urban biodiversity vulnerability --- 26. Feeding cities --- 27. Urban governance of biodiversity and ecosystem services --- 28. Regional assessment of Latin America --- 29. Local assessment of Rio de Janeiro.- 30. Urban landscapes as learning arenas for biodiversity and ecosystem services management --- 31. Restoration ecology in an urbanizing world --- 32. Indicators for management of urban biodiversity and ecosystem services --- 33. Stewardship of the Biosphere in the Urban Era
    Pages: Online-Ressource (XXVIII, 755 pages) , 150 illustrations, 23 illustrations in color
    ISBN: 9789400770881
    Language: English
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  • 8
    Keywords: Life sciences ; Cell biology ; Developmental biology ; Plant science ; Botany ; Life Sciences ; Developmental Biology ; Plant Sciences ; Cell Biology
    Description / Table of Contents: Part 1 Sperm Attraction, Activation and Acrosome Reaction --- 1 Sperm Chemotaxis: The First Authentication Events Between Conspecific Gametes Prior to Fertilization (Manabu Yoshida) --- 2 Respiratory CO2 Mediates Sperm Chemotaxis in Squids (Noritaka Hirohashi) --- 3 Specific Mechanism of Sperm Storage in Avian Oviducts (Tomohiro Sasanami) --- 4 Allurin: Exploring the Activity of a Frog Sperm Chemoattractant in Mammals (Douglas E. Chandler) --- 5 Structure, Function and Phylogenetic Consideration of Calaxin (Kazuo Inaba) --- 6 Cl- Channels and Transporters in Sperm Physiology (Alberto Darszon) --- 7 Equatorin-related Subcellular and Molecular Events During Sperm Priming for Fertilization in Mice (Kiyotaka Toshimori) --- 8 Acrosome Reaction-mediated Motility Initiation that is Critical for the Internal Fertilization of Urodele Amphibians (Akihiko Watanabe) --- 9 Analysis of the Mechanism that Brings Protein Disulfide Isomerase-P5 to Inhibit Oxidative Refolding of Lysozyme (Miho Miyakawa) --- Part 2 Gametogenesis, Gamete Recognition, Activation, and Evolution --- 10 Effect of Relaxin-like Gonad-Stimulating Substance (GSS) on Gamete Shedding and 1-Methyladenine Production in Starfish Ovaries (Masatoshi Mita) --- 11 Incapacity of 1-Methyladenine Production to Relaxin-like Gonad-Stimulating Substance (GSS) in Ca2+-free Seawater-treated Starfish Ovarian Follicle Cells (Masatoshi Mita) --- 12 Novel Isoform of Vitellogenin Expressed in Eggs is a Binding Partner of the Sperm Proteases, HrProacrosin and HrSermosin, in the Ascidian Halocynthia roretzi (Hitoshi Sawada) --- 13 Actin Cytoskeleton and Fertilization in Starfish Eggs (Luigia Santella) --- 14 Focused Proteomics on Egg Membrane Microdomains to Elucidate the Cellular and Molecular Mechanisms of Fertilization in the African Clawed Frog Xenopus laevis (Ken-ichi Sato) --- 15 Egg Activation in Polyspermy: Its Molecular Mechanisms and Evolution in Vertebrates (Yasuhiro Iwao ) --- 16 ATP Imaging in Xenopus laevis Oocyte (Takashi Ijiri) --- 17 Mitochondrial Activation and Nitric Oxide (NO) Release at Fertilization in Echinoderm Eggs (Tatsuma Mohri) --- 18 Functional Roles of Spe Genes in the Male Germline During Reproduction of Caenorhabditis elegans (Hitoshi Nishimura) --- 19 Origin of Female/Male Gender as Deduced by the Mating Type Loci of the Colonial Volvocalean Greens (Hisayoshi Nozaki) --- Part 3 Allorecognition in Male–Female Interaction --- 20 Allorecognition and Lysin Systems During Ascidian Fertilization (Hitoshi Sawada) --- 21 Self-incompatibility in the Brassicaceae (Megumi Iwano) --- 22 Signalling Events in Pollen Acceptance or Rejection in the Arabidopsis Species (Daphne R. Goring) --- 23 Papaver rhoeas S-Determinants and the Signaling Networks they Trigger (Vernonica E. Franklin-Tong ) --- 24 S-RNase-based Self-incompatibility in Petunia: A Complex Non-self Recognition System Between Pollen and Pistil (Teh-hui Kao) --- 25 Self-incompatibility System of Ipomoea trifida, a Wild-type Sweet Potato (Tohru Tsuchiya) --- Part 4 Male–Female Interaction and Gamete Fusion --- 26 Profiling the GCS1-based Gamete Fusion Mechanism (Toshiyuki Mori) --- 27 Fertilization Mechanisms of the Rodent Malarial Parasite Plasmodium berghei (Makoto Hirai) --- 28 Sexual Reproduction of a Unicellular Charophycean Alga, Closterium peracerosum-strogosum-littorale Complex (Hiroyuki Sekimoto) --- 29 Fertilization of Brown Algae: Flagellar Function in Phototaxis and Chemotaxis (Taizo Motomura ) --- 30 Gene and Protein Expression Profiles in Rice Gametes and Zygotes: A Cue for Understanding the Mechanisms of Gametic and Early Zygotic Development in Angiosperms (Takashi Okamoto) --- 31 Role of CD9 in Sperm-Egg Fusion and Virus-induced Cell Fusion in Mammals (Kenji Miyado) --- 32 The Mechanism of Sperm-Egg Fusion in Mouse and the Involvement of IZUMO1 (Naokazu Inoue) --- 33 A ZP2 Cleavage Model of Gamete Recognition and the Post-fertilization Block to Polyspermy (Jurrien Dean) --- 34 Involvement of Carbohydrate Residues of the Zona Pellucida in In Vitro Sperm Recognition in Pigs and Cattle (Naoto Yonezawa) --- Part 5 Organella, Proteolysis, and New Techniques --- 35 The Role of Peroxisomes in Plant Reproductive Processes (Shoji Mano) --- 36 Regulation of Vacuole-mediated Programmed Cell Death During Innate Immunity and Reproductive Development in Plants (Tomoko Koyano) --- 37 Sperm Proteasomes as a Putative Egg Coat Lysin in Mammals (Peter Sutovsky) --- 38 Germline Transformation in the Ascidian Ciona intestinalis (Yasunori Sasakura) --- BM Index.  
    Pages: Online-Ressource (XII, 480 pages) , 127 illustrations, 102 illustrations in color
    ISBN: 9784431545897
    Language: English
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  • 9
    Keywords: medical geology
    Description / Table of Contents: All living organisms are composed of major, minor, and trace elements, given by nature and supplied by geology. Medical geology is a rapidly growing discipline dealing with the influence of natural geological and environmental risk factors on the distribution of health problems in humans and animals. As a multi-disciplinary scientific field, medical geology has the potential of helping medical and public health communities all over the world in the pursuit of solutions to a wide range of environmental and naturally induced health issues. The natural environment can impact health in a variety of ways. The composition of rocks and minerals are imprinted on the air that we breathe, the water that we drink, and the food that we eat. For many people this transference of minerals and the trace elements they contain is beneficial as it is the primary source of nutrients (such as calcium, iron, magnesium, potassium, and about a dozen other elements) that are essential for a healthy life. However, sometimes the local geology can cause significant health problems because there is an insufficient amount of an essential element or an excess of a potentially toxic element (such as arsenic, mercury, lead, fluorine, etc.), or a harmful substance such as methane gas, dust-sized particles of asbestos, quartz or pyrite, or certain naturally occurring organic compounds. Current and future medical geology concerns include: dangerous levels of arsenic in drinking water in dozens of countries including the USA; mercury emissions from coal combustion and its bioaccumulation in the environment; the impacts of mercury and lead mobilizations in regions were artisanal gold mining is conducted; the residual health impacts of geologic processes such as volcanic emissions, earthquakes, tsunamis, hurricanes, and geogenic dust; exposure to fibrous minerals such as asbestos and erionite; and the health impacts of global climate change. Billions of people, most in developing countries, are afflicted by these and other environmental health issues that can be avoided, prevented, mitigated or minimized through research and educational outreach. This Special Issue of Geosciences discusses recent advances in medical geology, providing examples from research conducted all over the world. Among the topics to be discussed are: - Health effects from trace elements, metals and metalloids - Regional and global impacts of natural dust (including the study of nanoparticles) - Chemical and environmental pathology of diseases associated with natural environment - Novel analytical approaches to the study of natural geochemical and environmental agents - Research on beneficial health aspects of natural geological materials - Risk management, risk communication and risk mitigation on medical geology - Remote sensing and GIS applications on medical geology - Epidemiology and public health studies on medical geology - Climate change and medical geology - Clinical and toxicological research on biomarkers of exposure - Veterinary medical geology - Biosurveillance and biomonitoring studies on medical geology
    Pages: Online-Ressource (XIV, 238 Seiten)
    Edition: Printed Edition of the Special Issue Published in Geosciences
    ISBN: 9783038421986
    Language: English
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  • 10
    Keywords: Life sciences ; Ecology ; Wildlife ; Fish ; Life Sciences ; Fish & Wildlife Biology & Management ; Ecology ; Environmental Monitoring/Analysis
    Description / Table of Contents: 1 Introduction: Overview of Our Research on Impacts of the Fukushima Dai-ichi Nuclear Power Plant Accident on Fish and Fishing Grounds --- Part I Seawater and Plankton --- 2 134Cs and 137Cs in the Seawater Around Japan and in the North Pacific --- 3 Temporal Changes in 137Cs Concentration in Zooplankton and Seawater off the Joban–Sanriku Coast, and in Sendai Bay, After the Fukushima Dai-ichi Nuclear Accident --- Part II Sediments and Benthos --- 4 Three-Dimensional Distribution of Radiocesium in Sea Sediment Derived from the Fukushima Dai-ichi Nuclear Power Plant --- 5 Radiocesium Concentrations in the Organic Fraction of Sea Sediments --- 6 Bottom Turbidity, Boundary Layer Dynamics, and Associated Transport of Suspended Particulate Materials off the Fukushima Coast --- 7 Investigation of Radiocesium Translation from Contaminated Sediment to Benthic Organisms --- Part III Marine Fish --- 8 Detection of 131I, 134Cs, and 137Cs Released into the Atmosphere from FNPP in Small Epipelagic Fishes, Japanese Sardine and Japanese Anchovy, off the Kanto Area, Japan --- 9 Radiocesium Concentration of Small Epipelagic Fishes (Sardine and Japanese Anchovy) off the Kashima-Boso Area --- 10 Why Do the Radionuclide Concentrations of Pacific Cod Depend on the Body Size? --- 11 Radiocesium Contamination Histories of Japanese Flounder (Paralichthys olivaceus) After the 2011 Fukushima Nuclear Power Plant Accident --- Part IV Mechanisms of Severe Contamination in Fish --- 12 Evaluating the Probability of Catching Fat Greenlings (Hexagrammos otakii) Highly Contaminated with Radiocesium off the Coast of Fukushima --- 13 Analysis of the Contamination Process of the Extremely Contaminated Fat Greenling by Fukushima-Derived Radioactive Material --- 14 Contamination Levels of Radioactive Cesium in Fat Greenling Caught at the Main Port of the Fukushima Dai-ichi Nuclear Power Plant --- Part V Freshwater Systems --- 15 Comparison of Radioactive Cesium Contamination of Lake Water, Bottom Sediment, Plankton, and Freshwater Fish Among Lakes of Fukushima Prefecture, Japan, After the Fukushima Fallout --- 16 Radiocesium Concentrations and Body Size of Freshwater Fish in Lake Hayama 1 Year After the Fukushima Dai-Ichi Nuclear Power Plant Accident --- 17 Spatiotemporal Monitoring of 134Cs and 137Cs in Ayu, Plecoglossus altivelis, a Microalgae-Grazing Fish, and in Their Freshwater Habitats in Fukushima --- 18 Radiocesium Concentrations in the Muscle and Eggs of Salmonids from Lake Chuzenji, Japan, After the Fukushima Fallout --- 19 Assessment of Radiocesium Accumulation by Hatchery-Reared Salmonids After the Fukushima Nuclear Accident
    Pages: Online-Ressource (XI, 238 pages) , 103 illustrations, 37 illustrations in color
    ISBN: 9784431555377
    Language: English
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  • 11
    Keywords: Life sciences ; Management ; Industrial management ; Geography ; Agriculture ; Agricultural economics ; Life Sciences ; Agriculture ; Agricultural Economics ; Geography, general ; Innovation/Technology Management
    Description / Table of Contents: Foreword --- 1. Innovation for Marginalized Smallholder Farmers and Development: an Overview and Implications for Policy and Research --- Part 1 Innovation for the Rural Poor: Theory, Trends and Impacts --- 2. Institutional and technological innovations in polycentric systems –pathways for escaping marginality --- 3. Innovations for Food and Nutrition Security: Impacts and Trends --- 4. Psychology of Innovation: Innovating human psychology? --- 5. An optimization model for technology adoption of marginalized smallholders --- Part 2 Diversification of Agricultural Production and Income --- 6. The BRAC Approach to Small Farmers' Innovations --- 7. Agricultural Research and Extension Linkages in Amhara Region, Ethiopia --- 8. Transaction costs on the Ethiopian formal seed market and innovations for encouraging private sector investments --- 9. Agricultural Service Delivery Through Mobile Phone: Local innovations and Technological Opportunities in Kenya --- 10. Identification and Acceleration of Farmer Innovativeness in Upper East Ghana --- 11. Gender, social equity and innovations in smallholder farming systems: pitfalls and pathways --- 12. Assessing the Sustainability of Agricultural Technology Options for Poor Rural Farmers --- 13. Land Degradation and Sustainable Land Management Innovations in Central Asia --- 14. Biomass-based value web. A Novel Perspective for Emergng Bioeconomies in Sub-Saharan Africa --- Part 3 Sustainable Intensification of Agriculture --- 15. Adoption of Stress-tolerant Rice Varieties in Bangladesh --- 16. More than cereal based cropping innovations for improving food and livelihood security of poor small holders in marginal areas of Bangladesh --- 17. Integrated Rice-fish Farming System in Bangladesh: An Ex-Ante Value Chain Evaluation Framework --- 18. Technologies for Maize, Wheat, Rice and Pulses in Marginal Districts of Odisha and Bihar --- 19. Technological Innovations for Smallholder Farmers in Ghana --- 20. Potential impacts of yield increasing crop technologies on poverty reduction in two districts of Ethiopia
    Pages: Online-Ressource (XV, 435 pages) , 80 illustrations, 50 illustrations in color
    ISBN: 9783319257181
    Language: English
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  • 12
    Keywords: Life sciences ; Applied ecology ; Biodiversity ; Ecosystems ; Conservation biology ; Ecology ; Community psychology ; Environmental psychology ; Life Sciences ; Applied Ecology ; Biodiversity ; Conservation Biology/Ecology ; Ecosystems ; Community and Environmental Psychology
    Description / Table of Contents: 1. The Biodiversity Data Impediment to a Sustainable World (Working in a Networked World) --- 2. Essential Biodiversity Variables --- 3. Stratification and Terrestrial Ecosystem Observations --- 4. Ecosystem Services --- 5. Species Observations --- 6. Monitoring Changes in Genetic Diversity --- 7. Marine and Coastal Systems --- 8. Biodiversity Observations for Freshwater Ecosystems --- 9. Remote Sensing for Biodiversity --- 10. Involving Citizen Scientists in Biodiversity Observation --- 11. Biodiversity Modelling --- 12. Cyber-Architecture --- 13. Using Data for Decision-Making: From Observations To Indicators and Other Policy Tools --- 14. Capacity Building in Biodiversity Monitoring – Case Studies
    Pages: Online-Ressource (XII, 326 pages) , 34 illustrations, 27 illustrations in color
    ISBN: 9783319272887
    Language: English
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  • 13
    Keywords: Life sciences ; Agriculture ; Climate change ; Environmental management ; Soil science ; Soil conservation ; Air pollution ; Life Sciences ; Agriculture ; Climate Change ; Atmospheric Protection/Air Quality Control/Air Pollution ; Soil Science & Conservation ; Environmental Management
    Description / Table of Contents: Chapter 1 Introduction to the SAMPLES Approach --- Chapter 2 Targeting Landscapes to Identify Mitigation Options --- Chapter 3 Determining Greenhouse Gas Emissions and Removals Associated with Land Use and Land Cover Change --- Chapter 4 Quantifying Greenhouse Gas Emissions from Managed and Natural Soils --- Chapter 5 A Comparison of Methodologies for Measuring Methane Emissions from Ruminants --- Chapter 6 Quantifying Tree Biomass Carbon Stocks and Fluxes in Agricultural Landscapes --- Chapter 7 Methods for Smallholder Quantification of Soil Carbon Stocks and Stock Changes --- Chapter 8 Yield Estimation of Food and Non-Food Crops in Smallholder Production Systems --- Chapter 9 Scaling Point and Plot Measurements of Greenhouse Gas Fluxes, Balances and Intensities to Whole Farms and Landscapes --- Chapter 10 Methods for Environment-Productivity Trade-off Analysis in Agricultural Systems
    Pages: Online-Ressource (XV, 203 pages) , 33 illustrations, 27 illustrations in color
    ISBN: 9783319297941
    Language: English
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  • 14
    Unknown
    Cham : Springer
    Keywords: Medicine ; Human genetics ; Ethics ; Medical ethics ; Biomedicine ; Human Genetics ; Theory of Medicine/Bioethics ; Ethics
    Description / Table of Contents: This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved
    Pages: Online-Ressource (XV, 267 pages)
    ISBN: 9783319184289
    Language: English
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  • 15
    Keywords: Life sciences ; Agriculture ; Plant biochemistry ; Plant genetics ; Life Sciences ; Plant Genetics & Genomics ; Agriculture ; Plant Biochemistry
    Description / Table of Contents: Part I Wheat Genetics: Past, Present, and Future --- 1 Prof. H. Kihara’s genome concept and advancements in wheat cytogenetics in his school --- 2 How a gene from Japan revolutionized the world of wheat: CIMMYT’s quest for combining genes to mitigate threats to global food security --- Part II Germplasm and Genetic Diversity --- 3 Genetic resources of Triticum --- 4 Development of core set of wheat (Triticum spp.) germplasm conserved in the National Genebank in India --- 5 Transfer to wheat of potentially new stem rust resistance genes from Aegilops speltoides --- 6 Genetic variation and its geographical distribution in Aegilops caudata L.: morphology, hybrid sterility and gametocidal genes --- Part III Cytogenetics and Allopolyploid Evolution --- 7 Wheat chromosome analysis --- 8 New aneuploids of common wheat --- 9 Chromosomal changes over the course of polyploid wheat evolution and domestication --- Part IV Toward Whole Genome Sequencing --- 10 Comprehensive functional analyses of expressed sequence tags in common wheat --- 11 Development of the BAC physical maps of wheat chromosome 6B for its genomic sequencing --- Part V Structural and Functional Genomics --- 12 Sequencing of wheat chromosome 6B: toward functional genomics --- 13 Genetic mechanisms of vernalization requirement duration in winter wheat cultivars --- 14 Building ultra-dense genetic maps in the presence of genotyping errors and missing data --- Part VI Functional Gene Analysis and Molecular Tools --- 15 Exploiting comparative biology and genomics to understand a trait in wheat, Ph1 --- 16 The specific features of anthocyanin biosynthesis regulation in wheat --- 17 Association of wheat miRNAs with hybrid incompatibility in interspecific crosses of Triticum and Aegilops --- 18 High efficiency wheat transformation mediated by Agrobacterium tumefaciens --- 19 extra early-flowering (exe) mutants in einkorn wheat generated by heavy-ion beam irradiation --- Part VII Biotic Stress Response --- 20 Stem rust resistance - two approaches --- 21 Germplasm enhancement for resistance to Pyrenophora tritici-repentis in wheat --- 22 Next Generation Sequencing enabled genetics in hexaploid wheat --- Part VIII Abiotic Stress Response --- 23 Genomics approaches to dissect the genetic basis of drought resistance in durum wheat --- 24 Hybrid breeding in wheat --- 25 Broadening the genetic diversity of common and durum wheat for abiotic stress tolerance breeding --- 26 Early maturity in wheat for adaptation to high temperature stress --- 27 Gene expression profiles involved in development of freezing tolerance in common wheat --- Part IX Improvement of Grain Quality --- 28 Coping with wheat quality in a changing environment - Proteomics evidence for stress caused by environmental changes --- 29 Starch modification: a model for wheat MAS breeding --- 30 Quality characteristics of soft kernel durum - a new cereal crop --- 31 Proposal of international gluten research group --- 32 Enlargement of the genetic diversity for grain quality in bread wheat through alien introgression --- 33 Complex G x E interactions and QTL clusters govern end-use quality traits in hexaploid wheat --- 34 A consistent QTL for flour yield on chromosome 3B in the soft winter wheat variety, Kitahonami --- Part X Marker-Assisted Breeding --- 35 Recent improvements in Japanese wheat varieties --- 36 Determining the order of resistance genes Qsng-3BS, Fhb1 and Sr2 and combining them in coupling on wheat chromosome 3BS --- 37 Meta-analysis of resistance to Fusarium head blight in tetraploid wheat – implications for durum wheat breeding --- 38 Interest of a multiparental and outcrossing wheat population for fine mapping --- 39 The effect of Earliness per se (Eps) genes on flowering time in bread wheat --- Part XI Toward Sustainable Wheat Production --- 40 Recapitulating the OECD-CRP session (sponsored by the OECD’s Co-operative Research Program on Biological Resource Management for Sustainable Agricultural Systems --- 41 Exploring genetic resources to increase adaptation of wheat to climate change --- 42 Genomic approaches towards durable fungal disease resistance in wheat --- 43 Review and new progress in wheat wide hybridization for improving the resistance to biotic and abiotic stresses --- 44 Global crop improvement networks to bridge technology gaps --- 45 Genomic selection in plants: empirical results and implications for wheat breeding --- 46 Dietary fibre: wheat genes for enhanced human health --- BM Appendix I: Program --- Appendix II: Poster Presentation List --- Appendix III: Committees
    Pages: Online-Ressource (XVI, 445 pages)
    ISBN: 9784431556756
    Language: English
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  • 16
    Keywords: Life sciences ; Nucleic acids ; Plant breeding ; Biology ; Technique ; Life Sciences ; Plant Breeding/Biotechnology ; Biological Techniques ; Nucleic Acid Chemistry
    Description / Table of Contents: Introduction --- Health and Safety Considerations --- Sample Collection and Storage --- Low-Cost DNA Extraction --- PCR Amplification for Low-Cost Mutation Discovery --- Enzymatic Mismatch Cleavage and Agarose Gel Evaluation of Samples --- Alternative Enzymology for Mismatch Cleavage for TILLING and Ecotilling: Extraction of Enzymes form Common Weedy Plants --- Example Data --- Conclusions.  
    Pages: Online-Ressource (X, 35 pages) , 9 illustrations, 3 illustrations in color
    ISBN: 9783319162591
    Language: English
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  • 17
    Unknown
    Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering ; Robotics ; Automation ; Industrial engineering ; Production engineering ; Engineering economics ; Engineering economy ; Manufacturing industries ; Machines ; Tools ; Engineering ; Industrial and Production Engineering ; Robotics and Automation ; Engineering Economics, Organization, Logistics, Marketing ; Manufacturing, Machines, Tools ; Information Systems Applications (incl. Internet)
    Description / Table of Contents: Einordnung und Hintergründe --- Positionen der Sozialpartner --- Erfahrungen und Herausforderungen in der Industrie --- Forschungsfragen und Entwicklungsstrategien --- Ausblick
    Pages: Online-Ressource (VIII, 167 Seiten) , 38 Abbildungen
    ISBN: 9783662459157
    Language: German
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  • 18
    Keywords: Engineering ; Commercial law ; Automotive engineering ; Robotics ; Automation ; Community psychology ; Environmental psychology ; Engineering ; Automotive Engineering ; Robotics and Automation ; Community and Environmental Psychology ; Commercial Law
    Description / Table of Contents: Teil I Human and Machine --- Teil II Mobilität --- Teil III Verkehr --- Teil IV Sicherheit --- Teil V Recht und Haftung --- Teil VI Akzeptanz
    Pages: Online-Ressource (XIV, 732 Seiten)
    ISBN: 9783662458549
    Language: German
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  • 19
    Unknown
    Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering ; Humanities ; Digital libraries ; Computers ; Educational technology ; Electrical engineering ; Engineering ; Communications Engineering, Networks ; Information Systems and Communication Service ; Digital Humanities ; Technology and Digital Education
    Description / Table of Contents: Seit Jahren wird unser Alltag geprägt von zunehmender Automation und Vernetzung, die Digitalisierung genannt wird. Sensoren erfassen immer mehr unterschiedliche Daten und werden von intelligenten Algorithmen zunehmend präzisier analysiert. Dies führt nicht nur zu einem anderen Verhältnis im Umgang und bei der Nutzung von Daten durch Menschen und Maschinen, sondern wird auch dramatisch Aufgaben und Prozesse verändern. Die damit verbundenen Arbeitsanforderungen werden zum massiven Wandel von Berufsbildern führen, in dem einfache Tätigkeiten automatisiert und komplexe Tätigkeiten vereinfacht werden. Nicht nur das Arbeiten sondern auch das Lernen, Lehren und Forschen verändert sich durch die Digitalisierung. Die technischen Möglichkeiten wandeln die Lebenswelten mit ihren urbanen Versorgungs- und Infrastrukturen und eröffnen den Wirtschaftsräumen neue Geschäftsmodelle. Diese parallel einsetzenden Entwicklungen führen zu radikalen Umbrüchen, die in den kommenden Jahren sämtliche Aspekte der Gesellschaft verändern werden
    Pages: Online-Ressource (IX, 199 Seiten)
    ISBN: 9783662528549
    Language: German
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  • 20
    Unknown
    Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering ; Humanities ; Digital libraries ; Educational technology ; Electrical engineering ; Engineering ; Communications Engineering, Networks ; Digital Humanities ; Technology and Digital Education
    Description / Table of Contents: Vorwort --- Einleitung --- Bürger --- Wenn Bots sich unter Leute mischen: Social Bots in den Sozialen Medien --- Digitale Partizipation in Wissenschaft und Wirtschaft --- Entwicklung einer soziodigitalen Souveränität --- Unternehmen --- Digitale Souveränität – ein mehrdimensionales Handlungskonzept für die deutsche Wirtschaft --- Privatheit und digitale Souveränität in der Arbeitswelt 4.0 --- Staat --- Mehr Daten, weniger Vertrauen in Statistik – freie Fahrt für ‚alternative Fakten‘? --- Internationale Perspektiven auf digitale Souveränität --- Digitalisierung der Bildung als staatliche Aufgabe --- Ausblick
    Pages: Online-Ressource (IX, 187 Seiten) , 40 Abbildungen in Farbe
    ISBN: 9783662557969
    Language: German
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  • 21
    Keywords: Engineering ; Project management ; Engineering design ; Automotive Engineering ; Project Management ; Engineering Design
    Description / Table of Contents: A - Die Entwicklung: Drei Erfolgsstories --- Die StreetScooter-Gründer-Story --- Die StreetScooter-Meilensteine 2008-2017 --- Die StreetScooter-Entwicklungsstory --- Die StreetScooter-Protagonisten-Story --- B - Die Lösung: Return on Engineering: Die StreetScooter-Lösungsbausteine. C - Die Perspektive: Die StreetScooter-Netzwerk-Story --- Die StreetScooter-Produktions-Story --- Die StreetScooter-Post-Story --- Die StreetScooter-Mobilitätslösung --- Die StreetScooter-Vision. A - The Development: Three Stories of Success --- The StreetScooter Founder Story --- The StreetScooter Milestones 2008-2017 --- The StreetScooter Development Story --- The StreetScooter Protagonists Story --- B - The Solution: Return on Engineering: The StreetScooter Building Blocks --- C - The Perspective: The StreetScooter Network Story --- The StreetScooter Production Story --- The StreetScooter Post Story --- The StreetScooter Mobility Solution --- The StreetScooter Vision
    Pages: Online-Ressource (VII, 213 Seiten)
    ISBN: 9783662549971
    Language: German
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  • 22
    Keywords: Computer science ; Management ; Industrial management ; Information technology ; Business ; Data processing ; Computers ; Computer Science ; Information Systems and Communication Service ; Innovation/Technology Management ; IT in Business
    Description / Table of Contents: Modelle --- Modellierungssprachen --- Vorgehensweise von der Modellbildung zur Digitalisierung --- Vorbereitung der Prozessimplementierung --- Umsetzung --- Praxisbeispiel
    Pages: Online-Ressource (X, 254 Seiten) , 143 Abbildungen, 69 Abbildungen in Farbe
    ISBN: 9783658226480
    Language: German
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  • 23
    Unknown
    Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering ; Robotics ; Automation ; Industrial engineering ; Production engineering ; Economic sociology ; Engineering ; Industrial and Production Engineering ; Organizational Studies, Economic Sociology ; Robotics and Automation
    Description / Table of Contents: Einleitung --- Prognostizierte Veränderungen der gestaltbaren Arbeitssystemdimensionen --- Systeme zur Assistenz und Effizienzsteigerung in manuellen Produktionsprozessen der Industrie auf Basis von Projektion und Tiefendatenerkennung --- Betriebliche Auswirkungen industrieller Servicerobotik am Beispiel der Kleinteilemontage --- Erweiterte Horizonte – Ein technischer Blick in die Zukunft der Arbeit --- Soziotechnische Assistenzsysteme für die Produktionsarbeit in der Textilbranche --- Lernförderliche Arbeitssysteme für die Arbeitswelt von morgen --- Assistenz und Wissensvermittlung am Beispiel von Montage- und Instandhaltungstätigkeiten --- Der Mensch in Interaktion mit autonomen Planungs- und Steuerungssystemen für Cyber-Physische Produktionssysteme --- ReApp – Wiederverwendbare Roboterapplikationen für flexible Roboteranlagen - Auswirkungen der Ergebnisse aus ReApp auf betriebliche Funktionen am Beispiel eines Anwendungsfalls in der Elektroindustrie --- Modellierungsansatz für ein arbeitsplatznahes Beschreibungsmodell der »Arbeitswelt Industrie 4.0 --- Die Zukunft der Arbeit im demografischen Wandel --- “Social Manufacturing and Logistics“ – Arbeit in der digitalisierten Produktion --- Lernförderliche Arbeitsorganisation in der Industrie 4.0 --- Decision Support Pipelines – Durchgängige Datenverarbeitungsinfrastrukturen für die Entscheidungen von morgen --- Gerechtigkeit in flexiblen Arbeits- und Managementprozessen --- Technologie, Organisation, Qualifikation
    Pages: Online-Ressource (XI, 246 Seiten) , 62 Abbildungen, 56 Abbildungen in Farbe
    ISBN: 9783662492666
    Language: German
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  • 24
    Keywords: Life sciences ; Genetic engineering ; Agriculture ; Plant physiology ; Plant breeding ; Life Sciences ; Plant Breeding/Biotechnology ; Agriculture ; Genetic Engineering ; Plant Physiology
    Description / Table of Contents: Introduction --- Objectives --- Protocol for measuring soil salinity --- Protocol for screening for salt tolerance in rice --- Protocol for screening for salt tolerance in barley and wheat.  
    Pages: Online-Ressource (X, 37 pages) , 7 illustrations, 6 illustrations in color
    ISBN: 9783319265902
    Language: English
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  • 25
    Keywords: Biomedical engineering ; Sports medicine ; Biomedical Engineering/Biotechnology ; Sports Medicine ; Biomedical Engineering
    Description / Table of Contents: Retention Requirements for Alpine Ski Bindings --- Helmet Use and Self-Reported Risk Taking in Skiing and Snowboarding --- Evaluating the Performance of Helmet Linings Incorporating Fluid Channels --- Polarizing Filters in Ski Sports --- Emergency Release for Winter Sports Equipment --- Analyzing the Riding Behavior of Recreational Skiers and Snowboarders --- Reaction Times of Skiers and Snowboarders --- Gender-Specific Effects of Smoking and Alcohol Consumption on the Risk of Falling in Downhill Skiers --- Hydration Packs Modify Professional Skiers Hydration Levels in All Day Skiing: A Randomized Controlled Trial --- Are ACL Injuries Related to Perceived Fatigue in Female Skiers? --- Aging Trends in Alpine Skiing --- Skiing and Boarding Injuries on Norwegian Slopes during Two Winter Seasons --- Skiing and Snowboarding Injuries in the Czech Republic in Winter Seasons 2003–2008 --- Relative Motion of ACL Insertion Points In Vivo: A Case Study, Including Skiing Maneuvers --- Jumper Kinematics on Terrain Park Jumps: Relationship between Takeoff Speed and Distance Traveled --- Reaction Forces and Moments in Carved Turns
    Pages: Online-Ressource (X, 206 pages) , 61 illustrations, 39 illustrations in color
    ISBN: 9783319527550
    Language: English
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  • 26
    Keywords: Life sciences ; Animal ecology ; Community ecology, Biotic ; Environmental monitoring ; Life Sciences ; Animal Ecology ; Community & Population Ecology ; Monitoring/Environmental Analysis
    Description / Table of Contents: FOREWORD --- 2. GENERAL INTRODUCTION --- 2.1. Background analysis --- 2.2. Migratory Birds and HPAI --- 2.3. Using SIA to understand the dissemination of HPAI – The way ahead! --- 3. ANIMAL MIGRATION TRACKING METHODS --- 3.1. Extrinsic Markers --- 3.2. Intrinsic Markers --- 3.3. The Stable Isotopes of Water on a Spatial Scale --- 3.4. Deriving isoscapes in the absence of GNIP data --- 3.5. Use of Stable Isotopes in Migration Studies --- 3.6. Approaches for Determining Migratory Connectivity --- 4. PRACTICAL CONSIDERATIONS --- 4.1. Sample Collection and Tissue Preparation --- 4.2. Other Stable Isotopes for Migration Research --- 5. REFERENCES
    Pages: Online-Ressource (XII, 49 pages) , 15 illustrations, 4 illustrations in color
    ISBN: 9783319282985
    Language: English
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  • 27
    Unknown
    Cham : Springer
    Keywords: Life sciences ; Aquatic ecology ; Life Sciences ; Freshwater & Marine Ecology
    Description / Table of Contents: Foreword --- Preface --- Part 1 A brief history of marine litter research --- Part 2 Abiotic aspects of marine litter pollution --- Global distribution, composition and abundance of marine litter --- Persistence of plastic litter in the oceans --- Part 3 Biological implications of marine litter --- Deleterious effects of litter on marine life --- The complex mixture, fate and toxicity of chemicals associated with plastic debris in the marine environment --- Marine litter as habitat and dispersal vector --- Part 4 Micro plastics --- Micro plastics in the marine environment: sources, consequences and solutions --- Methodology used for the detection and identification of micro plastics – a critical appraisal --- Sources and pathways of micro plastics to habitats --- Micro plastics in the marine environment: distribution, interactions and effects --- Modeling the role of micro plastics in bioaccumulation of organic chemicals to marine aquatic organisms. A critical review --- Nano plastics in the aquatic environment. Critical review --- Part 5 Socio-economic implications of marine anthropogenic litter --- Micro and nano-plastics and human health --- The economics of marine litter --- Regulation and management of marine litter --- Marine litter and the contribution of citizen science
    Pages: Online-Ressource (XVIII, 447 pages) , 68 illustrations, 35 illustrations in color
    ISBN: 9783319165103
    Language: English
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  • 28
    Keywords: Toxicology ; Medicine ; Human physiology ; Immunology ; Cytology ; Pharmacology/Toxicology ; Molecular Medicine ; Human Physiology ; Immunology ; Cell Biology
    Description / Table of Contents: Preface --- Part 1. Physiology of HDL --- Part 2. Pathology of HDL --- Part 3. Possible Indications and Target Mechanisms of HDL Therapy --- Part 4. Treatments for Dyslipidemias and Dysfunction of HDL
    Pages: Online-Ressource (XIII, 694 pages) , 40 illustrations, 37 illustrations in color
    ISBN: 9783319096650
    Language: English
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  • 29
    Unknown
    Cham : Springer
    Keywords: Medicine ; Human physiology ; Neurosciences ; Endocrinology ; Cell biology ; Biomedicine ; Human Physiology ; Endocrinology ; Cell Biology ; Neurosciences
    Description / Table of Contents: The Epigenetic And Metabolic Language Of the Circadian Clock --- Molecular Architecture of the Circadian Clock in Mammals --- Circadian Mechanisms in Bioenergetics and Cell Metabolism --- Control of metabolism by central and peripheral clocks in Drosophila --- Circadian post-transcriptional control of metabolism --- Redox and Metabolic Oscillations in the Clockwork --- Rev-erbs: Integrating Metabolism Around the Clock --- Control of sleep-wake cycles in Drosophila --- Circadian metabolomics: insights for biology and medicine --- Rhythms within rhythms: the importance of oscillations for glucocorticoid hormones --- The genetics of autism spectrum disorders.
    Pages: Online-Ressource (XIII, 132 pages) , 28 illustrations, 26 illustrations in color
    ISBN: 9783319270692
    Language: English
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  • 30
    Keywords: Life sciences ; Genetic engineering ; Agriculture ; Plant genetics ; Plant breeding ; Life Sciences ; Plant Breeding/Biotechnology ; Agriculture ; Genetic Engineering ; Plant Genetics & Genomics
    Description / Table of Contents: Mutagenesis for Crop Breeding and Functional Genomics --- Chemical and Physical Mutagenesis in Jatropha curcas --- Chemical Mutagenesis and Chimera Dissolution in Vegetatively Propagated Banana --- Mutation Induction Using Gamma Irradiation and Embryogenic Cell Suspensions in Plantain (Musa spp.) --- Optimization of Somatic Embryogenesis in Cassava --- Creation of a TILLING Population in Barley after Chemical Mutagenesis with Sodium Azide and MNU --- Site-Directed Mutagenesis in Barley by Expression of TALE Nuclease in Embryogenic Pollen --- Doubled Haploidy as a Tool for Chimera Dissolution of TALEN-Induced Mutations in Barley --- Field Evaluation of Mutagenized Rice Material --- Root Phenotyping Pipeline for Cereal Plants --- Breeding New Aromatic Rice with High Iron using Gamma Radiation and Hybridization --- Utilizing NIRS for Qualitative and Non-Destructive Identification of Seed Mutants in Large Populations --- Protocols for Proteome Analyses of Jatropha curcas --- Low-Cost Methods for DNA Extraction and Quantification --- A Protocol for Benchtop Extraction of Single-Strand-Specific Nucleases for Mutation Discovery --- A Protocol for Validation of Doubled Haploid Plants by Enzymatic Mismatch Cleavage --- Bioinformatics-Based Assessment of the Relevance of Candidate Genes for Mutation Discovery --- Mutation Detection by Analysis of DNA Heteroduplexes in TILLING Populations of Diploid Species --- Determining Mutation Density using Restriction Enzyme Sequence Comparative Analysis (RESCAN) --- Next-Generation Sequencing for Targeted Discovery of Rare Mutations in Rice
    Pages: Online-Ressource (XX, 340 pages) , 76 illustrations, 69 illustrations in color
    ISBN: 9783319450216
    Language: English
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  • 31
    Keywords: Medicine ; Public health ; Medical research ; Quality of life ; Biomedicine ; Biomedicine general ; Public Health ; Quality of Life Research
    Description / Table of Contents: Preface.- Data and Methods.- Population Norms for the EQ-5D --- Cross-Country Analysis of EQ-5D Data --- Socio-demographic Indicators based on EQ-5D --- Annex 1 --- Annex 2
    Pages: Online-Ressource (XV, 196 pages) , 14 illustrations, 9 illustrations in color
    ISBN: 9789400775961
    Language: English
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  • 32
    Keywords: Medicine ; Public health ; Medical research ; Quality of life ; Biomedicine ; Biomedicine general ; Public Health ; Quality of Life Research
    Description / Table of Contents: Preface.- Data and Methods.- Population Norms for the EQ-5D --- Cross-Country Analysis of EQ-5D Data --- Socio-demographic Indicators based on EQ-5D --- Annex 1 --- Annex 2
    Pages: Online-Ressource (XV, 196 pages) , 14 illustrations, 9 illustrations in color
    ISBN: 9789400775961
    Language: English
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  • 33
    Unknown
    Cham : Springer
    Keywords: Life sciences ; Aquatic ecology ; Life Sciences ; Freshwater & Marine Ecology
    Description / Table of Contents: Foreword --- Preface --- Part 1 A brief history of marine litter research --- Part 2 Abiotic aspects of marine litter pollution --- Global distribution, composition and abundance of marine litter --- Persistence of plastic litter in the oceans --- Part 3 Biological implications of marine litter --- Deleterious effects of litter on marine life --- The complex mixture, fate and toxicity of chemicals associated with plastic debris in the marine environment --- Marine litter as habitat and dispersal vector --- Part 4 Micro plastics --- Micro plastics in the marine environment: sources, consequences and solutions --- Methodology used for the detection and identification of micro plastics – a critical appraisal --- Sources and pathways of micro plastics to habitats --- Micro plastics in the marine environment: distribution, interactions and effects --- Modeling the role of micro plastics in bioaccumulation of organic chemicals to marine aquatic organisms. A critical review --- Nano plastics in the aquatic environment. Critical review --- Part 5 Socio-economic implications of marine anthropogenic litter --- Micro and nano-plastics and human health --- The economics of marine litter --- Regulation and management of marine litter --- Marine litter and the contribution of citizen science
    Pages: Online-Ressource (XVIII, 447 pages) , 68 illustrations, 35 illustrations in color
    ISBN: 9783319165103
    Language: English
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  • 34
    Keywords: Life sciences ; Food ; Biotechnology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Food Science ; Environmental Science and Engineering
    Description / Table of Contents: Part I : Agro-Food Systems --- Food Security in the Southern Mediterranean/North Africa --- Sustainability in cereal crop production in Mediterranean environments --- Innovative crop productions for healthy foods: the case of Chia --- The hidden costs of livestock environmental sustainability: the case of Podolian cattle --- Feeding, nutrition and sustainability in dairy enterprises: the case of Mediterranean buffaloes (bubalus bubalis) --- Sustainability of sheep and goat production systems --- The role of local sheep and goat breeds and their products as a tool for sustainability and safeguard of the Mediterranean environment --- Innovative use of jenny milk from sustainable rearing --- Sustainable agricultural practices in disease defence of traditional crops in Southern Italy: the case study of tomato cherry protected by Trichoderma harzianum T-22 against Cucumber mosaic virus --- Development of integrated disease control measures for the valorisation of traditional crops in Southern Italy: the case study of "Fagiolo di Sarconi" --- Fostering sustainable climate change adaptations: a case study of the Turkish Cypriot Community’s adoption of pomegranate farming --- The role of women in the sustainability of the wine industry through the analysis of case studies --- Part II : Natural Resource Systems and Environment --- The effects of climate change on the multifunctional role of Basilicata’s forests: the effects induced on yield and CO2 absorption --- Wildlife agriculture interactions, spatial analysis and trade-off between environmental sustainability and risk of economic damage --- The sustainability of non-renewable resources use at regional level: a case study on allocation of oil royalties --- Land use sector involvement in mitigation policies across carbon markets --- Evaluating the role of soil variability on potential groundwater pollution and recharge in a Mediterranean agricultural watershed --- Grazing and biodiversity conservation: highlights on a Nature 2000 network site --- Evaluation of native grasses for sustainable turfgrass in the bioclimatic Mediterranean Region.-Biodiversity of hypogeous fungi in Basilicata --- Part III: New technologies --- New technologies for the sustainable management and planning of rural land and environment --- Processing plants and technologies for a sustainable Mediterranean food chain --- Geophysical techniques for plant, soil and root research related to Satellite technologies to support the sustainability of agricultural production --- Electrolyzed water in the food industry as supporting of environmental sustainability
    Pages: Online-Ressource (XXVIII, 397 pages) , 80 illustrations, 48 illustrations in color
    ISBN: 9783319163574
    Language: English
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  • 35
    Unknown
    Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering ; Humanities ; Digital libraries ; Computers ; Educational technology ; Electrical engineering ; Engineering ; Communications Engineering, Networks ; Information Systems and Communication Service ; Digital Humanities ; Technology and Digital Education
    Description / Table of Contents: Seit Jahren wird unser Alltag geprägt von zunehmender Automation und Vernetzung, die Digitalisierung genannt wird. Sensoren erfassen immer mehr unterschiedliche Daten und werden von intelligenten Algorithmen zunehmend präzisier analysiert. Dies führt nicht nur zu einem anderen Verhältnis im Umgang und bei der Nutzung von Daten durch Menschen und Maschinen, sondern wird auch dramatisch Aufgaben und Prozesse verändern. Die damit verbundenen Arbeitsanforderungen werden zum massiven Wandel von Berufsbildern führen, in dem einfache Tätigkeiten automatisiert und komplexe Tätigkeiten vereinfacht werden. Nicht nur das Arbeiten sondern auch das Lernen, Lehren und Forschen verändert sich durch die Digitalisierung. Die technischen Möglichkeiten wandeln die Lebenswelten mit ihren urbanen Versorgungs- und Infrastrukturen und eröffnen den Wirtschaftsräumen neue Geschäftsmodelle. Diese parallel einsetzenden Entwicklungen führen zu radikalen Umbrüchen, die in den kommenden Jahren sämtliche Aspekte der Gesellschaft verändern werden
    Pages: Online-Ressource (IX, 199 Seiten)
    ISBN: 9783662528549
    Language: German
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  • 36
    Keywords: Life sciences ; Biodiversity ; Nature conservation ; Life Sciences ; Biodiversity ; Nature Conservation ; Plant Systematics/Taxonomy/Biogeography ; Animal Systematics/Taxonomy/Biogeography
    Description / Table of Contents: Phylogenetics and conservation biology: drawing a path into the diversity of life --- The value of phylogenetic diversity --- The PD phylogenetic diversity framework: linking evolutionary history to feature diversity for biodiversity conservation --- Reconsidering the loss of evolutionary history: how does non-random extinction prune the tree-of-life?- Phylogenetics and conservation in New Zealand: the long and the short of it --- What is the meaning of extreme phylogenetic diversity? The case of phylogenetic relict species --- Using phylogenetic dissimilarities among sites for biodiversity assessments and conservation --- Phylogenetic diversity measures and their decomposition: a framework based on hill numbers --- Split diversity: measuring and optimizing biodiversity using phylogenetic split networks --- The rarefaction of phylogenetic diversity: formulation, extension and application --- Support in area prioritization using phylogenetic information --- Assessing hotspots of evolutionary history with data from multiple phylogenies: an analysis of endemic clades from New Caledonia --- Representing hotspots of evolutionary history in systematic conservation planning for European mammals --- Priorities for conservation of the evolutionary history of amphibians in the cerrado --- Global spatial analyses of phylogenetic conservation priorities for aquatic mammals --- Metapopulation capacity meets evolutionary distinctness: spatial fragmentation complements phylogenetic rarity in prioritization. - Patterns of species, phylogenetic and mimicry diversity of clearwing butterflies in the Neotropics --- Conservation of phylogenetic diversity in Madagascar’s largest endemic plant family, Sarcolaenaceae --- The future of phylogenetic systematics in conservation biology: linking biodiversity and society
    Pages: Online-Ressource (XVII, 390 pages) , 79 illustrations
    ISBN: 9783319224619
    Language: English
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  • 37
    Keywords: Life sciences ; Ecosystems ; Sustainable development ; Natural resources ; Agricultural economics ; Life Sciences ; Ecosystems ; Sustainable Development ; Agricultural Economics ; Natural Resource and Energy Economics ; Natural Resources
    Description / Table of Contents: 1. Introduction --- Part I: Bioeconomy Concepts and Research Methods --- Chapter 2: Context --- Chapter 3: Bioeconomy concepts --- Chapter 4: Core principles --- Chapter 4: Inter- and Transdisciplinarity in the Bioeconomy --- Part II: Knowledge Base for Biobased Value Chains --- Chapter 5:Biobased Resources and Value Chains --- Chapter 6: Primary Production --- Chapter 7: Processing of Biobased Resources --- Chapter 8: Markets, Sustainability management and Entrepreneurship.- Part III: Transition to a Sustainable Bioeconomy --- Chapter9:  Modelling and Tools Supporting the Transition to a Bioeconomy --- Chapter 10: Environmental Economics, the Bioeconomy and the Role of Government --- Chapter 11: Economic Growth, Development, and Innovation – The Transformation towards a Knowledge-based Bioeconomy --- Chapter 12: The Bioeconomist
    Pages: Online-Ressource (VI, 354 pages) , 165 illustrations, 139 illustrations in color
    ISBN: 9783319681528
    Language: English
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  • 38
    Keywords: aerospace ; microgravity ; space ethics ; aviation medicine
    Description / Table of Contents: 1. Reimagining Icarus: Ethics, Law and Policy Considerations for Commercial Human Spaceflight / By Sara M. Langston --- 2. Basic Methodology for Space Ethics / By Tony Milligan --- 3. From the Individual to the Cultural Space Group / By Carole Tafforin --- 4. Acute and Chronic Effects of Hypobaric Exposure upon the Brain / By Paul Sherman and John Sladky --- 5. Spaceflight Induced Changes in the Central Nervous System / By Alex P. Michael --- 6. The Effect of Gravity on the Nervous System / By Florian P.M. Kohn, Claudia Koch and Ramona Ritzmann --- 7. Spaceflight: Immune Effects and Nutritional Countermeasure / By Anil D Kulkarni, Marie-Francoise Doursout, Asmita Kulkarni, Alamelu Sundaresan, Takehito Miura, Koji Wakame and Hajime Fujii --- 8. Countermeasure Development for Lumbopelvic Deconditioning in Space / By Andrew Winnard, Dorothee Debuse and Nick Caplan --- 9. Tumor Cells in Microgravity / By Jun Chen --- 10. Plants in Space / By Bratislav Stankovic --- 11. Approaches to Assess the Suitability of Zooplankton for Bioregenerative Life Support Systems / By Miriam Knie, Bernard Wolfschoon Ribeiro, Jessica Fischer, Burkhard Schmitz, Kay Van Damme, Ruth Hemmersbach, Donat-P. Häder and Christian Laforsch --- 12. Are We Alone? The Search for Life on Mars and Other Planetary Bodies / By Stephanie A. Smith, Andrzej Paszczynski and Susan E. Childers --- 13. Exploring the Stratosphere: What We Missed by Shooting for the Moon / By Laura Galdamez --- 14. The Mortality of Space Explorers / By Robert J. Reynolds and Steven M. Day
    ISBN: 9781789232219
    Language: English
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  • 39
    Unknown
    Rijeka : InTech
    Keywords: waves ; microwave systems ; wireless communication ; antenna
    Description / Table of Contents: Microwave systems are key components of every modern wireless communication system. The main objective of this book was to collect as many different state-of-the-art studies as possible in order to cover in a single volume the main aspects of microwave systems and applications. This book contains 17 chapters written by acknowledged experts, researchers, academics, and microwave engineers, providing comprehensive information and covering a wide range of topics on all aspects of microwave systems and applications. This book is divided into four parts. The first part is devoted to microwave components. The second part deals with microwave ICs and innovative techniques for on-chip antenna design. The third part presents antenna design cases for microwave systems. Finally, the last part covers different applications of microwave systems.
    Pages: Online-Ressource (432 Seiten)
    ISBN: 9789535128687
    Language: English
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  • 40
    Keywords: fractal geometry ; fractal analysis ; fractals ; application ; medicine ; social sciences
    Description / Table of Contents: Chapter 1: Fractal Analysis of Cardiovascular Signals Empowering the Bioengineering Knowledge by Ricardo L. Armentano, Walter Legnani and Leandro J. Cymberknop --- Chapter 2: Complex Systems with Self-Elimination of Dissipation with Implication in Bio-Structural Behavior Via Nondifferentiability by Maricel Agop, Decebal Vasincu, Daniel Timofte, Elena Simona Bacaita, Andrei Agop and Stefan Andrei Irimiciuc --- Chapter 3: The Fractal Analysis of the Images and Signals in Medical Diagnostics by Tayurskii Dmitrii Albertovich and Rusanova Inna Aleksandrovna --- Chapter 4: Polyadic Cantor Fractals: Characterization, Generation, and Application as Ultrasonic Lenses by Sergio Castiñeira-Ibañez, Daniel Tarrazó-Serrano, José Miguel Fuster, Pilar Candelas and Constanza Rubio --- Chapter 5: Fractal to Non-Fractal Morphological Transitions in Stochastic Growth Processes by José Roberto Nicolás-Carlock, Víctor Dossetti and José Luis Carrillo- Estrada --- Chapter 6: The Altepetl: Fractal Modeling of a Pre-Hispanic Human Agency by Fernando López Aguilar --- Chapter 7: Fractal Analysis Based on Hierarchical Scaling in Complex Systems by Yanguang Chen --- Chapter 8: Characterization of Cultural Traits by Means of Fractal Analysis by Sabrina Farías-Pelayo --- Chapter 9: On Self-Affine and Self-Similar Graphs of Fractal Interpolation Functions Generated from Iterated Function Systems by Sean Dillon and Vasileios Drakopoulos --- Chapter 10: Pair-Pair Angular Correlation Function by Filipe Leoncio Braga and Alexandre Barbosa de Souza
    Pages: Online-Ressource (224 Seiten)
    ISBN: 9789535132141
    Language: English
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  • 41
    Keywords: drones ; robots
    Description / Table of Contents: Chapter 1: Computational Aeroelasticity of Flying Robots with Flexible Wings by Sergio Preidikman, Bruno Antonio Roccia, Marcos Leonardo Verstraete, Marcelo Federico Valdez, Dean T. Mook and Balakumar Balachandran --- Chapter 2: Overview of Coandă MAV as an Aerial Robotic Platform by Harijono Djojodihardjo --- Chapter 3: Innovative Propulsion Systems and CFD Simulation for Fixed Wings UAVs by Esteban Valencia and Victor Hidalgo --- Chapter 4: Comparison between Semiempirical and Computational Techniques in the Prediction of Aerodynamic Performance of the Rotor of a Quadcopter by Andres Mauricio Pérez Gordillo --- Chapter 5: Nonlinear Dynamics and Control of Aerial Robots by Mahmut Reyhanoglu and Muhammad Rehan --- Chapter 6: Design and Development of Aerial Robotic Systems for Sampling Operations in Industrial Environment by Rodrigo Munguia, Edmundo Guerra, Sarquis Urzua, Yolanda Bolea and Antoni Grau --- Chapter 7: On-Board High-Performance Computing For Multi-Robot Aerial Systems by Leonardo Camargo Forero, Pablo Royo and Xavier Prats --- Chapter 8: Unmanned Aerial Systems (UASs) for Environmental Monitoring: A Review with Applications in Coastal Habitats by Daniele Ventura, Andrea Bonifazi, Maria Flavia Gravina and Gian Domenico Ardizzone
    Pages: Online-Ressource (192 Seiten)
    ISBN: 9789535134640
    Language: English
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  • 42
    Keywords: Life sciences ; Virology ; Animal ecology ; Aquatic ecology ; Conservation biology ; Ecology ; Wildlife ; Fish ; Environmental health ; Life Sciences ; Animal Ecology ; Environmental Health ; Fish & Wildlife Biology & Management ; Virology ; Freshwater & Marine Ecology ; Conservation Biology/Ecology
    Description / Table of Contents: Introduction --- Distribution and Phylogeny of Ranaviruses --- Host-pathogen Ecology and Evolution --- Molecular Biology of Ranaviruses --- Immune Evasion and Host Immunity --- Pathology and Diagnostics --- Design and Analysis of Ranavirus Studies --- Global Ranavirus Consortium
    Pages: Online-Ressource (X, 246 pages) , 25 illustrations, 21 illustrations in color
    ISBN: 9783319137551
    Language: English
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  • 43
    Keywords: Life sciences ; Human physiology ; Food ; Biotechnology ; Microbiology ; Life Sciences ; Food Microbiology ; Food Science ; Human Physiology
    Description / Table of Contents: Introduction --- Gastrointestinal digestion models, general introduction --- Static digestion models general introduction --- InfoGest consensus method --- Approaches to static digestion models --- Dynamic digestion models general introduction --- The TNO gastro-Intestinal Model (TIM) --- Dynamic Gastric Model (DGM) --- Human Gastric Simulator (Riddet model) --- The DIDGI® System --- General introduction to cells, cell lines and cell culture --- Epithelial cell models; General introduction --- Caco-2 cell line --- HT29 cell line --- The IPEC-J2 cell line --- Co-cultivation of Caco-2 and HT-29MT --- Innate and adaptive immune cells; General introduction --- THP-1 and U937 cells --- Peripheral blood mononuclear cells --- PBMC-derived T cells --- Dendritic Cells --- Co-culture Caco-2/ immune cells --- Enteroendocrine Cell Models: General introduction --- STC-1 cells --- NCI-H716 cells --- Murine GLUTag cells --- In vitro intestinal tissue models: General introduction --- Intestinal crypt organoids as experimental models --- Porcine ex vivo intestinal segment model --- Ussing chamber --- In vitro fermentation models: General Introduction --- One compartment fermentation model --- The TNO in vitro model of the colon - TIM-2 --- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME® --- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
    Pages: Online-Ressource (XVII, 338 pages) , 57 illustrations, 35 illustrations in color
    ISBN: 9783319161044
    Language: English
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  • 44
    Keywords: Life sciences ; Developmental biology ; Evolutionary biology ; Animal genetics ; Entomology ; Biomathematics ; Life Sciences ; Animal Genetics and Genomics ; Evolutionary Biology ; Mathematical and Computational Biology ; Developmental Biology ; Entomology
    Description / Table of Contents: Foreword --- Preface --- Contributors --- Part I. The Nympalid Groundplan (NGP) and Diversification --- Chapter1:The common developmental origin of eyespots and parafocal elements;And a new model-mechanism for color pattern formation --- Chapter2:Exploring color pattern diversification in early lineages of Satyrinae (Nymphalidae) --- Chapter3:Camouflage variation on a theme of the Nymphalid Ground Plan --- Chapter4:Morphological evolution repeatedly caused by mutations in signaling ligand genes --- Part II. Eyespots and Evolution --- Chapter5:Physiology and evolution of wing pattern plasticity in Bicyclus butterflies: a critical review ofthe literature --- Chapter6:Spatial variation in boundary conditions can govern selection and location of eyespots inbutterfly wings --- Chapter7:Self-Similarity, Distortion Waves, and the Essence of Morphogenesis: A Generalized View ofColor Pattern Formation in Butterfly Wings --- Part III. Developmental Genetics --- Chapter8:A practical guide to CRISPR/Cas9 genome editing in Lepidoptera --- Chapter9:What can we learn about adaptation from the wing pattern genetics of Heliconiusbutterflies? --- Chapter10:Molecular mechanism and evolutionary process underlying female-limited Batesian mimicry in Papilio polytes --- Part IV. Ecological Aspects and Adaptation --- Chapter11:Chemical Ecology of Poisonous Butterflies: Model or Mimic?— A Paradox of Sexual Dimorphisms in Müllerian Mimicry --- Chapter12:A model for population dynamics of the mimetic butterfly Papilio polytesin Sakishima Islands, Japan (II) --- Chapter13:Evolutionary trends in phenotypic elements of seasonal forms of the tribe Junoniini(Lepidoptera: Nymphalidae) --- Chapter14:Estimating the mating success of male butterflies in the field.-Part V. Color Patterns of Larva and Other Insects --- Chapter15:Molecular Mechanisms of Larval Color Pattern Switch in the Swallowtail Butterfly --- Chapter16:Drosophila guttifera as a model system for elucidating color pattern formation --- Chapter17:Molecular mechanisms underlying color vision and color formation in dragonflies
    Pages: Online-Ressource (XII, 321 pages) , 103 illustrations, 89 illustrations in color
    ISBN: 9789811049569
    Language: English
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  • 45
    Unknown
    Cham : Springer
    Keywords: Medicine ; Human genetics ; Neurosciences ; Biomedical engineering ; Biomedicine ; Human Genetics ; Neurosciences ; Biomedical Engineering/Biotechnology
    Description / Table of Contents: Introduction --- In vitro modeling of complex neurological diseases --- Aquatic model organisms in neurosciences : the genome editing revolution --- Genome-wide genetic screening in the mammalian CNS --- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish --- Dissecting the role of synaptic proteins with CRISPR --- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer --- Neuroscience research using non-human primate models and genome editing --- Multiscale genome engineering: Genome-wide screens and targeted approaches --- Using Genome Engineering to Understand Huntington’s Disease --- Therapeutic gene editing in muscles and muscle stem cells
    Pages: Online-Ressource (XI, 123 pages) , 16 illustrations in color
    ISBN: 9783319601922
    Language: English
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  • 46
    Keywords: Life sciences ; Cell biology ; Developmental biology ; Plant science ; Botany ; Life Sciences ; Developmental Biology ; Plant Sciences ; Cell Biology
    Description / Table of Contents: Part 1 Sperm Attraction, Activation and Acrosome Reaction --- 1 Sperm Chemotaxis: The First Authentication Events Between Conspecific Gametes Prior to Fertilization (Manabu Yoshida) --- 2 Respiratory CO2 Mediates Sperm Chemotaxis in Squids (Noritaka Hirohashi) --- 3 Specific Mechanism of Sperm Storage in Avian Oviducts (Tomohiro Sasanami) --- 4 Allurin: Exploring the Activity of a Frog Sperm Chemoattractant in Mammals (Douglas E. Chandler) --- 5 Structure, Function and Phylogenetic Consideration of Calaxin (Kazuo Inaba) --- 6 Cl- Channels and Transporters in Sperm Physiology (Alberto Darszon) --- 7 Equatorin-related Subcellular and Molecular Events During Sperm Priming for Fertilization in Mice (Kiyotaka Toshimori) --- 8 Acrosome Reaction-mediated Motility Initiation that is Critical for the Internal Fertilization of Urodele Amphibians (Akihiko Watanabe) --- 9 Analysis of the Mechanism that Brings Protein Disulfide Isomerase-P5 to Inhibit Oxidative Refolding of Lysozyme (Miho Miyakawa) --- Part 2 Gametogenesis, Gamete Recognition, Activation, and Evolution --- 10 Effect of Relaxin-like Gonad-Stimulating Substance (GSS) on Gamete Shedding and 1-Methyladenine Production in Starfish Ovaries (Masatoshi Mita) --- 11 Incapacity of 1-Methyladenine Production to Relaxin-like Gonad-Stimulating Substance (GSS) in Ca2+-free Seawater-treated Starfish Ovarian Follicle Cells (Masatoshi Mita) --- 12 Novel Isoform of Vitellogenin Expressed in Eggs is a Binding Partner of the Sperm Proteases, HrProacrosin and HrSermosin, in the Ascidian Halocynthia roretzi (Hitoshi Sawada) --- 13 Actin Cytoskeleton and Fertilization in Starfish Eggs (Luigia Santella) --- 14 Focused Proteomics on Egg Membrane Microdomains to Elucidate the Cellular and Molecular Mechanisms of Fertilization in the African Clawed Frog Xenopus laevis (Ken-ichi Sato) --- 15 Egg Activation in Polyspermy: Its Molecular Mechanisms and Evolution in Vertebrates (Yasuhiro Iwao ) --- 16 ATP Imaging in Xenopus laevis Oocyte (Takashi Ijiri) --- 17 Mitochondrial Activation and Nitric Oxide (NO) Release at Fertilization in Echinoderm Eggs (Tatsuma Mohri) --- 18 Functional Roles of Spe Genes in the Male Germline During Reproduction of Caenorhabditis elegans (Hitoshi Nishimura) --- 19 Origin of Female/Male Gender as Deduced by the Mating Type Loci of the Colonial Volvocalean Greens (Hisayoshi Nozaki) --- Part 3 Allorecognition in Male–Female Interaction --- 20 Allorecognition and Lysin Systems During Ascidian Fertilization (Hitoshi Sawada) --- 21 Self-incompatibility in the Brassicaceae (Megumi Iwano) --- 22 Signalling Events in Pollen Acceptance or Rejection in the Arabidopsis Species (Daphne R. Goring) --- 23 Papaver rhoeas S-Determinants and the Signaling Networks they Trigger (Vernonica E. Franklin-Tong ) --- 24 S-RNase-based Self-incompatibility in Petunia: A Complex Non-self Recognition System Between Pollen and Pistil (Teh-hui Kao) --- 25 Self-incompatibility System of Ipomoea trifida, a Wild-type Sweet Potato (Tohru Tsuchiya) --- Part 4 Male–Female Interaction and Gamete Fusion --- 26 Profiling the GCS1-based Gamete Fusion Mechanism (Toshiyuki Mori) --- 27 Fertilization Mechanisms of the Rodent Malarial Parasite Plasmodium berghei (Makoto Hirai) --- 28 Sexual Reproduction of a Unicellular Charophycean Alga, Closterium peracerosum-strogosum-littorale Complex (Hiroyuki Sekimoto) --- 29 Fertilization of Brown Algae: Flagellar Function in Phototaxis and Chemotaxis (Taizo Motomura ) --- 30 Gene and Protein Expression Profiles in Rice Gametes and Zygotes: A Cue for Understanding the Mechanisms of Gametic and Early Zygotic Development in Angiosperms (Takashi Okamoto) --- 31 Role of CD9 in Sperm-Egg Fusion and Virus-induced Cell Fusion in Mammals (Kenji Miyado) --- 32 The Mechanism of Sperm-Egg Fusion in Mouse and the Involvement of IZUMO1 (Naokazu Inoue) --- 33 A ZP2 Cleavage Model of Gamete Recognition and the Post-fertilization Block to Polyspermy (Jurrien Dean) --- 34 Involvement of Carbohydrate Residues of the Zona Pellucida in In Vitro Sperm Recognition in Pigs and Cattle (Naoto Yonezawa) --- Part 5 Organella, Proteolysis, and New Techniques --- 35 The Role of Peroxisomes in Plant Reproductive Processes (Shoji Mano) --- 36 Regulation of Vacuole-mediated Programmed Cell Death During Innate Immunity and Reproductive Development in Plants (Tomoko Koyano) --- 37 Sperm Proteasomes as a Putative Egg Coat Lysin in Mammals (Peter Sutovsky) --- 38 Germline Transformation in the Ascidian Ciona intestinalis (Yasunori Sasakura) --- BM Index.  
    Pages: Online-Ressource (XII, 480 pages) , 127 illustrations, 102 illustrations in color
    ISBN: 9784431545897
    Language: English
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  • 47
    Keywords: Life sciences ; Science ; Urban planning ; City planning ; Urban ecology (Biology) ; System theory ; International environmental law ; Sustainable development ; Life Sciences ; Urban Ecology ; Urbanism ; Sustainable Development ; Complex Systems ; Science, general ; International Environmental Law
    Description / Table of Contents: 1. A global outlook on urbanization --- 2. History of urbanization and the missing ecology --- 3. Urbanization and global trends in biodiversity and ecosystem services --- 4. Regional assessment of Asia.- 5. Sub-regional assessment of China: Urbanization in biodiversity hotspots --- 6. Sub-regional assessment of India --- 7. Local assessment of Bangalore.- 8. Local assessment of Tokyo --- 9. Local assessment of Shanghai --- 10. Patterns and trends in urban biodiversity and landscape design --- 11. Urban ecosystem services.- 12. Shrinking cities, biodiversity and ecosystem services --- 13. Regional assessments of Europe --- 14. Regional assessment of North America --- 15. Regional assessment of Oceania --- 16. Local assessment of Istanbul: Biodiversity and ecosystem services --- 17. Local assessment of Stockholm --- 18. Local assessment of Chicago --- 19. Local assessment of New York City.-20. Local assessment of Melbourne --- 21. A synthesis of global urbanization projections --- 22. Urbanization forecasts, effects on land use, biodiversity, and ecosystem services --- 23. Regional assessment of Africa --- 24. Local assessment of Cape Town.- 25. Climate change and urban biodiversity vulnerability --- 26. Feeding cities --- 27. Urban governance of biodiversity and ecosystem services --- 28. Regional assessment of Latin America --- 29. Local assessment of Rio de Janeiro.- 30. Urban landscapes as learning arenas for biodiversity and ecosystem services management --- 31. Restoration ecology in an urbanizing world --- 32. Indicators for management of urban biodiversity and ecosystem services --- 33. Stewardship of the Biosphere in the Urban Era
    Pages: Online-Ressource (XXVIII, 755 pages) , 150 illustrations, 23 illustrations in color
    ISBN: 9789400770881
    Language: English
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  • 48
    Keywords: Life sciences ; Biodiversity ; Nature conservation ; Life Sciences ; Biodiversity ; Nature Conservation ; Plant Systematics/Taxonomy/Biogeography ; Animal Systematics/Taxonomy/Biogeography
    Description / Table of Contents: Phylogenetics and conservation biology: drawing a path into the diversity of life --- The value of phylogenetic diversity --- The PD phylogenetic diversity framework: linking evolutionary history to feature diversity for biodiversity conservation --- Reconsidering the loss of evolutionary history: how does non-random extinction prune the tree-of-life?- Phylogenetics and conservation in New Zealand: the long and the short of it --- What is the meaning of extreme phylogenetic diversity? The case of phylogenetic relict species --- Using phylogenetic dissimilarities among sites for biodiversity assessments and conservation --- Phylogenetic diversity measures and their decomposition: a framework based on hill numbers --- Split diversity: measuring and optimizing biodiversity using phylogenetic split networks --- The rarefaction of phylogenetic diversity: formulation, extension and application --- Support in area prioritization using phylogenetic information --- Assessing hotspots of evolutionary history with data from multiple phylogenies: an analysis of endemic clades from New Caledonia --- Representing hotspots of evolutionary history in systematic conservation planning for European mammals --- Priorities for conservation of the evolutionary history of amphibians in the cerrado --- Global spatial analyses of phylogenetic conservation priorities for aquatic mammals --- Metapopulation capacity meets evolutionary distinctness: spatial fragmentation complements phylogenetic rarity in prioritization. - Patterns of species, phylogenetic and mimicry diversity of clearwing butterflies in the Neotropics --- Conservation of phylogenetic diversity in Madagascar’s largest endemic plant family, Sarcolaenaceae --- The future of phylogenetic systematics in conservation biology: linking biodiversity and society
    Pages: Online-Ressource (XVII, 390 pages) , 79 illustrations
    ISBN: 9783319224619
    Language: English
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  • 49
    Keywords: Medicine ; Proteins ; Biology ; Technique ; Biomedicine ; Biomedicine general ; Protein Science ; Protein-Ligand Interactions ; Biological Techniques
    Description / Table of Contents: Supramolecular Protein Ligands – Unexplored Teritory Of Potential Pharmacological Activity --- Supramolecular Congo Red As Specific Ligand Of Antibodies Engaged In Immune Complex --- Protein Conditioning For Binding Congo Red And Other Supramolecular Ligands --- Metal Ions Introduced To Proteins By Supramolecular Ligands --- Possible Mechanism Of Amyloidogenesis Of V Domains --- Supramolecular Structures As Carrier Systems Enabling The Use Of Metal Ions In Antibacterial Therapy --- Congo Red Interactions With Single-Walled Carbon Nanotubes
    Pages: Online-Ressource (XII, 136 pages) , 98 illustrations, 44 illustrations in color
    ISBN: 9783319656397
    Language: English
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  • 50
    Keywords: Life sciences ; Food ; Biotechnology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Food Science ; Environmental Science and Engineering
    Description / Table of Contents: Part I : Agro-Food Systems --- Food Security in the Southern Mediterranean/North Africa --- Sustainability in cereal crop production in Mediterranean environments --- Innovative crop productions for healthy foods: the case of Chia --- The hidden costs of livestock environmental sustainability: the case of Podolian cattle --- Feeding, nutrition and sustainability in dairy enterprises: the case of Mediterranean buffaloes (bubalus bubalis) --- Sustainability of sheep and goat production systems --- The role of local sheep and goat breeds and their products as a tool for sustainability and safeguard of the Mediterranean environment --- Innovative use of jenny milk from sustainable rearing --- Sustainable agricultural practices in disease defence of traditional crops in Southern Italy: the case study of tomato cherry protected by Trichoderma harzianum T-22 against Cucumber mosaic virus --- Development of integrated disease control measures for the valorisation of traditional crops in Southern Italy: the case study of "Fagiolo di Sarconi" --- Fostering sustainable climate change adaptations: a case study of the Turkish Cypriot Community’s adoption of pomegranate farming --- The role of women in the sustainability of the wine industry through the analysis of case studies --- Part II : Natural Resource Systems and Environment --- The effects of climate change on the multifunctional role of Basilicata’s forests: the effects induced on yield and CO2 absorption --- Wildlife agriculture interactions, spatial analysis and trade-off between environmental sustainability and risk of economic damage --- The sustainability of non-renewable resources use at regional level: a case study on allocation of oil royalties --- Land use sector involvement in mitigation policies across carbon markets --- Evaluating the role of soil variability on potential groundwater pollution and recharge in a Mediterranean agricultural watershed --- Grazing and biodiversity conservation: highlights on a Nature 2000 network site --- Evaluation of native grasses for sustainable turfgrass in the bioclimatic Mediterranean Region.-Biodiversity of hypogeous fungi in Basilicata --- Part III: New technologies --- New technologies for the sustainable management and planning of rural land and environment --- Processing plants and technologies for a sustainable Mediterranean food chain --- Geophysical techniques for plant, soil and root research related to Satellite technologies to support the sustainability of agricultural production --- Electrolyzed water in the food industry as supporting of environmental sustainability
    Pages: Online-Ressource (XXVIII, 397 pages) , 80 illustrations, 48 illustrations in color
    ISBN: 9783319163574
    Language: English
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  • 51
    Keywords: Life sciences ; Ecosystems ; Sustainable development ; Natural resources ; Agricultural economics ; Life Sciences ; Ecosystems ; Sustainable Development ; Agricultural Economics ; Natural Resource and Energy Economics ; Natural Resources
    Description / Table of Contents: 1. Introduction --- Part I: Bioeconomy Concepts and Research Methods --- Chapter 2: Context --- Chapter 3: Bioeconomy concepts --- Chapter 4: Core principles --- Chapter 4: Inter- and Transdisciplinarity in the Bioeconomy --- Part II: Knowledge Base for Biobased Value Chains --- Chapter 5:Biobased Resources and Value Chains --- Chapter 6: Primary Production --- Chapter 7: Processing of Biobased Resources --- Chapter 8: Markets, Sustainability management and Entrepreneurship.- Part III: Transition to a Sustainable Bioeconomy --- Chapter9:  Modelling and Tools Supporting the Transition to a Bioeconomy --- Chapter 10: Environmental Economics, the Bioeconomy and the Role of Government --- Chapter 11: Economic Growth, Development, and Innovation – The Transformation towards a Knowledge-based Bioeconomy --- Chapter 12: The Bioeconomist
    Pages: Online-Ressource (VI, 354 pages) , 165 illustrations, 139 illustrations in color
    ISBN: 9783319681528
    Language: English
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  • 52
    Unknown
    Cham : Springer
    Keywords: Medicine ; Molecular biology ; Health promotion ; Cardiology ; Diabetes ; Endocrinology ; Metabolic diseases ; Biomedicine ; Molecular Medicine ; Health Promotion and Disease Prevention ; Endocrinology ; Cardiology ; Diabetes ; Metabolic Diseases
    Description / Table of Contents: Introduction --- Human brown adipose tissue plasticity: hormonal and environmental manipulation --- The energy sensor AMPK: Adaptations to exercise, nutritional and hormonal signals --- Plasma steroids and cardiorespiratory fitness response to regular exercise --- Sending the signal: Muscle glycogen availability as a regulator of training adaptation --- Optimized engagement of macrophages and satellite cells in the repair and regeneration of exercised muscle --- Skeletal muscle microRNAs: Roles in differentiation, disease and exercise --- Tryptophan-kynurenine metabolites in exercise and mental health --- FNDC5/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain
    Pages: Online-Ressource (X, 102 pages)
    ISBN: 9783319727905
    Language: English
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  • 53
    Keywords: Life sciences ; Agriculture ; Plant science ; Botany ; Sustainable development ; Life Sciences ; Agriculture ; Plant Sciences ; Sustainable Development
    Description / Table of Contents: Part 1. Introduction of Sago Resources- Chapter 1: Status and Outlook of Global Food Security and the Role of Under-Utilized Food Resource: Sago Palm (Hiroyuki Konuma) --- Chapter 2: Growing Area of Sago Palm and Its Environment (M. H. Bintoro) --- Chapter 3: Life and Livelihood in Sago Growing Area (Yukio Toyoda) --- Part 2. Diversity of Sago Resource in Asia and Pacific --- Chapter 4: Genetic Variation, Agronomic Features of Sago Palm in Asia and Pacific (Hiroshi Ehara) --- Chapter 5: Genetic Diversity of Sago Palm Resources in Indonesia (Barahima Abbas) --- Part 3. Sago Industry Contributes for Food Security and Rural Development in Core Producing Countries --- Chapter 6: An Overview of Sago Industry Development from 20th c. to 21st c. (Jong Foh Shoon) --- Chapter 7: Suitability of Peat Swamp Areas for Commercial Production of Sago Crop - Sarawak Experience (Roland Yong Chiew Ming) --- Chapter 8: Feasibility of Small Scale Sago Industries on Small Island in East Indonesia (Wardis Girsang) --- Chapter 9: Addressing Food Insecurity through Food Safety and Cropping of Sago in Papua New Guinea (Aisak G Pue) --- Chapter 10: Conservation and Sustainable Utilization of the Fiji Sago Palm (Dick Watling) --- Part 4. Agricultural Botany of Sago Palm --- Chapter 11: Matter Production as A Basis of Starch Production in Sago Palm (Yoshinori Yamamoto) --- Chapter 12: Morphogenesis of Sago Palm (Satoshi Nakamura) --- Chapter 13: Morphological and Anatomical Characteristics of Sago Palm Starch (Yoji Nitta) --- Part 5. Growth Environment --- Chapter 14: Soil Environment in Sago Palm Forest (Masanori Okazaki) --- Chapter 15: Interaction between Microbes Activities and Sago Palm Growth (Koki Toyoda) --- Part 6. Starch Production and Utilization --- Chapter 16: Study on the Transformation in Extraction and Consumption Processes of Sago Starch in a Traditional Society of Indonesia (Yoshihiko Nishimura) --- Chapter 17: Improvement of Sago Processing Machine (Darma) --- Chapter 18: The Structure and Characteristics of Sago Starch (Masanori Okazaki) --- Chapter 19: Recovery of Starch from Sago Pith Waste and Waste Water Treatment (Budi Santoso) --- Chapter 20: Acid modification of sago starch and its fiber for industrial application (Titi Candra Sunarti) --- Part 6. New Carbohydrate Resources --- Chapter 21: Starch Properties and Uses as food for Human Health and Welfare (Kazuko Hirao) --- Chapter 21: Production, Purification and Health Benefits of Sago Sugar (Kazuko Hirao) --- Chapter 22: Production, Purification and Health Benefits of Sago Sugar (Kopli Bujang) --- Chapter 23: New Sago Starch Resources and Its Properties from Starch Pith Waste and Pacific Sago Palms (Takashi Mishima) --- Part 8. Conclusion --- Chapter 24: Outcomes and Recommendations from the 12th International Sago Symposium (Yoshinori Yamamoto)
    Pages: Online-Ressource (XIII, 330 pages) , 106 illustrations, 71 illustrations in color
    ISBN: 9789811052699
    Language: English
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  • 54
    Keywords: Life sciences ; Hydrology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Hydrology/Water Resources ; Environmental Science and Engineering
    Description / Table of Contents: Foreword --- Summary --- 2. In-Situ Destructive Sampling --- 2.1 The Concept of Representivity --- 2.2 Plant Sampling Pattern and Design --- 2.3 Biomass Water Equivalent --- 2.4 Conclusions --- 3. Remote Sensing via Satellite Imagery Analysis --- 3.1 Photo-Reflective Properties of Plants --- 3.2 Satellite Image Analysis --- 3.3 Conclusions --- 4. Estimate of Biomass Water Equivalent via the Cosmic Ray Neutron Sensor --- 4.1 The role of Biomass in the CRNS Calibration --- 4.2 Relationship between Neutrons and Crop Biomass --- 4.3 Dire4ct Relationship between Neutrons and Biomass --- 4.4 Conclusions
    Pages: Online-Ressource (X, 33 pages) , 18 illustrations, 14 illustrations in color
    ISBN: 9783319695396
    Language: English
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  • 55
    Keywords: Medicine ; Neurosciences ; Pharmacology ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Pharmacology/Toxicology
    Description / Table of Contents: 1.Overview --- 2.In vivo imaging of nicotinic acetylcholine receptors in the central nervous system --- 3.A new aspect of cholinergic transmission in the central nervous system --- 4.Nicotinic acetylcholine receptor signaling: roles in neuroprotection --- 5.Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection --- 6.Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans --- 7.Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders --- 8.Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer’s and Parkinson’s diseases --- 9.SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors --- 10.Removal of blood amyloid as a therapeutic strategy for Alzheimer’s disease: the influence of smoking and nicotine
    Pages: Online-Ressource (X, 191 pages) , 62 illustrations, 20 illustrations in color
    ISBN: 9789811084881
    Language: English
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  • 56
    Keywords: Life sciences ; Ecosystems ; Aquatic ecology ; Conservation biology ; Ecology ; Nature conservation ; Marine sciences ; Freshwater ; Life Sciences ; Freshwater & Marine Ecology ; Ecosystems ; Conservation Biology/Ecology ; Nature Conservation ; Marine & Freshwater Sciences
    Description / Table of Contents: Chapter 1. Challenges in Riverine Ecosystem Management --- Part I Human Impacts, Mitigation and Restoration --- Chapter 2. Historic Milestones of Human River Uses and Ecological Impacts --- Chapter 3. River Morphology, Channelization, and Habitat Restoration --- Chapter 4. River Hydrology, Flow Alteration, and Environmental Flow --- Chapter 5. Hydropeaking Impacts and Mitigation --- Chapter 6. Dams: Ecological Impacts and Management --- Chapter 7. Aquatic Habitat Modeling in Running Waters --- Chapter 8. The Role of Sediment and Sediment Dynamics in the Aquatic Environment --- Chapter 9. River Connectivity, Habitat Fragmentation and Related Restoration Meas --- Chapter 10. Phosphorus and Nitrogen Dynamics in Riverine Systems: Human Impacts and Management Options --- Chapter 11. Climate Change Impacts in Riverine Ecosystems --- Chapter 12. Ecotoxicology --- Chapter 13. Land Use --- Chapter 14. Recreational Fisheries – The Need for Sustainability in Fisheries Management of Alpine Rivers --- Part II Management, Methodologies, Governance --- Chapter 15. Restoration in Integrated River Basin Management --- Chapter 16.Adaptive Management of Riverine Socio-ecological Systems --- Chapter 17. Legislative Framework for River Ecosystem Management on International and European Level --- Chapter 18. Ensuring Long-Term Cooperation Over Transboundary Water Resources Through Joint River Basin Management --- Chapter 19. Biomonitoring and Bioassessment --- Chapter 20. Biodiversity and Freshwater Information Systems --- Chapter 21. Ecosystem Services in River Landscapes --- Chapter 22. Public Participation and Environmental Education --- Chapter 23. NGOs in Freshwater Resource Management --- Part III Case Studies --- Chapter 24. Danube Under Pressure: Hydropower Rules the Fish --- Chapter 25. Danube Floodplain Lobau --- Chapter 26. Danube Sturgeons: Past and Future --- Chapter 27. Healthy Fisheries Sustain Society and Ecology in Burkina Faso --- Chapter 28. The Tisza River: Managing a Lowland River in the Carpathian Basin --- Part IV Summary --- Chapter 29. Landmarks, Advances and Future Challenges in Riverine Ecosystem Management
    Pages: Online-Ressource (VII, 571 pages) , 123 illustrations, 82 illustrations in color
    ISBN: 9783319732503
    Language: English
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  • 57
    Keywords: Medicine ; Neurosciences ; Neurology ; Psychiatry ; Biomedicine ; Neurosciences ; Neurology ; Psychiatry
    Description / Table of Contents: Hippocampal mechanisms for the segmentation of space by goals and boundaries --- Cortical Evolution: Introduction to the Reptilian Cortex --- Flow of information underlying a tactile decision in mice --- The Visual Brain: Computing through Multiscale Complexity --- Grid cells and spatial maps in entorhinal cortex and hippocampus --- The striatum and decision-making based on value --- Decoding the dynamics of conscious perception: The temporal generalization method --- Sleep and synaptic down-selection --- Federating and integrating what we know about the brain at all scales - a challenge for the future. Computer science meets the clinical neurosciences
    Pages: Online-Ressource (XIII, 172 pages) , 33 illustrations, 30 illustrations in color
    ISBN: 9783319288024
    Language: English
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  • 58
    Unknown
    Warsaw, Berlin : De Gruyter Open
    Keywords: Naval Architecture ; Mechanics ; Control
    Description / Table of Contents: The propulsion system behaviour is a key aspect for the overall dynamics of a ship. However, despite its great importance, numerical methodologies for detailed investigations on marine propulsion dynamics are not yet widely covered in scientific literature. This book presents the main steps for the development of a multi-physic simulation platform, able to represent the motions of a twin screw ship in six degrees of freedom, taking into account the whole propulsion system and automation effects. A number of mathematical sub-models had been developed and calibrated by a set of experimental tests, in model and full scale. Finally, the sea trials campaign of a ship is used to validate and tune the developed simulator. The proposed simulation methodology can be used in the ship preliminary design phase, in order to plan and test the propulsion system and automation. Further applications can include the design optimization and crew training.
    Pages: Online-Ressource (VII, 104 Seiten)
    ISBN: 9783110401509
    Language: English
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  • 59
    Keywords: Life sciences ; Human physiology ; Food ; Biotechnology ; Microbiology ; Life Sciences ; Food Microbiology ; Food Science ; Human Physiology
    Description / Table of Contents: Introduction --- Gastrointestinal digestion models, general introduction --- Static digestion models general introduction --- InfoGest consensus method --- Approaches to static digestion models --- Dynamic digestion models general introduction --- The TNO gastro-Intestinal Model (TIM) --- Dynamic Gastric Model (DGM) --- Human Gastric Simulator (Riddet model) --- The DIDGI® System --- General introduction to cells, cell lines and cell culture --- Epithelial cell models; General introduction --- Caco-2 cell line --- HT29 cell line --- The IPEC-J2 cell line --- Co-cultivation of Caco-2 and HT-29MT --- Innate and adaptive immune cells; General introduction --- THP-1 and U937 cells --- Peripheral blood mononuclear cells --- PBMC-derived T cells --- Dendritic Cells --- Co-culture Caco-2/ immune cells --- Enteroendocrine Cell Models: General introduction --- STC-1 cells --- NCI-H716 cells --- Murine GLUTag cells --- In vitro intestinal tissue models: General introduction --- Intestinal crypt organoids as experimental models --- Porcine ex vivo intestinal segment model --- Ussing chamber --- In vitro fermentation models: General Introduction --- One compartment fermentation model --- The TNO in vitro model of the colon - TIM-2 --- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME® --- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
    Pages: Online-Ressource (XVII, 338 pages) , 57 illustrations, 35 illustrations in color
    ISBN: 9783319161044
    Language: English
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  • 60
    Keywords: Life sciences ; Hydrology ; Environmental sciences ; Agriculture ; Life Sciences ; Agriculture ; Hydrology/Water Resources ; Environmental Science and Engineering
    Description / Table of Contents: Foreword --- Summary --- 2. In-Situ Destructive Sampling --- 2.1 The Concept of Representivity --- 2.2 Plant Sampling Pattern and Design --- 2.3 Biomass Water Equivalent --- 2.4 Conclusions --- 3. Remote Sensing via Satellite Imagery Analysis --- 3.1 Photo-Reflective Properties of Plants --- 3.2 Satellite Image Analysis --- 3.3 Conclusions --- 4. Estimate of Biomass Water Equivalent via the Cosmic Ray Neutron Sensor --- 4.1 The role of Biomass in the CRNS Calibration --- 4.2 Relationship between Neutrons and Crop Biomass --- 4.3 Dire4ct Relationship between Neutrons and Biomass --- 4.4 Conclusions
    Pages: Online-Ressource (X, 33 pages) , 18 illustrations, 14 illustrations in color
    ISBN: 9783319695396
    Language: English
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  • 61
    Unknown
    Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering ; Humanities ; Digital libraries ; Educational technology ; Electrical engineering ; Engineering ; Communications Engineering, Networks ; Digital Humanities ; Technology and Digital Education
    Description / Table of Contents: Vorwort --- Einleitung --- Bürger --- Wenn Bots sich unter Leute mischen: Social Bots in den Sozialen Medien --- Digitale Partizipation in Wissenschaft und Wirtschaft --- Entwicklung einer soziodigitalen Souveränität --- Unternehmen --- Digitale Souveränität – ein mehrdimensionales Handlungskonzept für die deutsche Wirtschaft --- Privatheit und digitale Souveränität in der Arbeitswelt 4.0 --- Staat --- Mehr Daten, weniger Vertrauen in Statistik – freie Fahrt für ‚alternative Fakten‘? --- Internationale Perspektiven auf digitale Souveränität --- Digitalisierung der Bildung als staatliche Aufgabe --- Ausblick
    Pages: Online-Ressource (IX, 187 Seiten) , 40 Abbildungen in Farbe
    ISBN: 9783662557969
    Language: German
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  • 62
    Keywords: Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology
    Description / Table of Contents: Parcellations and connectivity patterns in human and macaque cerebral cortex --- Nanoconnectomics --- Inhibitory cell cypes, circuits and receptive fields in mouse visual cortex --- Form meets function in the brain: observing the activity and structure of specific neural connections --- The network for intracortical communication in mouse visual cortex --- The brain in space --- In-vivo connectivity in monkeys --- Connectome networks: from cells to systems --- Intra- and Inter-hemispheric connectivity supporting hemispheric specialization --- Genetics of the connectome and the ENIGMA project
    Pages: Online-Ressource (X, 166 pages) , 32 illustrations, 28 illustrations in color
    ISBN: 9783319277776
    Language: English
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  • 63
    Keywords: Life sciences ; Climate change ; Animal ecology ; Conservation biology ; Ecology ; Vertebrates ; Life Sciences ; Conservation Biology/Ecology ; Vertebrates ; Animal Ecology ; Climate Change/Climate Change Impacts
    Description / Table of Contents: Bats in the Anthropocene --- Urbanisation and its effects on bats – a global meta-analysis --- Bats and roads --- Responses of tropical bats to habitat fragmentation, logging, and deforestation --- Insectivorous bats and silviculture: balancing timber production and bat conservation --- Bats in the anthropogenic matrix: Challenges and opportunities for the conservation of Chiroptera and their ecosystem services in agricultural landscapes --- Dark matters: the effects of artificial lighting on bats --- Bats and water: anthropogenic alterations threaten global bat populations --- White-nose syndrome in bats --- Zoonotic viruses and conservation of bats --- Impacts of Wind Energy Development on Bats: a Global Perspective --- Exploitation of Bats for Bushmeat and Medicine --- The conflict between pteropodid bats and fruit growers: species, legislation and mitigation --- Bats and buildings: The conservation of synanthropic bats --- Conservation ecology of cave bats --- The roles of taxonomy and systematics in bat conservation --- Networking networks for global bat conservation --- Cute, Creepy, or Crispy – how values, attitudes and norms shape human behavior toward bats. 
    Pages: Online-Ressource (IX, 606 pages) , 77 illustrations, 52 illustrations in color
    ISBN: 9783319252209
    Language: English
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  • 64
    Keywords: Medicine ; Neurosciences ; Otorhinolaryngology ; Biomedicine ; Neurosciences ; Otorhinolaryngology
    Description / Table of Contents: The International Symposium on Hearing is a prestigious,triennial gathering where world-class scientists present and discuss the most recent advances in the field of human and animal hearing research. The 2015 edition will particularly focus on integrative approaches linking physiological, psychophysical and cognitive aspects of normal and impaired hearing. Like previous editions, the proceedings will contain about 50 chapters ranging from basic to applied research, and of interest to neuroscientists, psychologists, audiologists, engineers, otolaryngologists, and artificial intelligent researchers
    Pages: Online-Ressource (XXIX, 484 pages) , 138 illustrations, 92 illustrations in color
    ISBN: 9783319254746
    Language: English
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  • 65
    Keywords: Life sciences ; Management ; Industrial management ; Geography ; Agriculture ; Agricultural economics ; Life Sciences ; Agriculture ; Agricultural Economics ; Geography, general ; Innovation/Technology Management
    Description / Table of Contents: Foreword --- 1. Innovation for Marginalized Smallholder Farmers and Development: an Overview and Implications for Policy and Research --- Part 1 Innovation for the Rural Poor: Theory, Trends and Impacts --- 2. Institutional and technological innovations in polycentric systems –pathways for escaping marginality --- 3. Innovations for Food and Nutrition Security: Impacts and Trends --- 4. Psychology of Innovation: Innovating human psychology? --- 5. An optimization model for technology adoption of marginalized smallholders --- Part 2 Diversification of Agricultural Production and Income --- 6. The BRAC Approach to Small Farmers' Innovations --- 7. Agricultural Research and Extension Linkages in Amhara Region, Ethiopia --- 8. Transaction costs on the Ethiopian formal seed market and innovations for encouraging private sector investments --- 9. Agricultural Service Delivery Through Mobile Phone: Local innovations and Technological Opportunities in Kenya --- 10. Identification and Acceleration of Farmer Innovativeness in Upper East Ghana --- 11. Gender, social equity and innovations in smallholder farming systems: pitfalls and pathways --- 12. Assessing the Sustainability of Agricultural Technology Options for Poor Rural Farmers --- 13. Land Degradation and Sustainable Land Management Innovations in Central Asia --- 14. Biomass-based value web. A Novel Perspective for Emergng Bioeconomies in Sub-Saharan Africa --- Part 3 Sustainable Intensification of Agriculture --- 15. Adoption of Stress-tolerant Rice Varieties in Bangladesh --- 16. More than cereal based cropping innovations for improving food and livelihood security of poor small holders in marginal areas of Bangladesh --- 17. Integrated Rice-fish Farming System in Bangladesh: An Ex-Ante Value Chain Evaluation Framework --- 18. Technologies for Maize, Wheat, Rice and Pulses in Marginal Districts of Odisha and Bihar --- 19. Technological Innovations for Smallholder Farmers in Ghana --- 20. Potential impacts of yield increasing crop technologies on poverty reduction in two districts of Ethiopia
    Pages: Online-Ressource (XV, 435 pages) , 80 illustrations, 50 illustrations in color
    ISBN: 9783319257181
    Language: English
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  • 66
    Keywords: Life sciences ; Applied ecology ; Biodiversity ; Ecosystems ; Conservation biology ; Ecology ; Community psychology ; Environmental psychology ; Life Sciences ; Applied Ecology ; Biodiversity ; Conservation Biology/Ecology ; Ecosystems ; Community and Environmental Psychology
    Description / Table of Contents: 1. The Biodiversity Data Impediment to a Sustainable World (Working in a Networked World) --- 2. Essential Biodiversity Variables --- 3. Stratification and Terrestrial Ecosystem Observations --- 4. Ecosystem Services --- 5. Species Observations --- 6. Monitoring Changes in Genetic Diversity --- 7. Marine and Coastal Systems --- 8. Biodiversity Observations for Freshwater Ecosystems --- 9. Remote Sensing for Biodiversity --- 10. Involving Citizen Scientists in Biodiversity Observation --- 11. Biodiversity Modelling --- 12. Cyber-Architecture --- 13. Using Data for Decision-Making: From Observations To Indicators and Other Policy Tools --- 14. Capacity Building in Biodiversity Monitoring – Case Studies
    Pages: Online-Ressource (XII, 326 pages) , 34 illustrations, 27 illustrations in color
    ISBN: 9783319272887
    Language: English
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  • 67
    Unknown
    Cham : Springer
    Keywords: Medicine ; Neurosciences ; Endocrinology ; Biomedicine ; Neurosciences ; Endocrinology
    Description / Table of Contents: A brief overview of techniques for modulating neuroendocrine and other neural systems --- Basics of stem cell biology as applied to the brain --- Human pluripotent-derived lineages for repairing hypopituitarism --- Recapitulating hypothalamus and pituitary development using ES/iPS cells --- Regulation of body weight and metabolism by tanycyte-derived neurogenesis in young adult mice --- Genetic dissection of the neuroendocrine and behavioral responses to stressful challenges --- Pituitary stem cells: quest for hidden functions --- Pituitary stem cells during normal physiology and disease --- Epigenetic mechanisms of pituitary cell fate specification --- Advances in stem cells biology: new approaches to understand depression --- Perspective on stem cells in developmental biology, with special reference to neuroendocrine systems.
    Pages: Online-Ressource (XII, 156 pages) , 16 illustrations in color
    ISBN: 9783319416038
    Language: English
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  • 68
    Unknown
    Cham : Springer
    Keywords: Life sciences ; Forest products ; Plant anatomy ; Plant development ; Plant physiology ; Life Sciences ; Plant Anatomy/Development ; Plant Physiology ; Plant Systematics/Taxonomy/Biogeography ; Wood Science & Technology
    Description / Table of Contents: Introduction --- Preparation techniques - Making anatomical structures visible --- Morphology of the plant body --- Cellular composition of the plant bodies --- Structure of cell walls and cell contents --- Primary, secondary and tertiary meristem --- Stem anatomical structures of major taxonomic units --- Evolution of stems --- Anatomical adaptions to permanent changed environmental conditions --- Anatomical adaptions to temporarily changed environmental conditions --- Coexistence of algae, fungi and vascular plants --- Wood decay --- Fossilization, permineralization, coalification, carbonization and wetwood conservation --- Technically altered wood products
    Pages: Online-Ressource (VII, 207 pages)
    ISBN: 9783319735245
    Language: English
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  • 69
    Keywords: Life sciences ; Agriculture ; Plant breeding ; Life Sciences ; Plant Breeding/Biotechnology ; Agriculture
    Description / Table of Contents: General Introduction --- Screening Protocols for Heat Tolerance in Rice at the Seedling and Reproductive Stages --- Validation of Screening Protocols for Heat Tolerance in Rice --- Conclusion --- References
    Pages: Online-Ressource (XII, 39 pages) , 16 illustrations, 10 illustrations in color
    ISBN: 9783319773384
    Language: English
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  • 70
    Keywords: Life sciences ; Agriculture ; Climate change ; Environmental management ; Soil science ; Soil conservation ; Air pollution ; Life Sciences ; Agriculture ; Climate Change ; Atmospheric Protection/Air Quality Control/Air Pollution ; Soil Science & Conservation ; Environmental Management
    Description / Table of Contents: Chapter 1 Introduction to the SAMPLES Approach --- Chapter 2 Targeting Landscapes to Identify Mitigation Options --- Chapter 3 Determining Greenhouse Gas Emissions and Removals Associated with Land Use and Land Cover Change --- Chapter 4 Quantifying Greenhouse Gas Emissions from Managed and Natural Soils --- Chapter 5 A Comparison of Methodologies for Measuring Methane Emissions from Ruminants --- Chapter 6 Quantifying Tree Biomass Carbon Stocks and Fluxes in Agricultural Landscapes --- Chapter 7 Methods for Smallholder Quantification of Soil Carbon Stocks and Stock Changes --- Chapter 8 Yield Estimation of Food and Non-Food Crops in Smallholder Production Systems --- Chapter 9 Scaling Point and Plot Measurements of Greenhouse Gas Fluxes, Balances and Intensities to Whole Farms and Landscapes --- Chapter 10 Methods for Environment-Productivity Trade-off Analysis in Agricultural Systems
    Pages: Online-Ressource (XV, 203 pages) , 33 illustrations, 27 illustrations in color
    ISBN: 9783319297941
    Language: English
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  • 71
    Keywords: Life sciences ; Ecology ; Wildlife ; Fish ; Life Sciences ; Fish & Wildlife Biology & Management ; Ecology ; Environmental Monitoring/Analysis
    Description / Table of Contents: 1 Introduction: Overview of Our Research on Impacts of the Fukushima Dai-ichi Nuclear Power Plant Accident on Fish and Fishing Grounds --- Part I Seawater and Plankton --- 2 134Cs and 137Cs in the Seawater Around Japan and in the North Pacific --- 3 Temporal Changes in 137Cs Concentration in Zooplankton and Seawater off the Joban–Sanriku Coast, and in Sendai Bay, After the Fukushima Dai-ichi Nuclear Accident --- Part II Sediments and Benthos --- 4 Three-Dimensional Distribution of Radiocesium in Sea Sediment Derived from the Fukushima Dai-ichi Nuclear Power Plant --- 5 Radiocesium Concentrations in the Organic Fraction of Sea Sediments --- 6 Bottom Turbidity, Boundary Layer Dynamics, and Associated Transport of Suspended Particulate Materials off the Fukushima Coast --- 7 Investigation of Radiocesium Translation from Contaminated Sediment to Benthic Organisms --- Part III Marine Fish --- 8 Detection of 131I, 134Cs, and 137Cs Released into the Atmosphere from FNPP in Small Epipelagic Fishes, Japanese Sardine and Japanese Anchovy, off the Kanto Area, Japan --- 9 Radiocesium Concentration of Small Epipelagic Fishes (Sardine and Japanese Anchovy) off the Kashima-Boso Area --- 10 Why Do the Radionuclide Concentrations of Pacific Cod Depend on the Body Size? --- 11 Radiocesium Contamination Histories of Japanese Flounder (Paralichthys olivaceus) After the 2011 Fukushima Nuclear Power Plant Accident --- Part IV Mechanisms of Severe Contamination in Fish --- 12 Evaluating the Probability of Catching Fat Greenlings (Hexagrammos otakii) Highly Contaminated with Radiocesium off the Coast of Fukushima --- 13 Analysis of the Contamination Process of the Extremely Contaminated Fat Greenling by Fukushima-Derived Radioactive Material --- 14 Contamination Levels of Radioactive Cesium in Fat Greenling Caught at the Main Port of the Fukushima Dai-ichi Nuclear Power Plant --- Part V Freshwater Systems --- 15 Comparison of Radioactive Cesium Contamination of Lake Water, Bottom Sediment, Plankton, and Freshwater Fish Among Lakes of Fukushima Prefecture, Japan, After the Fukushima Fallout --- 16 Radiocesium Concentrations and Body Size of Freshwater Fish in Lake Hayama 1 Year After the Fukushima Dai-Ichi Nuclear Power Plant Accident --- 17 Spatiotemporal Monitoring of 134Cs and 137Cs in Ayu, Plecoglossus altivelis, a Microalgae-Grazing Fish, and in Their Freshwater Habitats in Fukushima --- 18 Radiocesium Concentrations in the Muscle and Eggs of Salmonids from Lake Chuzenji, Japan, After the Fukushima Fallout --- 19 Assessment of Radiocesium Accumulation by Hatchery-Reared Salmonids After the Fukushima Nuclear Accident
    Pages: Online-Ressource (XI, 238 pages) , 103 illustrations, 37 illustrations in color
    ISBN: 9784431555377
    Language: English
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  • 72
    Keywords: Medicine ; Immunology ; Molecular biology ; Cell biology ; Biomedicine ; Molecular Medicine ; Immunology ; Cell Biology
    Description / Table of Contents: Part I Basic Research for Innovative Medicine --- 1. Diverting Glycolysis to Combat Oxidative Stress --- 2. Metabolic Regulation by Nuclear Receptors --- 3. Fighting Fire with Fire in Cancer --- 4. Linear Polyubiquitination: a Crucial Regulator of NF-kB Activation --- 5. VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders --- 6. Roles of E-cadherin in hepatocarcinogenesis --- 7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors --- 8. Inhibitory immunoreceptors on mast cells in allergy and inflammation --- 9. Doxycycline-inducible Autoimmune Blistering Skin Disease Model --- 10. T-cell Senescence and Autoimmunity --- Part II Translational Research for Innovative Medicine --- 11. IL-6: A new era for the treatment of autoimmune inflammatory diseases --- 12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies --- 13. Multifaceted translational approach of major mental illness --- 14. Translational research of leptin in lipodystrophy and its related diseases --- 15. Translational research of the activation of the C-type natriuretic peptide (CNP)-guanylyl cyclase-B pathway for skeletal dysplasia --- 16. Clarity and Challenges in Tissue Fibrosis --- 17. TRP Channels: Their Function and Potentiality as Drug Targets --- 18. Autophagic Cell Death and Cancer Chemotherapeutics --- 19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis --- 20. RNA activation --- Part III New Technology for Innovative Medicine --- 21. Cardiac Reprogramming for Heart Repair --- 22. Development of a new in vivo optical probe for biological diagnosis and therapy --- 23. Introduction of mesenchymal stem cells for liver surgery (hepatectomy and transplantation) --- 24. Synaptic and axonal plasticity induction in the human cerebral cortex --- 25. TIM-3 is a novel therapeutic target for eradicating acute myelogenous leukemia stem cells --- 26. TGF-beta LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis --- 27. Cell-based regenerative therapy for liver disease
    Pages: Online-Ressource (IX, 339 pages)
    ISBN: 9784431556510
    Language: English
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  • 73
    Unknown
    Basel, Beijing, Wuhan : MDPI
    Keywords: aerosol optical depth ; climate variability and health ; earth observation ; environmental health ; environmental remote sensing ; exposure to air pollutant ; geospatial technology ; health GIS ; landscape epidemiology ; public health ; public health tracking ; remote sensing ; spatial surveillance ; spatial epidemiology ; tele-epidemiology
    Description / Table of Contents: Editorial - Remote Sensing and Geospatial Technologies in Public Health / ISPRS Int. J. Geo-Inf. 2018, 7(8), 303; https://doi.org/10.3390/ijgi7080303 --- CALPUFF and CAFOs: Air Pollution Modeling and Environmental Justice Analysis in the North Carolina Hog Industry / ISPRS Int. J. Geo-Inf. 2015, 4(1), 150-171; https://doi.org/10.3390/ijgi4010150 --- Analyzing the Correlation between Deer Habitat and the Component of the Risk for Lyme Disease in Eastern Ontario, Canada: A GIS-Based Approach / ISPRS Int. J. Geo-Inf. 2015, 4(1), 105-123; https://doi.org/10.3390/ijgi4010105 --- Geospatial Technology: A Tool to Aid in the Elimination of Malaria in Bangladesh / ISPRS Int. J. Geo-Inf. 2015, 4(1), 47-58; https://doi.org/10.3390/ijgi4010047 --- Examining Personal Air Pollution Exposure, Intake, and Health Danger Zone Using Time Geography and 3D Geovisualization / ISPRS Int. J. Geo-Inf. 2015, 4(1), 32-46; https://doi.org/10.3390/ijgi4010032 --- Use of the NASA Giovanni Data System for Geospatial Public Health Research: Example of Weather-Influenza Connection / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1372-1386; https://doi.org/10.3390/ijgi3041372 --- Mapping Entomological Dengue Risk Levels in Martinique Using High-Resolution Remote-Sensing Environmental Data / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1352-1371; https://doi.org/10.3390/ijgi3041352 --- Improving Inland Water Quality Monitoring through Remote Sensing Techniques / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1234-1255; https://doi.org/10.3390/ijgi3041234 --- Impacts of Scale on Geographic Analysis of Health Data: An Example of Obesity Prevalence / ISPRS Int. J. Geo-Inf. 2014, 3(4), 1198-1210; https://doi.org/10.3390/ijgi3041198 --- Geographical Variation of Incidence of Chronic Obstructive Pulmonary Disease in Manitoba, Canada / ISPRS Int. J. Geo-Inf. 2014, 3(3), 1039-1057; https://doi.org/10.3390/ijgi3031039 --- Holistics 3.0 for Health / ISPRS Int. J. Geo-Inf. 2014, 3(3), 1023-1038; https://doi.org/10.3390/ijgi3031023 --- Dasymetric Mapping and Spatial Modeling of Mosquito Vector Exposure, Chesapeake, Virginia, USA / ISPRS Int. J. Geo-Inf. 2014, 3(3), 891-913; https://doi.org/10.3390/ijgi3030891 --- Modeling Properties of Influenza-Like Illness Peak Events with Crossing Theory / ISPRS Int. J. Geo-Inf. 2014, 3(2), 764-780; https://doi.org/10.3390/ijgi3020764 --- Correlating Remote Sensing Data with the Abundance of Pupae of the Dengue Virus Mosquito Vector, Aedes aegypti, in Central Mexico / ISPRS Int. J. Geo-Inf. 2014, 3(2), 732-749; https://doi.org/10.3390/ijgi3020732 --- Canadian Forest Fires and the Effects of Long-Range Transboundary Air Pollution on Hospitalizations among the Elderly / ISPRS Int. J. Geo-Inf. 2014, 3(2), 713-731; https://doi.org/10.3390/ijgi3020713 --- Nexus of Health and Development: Modelling Crude Birth Rate and Maternal Mortality Ratio Using Nighttime Satellite Images / ISPRS Int. J. Geo-Inf. 2014, 3(2), 693-712; https://doi.org/10.3390/ijgi3020693
    Pages: Online-Ressource (244 Seiten) , Illustrationen, Diagramme
    Edition: Printed Edition of the Special Issue Published in ISPRS International Journal of Geo-Information
    ISBN: 9783038971733
    Language: English
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  • 74
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 14 (1996), S. 301-331 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II regulation has recently come from the study of patients that suffer from a primary immunodeficiency resulting from regulatory defects in MHC-II expression. A genetic complementation cloning approach has led to the isolation of CIITA and RFX5, two essential MHC-II gene transactivators. CIITA and RFX5 are mutated in these patients, and the wild-type genes are capable of correcting their defect in MHC-II expression. The identification of these regulatory factors has furthered our understanding of the molecular mechanisms that regulate MHC-II genes. CIITA was found to be a non-DNA binding transactivator that functions as a molecular switch controlling both constitutive and inducible MHC-II expression. The finding that RFX5 is a subunit of the nuclear RFX-complex has confirmed that a deficiency in the binding of this complex is indeed the molecular basis for MHC-II deficiency in the majority of patients. Furthermore, the study of RFX has demonstrated that MHC-II promoter activity is dependent on the binding of higher-order complexes that are formed by highly specific cooperative binding interactions between certain MHC-II promoter-binding proteins. Two of these proteins belong to families of which the other members, although capable of binding to the same DNA motifs, are probably not directly involved in the control of MHC-II expression. Finally, the facts that CIITA and RFX5 are both essential and highly specific for MHC-II genes make possible novel strategies designed to achieve immunomodulation via transcriptional intervention.
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  • 75
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 14 (1996), S. 397-440 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNFalpha, IL-1, IL-6, GM-CSF, and chemokines such as IL-8 are abundant in all patients regardless of therapy. This is compensated to some degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGFbeta and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the TNFalpha and IL-1 produced. In rheumatoid joint cell cultures that spontaneously produce IL-1, TNFalpha was the major dominant regulator of IL-1. Subsequently, other proinflammatory cytokines were also inhibited if TNFalpha was neutralized, leading to the new concept that the proinflammatory cytokines were linked in a network with TNFalpha at its apex. This led to the hypothesis that TNFalpha was of major importance in rheumatoid arthritis and was a therapeutic target. This hypothesis has been successfully tested in animal models, of, for example, collagen-induced arthritis, and these studies have provided the rationale for clinical trials of anti-TNFalpha therapy in patients with long-standing rheumatoid arthritis. Several clinical trials using a chimeric anti-TNFalpha antibody have shown marked clinical benefit, verifying the hypothesis that TNFalpha is of major importance in rheumatoid arthritis. Retreatment studies have also shown benefit in repeated relapses, indicating that the disease remains TNFalpha dependent. Overall these studies demonstrate that analysis of cytokine expression and regulation may yield effective therapeutic targets in inflammatory disease.
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  • 76
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 14 (1996), S. 511-532 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract In contrast with the study of alphabeta T cells, that of gammadelta T cells is relatively recent and stems from the discovery of their rearranged genes, rather than from any knowledge of their biological function. Thus, experiments designed to characterize their specificity and function have drawn heavily on our knowledge of alphabeta T cells. During the past few years, many studies, especially with mice lacking either alphabeta or gammadelta T cells, have demonstrated that gammadelta T cells can contribute to immune competence, but they do so in a way that is distinct from alphabeta T cells. It is also evident that gammadelta T cells may not recognize antigen the same way as do alphabeta T cells. Analysis of three protein antigens-the murine MHC class II IEk, the nonclassical MHC T10/T22, and the Herpes virus glycoprotein gI-indicates that gammadelta T cell recognition does not require antigen processing and that the proteins are recognized directly. In all three cases, recognition by these T cell clones involves neither peptides bound to these proteins nor peptides derived from them. Moreover, a group of small phosphate-containing nonpeptide compounds derived from mycobacterial extracts has been found to stimulate a major population of human peripheral gammadelta T cells in a T cell receptor (TCR)-dependent manner. This indicates that gammadelta T cells can respond to ligands that are different from those of alphabeta T cells. Analysis of complementarity determining region (CDR3) length distributions of gamma and delta chains indicates that they are more similar to those of immunoglobulins than to TCR alpha and beta. This further supports the idea that gammadelta and alphabeta T cells recognize antigens differently and suggests that gammadelta T cells may be more like immunoglobulins in their recognition properties. gammadelta T cells share many cell surface proteins with alphabeta T cells and are able to secrete lymphokines and express cytolytic activities in response to antigenic stimulation. These, together with the results cited above, indicate that gammadelta T cells can mediate cellular immune functions without a requirement for antigen processing. Thus, pathogens, damaged tissues, or even B and T cells can be recognized directly, and cellular immune responses can be initiated without a requirement for antigen degradation or specialized antigen-presenting cells. This would give gammadelta T cells greater flexibility than the more classical type of alphabeta T cell-mediated cellular immunity.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 14 (1996), S. 649-681 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The transcription factor NF-kappaB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases. A primary level of control for NF-kappaB is through interactions with an inhibitor protein called IkappaB. Recent evidence confirms the existence of multiple forms of IkappaB that appear to regulate NF-kappaB by distinct mechanisms. NF-kappaB can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1, viral infection or expression of certain viral gene products, UV irradiation, B or T cell activation, and by other physiological and nonphysiological stimuli. Activation of NF-kappaB to move into the nucleus is controlled by the targeted phosphorylation and subsequent degradation of IkappaB. Exciting new research has elaborated several important and unexpected findings that explain mechanisms involved in the activation of NF-kappaB. In the nucleus, NF-kappaB dimers bind to target DNA elements and activate transcription of genes encoding proteins involved with immune or inflammation responses and with cell growth control. Recent data provide evidence that NF-kappaB is constitutively active in several cell types, potentially playing unexpected roles in regulation of gene expression. In addition to advances in describing the mechanisms of NF-kappaB activation, excitement in NF-kappaB research has been generated by the first report of a crystal structure for one form of NF-kappaB, the first gene knockout studies for different forms of NF-kappaB and of IkappaB, and the implications for therapies of diseases thought to involve the inappropriate activation of NF-kappaB.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 93-124 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 203-234 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract This review deals with membrane Fc receptors (FcR) of the immunoglobulin superfamily. It is focused on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed. FcR deliver signals when they are aggregated at the cell surface. The aggregation of FcR having immunoreceptor tyrosine-based activation motifs (ITAMs) activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors. FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis. The nature of responses depends primarily on the cell type. The aggregation of FcR without ITAM does not trigger cell activation. Most of these FcR internalize their ligands, which can be endocytosed, phagocytosed, or transcytosed. The fate of internalized receptor-ligand complexes depends on defined sequences in the intracytoplasmic domain of the receptors. The coaggregation of different FcR results in positive or negative cooperation. Some FcR without ITAM use FcR with ITAM as signal transduction subunits. The coaggregation of antigen receptors or of FcR having ITAMs with FcR having immunoreceptor tyrosine-based inhibition motifs (ITIMs) negatively regulates cell activation. FcR therefore appear as the subunits of multichain receptors whose constitution is not predetermined and which deliver adaptative messages as a function of the environment.
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  • 80
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 297-322 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses. The Th2 subset produces cytokines such as IL-4 and IL-5 that help B cells to proliferate and differentiate and is associated with humoral-type immune responses. The selective differentiation of either subset is established during priming and can be significantly influenced by a variety of factors. One of these factors, the cytokine environment, has been put forward as the major variable influencing Th development and is already well reviewed by others. Instead, in the current review, we focus on some of the alternative approaches for skewing Th1/Th2 responses. Specifically, we discuss the effects on Th priming of (a) using altered peptide ligands as antigens, (b) varying the dose of antigen, and (c) altering costimulatory signals. The potential importance of each of these variables to influence immune responses to pathogens in vivo is discussed throughout.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 405-431 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Epstein-Barr virus (EBV) provides one of the most informative systems with which to study cytotoxic T lymphocyte (CTL) responses in humans. The virus establishes a highly immunogenic growth-transforming infection of B lymphocytes, associated with the coordinate expression of six virus-coded nuclear antigens (EBNAs 1, 2, 3A, 3B, 3C, -LP) and two latent membrane proteins (LMPs 1 and 2). This elicits both primary and memory CT8+ CTL responses that are markedly skewed toward HLA allele-specific epitopes drawn from the EBNA3A, 3B, 3C subset of latent proteins, with reactivities to other antigens being generally much less frequent. This heirarchy of immunodominance among the different latent proteins may at least partly reflect their differential accessibility to the HLA class I-processing pathway. Furthermore, CTLs to some of the immunodominant epitopes involve highly conserved T cell receptor (TCR) usage, a level of focusing which evidence suggests could have immunopathological consequences from cross-reactive recognition of other target structures. EBV is associated with a range of human tumors, and there is increasing interest in the possibility of targeting such malignancies using virus-specific CTLs. The dramatic reversal of EBV-driven lymphoproliferations in bone marrow transplant patients following CTL infusion demonstrates the potential of this approach, and here we discuss prospects for its extension to other EBV-positive tumors in which the immunodominant EBNA3A, 3B, 3C proteins are not expressed.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 535-562 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract NK1 T cells are a specialized population of alpha/beta T cells that coexpress receptors of the NK lineage and have the unique potential to very rapidly secrete large amounts of cytokines, providing early help for effector cells and regulating the Th1 or Th2 differentiation of some immune responses. NK1 T cells express a restricted TCR repertoire made of an invariant TCR alpha chain, Valpha14-Jalpha281, associated with polyclonal Vbeta8, Vbeta7, and Vbeta2 TCR beta chains. NK1 T cells recognize the products of the conserved family of MHC class I-like CD1 genes, apparently in the absence of foreign antigens. Thus, this novel regulatory pathway, which straddles the innate and the adaptive immune systems, is unique in that its activation may not require associative recognition of antigen. Here, we review the specificity and function of mouse NK1 T cells, and we discuss the relationship of this lineage to mainstream T cells and NK cells.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 15 (1997), S. 797-819 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Receptors for most interleukins and cytokines that regulate immune and hematopoietic systems belong to the class I cytokine receptor family. These molecules form multichain receptor complexes in order to exhibit high-affinity binding to, and mediate biological functions of, their respective cytokines. In most cases, these functional receptor complexes share common signal transducing receptor components that are also in the class I cytokine receptor family, i.e. gp130, common beta, and common gamma molecules. Interleukin-6 and related cytokines, interleukin-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1 are all pleiotropic and exhibit overlapping biological functions. Functional receptor complexes for this interleukin-6 family of cytokines share gp130 as a component critical for signal transduction. Unlike cytokines sharing common beta and common gamma chains that mainly function in hematopoietic and lymphoid cell systems, the interleukin-6 family of cytokines function extensively outside these systems as well, e.g. from the cardiovascular to the nervous system, owing to ubiquitously expressed gp130. Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130.
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    Annual Review of Immunology 16 (1998), S. 1-25 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: At first one is very pleased at being invited to write a Prefatory Chapter, but as the delivery deadline draws closer one begins to think, "Oh my God! What on earth can I say that all but family members and few close friends will not find a great bore?" One solution is to write a scientific essay, but I concluded that that was a cop-out. I decided that perhaps the best tack to follow was to try to convey to the reader the personal characteristics I bring to my science and to other aspects of my professional career. The writing of this chapter has certainly convinced me that my particular background influenced what problems I chose to work on and how I approached their solution, but I hope that my results have a more ecumenical significance. There's been much written recently about how one's cultural background affects one's science, but I think that thesis can also be exaggerated. Science is a method of inquiry that by using certain guidelines permits rational individuals to observe Nature in a way that their findings will agree and have permanence. We shouldn't be diffident about defending that claim of objectivity.
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    Annual Review of Immunology 16 (1998), S. 111-135 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract CD40-CD154-mediated contact-dependent signals between B and T cells are required for the generation of thymus dependent (TD) humoral immune responses. CD40-CD154 interactions are however also important in many other cell systems. CD40 is expressed by a large variety of cell types other than B cells, and these include dendritic cells, follicular dendritic cells, monocytes, macrophages, mast cells, fibroblasts, and endothelial cells. CD40- and CD154-knockout mice and antibodies to CD40 and CD154 have helped to elucidate the role of the CD40-CD154 system in immune responses. Recently published studies indicate that CD40-CD154 interactions can influence T cell priming and T cell-mediated effector functions; they can also upregulate costimulatory molecules and activate macrophages, NK cells, and endothelia as well as participate in organ-specific autoimmune disease, graft rejection, and even atherosclerosis. This review focuses on the role of the CD40-CD154 system in the regulation of many newly discovered functions important in inflammation and cell-mediated immunity.
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    Annual Review of Immunology 16 (1998), S. 201-223 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Immunological memory can be defined as the faster and stronger response of an animal that follows reexposure to the same antigen. By this definition, it is an operational property of the whole animal or the immune system. Memory cells express a different pattern of cell surface markers, and they respond in several ways that are functionally different from those of naive cells. Murine memory cells are CD44 high and low in the expression of activation markers such as CD25 (IL-2R), whereas human memory cells are CD45RA-, CD45RO+. In contrast to naive cells, memory cells secrete a full range of T cell cytokines and can be polarized to secrete particular restricted patterns of secretion for both CD4 and CD8 T cells. The requirements for the activation of memory cells for proliferation and cytokine production are not quite as strict as those of naive cells, but costimulation in the broad sense is required for optimum responses and for responses to suboptimum antigen concentrations. It would appear that memory cells can persist in the absence of antigenic stimulation and persist as nondividing cells. Reencounter with the same antigen can expand the population to a new, stable, higher level and generate a separate population of CD44 high effectors that may be required for protection, while competition from other antigens can drive it down to a lower stable level. It is unclear how or where memory cells arise, but once generated they have different pathways of recirculation and homing.
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    Annual Review of Immunology 16 (1998), S. 359-393 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of co-stimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I. Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules. A common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors. Upon ligand binding and activation, the inhibitory NK cell receptors become tyrosine phosphorylated and recruit tyrosine phosphatases, SHP-1 and possibly SHP-2, resulting in inhibition of NK cell-mediated cytotoxicity and cytokine expression. Recent studies suggest these inhibitory NK cell receptors are members of a larger superfamily containing ITIM sequences, the inhibitory receptor superfamily (IRS).
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    Annual Review of Immunology 16 (1998), S. 433-470 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract This review summarizes the clinical history and rationale for xenotransplantation; recent progress in understanding the physiologic, immunologic, and infectious obstacles to the procedure's success; and some of the strategies being pursued to overcome these obstacles. The problems of xenotransplantation are complex, and a combination of approaches is required. The earliest and most striking immunologic obstacle, that of hyperacute rejection, appears to be the closest to being solved. This phenomenon depends on the binding of natural antibody to the vascular endothelium, fixation of complement by that antibody, and finally, activation of the endothelium and initiation of coagulation. Therefore, these three pathways have been targeted as sites for intervention in the process. The mechanisms responsible for the next immunologic barrier, that of delayed xenograft/acute vascular rejection, remain to be fully elucidated. They probably also involve multiple pathways, including antibody and/or immune cell binding and endothelial cell activation. The final immunologic barrier, that of the cellular immune response, involves mechanisms that are similar to those involved in allograft rejection. However, the strength of the cellular immune response to xenografts is so great that it is unlikely to be controlled by the types of nonspecific immunosuppression used routinely to prevent allograft rejection. For this reason, it may be essential to induce specific immunologic unresponsiveness to at least some of the most antigenic xenogeneic molecules.
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    Annual Review of Immunology 16 (1998), S. 545-568 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Covalent attachment of activated complement C3 (C3d) to antigen links innate and adaptive immunity by targeting antigen to follicular dendritic cells (FDC) and B cells via specific receptors CD21 and CD35. Recent characterization of knockout mice deficient in complement components C3, C4, or the receptors CD21 and CD35 as well as biochemical studies of the CD21/CD19/Tapa-1 coreceptor on B cells have helped to elucidate the mechanism of complement regulation of both B-1 and B-2 lymphocytes. Interestingly, natural antibody of the adaptive immune system provides a major recognition role in activation of the complement system, which in turn enhances activation of antigen-specific B cells. Enhancement of the primary and secondary immune response to T-dependent antigens is mediated by coligation of the coreceptor and the B cell antigen receptor, which dramatically increases follicular retention and B cell survival within the germinal center. Most recent evidence suggests that complement also regulates elimination of self-reactive B cells, as breeding of mice that are deficient in C4 or CD21/CD35 with the lupus-prone strain of lpr mice demonstrates an exacerbation of disease due to an increase in autoantibodies.
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    Annual Review of Immunology 17 (1999), S. 1-17 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Work done in the late 1950s and in the 1960s revealed the role of the thymus in virus-induced leukemia in mice. Thymectomizing mice at birth to test whether the virus first multiplied in thymus tissue and then spread elsewhere ultimately led to the conclusion that the thymus was essential to the normal development of the immune system. Subsequent testing to try to understand how the thymus contributes to the pool of immunocompetent lymphocytes opened a new chapter in immunology and required a reappraisal of many immunological phenomena and an understanding of the molecular interactions that take place during cell-to-cell interactions.
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    Annual Review of Immunology 17 (1999), S. 19-49 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Interleukin-15 (IL-15) is a 14- to 15-kDa member of the 4 alpha-helix bundle family of cytokines. IL-15 expression is controlled at the levels of transcription, translation, and intracellular trafficking. In particular, IL-15 protein is posttranscriptionally regulated by multiple controlling elements that impede translation, including 12 upstream AUGs of the 5' UTR, 2 unusual signal peptides, and the C-terminus of the mature protein. IL-15 uses two distinct receptor and signaling pathways. In T and NK cells the IL-15 receptor includes IL-2/15Rbeta and gammac, subunits, which are shared with IL-2, and an IL-15-specific receptor subunit, IL-15Ralpha. Mast cells respond to IL-15 with a receptor system that does not share elements with the IL-2 receptor but uses a novel 60- to 65-kDa IL-15RX subunit. In mast cells IL-15 signaling involves Jak2/STAT5 activation rather than the Jak1/Jak3 and STAT5/STAT3 system used in activated T cells. In addition to its other functional activities in immune and nonimmune cells, IL-15 plays a pivotal role in the development, survival, and function of NK cells. Abnormalities of IL-15 expression have been described in patients with rheumatoid arthritis or inflammatory bowel disease and in diseases associated with the retroviruses HIV and HTLV-I. New approaches directed toward IL-15, its receptor, or its signaling pathway may be of value in the therapy of these disorders.
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    Annual Review of Immunology 17 (1999), S. 189-220 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to mediate significant levels of cytotoxic activity and produce high levels of certain cytokines and chemokines. NK cells respond to and are important in defense against a number of different infectious agents. The first indications for this function came from the observations that virus-induced interferons alpha/beta (IFN-alpha and -beta) are potent inducers of NK cell-mediated cytotoxicity, and that NK cells are important contributors to innate defense against viral infections. In addition to IFN-alpha/beta, a wide range of other innate cytokines can mediate biological functions regulating the NK cell responses of cytotoxicity, proliferation, and gamma interferon (IFN-gamma) production. Certain, but not all, viral infections induce interleukin 12 (IL-12) to elicit NK cell IFN-gamma production and antiviral mechanisms. However, high levels of IFN-alpha/beta appear to be unique and/or uniquely dominant in the context of viral infections and act to regulate other innate responses, including induction of NK cell proliferation in vivo and overall negative regulation of IL-12 production. A detailed picture is developing of particular innate cytokines activating NK cell responses and their consorted effects in providing unique endogenous milieus promoting downstream adaptive responses, most beneficial in defense against viral infections.
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    Annual Review of Immunology 17 (1999), S. 331-367 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-alpha, LT-alpha, LT-beta, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LTbetaR), and herpes virus entry mediator (HVEM) to control a wide range of innate and adaptive immune response functions. Of these, the most thoroughly studied are cell death induction and regulation of the inflammatory process. Fas/Apo1 (CD95), a receptor of the TNF receptor family activated by a distinct ligand, induces death in cells through mechanisms shared with CD120a. The last four years have seen a proliferation in knowledge of the proteins participating in the signaling by the TNF system and CD95. The downstream signaling molecules identified so far-caspases, phospholipases, the three known mitogen activated protein (MAP) kinase pathways, and the NF-kappaB activation cascade-mediate the effects of other inducers as well. However, the molecules that initiate these signaling events, including the death domain- and TNF receptor associated factor (TRAF) domain-containing adapter proteins and the signaling enzymes associated with them, are largely unique to the TNF/nerve growth factor receptor family.
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    Annual Review of Immunology 17 (1999), S. 369-397 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural basis of cellular immune recognition. Crystal structures have been determined for full-length and truncated forms of alphabeta T cell receptor (TCR) heterodimers, both alone and in complex with their peptide-MHC (pMHC) ligands or with anti-TCR antibodies. In addition, a truncated CD8 coreceptor has been visualized with a pMHC. Aided in large part by the substantial body of knowledge accumulated over the last 25 years on antibody structure, a number of general conclusions about TCR structure and its recognition of antigen can already be derived from the relatively few TCR structures that have been determined. Small, but important, variations between TCR and antibody structures bear on their functional differences as well as on their specific antigen recognition requirements. As observed in antibodies, canonical CDR loop structures are already emerging for some of the TCR CDR loops. Highly similar docking orientations of the TCR Valpha domains in the TCR/pMHC complex appear to play a primary role in dictating orientation, but the Vbeta positions diverge widely. Similar TCR contact positions, but whose exact amino acid content can vary, coupled with relatively poor interface shape complementarity, may explain the flexibility and short half-lives of many TCR interactions with pMHC. Here we summarize the current state of this field, and suggest that the knowledge gap between the three-dimensional structure and the signaling function of the TCR can be bridged through a synthesis of molecular biological and biophysical techniques.
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    Annual Review of Immunology 17 (1999), S. 555-592 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.
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    Annual Review of Immunology 17 (1999), S. 593-623 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic receptors, like the mannose receptor, that recognize conserved motifs on pathogens. Pathogens are also phagocytosed by complement receptors after relatively nonspecific opsonization with complement and by Fc receptors after specific opsonization with antibodies. All these receptors induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle. However, important differences in the molecular mechanisms underlying phagocytosis by different receptors are now being appreciated. These include differences in the cytoskeletal elements that mediate ingestion, differences in vacuole maturation, and differences in inflammatory responses. Infectious agents, such as M. tuberculosis, Legionella pneumophila, and Salmonella typhimurium, enter macrophages via heterogeneous pathways and modify vacuolar maturation in a manner that favors their survival. Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response.
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    Annual Review of Immunology 17 (1999), S. 781-828 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The immune system relies on cell death to maintain lymphoid homeostasis and avoid disease. Recent evidence has indicated that the caspase family of cysteine proteases is a central effector in apoptotic cell death and is absolutely responsible for many of the morphological features of apoptosis. Cell death, however, can occur through caspase-independent and caspase-dependent pathways. In the case of cells that are irreversibly neglected or damaged, death occurs even in the absence of caspase activity. In contrast, healthy cells require caspase activation to undergo cell death induced by surface receptors. This review summarizes the current understanding of these two pathways of cell death in the immune system.
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    Annual Review of Immunology 17 (1999), S. 973-976 
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    Annual Review of Immunology 18 (2000), S. 1-17 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The discovery that genes in the major histocompatibility complex (MHC) play an important role in the immune response depended on the chance interaction of several unrelated events. The first, and most important, was the decision by Michael Sela to synthesize a series of branched, multichain, synthetic polypeptides based on a backbone of poly-l-lysine. The prototype compound, (T,G)-A-L, was tipped with short random sequences of tyrosine and glutamic acid. This resulted in a restricted range of antigenic determinants composed of only two or three amino acids with a variable length-ideal for binding to the peptide binding groove of MHC class II molecules. The second was the decision by John Humphrey to immunize various strains of rabbits with this synthetic polypeptide. Two of these rabbit strains showed very large quantitative differences in antibody response to (T,G)-A-L. In transferring this system to inbred mouse strains, the third bit of good fortune was the availability at the National Institute of Medical Research, in Mill Hill (London), of the CBA (H2k) and C57 (H2b) strains. The H2b haplotype is the only one mediating a uniform high antibody response to (T,G)-A-L. The fourth critical ingredient was the availability of numerous congenic and H2 recombinant inbred strains of mice produced earlier by Snell, Stimpfling, Shreffler, and Klein. A search for congenic pairs of mice expressing the responder and nonresponder H2 haplotypes on the same background revealed that these strains responded as a function of their H2 haplotype, not of their inbred background. Extensive studies in a variety of inbred strains carrying recombinant H2 haplotypes, as well as a four-point linkage cross, mapped immune response to (T,G)A-L within the murine MHC, between the K and Ss loci. The demonstration that stimulation in the mixed lymphocyte reaction (MLR) mapped to the same region quickly led to attempts to produce antisera in congenic H2 recombinant strain combinations. These antisera identified I-region associated (Ia) antigens. Immunoprecipitation and blocking studies showed that the gene products controlling specific immune responses, the mixed lymphocyte reaction, and the structure of Ia antigens were one and the same-now designated as the I-A MHC class II molecules. These antisera and inbred strains enabled Unanue to demonstrate the peptide binding function of class II MHC molecules.
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    Annual Review of Immunology 18 (2000), S. 165-184 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Ligation of the T cell antigen receptor (TCR) stimulates protein tyrosine kinases (PTKs), which regulate intracellular calcium and control the activity of protein kinase C (PKC) isozymes. PTKs activated by antigen receptors and costimulatory molecules also couple to phosphatidylinositol-3 kinase (PI3K) and control the activity of Ras- and Rho-family GTPases. T cell signal transduction is triggered physiologically by antigen in the context of antigen presenting cells (APC). The formation of stable and prolonged contacts between T cells and APCs is not neccessary to initiate T cell signaling but is required for effective T cell proliferation and differentiation. The stabilization of the T cell/ APC conjugate is regulated by intracellular signals induced by antigen receptors and costimulators. These coordinate the regulation of the actin and microtubule cytoskeleton and organize a specialized signaling zone that allows sustained TCR signaling.
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