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  • 1
    Online Resource
    Online Resource
    Coronary Artery Disease: Therapeutics and Drug Discovery (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    URL: https://doi.org/10.1007/978-981-15-2517-9
    DOI: 10.1007/978-981-15-2517-9
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Pediatric Pharmacotherapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    URL: https://doi.org/10.1007/978-3-030-50494-6
    DOI: 10.1007/978-3-030-50494-6
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Waste to Energy: Prospects and Applications (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Biotechnology. ; Refuse and refuse disposal. ; Microbiology. ; Biotechnology. ; Waste Management/Waste Technology.
    Description / Table of Contents: Part 1 Introductory Chapters -- 1 Emerging Frontiers of Microbes as Agro-waste Recycler -- 2 Microbes: the next generation bioenergy producers -- 3 Emerging and eco-friendly approaches for waste management -- 4 Ecofriendly microbial biofuel production from waste -- 5 Bioremediation: Current research trends and applications -- 6 Bioremediation: an approach for environmental pollutants detoxification -- 7 Bioethanol extraction and its production from agricultural residues for sustainable development -- Part 2 Biotechnological approaches -- 8 Byproduct valorization of vegetable oil industry through biotechnological approach -- 9 Omics tools: Approaches for microbiomes analysis to enhance bioenergy production -- 10 Omics (genomics, proteomics, metabolomics etc.) tools to study the environmental microbiome and Bioremediation -- Part 3 Industrial waste management -- 11 Microalgae: Omics approaches for biofuel production and biomedical research -- 12 Waste Utilization and Minimization in Food Industry.-13 Ligninolytic microbes and their role in effluent management of pulp and paper industry -- 14 Production of Polyhydroxyalkanoates using waste as raw materials. 15 Newer Aspects of Waste-to-Valorisation Technologies in Food Industry -- 16 Xylanase in waste management and its industrial applications -- 17 Organic Acid Production from Agricultural Waste. .
    Abstract: This book addresses waste generation problems from various sectors, including industries, agriculture, and household. It focuses on how modern biotechnological approaches could help manage waste in an eco-friendly manner and generate precious bioenergy. It discusses the inadequate waste management systems damaging the environment and its adverse impacts on climate change-related problems. This book covers all the essential information regarding various types of waste and their management. It is a comprehensive compilation for understanding the efficient generation of bioenergy. It is a relevant reading material (resource) for anyone who wishes to study waste management as Chemist, Biologist, Biotechnologist, Industrialist, Ecologist, Microbiologist, Economist, and all disciplines related to the environment.
    Type of Medium: Online Resource
    Pages: VIII, 438 p. 60 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813343474
    URL: https://doi.org/10.1007/978-981-33-4347-4
    DOI: 10.1007/978-981-33-4347-4
    DDC: 579
    Language: English
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  • 4
    Online Resource
    Online Resource
    Reactive Oxygen Species : Network Pharmacology and Therapeutic Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    URL: https://doi.org/10.1007/978-3-030-68510-2
    DOI: 10.1007/978-3-030-68510-2
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Organotypic Models in Drug Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    URL: https://doi.org/10.1007/978-3-030-70063-8
    DOI: 10.1007/978-3-030-70063-8
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Advances in Agricultural and Industrial Microbiology : Volume-2: Applications of Microbes for Sustainable Agriculture and in-silico Strategies (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Agriculture. ; Industrial microbiology. ; Microbiology. ; Agriculture. ; Industrial Microbiology.
    Description / Table of Contents: Chapter 1. Plant Growth Promoting Rhizobacteria for Sustainable Agriculture -- Chapter 2. Plant Microbes Interactions and Its Effect on Crop Productivity -- Chapter 3. Rhizobacterial biostimulants: efficacy in enhanced productivity and sustainable agriculture -- Chapter 4. The Role of Arbuscular Mycorrhiza in Sustainable Agriculture -- Chapter 5. Biocontrol Efficacy of Biomass and Secondary Metabolites of P. fluorescens Against Predominant Pest Affecting Agricultural Fields -- Chapter 6. Exopolysaccharide-producing Azotobacter for bioremediation of heavy metal-contaminated soil -- Chapter 7. Utilization of Arbuscular Mycorrhizal Fungi to boom the Efficiency and Product nature of Horticultural Crops -- Chapter 8. Microbial Remediation of Persistent Agrochemicals -- Chapter 9. Microbes Based Pesticides for Insect Pest Control and Their Management -- Chapter 10. In-silico Tools and Approach of CRISPR Application in Agriculture -- Chapter 11. Application of Bioinformatics in the Plant Pathology Research -- Chapter 12. New Age Genomic Measures for Uncovering Plant-Microbiome Interactions: Tools, Pipelines and Guidance Map for Genomic Data Mining -- Chapter 13. Bioinformatics: A Tool for Sustainable Agriculture -- Chapter 14. Recent Advances in Deep Learning CNN Models for Plant Disease Detection.
    Abstract: This book, the second volume of Advances in Agricultural and Industrial Microbiology is the compilation of modern technologies with scientific advancement in promoting plant growth by rhizobacterial biostimulants, endophytic microbes, and arbuscular mycorrhizal fungi. The volume also highlights the critical roles of soil microbes in the biocontrol of plant pathogens/diseases, bioremediation of toxic agrochemicals, and nitrogen fixation. Agricultural sustainability and environmental management strongly depend on microbial communities. Management of soil fertility is the key aspect that is facilitated by soil microbes and their interactions.The book also has a section focuses on the in-silico approaches and techniques involved in agriculture which enhances the readers’ understandings of plant-pathogen interactions, prediction of pathogenicity, improving variety through CRISPER, and its role in the agroindustry. Additionally, the interventions of ICTs (Information and Communication Technologies) have benefited agricultural stakeholders, i.e., farmers to policymakers, in predicting and combating them. The covered topics of the microbial domain and computational tools have high implications for the researchers, students, faculty, and scientists working on these areas.
    Type of Medium: Online Resource
    Pages: IX, 263 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811696824
    URL: https://doi.org/10.1007/978-981-16-9682-4
    DOI: 10.1007/978-981-16-9682-4
    DDC: 579
    Language: English
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  • 7
    Online Resource
    Online Resource
    Vaccination Strategies Against Highly Variable Pathogens (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    URL: https://doi.org/10.1007/978-3-030-58004-9
    DOI: 10.1007/978-3-030-58004-9
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Bioenergy Research: Biomass Waste to Energy (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Renewable energy sources. ; Microbiology. ; Renewable Energy.
    Description / Table of Contents: Chapter 1. Advancements in Biofuel Production -- Chapter 2. Bionenergy: Sustainable Renewable Energy -- Chapter 3. Biofuel from Microalgae -- Chapter 4. Waste to bioenergy: Recent Technologies -- Chapter 5. Bioenergy from Agricultural Wastes -- Chapter 6. Bio-Processing: Biomass to Commercial Alcohol -- Chapter 7. Hydrogen Production by Utilizing Bio-Processing Techniques -- Chapter 8. Bacterial Hydrogen Production: Prospects and Challenges -- Chapter 9. Bioethanol Production from Biodiesel Derived Glycerol – A Case Study -- Chapter 10. Advancement on biomass classification, analytical methods for characterization and its economic importance.
    Abstract: This volume is fourth part of the five-part set on bioenergy research. This volume covers biomass to bioenergy production concept. The book is focused on the possible and versatile biomass options available for the generation of bioenergy. Additionally, the book also explores different types of biomass for bioenergy generation at a commercial level. Further, the book elaborates on different kind of cellulose and sugar rich waste which can also be utilized for bioenergy production. It covers other relevant issues such as recent technological advancement in biomass to bioenergy conversion, waste management in the context of biomass to biofuels production technologies, green methods of energy production, alternates of fossil fuels in the near future. It also explores biomass waste valorization, utilizing microbial processes in bioenergy production. This is a useful reading material for students, researchers, industry and policy experts. Other four volumes of this set explore basic concepts, latest progress, commercial opportunities and integrated solution for bioenergy concerns. .
    Type of Medium: Online Resource
    Pages: XI, 272 p. 35 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618628
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-16-1862-8
    DOI: 10.1007/978-981-16-1862-8
    DDC: 579
    Language: English
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  • 9
    Online Resource
    Online Resource
    Drug Stability and Chemical Kinetics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.
    Abstract: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
    Type of Medium: Online Resource
    Pages: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564260
    URL: https://doi.org/10.1007/978-981-15-6426-0
    DOI: 10.1007/978-981-15-6426-0
    DDC: 615
    Language: English
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  • 10
    Online Resource
    Online Resource
    Bacterial Volatile Compounds as Mediators of Airborne Interactions (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Botany. ; Industrial microbiology. ; Biotechnology. ; Microbiology. ; Plant Science. ; Industrial Microbiology. ; Biotechnology.
    Description / Table of Contents: Preface -- Chapter 1: The domain of bacteria and their metabolic potentials -- Chapter 2: The domain of bacteria and their metabolic potentials -- Chapter 3: Structural diversity of bacterial volatiles -- Chapter 4: In vivo and in vitro volatile organic compound (VOCs) analyses in bacterial diagnostics: case studies in agriculture and human diseases -- Chapter 5: How plants might recognize bacterial volatiles -- Chapter 6: Contribution of bacterial biogenic volatiles to chemical ecology -- Chapter 7: Bacterial volatile-mediated plant abiotic stress resistance -- Chapter 8: Integration of bacterial volatile organic compounds with plant health -- Chapter 9: Volatile interplay between microbes – friends and foes -- Chapter 10: Role and function of bacterial volatiles in tritrophic interactions -- Chapter 11: Cyanobacterial VOCs as allelopathic tools -- Chapter 12: Collection, detection, identification and analysis of bacterial VOCs -- Chapter 13: Using bacteria-derived Volatile Organic Compounds (VOCs) for industrial processes -- Chapter 14: Formulation and agricultural application of bacterial volatile compounds.
    Abstract: This book covers the fundamentals of bacterial volatile-mediated communication with other organisms, starting with the biosyntheses of volatile organic compounds (VOC), interactions with plants and animals, interactions with microbes, tools for data analysis, and their applications. With this foundation in place, the book subsequently focuses on understanding the effect of bacterial volatiles on plant growth promotion, discusses plant immunity, and lastly shares insights into future research directions. The book is divided into fourteen-in-depth chapters, each of which is designed to enrich readers’ understanding of bacterial volatile compounds’ functions and various applications. The pivotal roles of bacterial volatile compounds make this book essential reading for scientists and students of all biological disciplines seeking to fully understand microorganism responses and environmental adaptations. In addition to its value as a fundamental book for graduate students, it offers a clearly structured reference guide for all individuals working in microbiology.
    Type of Medium: Online Resource
    Pages: VIII, 336 p. 71 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811572937
    URL: https://doi.org/10.1007/978-981-15-7293-7
    DOI: 10.1007/978-981-15-7293-7
    DDC: 579
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  • 11
    Online Resource
    Online Resource
    Plant Microbiome Paradigm (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Botany. ; Microbiology. ; Microbial Ecology. ; Plant Science.
    Description / Table of Contents: Interaction of Epiphyllic Bacteria with Plant Cuticles -- Plant Microbiome and Its Important in Stressful Agriculture -- Plant-Microbe Interactions: Applications for Plant‐Growth Promotion and In-Situ Agri-Waste Management -- Plant-Microbe-Metal Interactions: A Biochemical and Molecular Analysis for Phytoremediation -- Ecosystem Diversity as a Function of Plant and Soil-Microbe Interactions -- Plant Growth Promoting Potentials of Endophytic Fungi for the Management of Agricultural Crops and Grasses -- Biological Control of Plant Diseases: Opportunities and Limitations -- Circadian Redox Rhythms Play an Important Role in Plant-Pathogen Interaction -- Rhizospheric Microorganisms for the Remediation of Contaminants for Ecological Restoration -- The Rhizosphere Microbiome: Microbial Communities and Plant Health -- On the Possibility of Accelerating Succession by Manipulating Soil Microorganisms -- Composition and Dynamics of Microbial Communities in Fly Ash-Amended Soil -- Molecular Insight into Plant-Fungal Pathogen Interaction: Emerging Trends and Implication in Designing Climate Smart Filed Crops -- Biochemical Dynamics of Plant Microbe Interactions -- Endophytic Secondary Metabolites for Biological Control - A Latest Perspective.
    Abstract: This book provides a comprehensive overview of the current state of knowledge on plant-microbiome interactions and associations. It covers all major mechanistic approaches used to investigate microbes’ impacts on plant growth promotion, disease control and health. The industrial manufacture of nitrogen currently accounts for roughly 2% of the world’s total energy consumption. Microbial products are expected to reduce the need for costly fertilizers, as well as chemical pesticides and fungicides. While beneficial microorganisms are increasingly being used in agriculture, abiotic and biotic stresses such as heat, drought, cold, and salt can quickly kill or render them useless in the field. However, discovering new and better treatments is a lengthy process due to the considerable microbial diversity found in soils. Researchers have now proposed using biotechnological approaches to accelerate the process of microbial technology development. The fact that plant-associated microbes stimulate plant growth and development is well known, as the examples of rhizobia and mycorrhizal fungi show. The mechanisms by which these microorganisms maintain plant growth include the production of phytohormones, fixation of nitrogen, and the mobilization of phosphorus and minerals. The plant microbiome is also involved in pathogen suppression, and especially the root microbiome acts as a protective shield against soil-borne pathogens. A special feature of this book is its multidisciplinary approach, spanning from plant microbiology/biocontrol, fungal and bacterial endophytes, plant physiology, to biochemistry, proteomics and genomics. It is ideally suited for researchers and student of agri-biotechnology, soil biology and fungal biology.
    Type of Medium: Online Resource
    Pages: VI, 307 p. 31 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030503956
    URL: https://doi.org/10.1007/978-3-030-50395-6
    DOI: 10.1007/978-3-030-50395-6
    DDC: 579
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  • 12
    Online Resource
    Online Resource
    Plant Relationships : Fungal-Plant Interactions (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Plant diseases. ; Microbial genetics. ; Plant physiology. ; Fungi. ; Mycology. ; Plants. ; Microbiology. ; Plant Pathology. ; Microbial Genetics. ; Plant Physiology. ; Fungi. ; Plant Signalling.
    Description / Table of Contents: Part I. Pathogenic Fungus – Plant Interactions -- Modulation of Host Immunity and Development by Ustilago Maydis -- RNA Dialogues in Fungal-Plant Relationships -- The Role of Tox Effector Proteins in the Parastagonospora Nodorum-Wheat Interaction -- Part II. Mutualistic Fungus – Plant Interactions -- Genomes of Arbuscular Mycorrhizal Fungi -- Diversity of Seed Endophytes: Causes and Implications -- Lichens and Their Allies Past and Present -- Lichen Fungal Secondary Metabolites: Progress in the Genomic Era Towards Ecological Roles in the Interaction -- Part III. Sensing and Signalling in Fungus-Plant Interactions -- Regulation of Plant Infection Processes by MAP Kinase Pathways in Ascomycetous Pathogens -- Role of pH in the Control of Fungal MAPK Signalling and Pathogenicity -- Role of Volatile Organic Compounds in Establishment of the Trichoderma-Plant Interaction -- Part IV. Regulation of Fungal Gene Expression and Development -- Epigenetic Regulation of Fungal Genes Involved in Plant Colonization -- Toward Understanding the Role of Chromatin in Secondary Metabolite Gene Regulation in the Rice Pathogen Fusarium Fujikuroi -- The Rice Blast Fungus Magnaporthe Oryzae Uses a Turgor-Dependent, Septin-Mediated Mechanism to Invade Rice -- Role of Light in the Life Cycle of Botrytis Cinerea -- Part V. Genomes and Evolution -- Species of Zymoseptoria (Dothideomycetes) as a Model System to Study Plant Pathogen Genome Evolution -- Accessory Chromosomes of the Fusarium Oxysporum Species Complex and Their Contribution to Host Niche Adaptation -- Part VI. Global Pandemics and Food Security -- Global Landscape of Rust Epidemics by Puccinia Species: Current and Future Perspectives -- Magnaporthe oryzae and Its Pathotypes: A Potential Plant Pandemic Threat to Global Food Security.
    Abstract: This fully revised 3rd edition provides a comprehensive overview of the biology of fungi associated with plants. Since the publication of the 2nd Edition in 2009, tremendous new knowledge has been gained in the field of fungal-plant interactions, which is reflected in the contributions of this book. World-leading scientists in the field provide authoritative insights into fungal-plant interactions covering the following main topics: Mutualistic and pathogenic fungal-plant interactions in natural and agricultural ecosystems Sensing and signalling in fungus-plant interactions Regulation of fungal gene expression and development Fungal genomes and evolution Global pandemics caused by fungal pathogens and their implications for food security This volume will be of great interest to both specialists and generalists. It is an indispensable resource for researchers, lecturers and students in microbiology, mycology, and plant sciences, as well as agriculture and biotechnology.
    Type of Medium: Online Resource
    Pages: XXII, 462 p. 70 illus., 62 illus. in color. , online resource.
    Edition: 3rd ed. 2023.
    ISBN: 9783031165030
    Series Statement: The Mycota, A Comprehensive Treatise on Fungi as Experimental Systems for Basic and Applied Research, 5
    URL: https://doi.org/10.1007/978-3-031-16503-0
    DOI: 10.1007/978-3-031-16503-0
    DDC: 579
    Language: English
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  • 13
    Online Resource
    Online Resource
    Handbook of 200 Medicinal Plants : A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Medicinal Chemistry.
    Description / Table of Contents: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.
    Abstract: This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective. Chemical constituents of each plant with the putative active constituent, and available up to date pharmacological studies (until 2017 on PubMed) with each medical activity explored and its relationship with traditional uses, are described for each plant. Any variations in chemical constituents and their effects on pharmacological studies outcome have been highlighted. All clinical trials conducted, with sufficient details, have been included. Nationalities and racial identities of participants of clinical trials are identified to impress upon the social, cultural and dietary influences on the clinical outcomes. Toxicity studies and potential interactions with prescribed drugs, and full spectrum of references are included.
    Type of Medium: Online Resource
    Pages: XXX, 2156 p. 199 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030168070
    URL: https://doi.org/10.1007/978-3-030-16807-0
    DOI: 10.1007/978-3-030-16807-0
    DDC: 615
    Language: English
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  • 14
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    Online Resource
    Therapeutic Applications of Dopamine D3 Receptor Function : New Insight After 30 Years Of Research (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.
    Abstract: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031230585
    Series Statement: Current Topics in Behavioral Neurosciences, 60
    URL: https://doi.org/10.1007/978-3-031-23058-5
    DOI: 10.1007/978-3-031-23058-5
    DDC: 615
    Language: English
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  • 15
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    Approaching Complex Diseases : Network-Based Pharmacology and Systems Approach in Bio-Medicine (2020)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Bioinformatics. ; Oncology. ; Medicine Philosophy. ; Pharmacology. ; Computational and Systems Biology. ; Oncology. ; Philosophy of Medicine.
    Description / Table of Contents: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).
    Abstract: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
    Type of Medium: Online Resource
    Pages: XVI, 483 p. 49 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030328573
    Series Statement: Human Perspectives in Health Sciences and Technology, 2
    URL: https://doi.org/10.1007/978-3-030-32857-3
    DOI: 10.1007/978-3-030-32857-3
    DDC: 615
    Language: English
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  • 16
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    Plant Growth Promoting Microorganisms of Arid Region (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Agriculture. ; Ecology . ; Microbiology. ; Agriculture. ; Ecology.
    Description / Table of Contents: 1. Exploring Microbial Diversity of Arid Regions of Globe for Agricultural Sustainability: A Revisit -- 2. Harnessing drought tolerant PGPM in arid agro ecosystem for plant disease management and soil amelioration -- 3. Role of Plant Growth-promoting Bacteria in Rainfed and Irrigated Crops -- 4. Plant Growth Promoting Microbes: The Potential Phosphorus Solubilizers in Soils of Arid Agro-ecosystem -- 5. Diversity of PGPM and Ecosystem Services -- 6. Plant Growth Promoting Microorganisms: An Option for Drought and Salinity Management in Arid Agriculture -- 7. Plant Growth Promoting Microbes: Key Players in Organic Agriculture -- 8. Interceding Microbial Biofertilizers in Agroforestry System for Enhancing Productivity -- 9. Role of PGPM in Managing Soil Borne Plant Pathogens in Horticulture Crops -- 10. The Use of Plant Growth Promoting Microorganisms in the Managementof Soil-Borne Plant Pathogenic Organisms -- 11. Role of plant growth promoting microbes in managing soil-borne pathogens in forestry -- 12. Secondary Metabolites and Bioprospecting -- 13. PGPM: Fundamental, Bioformulation, Commercialization and Success at Farmer’s Field -- 14. PGPR: A Sustainable Agricultural Mitigator For Stressed Agro-Environments -- 15. Endophytic PGPM derived metabolites and their role in arid ecosystem -- 16. Current regulatory requirements for PGPM products for management of seed, soil and plant health: An overview -- 17. Evolving Concepts of Biocontrol of Phytopathogens by Endophytic Pseudomonas fluorescence -- 18. Symbiotic Effectiveness of Rhizobium Strains in Agriculture -- 19. Inoculant Production and Formulation of Azospirillum Species.
    Abstract: This edited book aims to focus on microbial diversity in arid lands and deserts versus specific microbial assemblages associated with plants. The book explains ecological drivers that shape this diversity, how plant-associated microbiomes are selected, and their biotechnological potential are discussed. Diversity and functional redundancy of these associated PGPM make them very active in supporting plant improvement, health and resistance to drought, salt and other stresses, and these dimensions will be explored in this book. Implementing proper biotechnological applications of the arid and desert-adapted PGPM constitutes a sizeable challenge, and the book attempts to take up that challenge and help researchers in this field to gain a detailed understanding of PGPM from arid ecosystems. This book serves as a handbook for research workers, teachers, postgraduate students and extension personnel, other development workers, and policy planners engaged in arid zone development.
    Type of Medium: Online Resource
    Pages: XXII, 455 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811941245
    URL: https://doi.org/10.1007/978-981-19-4124-5
    DOI: 10.1007/978-981-19-4124-5
    DDC: 579
    Language: English
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  • 17
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    Biogas Production : From Anaerobic Digestion to a Sustainable Bioenergy Industry (2020)
    Cham :Springer International Publishing :
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    Keywords: Microbiology. ; Energy policy. ; Energy and state. ; Refuse and refuse disposal. ; Industrial microbiology. ; Microbiology. ; Energy Policy, Economics and Management. ; Waste Management/Waste Technology. ; Industrial Microbiology.
    Description / Table of Contents: Part 1: Trends in Biogas Production Technologies -- Chapter 1: Technological routes for biogas production: Current status and future perspectives -- Chapter 2: Prospects and challenges in Biogas Technology: Indian Scenario -- Chapter 3: Anaerobic digestion technology for management of organic wastes: Latin American context -- Chapter 4: Biogas technology for animal manure management in USA: State of art, opportunities, challenges and perspectives -- Chapter 5: Anaerobic digestion in Europe: Key to sustainable waste management, challenges and perspectives -- Chapter 6: Advances and challenges of anaerobic digestion of wastes and wastewaters from different industrial sectors -- Chapter 7: Comparative analysis of biogas with renewable fuels and energy: physio-chemical properties, and carbon footprints -- Part 2: Improving biogas production: Progress, challenges and perspectives -- Chapter 8: Potential feedstock for sustainable biogas production, transportation and supply chain analysis -- Chapter 9: Potentials and challenges of micro and macroalgae as feedstock for biogas production -- Chapter 10: The realm of microorganisms in Biogas production: Microbial diversity, functional role, community interactions and monitoring the status of biogas plants -- Chapter 11: Metabolic engineering: A tool to increase the methane yield and efficiency of anaerobic digestion process -- Chapter 12: Scale-up operations for biogas production: Analysis on critical factors governing large scale operations -- Chapter 13: Biogas processing, storage and distribution, transportation and value chain analysis -- Chapter 14: Potentials and challenges of biogas upgradation as liquid biomethane -- Chapter 15: Nutrient value of digestates in soil fertility and productivity -- Part 3: Economics of Biogas Technology -- Chapter 16: Biogas commercialization: Commercial players, key business drivers, potential market and fostering investment -- Chapter 17: Biogas in circular bio-economy: Sustainable practice for rural farm waste management & techno-economic analyses -- Chapter 18: Biogas technology in Africa: An assessment of feedstock, barriers, socio-economic impact and the way forward -- Chapter 19: Governmental policies to promote biogas production, boosting role of biogas in economic growth of developing nations.
    Abstract: This book focuses on biogas production by anaerobic digestion, which is the most popular bioenergy technology of today. Using anaerobic digestion for the production of biogas is a sustainable approach that simultaneously also allows the treatment of organic waste. The energy contained in the substrate is released in the form of biogas, which can be employed as a renewable fuel in diverse industrial sectors. Although biogas generation is considered an established process, it continues to evolve, e.g. by incorporating modifications and improvements to increase its efficiency and its downstream applications. The chapters of this book review the progress made related to feedstock, system configuration and operational conditions. It also addresses microbial pathways utilized, as well as storage, transportation and usage of biogas. This book is an up-to-date resource for scientists and students working on improving biogas production.
    Type of Medium: Online Resource
    Pages: XI, 469 p. 57 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030588274
    URL: https://doi.org/10.1007/978-3-030-58827-4
    DOI: 10.1007/978-3-030-58827-4
    DDC: 579
    Language: English
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  • 18
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    Role of Microbial Communities for Sustainability (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Biotechnology. ; Microbial ecology. ; Microbiology. ; Biotechnology. ; Microbial Ecology.
    Description / Table of Contents: 1 Role of Microbial Communities in Plant-Microbe Interactions, Metabolic Cooperation and Self-Sufficiency Leading to Sustainable Agriculture -- 2 Symbiotic Interactions of Phototrophic Microbes: Engineering Synthetic Consortia for Biotechnology -- 3 Understanding Agriculturally Indispensable Bacterial Biofilms in Sustainable Agriculture -- 4 Global Food Demand and The Roles of Microbial Communities in Sustainable Crop Protection and Food Security: An Overview -- 5 Sustaining Productivity through Integrated use of Microbes in Agriculture -- 6 Arbuscular Mycorrhizal Fungi for Sustainable Crop Protection and Production -- 7 Role of Microbial Communities in Sustainable Rice Cultivation -- 8 Applications of Soil Bacterial Community in Carbon Sequestration: An Accost towards Advanced Eco-Sustainability -- 9 Approach Towards Sustainable Crop Production by Utilizing Potential Microbiome -- 10 Diversity, Function and Application of Fungal Iron Chelators (Siderophores) for Integrated Disease Management -- 11 Role of Microbial Communities in the Low-Cost, Sustainable Treatment of Pig Effluent Waste -- 12 Metal Stress Impacting Plant Growth in Contaminated Soil is Alleviated by Microbial Siderophores -- 13 Natural and Constructed Cyanobacteria-based Consortia for Enhancing Crop Growth and Soil Fertility -- 14 Microbial Communities Based Biofilmed Biofertilizers Enhance Soil Fertility and Plant Growth in Hevea Ecosystem: Evidences from Seedlings and Immature Plants.
    Abstract: This book is about the role played by microbes in their community mode in sustaining ecosystems. The descriptions given in its chapters indicate clearly that microbial communities are more effective in delivering multifaceted benefits to the soil-plant system than those offered by microbial monocultures in planktonic modes. The role these communities play in a multitude of microbe-microbe and plant-microbe interactions have not yet been fully exploited to gain benefits in this field as well as to achieve sustainability in agriculture practices. Amply discussed are the beneficial characteristics and metabolic capacities of specific microbial groups and the use of microbial traits for the benefit of plant growth. The book suggests the need to develop new microbial technologies to utilize plant-associated microbes for increased crop productivity and agroecosystem balance in order to ensure sustainability. This also provides an effective guidance to scientists, academics, researchers, students and policy makers of the sphere to achieve the above outcomes.
    Type of Medium: Online Resource
    Pages: XIII, 379 p. 45 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599125
    Series Statement: Microorganisms for Sustainability, 29
    URL: https://doi.org/10.1007/978-981-15-9912-5
    DOI: 10.1007/978-981-15-9912-5
    DDC: 579
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  • 19
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    Online Resource
    Microbial Genomic Islands in Adaptation and Pathogenicity (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Diseases Causes and theories of causation. ; Microbial genetics. ; Microbiology. ; Pathogenesis. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. An introduction of microbial genomic islands for evolutionary adaptation and pathogenicity -- Chapter 2. Computation tools for prediction and analysis of genomic islands -- Chapter 3. An overview of genomic islands’ main features and computational prediction: the CMNR group of bacteria as a case study -- Chapter 4. Microbial genomic island discovery, visualization and analysis -- Chapter 5. Genomic islands in bacterial genome evolution and speciation -- Chapter 6. Genomic islands in the gut microbiome: current knowledge and the application in the probiotics field -- Chapter 7. Genomic islands in nutritional fitness and adaptation -- Chapter 8. Genomic islands involved in iron uptake -- Chapter 9. Genomic islands in uropathogeneic E. coli -- Chapter 10. Genomic islands in Helicobacter species -- Chapter 11. Genomic islands in Staphylococcus -- Chapter 12. Genomic islands in Pseudomonas species -- Chapter 13. Genomic islands in Klebsiella pneumonia -- Chapter 14. Molecular Insights into Genomic Islands and Evolution of Vibrio cholerae -- Chapter 15. Genomic islands in marine bacteria -- Chapter 16. Challenges in Eventing Horizontal Gene Transfer -- chapter 17. Artificial Intelligence and machine learning for prediction and analysis of genomic islands.
    Abstract: This book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms.
    Type of Medium: Online Resource
    Pages: XXIII, 356 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811993428
    URL: https://doi.org/10.1007/978-981-19-9342-8
    DOI: 10.1007/978-981-19-9342-8
    DDC: 579
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  • 20
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    Online Resource
    Pharmacology of Potassium Channels (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    URL: https://doi.org/10.1007/978-3-030-84052-5
    DOI: 10.1007/978-3-030-84052-5
    DDC: 615
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  • 21
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    Online Resource
    Bio-Clean Energy Technologies Volume 2 (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Industrial microbiology. ; Microbial ecology. ; Refuse and refuse disposal. ; Microbiology. ; Industrial Microbiology. ; Environmental Microbiology. ; Waste Management/Waste Technology.
    Description / Table of Contents: 1 Green Energy Solution to Combat Global Warming -- 2 Renewable Biofuels: Sources and Types -- 3 Introduction to Renewable Biofuel resources, their production technologies, Challenges and Applications -- 4 Conversion of biogas generated from anaerobic digestion of food waste to electricity using internal combustion engine and fuel cell -- 5 Biofilm Based production of Biomethane -- 6 Bioelectrochemical systems: Recent Advancements and Future Prospects -- 7 A brief review of the waste generation in India and biofuel applications -- 8 Biohydrogen Production by Immobilized Microbes -- 9 Conventional liquid biofuels -- 10 Sustainability of bioethanol production -- 11 Biofuels from algae -- 12 Bioethanol production from marine algae: a novel approach to curb global warming -- 13 Biofilms for Biofuel Production -- 14 Enzyme Technology in Biofuel Production -- 15 Immobilized Lipase for Industrial Biodiesel Production -- 16 An overview, current trends, and prospects of Biophotovoltaic Systems (BPVs) -- 17 Applications of Nanotechnology in Biofuel Production -- 18 Waste to Bio-Energy Perspective through Life-Cycle Inventory. .
    Abstract: This edited book discusses the latest advancements in the area of biofuel development. It covers extensive information regarding different aspects and types of biofuels. The book provides a road map of the various kinds of biofuels available for consideration. It focuses on microbial based power generation, applications of nanotechnology in biofuel development, advancements in molecular techniques, economic and life cycle assessments. The book also highlights the commercialization prospects and economics of the various processes and an overview of the life cycle assessment of the various different kinds of biofuels. The contributors are experienced professors, academicians and scientists associated with renowned laboratories and institutes in India and abroad. This book is of interest to teachers, researchers, biofuel scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students. National and international scientists, policy makers will also find this to be a useful read.
    Type of Medium: Online Resource
    Pages: XI, 342 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811680946
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-16-8094-6
    DOI: 10.1007/978-981-16-8094-6
    DDC: 579
    Language: English
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    Online Resource
    Green Nano Solution for Bioenergy Production Enhancement (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Renewable energy sources. ; Microbiology. ; Renewable Energy.
    Description / Table of Contents: 1 Green Route Synthesis of Biomass Based Materials for Energy Production -- 2 Green Synthesized Bimetallic Nanomaterials for Bio-energy Applications -- 3 Green Synthesis of Metallic Nanoparticles for Biofuel Production -- 4 Recent advances in synthesis of Iron nanoparticles via green route and their application in biofuel production -- 5 Green synthesized carbon and metallic nanomaterials for biofuel production: Effect of operating parameters -- 6 Biosynthesis of TiO2 Nanoparticles and their Application as Catalyst in Biodiesel Production -- 7 Phyco-Nanotechnology: An Emerging Nanomaterial Synthesis Method and its Applicability in Biofuel Production -- 8 Fungi mediated green synthesis of Nanoparticles and their Renewable energy applications -- 9 Green synthesis of nanoparticles by plants and their renewable energy applications -- 10 Recent Advances in Conversion of Agricultural Waste to Biofuel by Nanoparticles.
    Abstract: This edited book presents nanotechnology-based approaches to improve quality of biofuels production. It covers the use of different nanomaterials in various biofuels production methods and their sustainable utility analysis to improve production of biofuels at economical and mass scale. Environmentally friendly, low cost, and synthesis via green and renewable resources are the main key features covered by this book. Advantages and sustainability scope of green and renewable material to synthesize nanomaterial and reduction in synthesis cost over to chemical synthesis cost have been discussed in this book. The book also explores various green synthesis possibilities to synthesize nanomaterials that are frequently involved in biofuels production process as catalysts. Various feasible mechanisms have also been explained. Maximum and sustainable use of green nanomaterials at every step of biofuels production is also one of the major focuses of this book. It covers mega audiences, which include academician, researchers, and industries people. This book will be highly interesting for researchers and scientists as well as related industries.
    Type of Medium: Online Resource
    Pages: VI, 273 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811693564
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-16-9356-4
    DOI: 10.1007/978-981-16-9356-4
    DDC: 579
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    Nutritional Toxicology (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Nutrition   . ; Food science. ; Pharmacology. ; Nutrition. ; Food Science.
    Description / Table of Contents: 1 Preface -- 2 Effects of Nutrients/nutrition on Toxicants/toxicity -- 3 Effects of Xenobiotics on Nutrition -- 4 Effects of Antinutritional Factors on the Digestibility, Bioavailability and Quality of Protein -- 5 Natural Toxicants Originating from Food/Diet -- 6 Food contaminants -- 7 Food additives -- 8 Food contact materials -- 9 Genetically modified food -- 10 Tolerable upper limits of nutrients -- 11 Risk assessment and Risk-benefit assessment -- 12 Nutrients/Nutrition and Drug Interaction -- 13 Phytochemicals and Health -- 14 Adverse Effects of Phytochemicals.
    Abstract: This book provides a broad overview of the chemicals in food that have the potential to induce adverse health effects. Nutritional Toxicology is an interaction of nutrition, toxicology, biochemistry and food science, etc. Its main research scope involves the effects of nutrients on metabolisms of toxicants and their mechanisms, the interaction of the toxicants and contaminants originated from diet with nutrients and nutrition process, the adverse health outcome of nutrients excess, as well as methodology of research and related food and nutrition regulation process. Also the risk assessment of toxicants and contaminants in foods, and risk benefit assessment of nutrients (dietary supplementation) has become an emerging topic. This book provides novel and provocative insights into the fields of nutrition, food science and toxicology. It also offers a state-of-the-art report on recent discoveries concerning nutritional toxicology and where the field is going. It mainly focuses on advances made over the past 20 years. It will benefit graduate students, researchers and food and nutrition related regulation parties.
    Type of Medium: Online Resource
    Pages: X, 384 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811908729
    URL: https://doi.org/10.1007/978-981-19-0872-9
    DOI: 10.1007/978-981-19-0872-9
    DDC: 615
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    Bioenergy Research: Commercial Opportunities & Challenges (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Renewable energy sources. ; Microbiology. ; Renewable Energy.
    Description / Table of Contents: Chapter 1.Bioenergy Production: Opportunities for Microorganisms (Part I) -- Chapter 2. Bioenergy Production: Opportunities for Microorganisms (Part II) -- Chapter 3. Value Added Products From Agriculture, Paper And Food Waste: A Source Of Bioenergy Production -- Chapter 4. Advancements in Diatom Algae based Biofuels -- Chapter 5. Valorization of Cellulosic and SAP based Baby Diaper Waste into Functional Products: Analyses and Bioenergy Potential -- Chapter 6. Role of Operational Parameters to Enhance Biofuel Production -- Chapter 7. Advances In Bioethanol Production: Processess And Technologies -- Chapter 8. Sustainable routes for renewable energy carriers in modern energy systems -- Chapter 9. Microalgae based biofuel- integrated biorefinery approach as sustainable feedstock for resolving energy crisis. Chapter 10. Substrate characterization in the anaerobic digestion process.
    Abstract: This volume is third part of the five-part set on bioenergy research. This book provides insights into commercial advantages of commonly running bioenergy options. It explores various opportunities present at technical scale to produce biofuels. Moreover, the additional practical feasibility of the commercialization of existing biofuels including existing challenges and sustainable solutions to overcome from these technical hurdles. This Volume also focuses on the durability and long run sustainability on the new arrival of biofuels options which can be a suitable and easy replacement of currently available biofuels at pilot scale. Other four volumes of this set explore basic concepts, latest progress, bio-waste to energy conversion and integrated solution for bioenergy concerns. .
    Type of Medium: Online Resource
    Pages: XII, 317 p. 59 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811611902
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-16-1190-2
    DOI: 10.1007/978-981-16-1190-2
    DDC: 579
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    Network Pharmacology (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    URL: https://doi.org/10.1007/978-981-16-0753-0
    DOI: 10.1007/978-981-16-0753-0
    DDC: 615
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    Environment and Female Reproductive Health (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Midwifery. ; Public health. ; Pharmacology. ; Midwifery. ; Public Health.
    Description / Table of Contents: Part I Environmental Harmful Factors -- 1 Introduction to Environmental Harmful Factors -- Part II Female Reproductive Processes and Diseases -- 2 Introduction of Female Reproductive Processes and Reproductive Diseases -- Part III Effects of Environmental Factors on Reproductive Process -- 3 The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality -- 4 Effects of environment and lifestyle factors on premature ovarian failure -- 5 Effects of Environment and Lifestyle Factors on Anovulatory Disorder -- 6 Effects of Cigarette Smoking on Preimplantation Embryo Development -- 7 Toxicical effects of BPDE on dysfunctions of female trophoblast cells -- 8 The Roles of Stress-Induced Immune Response in Female Reproduction -- 9 Effects of Environmental EDCs on Oocyte Quality, Embryo Development and the Outcome in Human IVF Process -- Part IV Effects of Environmental Factors on Reproductive Diseases -- 10 Effects of environmental endocrine-disrupting chemicals on female reproductive health -- 11 Definition and Multiple Factors of Recurrent Spontaneous Abortion -- 12 The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and their Diagnosis Strategy -- Part V Effects of Environmental Factors on Fertility Preservation -- 13 The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.
    Abstract: This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.
    Type of Medium: Online Resource
    Pages: XI, 313 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341876
    Series Statement: Advances in Experimental Medicine and Biology, 1300
    URL: https://doi.org/10.1007/978-981-33-4187-6
    DOI: 10.1007/978-981-33-4187-6
    DDC: 615
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    Organic Cation Transporters in the Central Nervous System (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Human physiology. ; Molecular biology. ; Pharmacology. ; Human Physiology. ; Molecular Biology.
    Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
    Abstract: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030829841
    Series Statement: Handbook of Experimental Pharmacology, 266
    URL: https://doi.org/10.1007/978-3-030-82984-1
    DOI: 10.1007/978-3-030-82984-1
    DDC: 615
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    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    URL: https://doi.org/10.1007/978-3-030-79511-5
    DOI: 10.1007/978-3-030-79511-5
    DDC: 615
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    Pharmacology of the WNT Signaling System (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Physiology. ; Oncology. ; Neurosciences. ; Developmental biology. ; Pharmacology. ; Physiology. ; Oncology. ; Neuroscience. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.
    Abstract: This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
    Type of Medium: Online Resource
    Pages: VIII, 422 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030854997
    Series Statement: Handbook of Experimental Pharmacology, 269
    URL: https://doi.org/10.1007/978-3-030-85499-7
    DOI: 10.1007/978-3-030-85499-7
    DDC: 615
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    The Art of Carbohydrate Analysis (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Chemistry, Organic. ; Food science. ; Biotechnology. ; Pharmacology. ; Organic Chemistry. ; Food Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .
    Abstract: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
    Type of Medium: Online Resource
    Pages: XXV, 350 p. 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777913
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-77791-3
    DOI: 10.1007/978-3-030-77791-3
    DDC: 615
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    Sulfate-Reducing Bacteria and Archaea (2022)
    Cham :Springer International Publishing :
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    Keywords: Microbiology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Microbial ecology. ; Industrial microbiology. ; Microbiology. ; Environmental Engineering/Biotechnology. ; Microbial Ecology. ; Industrial Microbiology.
    Description / Table of Contents: 1. Sulfate-reducing prokaryotes: Changing paradigms -- 2. Characteristics and taxonomy -- 3. Reduction of sulfur and nitrogen compounds -- 4. Electron transport proteins and cytochromes -- 5. Systems contributing to the energetics of SRP -- 6. Cell biology and metabolism -- 7. Geomicrobiology, biotechnology, and industrial applications -- 8. Biocorrosion -- 9. Ecology of dissimilatory sulfate reducers: Life in extreme conditions and activities of SRB -- 10. Interactions of SRB with animals and plants.
    Abstract: The abundance of sulfate-reducing bacteria and archaea (SRBA) is impressive and new isolates are being reported continuously. A few decades ago, only two genera of dissimilatory sulfate reducers had been identified and as of 2018, 92 genera containing more than 420 species of SRB and several species of archaea have been isolated. This book addresses the historical background of SRBA research and reviews the current status of research examining the growth of these anaerobic microorganisms. Additionally, this book covers metabolic and genomic diversity, enzymatic processes, response to stress, biocorrosion of ferrous metals, biogeochemical processes and interactions with other microorganisms in the anaerobic biosphere. It highlights the unique cellular and molecular features of these microorganisms, discusses the production and consumption of gases and reviews genomic content influencing their metabolic capabilities. Examples are provided of detoxification reactions to alleviate pollution situations, growth in in hostile environments including low nutrient availability, and the effects of sulfate-reducing bacteria (SRB) on human and animal hosts.
    Type of Medium: Online Resource
    Pages: XI, 564 p. 62 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030967031
    URL: https://doi.org/10.1007/978-3-030-96703-1
    DOI: 10.1007/978-3-030-96703-1
    DDC: 579
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    Polypharmacology : Principles and Methodologies (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Neuropharmacology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Neuropharmacology.
    Description / Table of Contents: PART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles -- Basics of Polypharmacology -- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C) -- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF) -- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD) -- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD -- Anti-cancer Polypharmacology -- Cardiovascular Polypharmacology -- Neuronal Polypharmacology -- Pulmonary Polypharmacology -- Polypharmacology of Metabolic Disease -- Polypharmacology of Infectious Disease -- Polypharmacology of Inflammation -- Anti-psychotics Polypharmacology -- Anti-aging Polypharmacology -- Polypharmacology in Drug Repurposing -- Polypharmacology and Unintended Drug Promiscuity -- Polypharmacology Pharmacokinetics -- The Future of Polypharmacology -- PART II. Polypharmacology in New Drug Development: Strategies and Protocols -- Designed MTSD Discovery Process -- Designed MTSD Discovery Strategies -- Designed MTSD Discovery Technologies -- Designed MTSD Discovery Databases -- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation -- Designed MTSD Lead Identification and Optimization -- Designed MTSD Discovery Protocols -- Natural Products in MTSD Discovery -- Polypharmacology Procedures for Drug Repurposing -- Polypharmacology Procedures for Drug Promiscuity Discovery.
    Abstract: There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on Polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology on Polypharmacology. This book aims to meet the needs of making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of Polypharmacology targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy. Rich in illustrations and tables to showcase readers for better understanding the concepts and technologies related to Polypharmacology; Provides comprehensive, systemic, holistic, and explicit explanations and discussion of the fundamental knowledge, background information, conceptual evolution, and updated methodology, as well as in-depth mechanisms behind the knowledge and methodology of Polypharmacology; Main emphasis on rationally designed Polypharmacology or “multi-target, single-drug (MTD)” pharmacology, which represents the major future direction of Polypharmacology and Pharmacology; Describes the clinical applications of Polypharmacology to various human diseases in the clinical and preclinical settings; Contains a wide collection of the state-of-the-art Polypharmacology technologies applicable to the designed MTD discovery and the step-by-step descriptions of drug discovery process applying Polypharmacology principles and methodologies.
    Type of Medium: Online Resource
    Pages: XXV, 856 p. 12 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031049989
    URL: https://doi.org/10.1007/978-3-031-04998-9
    DOI: 10.1007/978-3-031-04998-9
    DDC: 615
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    Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nanobiotechnology. ; Biomedical engineering. ; Drug delivery systems. ; Pharmaceutical chemistry. ; Pharmacology. ; Nanobiotechnology. ; Biomedical Engineering and Bioengineering. ; Drug Delivery. ; Pharmaceutics.
    Description / Table of Contents: Chapter 1. An introduction to respiratory diseases and an emerging need for efficient drug delivery systems -- Chapter 2. Inflammatory respiratory diseases: Correlation between Lung cancer and CoVid-19 -- Chapter 3. Advancements in translational respiratory research using nanotechnology -- Chapter 4. Chemical moieties as advanced therapeutics for targeting respiratory disorders -- Chapter 5. Phytochemicals and their nanoformulations targeted for pulmonary diseases -- Chapter 6. Nanocarriers: an advanced and highly effective approach for targeting chronic lung diseases -- Chapter 7. Vesicular drug delivery systems in respiratory diseases -- Chapter 8. Nanoparticles in chronic respiratory diseases -- Chapter 9. Applications of nanotechnology in pulmonary disease diagnosis -- Chapter 10. Nanotechnology in pulmonary disease diagnosis -- Chapter 11. Recent trends in Nanomedicine for diagnosis and treatment of pulmonary diseases -- Chapter 12. Strategies for enhanced drug targeting to inflamed lungs: Novel perspectives -- Chapter 13. Solid-Lipid Nanocarriers (SLN’s) based drug delivery for treating various pulmonary diseases -- Chapter 14. Microparticles, microspheres and microemulsions as pulmonary drug delivery systems for the treatment of respiratory diseases -- Chapter 15. Microparticles, microspheres and microemulsions in respiratory diseases -- Chapter 16. Advanced drug delivery systems targeting the immune system at cellular level in chronic respiratory diseases -- Chapter 17. Targeted Micellar Systems for Pulmonary Disease Intervention -- Chapter 18. Polymeric and inorganic nanoparticles targeting chronic respiratory diseases -- Chapter 19. Mucoadhesive drug delivery system in chronic respiratory diseases -- Chapter 20. Liposomal Drug Delivery: Therapeutic Applications in Chronic Respiratory Diseases -- Chapter 21. Biologics and vaccines for nasal and pulmonary drug delivery -- Chapter 22. Drug delivery systems for respiratory infections -- Chapter 23. Cell and Gene Therapies for Chronic Inflammatory Lung Diseases - Emerging Technological Trends and Advancements in Respiratory Medicine -- Chapter 24. Targeting biofilms in respiratory diseases using novel drug delivery systems -- Chapter 25. Advanced nanomaterials for drug delivery in chronic respiratory disorders -- Chapter 26. Emerging technological trends and advancements in respiratory medicine -- Chapter 27. Pulmonary pharmacokinetics and Biophysics -- Chapter 28. Clinical trials on novel advanced drugs for chronic respiratory disorders.
    Abstract: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
    Type of Medium: Online Resource
    Pages: X, 655 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811643927
    URL: https://doi.org/10.1007/978-981-16-4392-7
    DOI: 10.1007/978-981-16-4392-7
    DDC: 615
    Language: English
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  • 34
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    Online Resource
    Data Monitoring Committees (DMCs) : Past, Present, and Future (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    URL: https://doi.org/10.1007/978-3-031-28760-2
    DOI: 10.1007/978-3-031-28760-2
    DDC: 615
    Language: English
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  • 35
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    Online Resource
    Phytoremediation for Environmental Sustainability (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Botany. ; Bioremediation. ; Microbiology. ; Plant Science. ; Environmental Biotechnology.
    Description / Table of Contents: Chapter 1. Metal hyperaccumulator plants and their role in phytoremediation -- Chapter 2. Role of soil microflora in phytoremediation of heavy metal contaminated soils -- Chapter 3. Phytoremediation of heavy metal contaminated soil and water -- Chapter 4. "Effective removal of radioactive waste from environment using plants -- Chapter 5. Phytoremediation of Heavy Metals and Radionuclides: Sustainable Approach to Environmental Management -- Chapter 6. Remediation technologies, from incineration to phytoremediation: the rediscovery of the essential role of soil quality -- Chapter 7. Morphology and physiology of plants growing on highly polluted mining wastes -- Chapter 8. Potential impacts of climatic stress on the performance of phyto-bioremediation techniques -- Chapter 9. Invasive Alien Plant Species: An Exploration of Social Aspect and Phytoremediation Acceptability -- Chapter 10. Phytotechnologies for bioremediation of textile dye wastewater -- Chapter 11. Assessment of pharmaceuticals in water systems: Sustainable phytoremediation strategies -- Chapter 12.Fluoride (F) remediation using phytoremediation and nanomaterials -- Chapter 13. Sustainable use of African palm shell waste applied to paraben adsorption from aqueous solutions -- Chapter 14. Removal of indoor environmental pollutants VOCs: Phytoremediation applications and adsorption studies using immersion calorimetry -- Chapter 15. Phytoremediation: A tool for environmental sustainability -- Chapter 16. Role of phytoremediation as a promising technology to combat environmental pollution -- Chapter 17. Exploring the potential of PGPR in Phytoremediation -- Chapter 18. Phycoremediation: Treatment of Pollutants and an Initiative Towards Sustainable Environment -- Chapter 19. Phytoremediation: Mechanistic approach for eliminating heavy metal toxicity from environment.
    Abstract: This edited book details the plant-assisted remediation methods, which involves the interaction of plant roots with associated rhizospheric microorganisms for the remediation of soil and water contaminated with high levels of heavy metals, pesticides, radionuclides, agricultural by-products, municipal wastes, industrial solvents, petroleum hydrocarbons, organic compounds, and various other contaminants. Each chapter highlights and compares the beneficial and economical alternatives of phytoremediation to currently practiced soil, water, and air removal. This book covers state-of-the-art approaches in phytoremediation contributed by leading and eminent scientists from across the world. Phytoremediation approaches for environmental sustainability dealing the readers with a cutting-edge of multidisciplinary understanding in the principal and practical approaches of phytoremediation from laboratory research to field application. This book is of interest to researchers, teachers, environmental scientists, environmental engineers, environmentalists, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of environmental microbiology, biotechnology, eco-toxicology, environmental remediation, waste management, and environmental sciences as well as the general audience.
    Type of Medium: Online Resource
    Pages: XI, 543 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811656217
    URL: https://doi.org/10.1007/978-981-16-5621-7
    DOI: 10.1007/978-981-16-5621-7
    DDC: 579
    Language: English
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  • 36
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    Online Resource
    The Biological Role of a Virus (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Evolution (Biology). ; Microbiology. ; Microbial Ecology. ; Evolutionary Biology.
    Description / Table of Contents: PART I. Viral Control of Community Energetics -- Chapter 1. Viral Nature of the Aquatic Ecosystems -- Chapter 2. Life Continues as Viruses Close Land, Water and Atmosphere Nutrient Cycle -- PART II. Understanding the Genetic Partnership Between a Host and Its Viruses -- Chapter 3. Cataloging the Presence of Endogenous Viruses -- Chapter 4. Do the Biological Roles of Endogenous and Lysogenous Viruses Represent Faustian Bargains? -- Chapter 5. Einstein's Capsid: Bacteriophages Solve the Problems of Space and Time for Bacteria with Emergency Dead to Alive Horizontal Gene Transfer (EDA-HGT) -- Chapter 6. Diverse Phage-Encoded Toxins and Their Role in Bacterial Ecology -- Chapter 7. Mycoviruses as Antivirulence Elements of Fungal Pathogens -- PART III. Defending the Health of Its Hosts -- Chapter 8. The Contribution of Viruses to Immune Systems -- Chapter 9. Application of Viruses for Gene Therapy and Vaccine Development -- Chapter 10. Eukaryotic Virus Interactions with Bacteria: Implications for Pathogenesis and Control.
    Abstract: This book answers the question “What is it that viruses do?” by presenting three aspects of viral ecology. The first aspect explains how viruses affect the population diversity and energetics of their host communities. Perhaps the most notable example of this concept is our understanding that primary production within ecosystems often depends upon those viruses which serve as controllers of nutrient recycling, connecting the aquatic and terrestrial realms in ways that can be assessed locally and globally. The second aspect describes genetic partnerships which exist between hosts and their viruses. These include processes termed endogeny and lysogeny by which the host carries at least a partial genomic copy of the virus. Fluidity of these collective genomes is expressed on an evolutionary time scale and the mutual life cycles which they produce represent a forging of shared genomic fate that obligates partnership of the virus and its host. The viral sequences represent a source of potential benefit as well as potential peril for the host and can implement phenotypic changes in the host. Hosts often use those changes as tools. As humans, the most notable example would be that mammals rely upon temporary activation of their endogenous viral genes in order to successfully develop a placenta. The third aspect is defending the health of a host, which relies upon activity in two directions. Hosts often use their captured viral genes to identify and subsequently direct battle against invading viruses. This natural concept has been engineered for combating cancer, is useful for suppressing the detrimental consequences of genetic diseases, and has been developed to create targeted antiviral vaccines. But, the defense has to work in two directions and the host can use other symbiotic microorganisms as protection against its viruses. This book will appeal to a wide readership by providing a broad perspective of viral ecology, and all scientists will find it helpful for gaining a view of fields beyond their specialization.
    Type of Medium: Online Resource
    Pages: XVI, 367 p. 28 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030853952
    Series Statement: Advances in Environmental Microbiology, 9
    URL: https://doi.org/10.1007/978-3-030-85395-2
    DOI: 10.1007/978-3-030-85395-2
    DDC: 579
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  • 37
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    Online Resource
    Actinobacteria : Ecology, Diversity, Classification and Extensive Applications (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Microbial genetics. ; Biodiversity. ; Biotechnology. ; Microbiology. ; Microbial Ecology. ; Microbial Genetics. ; Biodiversity. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Microbial Ecology -- Chapter 2. Actinobacteria in Marine environments -- Chapter 3. Terrestrial Ecology of Actinobacteria -- Chapter 4. Extremophilic Actinobacteria -- Chapter 5. Actinobacteria: Basic adaptation to the harsh environments -- Chapter 6. Diversity and classification of Streptomyces -- Chapter 7. Diversity and classification of rare Actinomycetes -- Chapter 8. Identification of Novel Actinomycetes -- Chapter 9. Screening of Novel Metabolites from Actinobacteria -- Chapter 10. Scope of Actinobacteria in Bioengineering -- Chapter 11. Recent trends of Actinomycetes in Nanotechnology -- Chapter 12. Actinomycetes in agriculture and forestry -- Chapter 13. Role of Actinomycetes in Biodegradation of Pesticides -- Chapter 14. Actinomycetes in Environmental applications -- Chapter 15. Biotechnological importance of actinomycetes -- Chapter 16. Actinomycetes in medical and pharmaceutical industries.
    Abstract: Through this book, the readers will learn about the different aspects of Actinobacteria- beginning with its ecology and occurrence, to the ways of its adaptation to harsh climates, and finally to its practical applications. The book also presents methods of identifying and characterizing this diverse group of bacteria through advanced techniques like MALDI-TOF, 16S rRNA analysis, etc. Different chapters describe the various biotechnological applications of Actinobacteria, including bioremediation, secondary metabolite production, and in producing antibiotics, anti-cancer therapeutics. It also provides insights into the applications in agriculture and forestry by inhibiting plant pathogenic bacteria's growth. .
    Type of Medium: Online Resource
    Pages: XIV, 320 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811633539
    Series Statement: Rhizosphere Biology,
    URL: https://doi.org/10.1007/978-981-16-3353-9
    DOI: 10.1007/978-981-16-3353-9
    DDC: 579
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  • 38
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    Online Resource
    Macrophage Targeted Delivery Systems : Basic Concepts and Therapeutic Applications (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Cytology. ; Toxicology. ; Immunology. ; Pharmacology. ; Pharmaceutics. ; Cell Biology. ; Toxicology. ; Immunology.
    Description / Table of Contents: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .
    Abstract: The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
    Type of Medium: Online Resource
    Pages: XVIII, 556 p. 76 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030841645
    URL: https://doi.org/10.1007/978-3-030-84164-5
    DOI: 10.1007/978-3-030-84164-5
    DDC: 615
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  • 39
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    Online Resource
    Microbial Rejuvenation of Polluted Environment : Volume 1 (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Agricultural biotechnology. ; Soil science. ; Biotechnology. ; Microbiology. ; Microbial Ecology. ; Agricultural Biotechnology. ; Soil Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1: Rhizosphere - Niche for Microbial Rejuvenation and Biodegradation of Pollutants -- Chapter 2: Bioremediation of Pesticides: An Eco-friendly Approach for Environment Sustainability -- Chapter 3: Microbial Indicators of Bioremediation-Potential and Success -- Chapter 4: Phycoremediation: A Sustainable Biorefinery Approach -- Chapter 5: Cyanobacteria Mediated Bioremediation of Problem Soils -- Chapter 6: VAM- An Alternate Strategy for Bioremediation of Polluted Environment -- Chapter 7: Strategies to Improve Remediation Technology Using Fungi -- Chapter 8: Bioremediation of Polluted Soil by Using Plant Growth Promoting Rhizobacteria -- Chapter 9: The Utilization of Microbial Biofilm for the Biotransformation and Bioremediation of heavily Polluted Environment -- Chapter 10: Microbes: A Novel Source of Bioremediation for Degradation of Hydrocarbon -- Chapter 11: Microbial Bioremediation of Petroleum Hydrocarbons.-Chapter 12: Potential of Extremophiles for Bioremediation -- Chapter 13: Role of Microbes in Bioremediation of Radioactive Waste -- Chapter 14: Plastic Eating Microorganism: Recent Biotechnological Techniques for Recycling of Plastic -- Chapter 15: Bioaugmentation: A Powerful Biotechnological Techniques for Sustainable Ecorestoration of Soil and Groundwater Contaminants.
    Abstract: Pollution is one of the most serious issues facing mankind and other life forms on earth. Environmental pollution leads to the degradation of ecosystems, loss of services, economic losses, and various other problems. The eco-friendliest approach to rejuvenating polluted ecosystems is with the help of microorganism-based bioremediation. Microorganisms are characterized by great biodiversity, genetic and metabolic machinery, and by their ability to survive, even in extremely polluted environments. As such, they are and will remain the most important tools for restoring polluted ecosystems / habitats. This three-volume book sheds light on the utilization of microorganisms and the latest technologies for cleaning up polluted sites. It also discusses the remediation or degradation of various important pollutants such as pesticides, wastewater, plastics, PAHs, oil spills etc. The book also explains the latest technologies used for the degradation of pollutants in several niche ecosystems. Given its scope, the book will be of interest to teachers, researchers, bioremediation scientists, capacity builders and policymakers. It also offers valuable additional reading material for undergraduate and graduate students of microbiology, ecology, soil science, and the environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 398 p. 37 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811574474
    Series Statement: Microorganisms for Sustainability, 25
    URL: https://doi.org/10.1007/978-981-15-7447-4
    DOI: 10.1007/978-981-15-7447-4
    DDC: 579
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    Online Resource
    Microbial Rejuvenation of Polluted Environment : Volume 3 (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Restoration Ecology. ; Pollution. ; Microbiology. ; Microbial Ecology. ; Restoration Ecology. ; Pollution.
    Description / Table of Contents: Chapter 1: Strain Improvement and Mass Production of Beneficial Microorganisms for Their Environmental and Agricultural Benefit -- Chapter 2: Biochemical Role of Beneficial Microorganisms: An Overview on Recent Development in Environmental and Agro-Science -- Chapter 3: Recent Advances in Application of Microbial Enzymes for Biodegradation Waste and Hazardous Waste Material -- Chapter 4: Biological, Biochemical and Biodiversity of Biomolecules from Marine based beneficial Microorganisms: Industrial Perspective -- Chapter 5: Climate Change and Pesticides: Their Consequence on Microorganisms -- Chapter 6: Effect of Heavy Metals on Activities of Soil Microorganism -- Chapter 7: Microbial Community Dynamics in Anaerobic Digestors for Biogas Production -- Chapter 8: Effect of Microbially Produced Silver Nanoparticles on Bioremediation of Waste Dye: Nanobioremediation -- Chapter 9: Bioremoval of Fluoride: Process and Mechanism -- Chapter 10: A Critical Review of Microbial Transport in Effluent Waste and Sewage Sludge Treatment -- Chapter 11: Recent Trends in Utilization of Biotechnological Tools for Environmental Sustainability -- Chapter 12: Artificial Intelligence and Internet of Things in Instrumentation and Control in Waste Biodegradation Plants: Recent Developments -- Chapter 13: Bioremediation of Polythene and Plastics Using Beneficial Microorganisms -- Chapter 14: Recent Advances in the Application of Genetically Engineered Microorganisms for Microbial Rejuvenation of Contaminated Environment -- Chapter 15: Efficacy of Microorganisms in the Removal of Toxic Materials from Industrial Effluents.
    Abstract: Pollution is one of the most serious issues facing mankind and other life forms on earth. Environmental pollution leads to the degradation of ecosystems, loss of services, economic losses, and various other problems. The eco-friendliest approach to rejuvenating polluted ecosystems is with the help of microorganism-based bioremediation. Microorganisms are characterized by great biodiversity, genetic and metabolic machinery, and by their ability to survive, even in extremely polluted environments. As such, they are and will remain the most important tools for restoring polluted ecosystems / habitats. This three-volume book sheds light on the utilization of microorganisms and the latest technologies for cleaning up polluted sites. It also discusses the remediation or degradation of various important pollutants such as pesticides, wastewater, plastics, PAHs, oil spills etc. The book also explains the latest technologies used for the degradation of pollutants in several niche ecosystems. Given its scope, the book will be of interest to teachers, researchers, bioremediation scientists, capacity builders and policymakers. It also offers valuable additional reading material for undergraduate and graduate students of microbiology, ecology, soil science, and the environmental sciences.
    Type of Medium: Online Resource
    Pages: XVI, 358 p. 27 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811574597
    Series Statement: Microorganisms for Sustainability, 27
    URL: https://doi.org/10.1007/978-981-15-7459-7
    DOI: 10.1007/978-981-15-7459-7
    DDC: 579
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  • 41
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    Online Resource
    Microbial Rejuvenation of Polluted Environment : Volume 2 (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Soil science. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Pollution. ; Microbiology. ; Microbial Ecology. ; Soil Science. ; Environmental Engineering/Biotechnology. ; Pollution.
    Description / Table of Contents: Chapter 1: Bioremediation of Industrial Pollutants -- Chapter 2: Bioremediation of Metals, Metalloids and Non-metals -- Chapter 3: Fungal Mediated Bioremediation of Heavy Metal Polluted Environment -- Chapter 4: Biological Decolorization and Degradation of Synthetic Dyes: A Green Step towards Sustainable Environment -- Chapter 5: Bioremediation of Waste Gases and Polluted Soils -- Chapter 6: E-Waste and its Hazard Management by Specific Microbial Bioremediation Processes -- Chapter 7: Current Methods of Enhancing Bacterial Bioremediation of Pesticide Residues in Agricultural Farmlands -- Chapter 8: Mechanism of Actions involved in Sustainable Ecorestoration of Petroleum Hydrocarbons Polluted Soil by the Beneficial Microorganism -- Chapter 9: Biosorption: An Ecofriendly Technology for Pollutant Removal -- Chapter 10: Synergistic and Aantagonistic Effects of Microbial Co-culture on Bioremediation of Polluted Environments -- Chapter 11: Enzymes-Oriented Strategies to Mitigate Polluting Agents from Environment -- Chapter 12: Non Aqueous Catalysis-A Way Forward for the Intermediation of Phenolic Environmental Pollutant Bisphenol A -- Chapter 13: Nanoparticles Mediated Adsorption of Pollutants- A way forward to Mitigation of Environmental Pollution -- Chapter 14: Nano-Bio remediation Application for Environment Contamination by Microorganism -- Chapter 15: Biosorption and Bioaccumulation of Pollutants for Environmental Remediation.
    Abstract: Pollution is one of the most serious issues facing mankind and other life forms on earth. Environmental pollution leads to the degradation of ecosystems, loss of services, economic losses, and various other problems. The eco-friendliest approach to rejuvenating polluted ecosystems is with the help of microorganism-based bioremediation. Microorganisms are characterized by great biodiversity, genetic and metabolic machinery, and by their ability to survive, even in extremely polluted environments. As such, they are and will remain the most important tools for restoring polluted ecosystems / habitats. This three-volume book sheds light on the utilization of microorganisms and the latest technologies for cleaning up polluted sites. It also discusses the remediation or degradation of various important pollutants such as pesticides, wastewater, plastics, PAHs, oil spills etc. The book also explains the latest technologies used for the degradation of pollutants in several niche ecosystems. Given its scope, the book will be of interest to teachers, researchers, bioremediation scientists, capacity builders and policymakers. It also offers valuable additional reading material for undergraduate and graduate students of microbiology, ecology, soil science, and the environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 405 p. 57 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811574559
    Series Statement: Microorganisms for Sustainability, 26
    URL: https://doi.org/10.1007/978-981-15-7455-9
    DOI: 10.1007/978-981-15-7455-9
    DDC: 579
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  • 42
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    Online Resource
    Rhizosphere Microbes : Biotic Stress Management (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Stress (Physiology). ; Plants. ; Microbiology. ; Microbial Ecology. ; Plant Stress Responses.
    Description / Table of Contents: Chapter 1. Detection and identification of soil borne pathogens: Classical to Recent updates -- Chapter 2. Microarray-based detection and identification of bacterial and viral plant pathogens -- Chapter 3. Application molecular ecology approaches in sustainable agriculture for a better understanding of plant microbiome interactions -- Chapter 4. Advancements in detection and diagnosis of important soil-borne diseases -- Chapter 5. Omics approaches to revisit rhizo-bacterial biome -- Chapter 6. Engineering the Plant Microbiome for Biotic Stress tolerance: Biotechnological Advances -- Chapter 7. Potential of bacterial endophytes in biological control of soil borne phytopathogens -- Chapter 8. Endophytes: Rendering systemic resistance to plant -- Chapter 9. Arbuscular Mycorrhizal Fungi (AMF) as Potential Biocontrol Agents -- Chapter 10. Rhizosphere microbes and Wheat Health Management -- Chapter 11. Exploring the potential of secondary metabolites from indigenous Trichoderma spp. for their plant growth promotion and disease suppression ability in pulses -- Chapter 12. Uncultivable soil microbes contributing to sustainable agriculture -- Chapter 13. Rhizosphere microbiome: Significance in sustainable crop protection -- Chapter 14. Bacterial inoculants for control of fungal diseases in tomatoes (Solanum lycopersicum L.): A comprehensive overview -- Chapter 15. Plant-Microbe Interaction and Rhizosphere Biology Lab, ICAR-National Bureau of Agriculturally Important -- Chapter 16. Prior weakening as a tool to control soilborne plant pathogens and associated disease pressure.
    Abstract: This edited book volume aims to bringing out a comprehensive collection of latest information and developments on the management of biotic stresses by the use of rhizospheric microbes across the globe. The main focus of this book is to address the scientific and practical significance of rhizosphere microbes in biotic stress management. The microbial communities in the rhizosphere ecosystem play multitude of microbe-microbe, microbe-insect/pest and plant-microbe interactions and they have not yet been fully exploited to gain benefits in this field as well as to achieve sustainability in agriculture. Among the more recent strategies, stress tolerance/resistance induced by environment-friendly elicitors of microbial origin and/or rhizosphere microorganisms has emerged as a promising supplement in the approaches to crop protection. The proposed book entitled "Rhizosphere Microbes: Biotic Stress Management” is pertinent to rhizospheric microbe-mediated biotic stress management covering all spheres of biotic stress tolerance viz., bio-resources, diversity, ecology, and functioning of microbial bio-control agents, host–parasite interaction, strategies to characterize microbial bioinoculants, interactions of rhizosphere microbes by developing a fundamental understanding of the microbial communities, exploration of the diverse roles of microbes and microbial communities and their role in biotic stress tolerance, microbe-mediated mitigation of biotic stresses, quorum sensing, microbial signalling and cross-talk in the rhizosphere, biofilm formation, cell-to-cell communication, role of microorganisms in ecosystems functioning under various biotic stress conditions, application of microbial bio-pesticides, molecular studies using microbial systems, etc. This book is of interest to teachers, researchers, crop protection scientists, capacity builders and policymakers. Also the book serves as additional reading material for under-graduate, post-graduate, and post-doctorate fellow of agriculture, forestry, ecology, life science, and environmental sciences. National and international agricultural scientists, policy makers will also find this to be a useful read.
    Type of Medium: Online Resource
    Pages: XVII, 370 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811958724
    Series Statement: Microorganisms for Sustainability, 40
    URL: https://doi.org/10.1007/978-981-19-5872-4
    DOI: 10.1007/978-981-19-5872-4
    DDC: 579
    Language: English
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  • 43
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    Online Resource
    Synbiotics for the Management of Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Cancer. ; Cancer Treatment. ; Pharmacology. ; Cancers. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Effect of anticancer treatment approches on gut microbiota -- Chapter 3_Synbiotic: A promising approach for the treatment of cancer -- Chapter 4_Correlation between ROS and Synbiotics for effective treatment of cancer -- Chapter 5_Influence of synbiotics on inflammation and immune microenvironment for the treatment of cancer -- Chapter 6_Synbiotics in colorectal cancer -- Chapter 7_Synbiotics in cervical cancer -- Chapter 8_Synbiotics in prostate cancer -- Chapter 9_Synbiotics in gastric cancer -- Chapter 10_Synbiotics in lung cancer -- Chapter 11_Synbiotics in small cell pancretatic cancer -- Chapter 12_Synbiotics in breast cancer -- Chapter 13_Synbiotics in hepatocellular carcinoma -- Chapter 14_Synbiotics in ovarian cancer -- Chapter 15_Regulatory issues of synbiotics in cancer.
    Abstract: This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.
    Type of Medium: Online Resource
    Pages: XVII, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811975509
    URL: https://doi.org/10.1007/978-981-19-7550-9
    DOI: 10.1007/978-981-19-7550-9
    DDC: 615
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  • 44
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    Online Resource
    Recent Advances in Pharmaceutical Innovation and Research (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Nanobiotechnology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Nanobiotechnology.
    Description / Table of Contents: Part 1. Pharmaceutical Innovation and Research -- Chapter 1. Innovation in stabilization of biopharmaceuticals -- Chapter 2. Concepts in pharmacogenomics: tools and applications -- Chapter 3. Pharmacogenetics–a new approach for the selection of the right drug -- Chapter 4. Meeting the unmet challenges of pharmaceutical research using artificial intelligence -- Chapter 5. Pharmaceutical innovation and research in ayurved -- Chapter 6. Ayurveda intervention in perimenopausal syndrome -- Part 2. Drug Discovery and Development -- Chapter 7. Innovative strategies in drug discovery and pharmacoinformatics -- Chapter 8. Advances in peptide synthesis -- Chapter 9. Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs -- Chapter 10. Diverse Pharmacological Activities of 4-aminoquinoline and its Derivatives -- Chapter 11. Thiourea catalysts for synthesis of active pharmaceutical ingredients -- Chapter 12. The Chemistry and Pharmacology of Mandarin Orange -- Chapter 13. Recent progress in the pharmacology of phytoestrogens: emerging neuromodulators for treating anxiety and depression -- Chapter 14. Next-generation cell-based therapies to combat metastaticbrain tumor -- Chapter 15. Pharmacokinetics and Pharmacodynamics: Fundamentals and Role(s) in Drug Discovery and Development -- Chapter 16. An update on pharmacokinetic models -- Chapter 17. Pharmacodynamics: Basics and Applications in Drug Research -- Part 3. Drug Delivery and Nanotechnology -- Chapter 18. Technological innovations in pharmaceutical drug nanocrystals -- Chapter 19. Fixed Dose Combinations: Innovations and Research -- Chapter 20. Significance of Intranasal Drug Delivery Systems: Recent Trends and Clinical Investigations in Brain Disorders -- Chapter 21. Current challenges and nanotechnology-based pharmaceutical approaches for the treatment and control of visceral leishmaniasis -- Chapter 22. Polymeric Nanoparticles-based Drug Delivery Systems for Anticancer Therapy. Chapter 23. Carbon nanotubes: a review of toxicity and applicability in biomedical applications -- Chapter 24. Recent trends in topical herbal nanotherapeutics for psoriasis -- Part 4. Pharmaceutical Microbiology -- Chapter 25. Antibiotics: past, present, future, and clinical pipeline -- Chapter 26. Innovative strategies to tackle antimicrobial resistance -- Chapter 27. Molecular and mechanistic insights of yeast flocculation -- Chapter 28. Management of hepatitis virus C: current and future treatments -- Chapter 29. Tuberculosis: experimental models, innovations and challenges -- Chapter 30. Targeting outer membrane to tackle multi-drug resistant bacterial pathogens -- Chapter 31. Diphtheria-A Paradigmatic Vaccine Preventable Toxigenic Disease with Changing Epidemiology -- Chapter 32. Emerging and re-emerging infections: an overview.
    Abstract: This book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.
    Type of Medium: Online Resource
    Pages: XXI, 770 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819923021
    URL: https://doi.org/10.1007/978-981-99-2302-1
    DOI: 10.1007/978-981-99-2302-1
    DDC: 615
    Language: English
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    Online Resource
    Sustainable and Clean Energy Production Technologies (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Renewable energy sources. ; Microbiology. ; Renewable Energy.
    Description / Table of Contents: Chapter 1. Tiny Renewable Engines: Microalgae and Cyanobacteria as biofuel providers -- Chapter 2. Different Energy Management Strategies for Clean Energy -- Chapter 3. Recycle of Plastic Waste to Liquid Fuel: A sustainable energy production -- Chapter 4. Nanomaterials for Energy Storage Applications -- Chapter 5. Biomass Energy Conversion using Thermochemical and Biochemical Technologies -- Chapter 6. Pyrolysis of waste biomass using solar energy for Clean Energy Production -- Chapter 7. Biomass Digestion for Production of Electrical Energy -- Chapter 8. Solar Energy Conversion Techniques and Practical Approaches to Design Solar PV Power Station -- Chapter 9. Recent Advancement in Preparation Strategy of Efficient Graphene-Cds Based Photocatalysts for H2 Production by Water Splitting -- Chapter 10. Design and Storage of Solar Thermal Energy Production -- Chapter 11. Clean Energy using Hydroelectric generation from Rivers -- Chapter 12. Clean Energy Production using Solar Energy Resources.
    Abstract: This edited book is a comprehensive collection of chapters on various clean energy technology such as solar energy, waste biomass as energy, hydro-electricity generation, biodiesel production from biomass and strategies to cater the demand of clean renewable energy. Clean energy technologies also enhance economic growth by increasing the supply of energy demand and tackling environmental challenges and their impacts due to the use of other conventional sources of energy. The conventional/non-conventional energy production methods are efficient but it has adverse effects on environment and human health. As environmental concerns are not avoidable therefore the necessity of clean energy production comes in to the picture. The clean energy can be produced by different wastes which are caused for the environmental pollution. This book covers various aspects of new and renewable clean energy production technology and its utilization in different fields. This is a useful reading material for students and researchers involved in clean energy study.
    Type of Medium: Online Resource
    Pages: VII, 288 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811691355
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-16-9135-5
    DOI: 10.1007/978-981-16-9135-5
    DDC: 579
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  • 46
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    Online Resource
    Current Research Trends and Applications in Waste Management (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Refuse and refuse disposal. ; Bioenergetics. ; Microbiology. ; Waste Management/Waste Technology. ; Bioenergetics.
    Description / Table of Contents: Chapter 1 Emerging Frontiers of Microbes in Liquid Waste Management -- Chapter 2 Municipal wastewater treatment by microalgae with simultaneous resource recovery: A biorefinery approach -- Chapter 3 An economic and sustainable method of bio-ethanol production from Agro-waste: A waste to energy approach -- Chapter 4 Sewage and wastewater management to combat different mosquito vector species -- Chapter 5 Keratinase role in management of poultry Waste -- Chapter 6 Biomedical Waste: Impact on Environment and its Management in Health Care Facilities -- chpater 7 Microbial intervention in waste remediation for Bio-energy production -- Chapter 8 Role of Microorganisms in Biogas Production From Animal Waste and Slurries -- Chapter 9 Bioelectricity generation from organic waste using microbial fuel cell -- Chapter 10 Bioremediation: Remedy for Emerging Environmental Pollutants -- Chapter 11 Rhizoremediation: A Plant Microbe Based Probiotic Science -- Chapter 12 Microbial fermentation system for the production of biopolymers and bioenergy from various organic wastes and by-products -- Chapter 13 Nanotechnology: Opportunity and Challenges in Waste Management -- Chapter 14 ‘Omics’ approaches for structural and functional insights of ‘Waste to Energy’ Microbiome.
    Abstract: This book covers latest information on organic and inorganic waste management, and how the waste can be utilized as an energy source. An increasing world population and climate change rate hint that environmental health needs a sustainable waste recycling system worldwide. Management of wastes material plays a substantial role in the environment and climate regulation. Chapters contain modern tools and techniques for managing inorganic, biomedical, municipality, and food waste. The title covers the role of contemporary microbiology and biotechnological tools in waste management and how these microbial agents can enhance waste degradation and bioenergy production. The book covers interesting topics such as bio-ethanol production from agro-waste, microbial fuel cells, biogas production from animal waste, nanotechnology in waste recycling, etc. The primary audiences are researchers, scientists, students, and policymakers interlinked with waste management and applied microbial sectors.
    Type of Medium: Online Resource
    Pages: VII, 402 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931064
    URL: https://doi.org/10.1007/978-981-99-3106-4
    DOI: 10.1007/978-981-99-3106-4
    DDC: 579
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  • 47
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    Online Resource
    Diagnosis of Mycobacterium (2023)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Diagnosis. ; Diseases. ; Internal medicine. ; Microbiology. ; Diagnosis. ; Diseases. ; Internal Medicine.
    Description / Table of Contents: Chapter 1. Introduction to Diagnosis of Mycobacterium -- Chapter 2. Clinical and Radiological Diagnosis of Tuberculosis -- Chapter 3. Pathology based Diagnosis of Tuberculosis -- Chapter 4. Assessment of Hematological and Biochemical Parameters in the Diagnosis and Prognosis of Tuberculosis -- Chapter 5. Different Methods of Microscopic and Bacteriological Diagnosis of Tuberculosis -- Chapter 6. Molecular Diagnosis of Tuberculosis -- Chapter 7. Diagnosis and Challenges of Pediatric Tuberculosis -- Chapter 8. Diagnosis of Latent Tuberculosis -- Chapter 9. The Future of Serology-Based Diagnosis for Tuberculosis in India -- Chapter 10. Point of Care (POC) Detection Technique for Mycobacterium -- Chapter 11. Recent Advances in the Diagnosis and Treatment of Non-tuberculous Mycobacteria Infection -- Chapter 12. Sensor and Nanotechnology based Diagnostics in the Field of Mycobacteriology -- Chapter 13. Non-tuberculous Mycobacterium Infections in Lung Disease and Medical Interventions -- Chapter 14. Laboratory Diagnosis of Zoonotic Tuberculosis: An Update.
    Abstract: This book covers all the aspects related to the laboratory diagnosis of Mycobacterium. Laboratory diagnosis includes microscopic to advance molecular diagnosis. Moreover, it deals with the methods used to detect antimycobacterial susceptibility tests and drug resistance.Chapters cover most potential methods and techniques from traditional to advanced future diagnostics for identifying tuberculosis, NTM, and latent TB infections. Also discussed are the challenges and opportunities in the diagnostic science of infectious disease. This book offers assistance to students, postgraduate medical students, researchers, medical practitioners, postdoctoral fellows, microbiologists, nurses, and public health officers working in tuberculosis control programs to understand various modalities for diagnosis and drug-resistance tuberculosis.
    Type of Medium: Online Resource
    Pages: XXIV, 258 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819956241
    URL: https://doi.org/10.1007/978-981-99-5624-1
    DOI: 10.1007/978-981-99-5624-1
    DDC: 579
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  • 48
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    Online Resource
    Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nanobiotechnology. ; Drug delivery systems. ; Pharmacology. ; Nanobiotechnology. ; Drug Delivery.
    Description / Table of Contents: Ch 1 Introduction to block co-polymers -- Ch 2 Role of block co-polymers in drug delivery -- Ch 3 Role of block co-polymers in enhancement of poor solubility of drugs -- Ch 4 Synthesis and Self–assembly of block copolymers -- Ch 5 Role of block co-polymers in treatment of brain disorders -- Ch 6 Role of block co-polymers in treatment of neurodegenerative disorders -- Ch 7 Role of block co-polymers in colon cancer -- Ch 8 Role of block co-polymers in lung cancer -- Ch 9 Role of block co-polymers in IBD -- Ch 10 Role of block co-polymers in vaccine -- Ch 11 Role of block co-polymers in treatment of GIT disorders -- Ch 12 Role of block co-polymers in topical drug delivery -- Ch 13 Role of block co-polymers in targeted drug delivery -- Ch 14 Role of block co-polymers in ocular drug delivery -- Ch 15 Role of block co-polymeric micelles in drug delivery -- Ch 16 Applications of block co-polymers as Stimuli Responsive Copolymers -- Ch 17 Patented block co-polymers for various Therapeutics Applications.
    Abstract: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.
    Type of Medium: Online Resource
    Pages: XVII, 429 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819969173
    URL: https://doi.org/10.1007/978-981-99-6917-3
    DOI: 10.1007/978-981-99-6917-3
    DDC: 615
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  • 49
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    Metabolomics, Proteomes and Gene Editing Approaches in Biofertilizer Industry (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Biotechnology. ; Botanical chemistry. ; Botany. ; Microbiology. ; Biotechnology. ; Plant Biochemistry. ; Plant Science.
    Description / Table of Contents: Chapter 1. Constrains in biofertilizer industry and future scopes -- Chapter 2. Present scenario: Status of biofertilizer industry in India -- Chapter 3. Mode of application of biofertilizer in crop fields -- Chapter 4. Carrier based Biofertilizers -- Chapter 5. Liquid biofertilizers -- Chapter 6. Interaction of efficient rhizospheric bacteria and response in farmer’s field -- Chapter 7. Enhancing productivity through multiple microbial inoculants -- Chapter 8. Challages in compatibility of microbial inoculants with agrochemicals -- Chapter 9. Microbial metabolite-based products for plant growth promotion -- Chapter 10. Microbes from wild plants: Challenges and opportunities to be used as inoculant -- Chapter 11. Fungal biofertilizers: present trends and future prospects -- Chapter 12. Endophytes as plant growth inducers: a whole new arena in the inoculant industry -- Chapter 13. Immobilization and co-mobilization: An unexploited biotechnological tool for enhancing efficiency of biofertilizers -- Chapter 14. Microbial biostimulants: Bioformulations for enhanced biofertilizer efficacy and sustainable crop management -- Chapter 15. Omics approaches in strain improvement and new vistas in next-generation biofertilizers -- Chapter 16. Metabolomics and proteomics behind plant growth promoting potential of rhizobacteria -- Chapter 17. Proteomics in shaping future of biofertilizer delivery technique -- Chapter 18. Application of nanosilica for plant growth promotion and crop improvement -- Chapter 19. Industrial sustainability: Economics, cost and bioavailability of biofertilizers -- Chapter 20. Phyllosphere engineering: tailoring leaf surface microbes for boosting plant tolerance. .
    Abstract: This edited book covers the major aspects of plant growth promoting bacteria and mechanisms underlining the phenotype in rhizobacteria. This book guides the researchers about the potential of plant growth promoting bacteria to be used as biofertilizers. The process of biofertilizer development and the process of testing its efficacy for commercial use and the potency is elaborated in this volume using suitable figures. The information in this book regarding the secretion of various secondary metabolites responsible for nutrient management is helpful for designing bioformulations that assist plant growth. This book provides substantial number of evidences that underlines the genomic basis of nutrient management by microbes. Essential information is provided regarding the genomic and proteomic background of the biofertilizers. The chapters in the book are divided into three sections. The first section of the book includes chapter 1-5 outlining the importance of rhizobacteria in elevating the nutrient levels in soil and augmenting the biotic and abiotic stress. Second section of the book includes chapter 6-11 elaborating the details about the biofertilizer, types of biofertilizer available and techniques involved in mass production of biofertilizers. Section third covers chapters from 12-15 providing the explicit information about metabolomics and proteomics basis of plant growth development. This collective work is distinct as it has focus on diverse emerging technologies which are high-throughput, scalable and applicable to different countries regardless of their socio-economic conditions. This book can improve the current state of knowledge and invoke researchers and innovators to take ahead the current inter-disciplinary knowledge into technologies that are readily available and effectively minimize hazards associated with chemical fertilizer.
    Type of Medium: Online Resource
    Pages: XIV, 402 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819935611
    URL: https://doi.org/10.1007/978-981-99-3561-1
    DOI: 10.1007/978-981-99-3561-1
    DDC: 579
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  • 50
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    Principles of Microbial Metabolism and Metabolic Ecology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Life sciences. ; Microbial ecology. ; Industrial microbiology. ; Microbial genetics. ; Microbiology. ; Life Sciences. ; Microbial Ecology. ; Industrial Microbiology. ; Microbial Genetics.
    Description / Table of Contents: Microbial Life on Earth, Metabolism, and Metabolic Diversity -- A Microbe’s Environment and Natural Selection -- Microbial Energetics -- Catabolism and Its Coupling to Anabolism -- Microbial Kinetics -- Mechanisms of Microbial Energy Conservation -- Prototypic Reactions of Prokaryotic Carbon Catabolism -- Metabolic Modules, Pathways, and Nodes of Intermediates -- Fermentative Metabolism -- Prototypic Reactions, Modules, and Pathways of C1 Catabolism.
    Abstract: This textbook examines the fundamental principles of microbial metabolism and how a microbe's ecology is intrinsically interwoven with and a consequence of its metabolism. Further, it answers many questions frequently asked by students, such as: What are the mechanistic connections between simple phenotypic traits, ecological patterns and microbial metabolism and diversity? In the process, readers will be introduced to essential topics like metabolism and metabolic pathways, flux of energy and nutrients, genome size and fitness, competition, selection and drift. Moreover, the book conveys fundamental principles that show students how to approach the field of microbiology from a different, more unifying angle, e.g., how microbes’ access to environmentally available energy resources and the specific metabolism involved lies at the root of every ecologically significant microbial speciation. This aspect, together with its special focus on metabolism and ecological implications, make the book a must-read for all students of microbiology.
    Type of Medium: Online Resource
    Pages: XVII, 338 p. 198 illus., 165 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031282188
    URL: https://doi.org/10.1007/978-3-031-28218-8
    DOI: 10.1007/978-3-031-28218-8
    DDC: 579
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    Pharmacology of Immunotherapeutic Drugs (2020)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.
    Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.
    Abstract: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
    Type of Medium: Online Resource
    Pages: XIX, 399 p. 118 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030199227
    URL: https://doi.org/10.1007/978-3-030-19922-7
    DOI: 10.1007/978-3-030-19922-7
    DDC: 615
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    Minimal Cells: Design, Construction, Biotechnological Applications (2020)
    Cham :Springer International Publishing :
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    Keywords: Microbiology. ; Biotechnology. ; Evolution (Biology). ; Biomaterials. ; Nucleic acids. ; Cytology. ; Microbiology. ; Biotechnology. ; Evolutionary Biology. ; Nucleic Acid. ; Cell Biology.
    Description / Table of Contents: Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis -- Construction of minimal genomes and synthetic cells -- Engineering reduced-genome strains of Pseudomonas putida for product valorization -- Genome-reduced Corynebacterium glutamicum fit for biotechnological applications -- Reduction of the Saccharomyces cerevisiae genome: challenges and perspectives -- The use of in silico genome-scale models for the rational design of minimal cells -- From minimal to minimized genomes: Functional design of microbial cell factories -- Resource allocation principles and minimal cell design.
    Abstract: This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.
    Type of Medium: Online Resource
    Pages: VII, 230 p. 35 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030318970
    URL: https://doi.org/10.1007/978-3-030-31897-0
    DOI: 10.1007/978-3-030-31897-0
    DDC: 579
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    Biomedical Applications and Toxicity of Nanomaterials (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Nanobiotechnology. ; Nanomedicine. ; Pharmacology. ; Nanobiotechnology. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Chapter 1. Macroporous cryogel-based systems for water treatment applications and Safety: nanocomposite-based cryogels and bacteria-based bioreactors -- Chapter 2. One dimensional Semiconducting Nanomaterials: Toxicity and Clinical Applications -- Chapter 3. Prospects of Safe use of Nanomaterials in Biomedicalapplications -- Chapter 4. Hyaluronic acid-based nanotechnologies for delivery and treatment -- Chapter 5. Theranostics nanomaterials for safe cancer treatment -- Chapter 6. Cardiovascular safety assessment of new chemical entities: current perspective and emerging technologies -- Chapter 7. Toxicology of pharmaceutical products during drug development -- Chapter 8. Safety and Risk assessment of food items -- Chapter 9. Non toxic Natural products as regulators of tumour suppressor gene function -- Chapter 10. Advancements in the safety of Plant medicine: Back to nature -- Chapter 11. Chemicals and their interaction in the aquaculture system -- Chapter 12. Zebrafish as a biomedical model to define developmental origins of chemical toxicity -- Chapter 13. Green synthesis of non toxic nanoparticles -- Chapter 14. Synthesis, characterisation and safety of titanium oxide nanoparticles -- Chapter 15. Characterisation of non toxic nanomaterials for biological applications -- Chapter 16. Toxicity assessment of nanoparticle -- Chapter 17. Safety of nanoparticles: emphasis on antimicrobial properties -- Chapter 18. Quantum dots for imaging and its safety -- Chapter 19. Genotoxicity evaluation of nanosized materia -- Chapter 20. Scaffoldmaterials and toxicity -- Chapter 21 Biological Safety and Cellular interactions of nanoparticles -- Chapter 22. Role of artificial intelligence in the toxicity prediction of drugs -- Chapter 23. Chemicals and rodent models for the safety study of alzheimer’s disease -- Chapter 24. Mitochondria-targeted liposomal delivery in Parkinson's disease: safety concerns -- Chapter 25. Routes of Nano-drug Administration and Nano-based drug delivery system and toxicity -- Chapter 26. Green Synthesised silver nanoparticles phytotoxicity and applications in agriculture: An overview -- Chapter 27 status of safety concerns of microplastic detection strategies -- Chapter 28. Impact of insecticides on man and environment.
    Abstract: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
    Type of Medium: Online Resource
    Pages: XVIII, 768 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811978340
    URL: https://doi.org/10.1007/978-981-19-7834-0
    DOI: 10.1007/978-981-19-7834-0
    DDC: 615
    Language: English
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    Online Resource
    Biology of Composts (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Botany. ; Biotechnology. ; Refuse and refuse disposal. ; Physical geography. ; Microbiology. ; Microbial Ecology. ; Plant Science. ; Biotechnology. ; Waste Management/Waste Technology. ; Earth System Sciences.
    Description / Table of Contents: Part 1. Composting: Paradigms and Mechanisms -- 1. Compost and Compost Tea Microbiology: the “-Omics” Era -- 2. Biological Sterilisation, Detoxification and Stimulation of Cucurbitacin-containing Manure -- 3. Nematode succession during composting process -- 4. Review on Physiological Effects of Vermicomposts on Plants -- 5. Interaction of Earthworm Activity with Soil Structure and Enzymes -- 6. Survival of Pathogenic and Antibiotic Resistant Bacteria in Vermicompost, Sewage Sludge and other Types of Composts in Temperate Climate Conditions -- Part 2. Modern Tools and Techniques for Composting Research -- 7. Molecular Tools and Techniques for Understanding the Microbial Community Dynamics of Vermicomposting -- 8. Molecular Tools and Techniques for Understanding the Microbial Community Dynamics of Vermicomposting -- 9. Recent Advances in Assessing the Maturity and Stability of Compost -- 10. Application of Nanotechnology to Research on the Microbiology of Composting -- Part 3. Composting Applications -- 11. Bioremediation of Pesticides in Soil Through Composting: Potential and Challenges -- 12. Current Trends and Insights on Compost Utilization Studies - Crop Residue Composting to Improve Soil Organic Matter in Sugarcane Cultivation, Tamil Nadu, India -- 13. Applications of Streptomyces spp. Enhanced Compost in Sustainable Agriculture.
    Abstract: This book highlights the latest findings on fundamental aspects of composting, the interaction of various microorganisms, and the underlying mechanisms. In addition to addressing modern tools and techniques used for composting research, it provides an overview of potential composting applications in both agriculture and environmental reclamation. Composting is the process of organic waste decomposition, mediated by microorganisms. The end-product is called ‘compost’ and can be used as a supplement to improve soil fertility. As the municipal waste generated in most developing countries contains a substantial amount of organic matter suitable for composting, this technology offers a win-win opportunity for stakeholders in terms of disposing of organic waste and providing organic fertilizers for agriculture. In addition, using compost reduces the dependency on harmful chemical fertilizers, and represents a sustainable and environmentally friendly alternative.
    Type of Medium: Online Resource
    Pages: XI, 291 p. 39 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030391737
    Series Statement: Soil Biology, 58
    URL: https://doi.org/10.1007/978-3-030-39173-7
    DOI: 10.1007/978-3-030-39173-7
    DDC: 579
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    Pharmacology of Drug Stereoisomers (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Biotechnology. ; Biochemical engineering. ; Pharmacology. ; Medicinal Chemistry. ; Pharmaceutics. ; Biotechnology. ; Bioprocess Engineering.
    Description / Table of Contents: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
    Abstract: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
    Type of Medium: Online Resource
    Pages: XI, 207 p. 174 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811923203
    Series Statement: Progress in Drug Research, 76
    URL: https://doi.org/10.1007/978-981-19-2320-3
    DOI: 10.1007/978-981-19-2320-3
    DDC: 615
    Language: English
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    Sustainable Environmental Protection Technologies : Contaminant Biofiltration, Adsorption and Stabilization (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental policy. ; Sociology. ; Physical geography. ; Pollution. ; Microbiology. ; Environmental Engineering/Biotechnology. ; Environmental Policy. ; Sociology. ; Physical Geography. ; Pollution.
    Description / Table of Contents: Chapter 1 -- The importance of technogenesis and sustainable environmental protection technologies. Chapter 2 -- Natural and artificial biogeochemical barriers as natural technologies. Chapter 3 -- The sustainable natural materials and their role in waste management and soil contamination stabilizing. Chapter 4 -- The sustainable natural materials used for adsorbing contaminants from aqueous medium. Chapter 5 -- Biotechnologies as the sustainable environmental protection technologies. Chapter 6 -- The major properties of natural materials used in biofiltration systems. Chapter 7 -- Operational parameters of biofiltration systems required for efficient operation of components ensuring system’s sustainability. Chapter 8 -- Natural and inoculated microorganisms as important component for sustainability of biofiltration system. Chapter 9 -- The technologies of the sustainable environmental protection in real conditions in the case of biofiltration systems.
    Abstract: This book discusses the need for the development of sustainable environmental protection technologies to reduce the impact of environmental contaminants. Three levels of sustainable technologies are addressed. The first level involves the concept of sustainable technologies as natural technologies, or ecotechnologies, whereby contamination level is assessed based on the contamination footprint through the use of biogeochemical barriers (e.g. methods utilizing the bioaccumulation properties of plants). The second level concerns the use of sustainable natural materials, such as biochar, in environmental engineering systems, an approach that is used for analyzing the processes of adsorption and biofiltration, as well as immobilization of contaminants in soil. The third level discusses the optimal components necessary to achieve sustainability in environmental engineering systems, including system operation principles, structural solutions, and the synergies between various system components such as microorganisms. The book will be of interest to specialists of industrial enterprises engaged in environmental protection, as well as environmental system designers, stakeholders from environmental protection ministries and institutions, researchers, doctoral students and masters and bachelors of science in the field of environmental engineering.
    Type of Medium: Online Resource
    Pages: XXI, 645 p. 287 illus., 123 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030477257
    URL: https://doi.org/10.1007/978-3-030-47725-7
    DOI: 10.1007/978-3-030-47725-7
    DDC: 579
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    Online Resource
    Plant Microbe Symbiosis (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Botany. ; Microbiology. ; Microbial Ecology. ; Plant Science.
    Description / Table of Contents: The Rhizobium–Plant Symbiosis: State of the Art -- Diversity and Importance of the Relationship Between Arbuscular Mycorrhizal Fungi and Nitrogen-Fixing Bacteria in Tropical Agroforestry Systems in Mexico -- Nitrogen Fixation in a Legume-Rhizobium Symbiosis: The Roots of a Success Story -- A Genome-Wide Investigation on Symbiotic Nitrogen-Fixing Bacteria in Leguminous Plants -- Symbiotic Signaling: Insights from Arbuscular Mycorrhizal Symbiosis -- Contribution of Beneficial Fungi for Maintaining Sustainable Plant Growth and Soil Fertility -- Biofertilizers Toward Sustainable Agricultural Development -- Plant Microbiome: Trends and Prospects for Sustainable Agriculture -- Plants and Microbes: Bioresources for Sustainable Development and Biocontrol -- Plant-Microbiome Interactions in Hydrocarbon-Contaminated Soils -- Rhizoremediation: A Unique Plant Microbiome Association of Biodegradation -- Pesticide Tolerant Rhizobacteria: Paradigm of Disease Management and Plant Growth Promotion -- Structure and Function of Rhizobiome -- Soil Microbes-Medicinal Plants Interactions: Ecological Diversity and Future Prospect -- Insight to Biotechnological Advances in the Study of Beneficial Plant-Microbe Interaction with Special Reference to Agrobacterium tumefaciens -- Amelioration of Salt Stress Tolerance in Plants by Plant Growth-Promoting Rhizobacteria: Insights from “Omics” Approaches -- Plant Microbial Ecology as a Potential Option for Stress Management in Plants.
    Abstract: This book provides an overview of the latest advances concerning symbiotic relationships between plants and microbes, and their applications in plant productivity and agricultural sustainability. Symbiosis is a living phenomenon including dynamic variations in the genome, metabolism and signaling network, and adopting a multidirectional perspective on their interactions is required when studying symbiotic organisms. Although various plant-microbe symbiotic systems are covered in this book, it especially focuses on arbuscular mycorrhiza (AM) symbiosis and root nodule symbiosis, the two most prevalent systems. AM symbiosis involves the most extensive interaction between plants and microbes, in the context of phylogeny and ecology. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition, as well as the diversity of natural ecosystems, are frequently dependent upon the presence and activity of mycorrhizas. In turn, root nodule symbiosis includes morphogenesis and is formed by communication between plants and nitrogen-fixing bacteria. The biotechnological application of plant–microbe symbiosis is expected to foster the production of agricultural and horticultural products while maintaining ecologically and economically sustainable production systems. Designed as a hands-on guide, this book offers an essential resource for researchers and students in the areas of agri-biotechnology, soil biology and fungal biology.
    Type of Medium: Online Resource
    Pages: VI, 360 p. 33 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030362485
    URL: https://doi.org/10.1007/978-3-030-36248-5
    DOI: 10.1007/978-3-030-36248-5
    DDC: 579
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    Online Resource
    Rabies and Rabies Vaccines (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology. ; Immunology.
    Description / Table of Contents: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.
    Abstract: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. .
    Type of Medium: Online Resource
    Pages: VII, 205 p. 15 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030210847
    URL: https://doi.org/10.1007/978-3-030-21084-7
    DOI: 10.1007/978-3-030-21084-7
    DDC: 615
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    A Practical Guide to Environmental Biotechnology (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Water. ; Hydrology. ; Soil science. ; Microbiology. ; Water. ; Soil Science.
    Description / Table of Contents: Chapter 1: General Guidelines of Laboratory Safety, Calculations Used In Laboratory Experiments, Basic Laboratory Glassware And Instruments -- Chapter 2: Analysis of Quality of Water and Its Nutrient Contents -- Chapter 3: Analysis of Quality of Soil and Its Nutrient Contents -- Chapter 4: Isolation, Culture and Biochemical Characterization of Microbes -- Chapter 5: Plant Tissue Culture Techniques and Nutrient Analysis.
    Abstract: This textbook provides practical guidelines on conducting experiments across the entire spectrum of environmental biotechnology. It opens with general information on laboratory safety, rules and regulations, as well as a description of various equipment commonly used in environmental laboratories. It then discusses in detail the major experiments in basic and advanced environmental studies, including the analysis of water and soil samples; the isolation, culture, and biochemical characterization of microbes; and plant tissue culture techniques and nutrient analyses. Each chapter features detailed method sections and easy-to-follow protocols, and offers guidance on calculations and formulas, as well as illustrative flow charts to assist with troubleshooting for each experiment. Given its scope, the book is an invaluable aid for laboratory researchers studying environmental biotechnology, and a rich source of information and advice for advanced undergraduates and graduates in the fields of environmental science and biotechnology.
    Type of Medium: Online Resource
    Pages: XI, 175 p. 145 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811562525
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-981-15-6252-5
    DOI: 10.1007/978-981-15-6252-5
    DDC: 579
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    Principles of Forensic Toxicology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Forensic sciences. ; Medical jurisprudence. ; Pharmacology. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.
    Abstract: The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.
    Type of Medium: Online Resource
    Pages: XIII, 691 p. 188 illus., 23 illus. in color. , online resource.
    Edition: 5th ed. 2020.
    ISBN: 9783030429171
    URL: https://doi.org/10.1007/978-3-030-42917-1
    DOI: 10.1007/978-3-030-42917-1
    DDC: 615
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    Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Pharmacology. ; Toxicology. ; Pharmaceutics.
    Description / Table of Contents: Therapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions.
    Abstract: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges .
    Type of Medium: Online Resource
    Pages: XVIII, 381 p. 43 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031123986
    URL: https://doi.org/10.1007/978-3-031-12398-6
    DOI: 10.1007/978-3-031-12398-6
    DDC: 615
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    Fungi and Fungal Products in Human Welfare and Biotechnology (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Fungi. ; Mycology. ; Biotechnology. ; Microbiology. ; Fungi. ; Biotechnology.
    Description / Table of Contents: Part I. Plant Growth Promotion and Sustainability -- Chapter 1. Arbuscular mycorrhizal fungi: role as biofertilizers, technology development and economics -- Chapter 2. Role of ectomycorrhizal fungi in human welfare -- Chapter 3. Fungal ministrations in soil detoxification, building and health restoration -- Chapter 4. Emerging mucormycosis: problems and treatments -- Chapter 5. Microplastic pollution: sources, environmental hazards and mycoremediation as a sustainable solution -- Part II. Fungal metabolic Products -- Chapter 6. A bird’s eye view of fungal peptides -- Chapter 7. Cultivation, bioactive metabolites and application of caterpillar mushroom Cordyceps militaris: Current status, issues and perspectives -- Chapter 8. Lactic acid production from fungal machineries and mechanism of PLA synthesis: Application of AI based technology for improved productivity -- Chapter 9. Discovery of bioactive metabolites from the genus Arthrinium -- Chapter Chapter 10. Wide range applications of fungal pigments in textile dyeing -- Part III. Fungi in Food Biotechnology -- Chapter Chapter 11. The potential of mushrooms in developing healthy food and biotech products -- Chapter 12. Fungal enzyme-based nutraceutical oligosaccharides -- Chapter 13. Applications of fungi for alternative protein -- Part IV. Fungal Enzymes and Other Biotech Products -- Chapter 14. Fungal enzymes in the production of biofuels -- Chapter 15. Fungal pectinases: Diversity and multifarious applications -- Chapter 16. Applicability of fungal xylanases in food biotechnology -- Chapter 17. Fungal therapeutic enzymes: Utility in the treatment of human ailments -- Chapter 18. Heterologous gene expression in Pichia pastoris: Success stories and commercial ventures -- Chapter 19. Agro-industrial residues: an ecofriendly and inexpensive substrate for fungi in the development of white biotechnology -- Chapter 20. Design strategies for mycelium-based composites -- Chapter 21. Development of building insulation material from fr fungal mycelium.
    Abstract: This book presents various biotechnological applications of the fungal systems in pharmaceuticals, nutraceuticals, textile industry, bioremediation, biofuel, and the production of biomolecules. It discusses the important role of fungal secondary metabolites in human welfare and nutrition. It explores fungi as the vital sources of novel substances with antidiabetic, antibiotic as well as prebiotic properties. The book further describes the natural and unique ability of fungi to biodegrade macro- and microplastics by using them as a source of carbon and energy. Notably, it presents the properties and applications of bioactive fungal polysaccharides and discusses the latest developments in utilizing these biopolymers in human nutrition. In addition, the book examines the production of biodegradable and sustainable natural colorants from fungal sources. This book is a valuable source for mycologists, biotechnologists, and microbiologists for understanding the important role of fungi in biotechnology.
    Type of Medium: Online Resource
    Pages: XVI, 678 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811988530
    URL: https://doi.org/10.1007/978-981-19-8853-0
    DOI: 10.1007/978-981-19-8853-0
    DDC: 579
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    From PharmD to Industry : A Fellowship Guide (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Career education. ; Pharmacology. ; Pharmacy. ; Career Skills.
    Description / Table of Contents: Fellowship 101 -- The First Professional Year (P1) -- The Second Professional Year (P2) -- The Third Professional Year (P3) -- The Fourth Professional Year (P4) -- Midyear Applications, Interviews, and Receptions -- Transitioning from Student to Fellow -- Navigating the Virtual Landscape.
    Abstract: For many Doctor of Pharmacy (PharmD) candidates, post-graduate training is a highly prestigious and sought after experience that can further one’s pre-existing education. Some of these post-graduate training opportunities include but are not limited to pharmacy residencies, pharmaceutical industry fellowships, and PhD/Masters programs. There is a large gap in the current Doctor of Pharmacy curriculum about pharmaceutical industry fellowship programs and potential pharmaceutical industry opportunities. Through the eyes of current industry fellows and professionals, this book serves as a resource to learn more about fellowship opportunities and their respective application processes. In addition, this manual aims to provide a clear and concise roadmap to achieving a career in industry through a fellowship program. Whether you are a current student pharmacist, post-graduate pharmacy trainee (pharmacy resident), or industry professional, this manual addresses the current landscape of industry fellowship programs, an overview of industry opportunities, and a glimpse into what being a fellow entails. Readers of this book can expect to gain: An overview of pharmaceutical industry fellowship programs and opportunities Helpful advice and insight from current fellows and industry professionals A streamlined pathway to navigating the fellowship application process An understanding of the journey from being a student, to achieving a fellowship, to becoming an industry professional This book bridges the gap in education surrounding pharmaceutical industry fellowships and pharmacy careers in industry and increases access to first-hand information and real-world perspectives of current professionals to provide a firm foundation for those interested in pursuing a career in industry or learning more about fellowship programs.
    Type of Medium: Online Resource
    Pages: XIX, 92 p. 4 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031357879
    Series Statement: SpringerBriefs in Pharmaceutical Science & Drug Development,
    URL: https://doi.org/10.1007/978-3-031-35787-9
    DOI: 10.1007/978-3-031-35787-9
    DDC: 615
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    Contract Research and Development Organizations-Their History, Selection, and Utilization (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmacology. ; Pharmacy.
    Description / Table of Contents: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .
    Abstract: This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
    Type of Medium: Online Resource
    Pages: XIII, 519 p. 19 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030430733
    URL: https://doi.org/10.1007/978-3-030-43073-3
    DOI: 10.1007/978-3-030-43073-3
    DDC: 615
    Language: English
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    Bacteriocins (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Toxicology. ; Food science. ; Biotechnology. ; Microbiology. ; Toxicology. ; Food Science. ; Chemical Bioengineering.
    Description / Table of Contents: Chapter 1 Biosynthesis, structure and function of bacteriocin -- Chapter 2 Antibacterial mechanism of bacteriocin in lactic acid bacteria -- Chapter 3 Characteristics of lantibiotics -- Chapter 4 Genetic modification of bacteriocins -- Chapter 5 Potential use of bacteriocins as antibacterial agents -- Chapter 6 Application of bacteriocin in food industry -- Chapter 7 Application of bacteriocin in livesock and poultry -- Chapter 8 Bacteriocins of plant-related bacteria and biocontrol of plant pathogens -- Chapter 9 Cytotoxicity of bacteriocins to eukaryotic cells -- Chapter 10 Bacteriocins and human nutrition and health.
    Abstract: This book intends to report the new results of the study of bacteriocins, from basic research to application fields. It mainly introduces the biological characteristics of bacteriocins, the relationship between their structure and function, the antibacterial mode of action, and their application as antibacterial agents in food industry, medical care, and other areas, especially their application potential in human health. This book can be used as a reference book for researchers, undergraduates, and graduated students in the professional fields of food science and engineering, bioengineering, medicine, and agriculture.
    Type of Medium: Online Resource
    Pages: XI, 219 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819926619
    URL: https://doi.org/10.1007/978-981-99-2661-9
    DOI: 10.1007/978-981-99-2661-9
    DDC: 579
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    Toll-like Receptors in Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Immunology. ; Inflammation. ; Pharmacology. ; Immunology. ; Inflammation.
    Description / Table of Contents: Intracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells -- Toll-like receptors as drug targets in the intestinal epithelium -- Innate immune memory-priming, tolerance and exhaustion-in health and disease -- TLRs in brain immunity -- TLRs in cerebrovascular diseases -- TLRs in stem cells or progenitor cells -- TLRs in adaptive immunity -- Overview on TLRs in immunity -- TLR10 and its role in immunity.
    Abstract: The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
    Type of Medium: Online Resource
    Pages: VIII, 314 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065125
    Series Statement: Handbook of Experimental Pharmacology, 276
    URL: https://doi.org/10.1007/978-3-031-06512-5
    DOI: 10.1007/978-3-031-06512-5
    DDC: 615
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    Prebiotics, Probiotics and Nutraceuticals (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Clinical medicine Research. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Clinical Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Potentiality of Probiotics in Inactivation of Tetrodotoxin -- Chapter 2. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 3. Plant based Bioactive compounds in Cancer Therapeutics -- Chapter 4. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 5. Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immunobiological perspectives -- Chapter 6. The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery -- Chapter 7. The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study -- Chapter 8. Prebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives -- Chapter 9. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases. Chapter 10. Implications of probiotics and prebiotics on immune functions -- Chapter 11. Recent Trends in Natural Medicines and Nutraceuticals Research -- Chapter 12. Nutraceuticals-are alternative to modern medicines- Chapter 13. Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban -- Chapter 14. Drosophila melanogaster as an in-vivo model for the investigation of host microbiota interaction -- Chapter 15. Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development of Aquaculture.
    Abstract: The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.
    Type of Medium: Online Resource
    Pages: XVI, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811689901
    URL: https://doi.org/10.1007/978-981-16-8990-1
    DOI: 10.1007/978-981-16-8990-1
    DDC: 615
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    Symbiotic Soil Microorganisms : Biology and Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Botany. ; Biotechnology. ; Physical geography. ; Microbial ecology. ; Forestry. ; Microbiology. ; Plant Science. ; Biotechnology. ; Earth System Sciences. ; Microbial Ecology. ; Forestry.
    Description / Table of Contents: Part I. Fungal Symbiosis -- Current Status–Enlightens in Its Biology and Omics Approach on Arbuscular Mycorrhizal Community -- An Insight through Root-Endophytic-Mutualistic Association in Improving Crop Productivity and Sustainability -- Interaction Between Root Endophytes and Plants: Their Bioactive Products and Significant Functions -- Unravelling the Role of Endophytes in Micronutrient Uptake and Enhanced Crop Productivity -- Dual and Tripartite Symbiosis of Invasive Woody Plants -- Eco-friendly Association of Plants and Actinomycetes -- The Arbuscular Mycorrhizal Symbiosis of Trees: Structure, Function, and Regulating Factors -- Effectiveness of Arbuscular Mycorrhizas in Improving Carob Culture in the Mediterranean Regions -- Leaf Endophytes and Their Bioactive Compounds -- Role of Endophytic Fungus Piriformospora indica in Nutrient Acquisition and Plant Health -- The Role of Symbiotic Fungi in Nutri-Farms -- Part II. Bacterial Symbiosis -- Understanding the Evolution of Plant Growth-Promoting Rhizobacteria -- Rhizobia–Legume Symbiosis During Environmental Stress -- Archaeal Symbiosis for Plant Health and Soil Fertility -- Microbial Symbionts of Aquatic Plants -- Rhizobium Presence and Functions in Microbiomes of Non-leguminous Plants -- Part III. Insect–Fungus Mutualism -- Symbiotic Harmony Between Insects and Fungi: A Mutualistic Approach -- Panorama of Metarhizium: Host Interaction and Its Uses in Biocontrol and Plant Growth Promotion -- Arbuscular Mycorrhizal Fungi: Potential Plant Protective Agent Against Herbivorous Insect and Its Importance in Sustainable Agriculture -- Eradication of Malaria by the Mutualistic Interaction Between Wickerhamomyces anomalus and Anopheles sp -- Part IV. Microbial Symbiosis in Disease and Stress Management -- Halophyte–Endophyte Interactions: Linking Microbiome Community Distribution and Functionality to Salinity -- Root Endophytic Microbes and Their Potential Applications in Crop Disease Management -- Do Mycorrhizal Fungi Enable Plants to Cope with Abiotic Stresses by Overcoming the Detrimental Effects of Salinity and Improving Drought Tolerance? -- Combined Use of Beneficial Bacteria and Arbuscular Mycorrhizal Fungi for the Biocontrol of Plant Cryptogamic Diseases: Evidence, Methodology, and Limits -- Remediation of Toxic Metal-Contaminated Soil and Its Revitalisation with Arbuscular Mycorrhizal Fungi.
    Abstract: This book explores microbial symbiosis, with a particular focus on soil microorganisms, highlighting their application in enhancing plant growth and yield. It addresses various types of bacterial and fungal microbes associated with symbiotic phenomena, including rhizobium symbiosis, arbuscular mycorrhizal symbiosis, ectomycorrhizal symbiosis, algal/lichen symbiosis, and Archeal symbiosis. Presenting strategies for employing a diverse range of bacterial and fungal symbioses in nutrient fortification, adaptation of plants in contaminated soils, and mitigating pathogenesis, it investigates ways of integrating diverse approaches to increase crop production under the current conventional agroecosystem. Providing insights into microbial symbioses and the challenges of adopting a plant-microbe synergistic approach towards plant health, this book is a valuable resource for researchers, graduate students and anyone in industry working on bio-fertilizers and their agricultural applications. .
    Type of Medium: Online Resource
    Pages: VII, 489 p. 49 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030519162
    Series Statement: Soil Biology, 60
    URL: https://doi.org/10.1007/978-3-030-51916-2
    DOI: 10.1007/978-3-030-51916-2
    DDC: 579
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    Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Surgery. ; Dentistry. ; Veterinary medicine. ; Neurology . ; Orthopedic surgery. ; Pharmacology. ; Surgery. ; Dentistry. ; Veterinary Science. ; Neurology. ; Surgical Orthopedics.
    Description / Table of Contents: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.
    Abstract: All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine and furnishes the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.
    Type of Medium: Online Resource
    Pages: VIII, 398 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506919
    URL: https://doi.org/10.1007/978-3-030-50691-9
    DOI: 10.1007/978-3-030-50691-9
    DDC: 615
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    Emerging Treatment Technologies for Waste Management (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbiology Technique. ; Refuse and refuse disposal. ; Environmental chemistry. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Microbiology. ; Microbiology Techniques. ; Waste Management/Waste Technology. ; Environmental Chemistry. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Chapter 1. Recent advances in physicochemical and biological approaches for degradation and detoxification of industrial wastewater -- Chapter 2. Bioremediation of Hexavalent Chromium from industrial effluents -- Chapter 3. Integration of nanotechnologies for sustainable remediation of environmental pollutants -- Chapter 4. Arsenic removal using nanotechnology -- 5. Emerging Contaminants in wastewater: Sources of contamination, toxicity, and removal approaches -- Chapter 6. Application of biochar for sustainable development in agriculture and environmental remediation -- Chapter 7. Life cycle analysis to estimate environmental impact of the food industry -- Chapter 8. Food Wastes: Perceptions, Impacts and Management -- Chapter 9. Hydrothermal Carbonization of Organic Fraction of Municipal Solid Waste: Advantage, Disadvantage and Different Application of Hydrochar -- Chapter 10. Pollutants characterization and toxicity assessment of pulp and paper industry sludge for safe environmental disposal -- Chapter 11. Use of flue gas as a carbon source for algal cultivation.
    Abstract: This book is focused on the current status of industrial pollution, its source, characteristics, and management through various advanced treatment technologies. The book covers the recycle, reuse and recovery of waste for the production of value-added products. The book explores industrial wastewater pollution and its treatment through various advanced technologies and also the source and characteristics of solid waste and its management for environmental safety. It discusses new methods and technologies to combat the waste-related pollution and focuses on the use of recycled products. This book is of value to upcoming students, researchers, scientists, industry persons and professionals in the field of environmental science and engineering, microbiology, biotechnology, toxicology, further it is useful for global and local authorities and policy makers responsible for the management of liquid and solid wastes.
    Type of Medium: Online Resource
    Pages: XIV, 257 p. 36 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811620157
    URL: https://doi.org/10.1007/978-981-16-2015-7
    DOI: 10.1007/978-981-16-2015-7
    DDC: 579
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    Metabolomics and Its Impact on Health and Diseases (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Biochemical markers. ; Cytology. ; Analytical biochemistry. ; Pharmacology. ; Biomarkers. ; Cell Biology. ; Analytical Biochemistry.
    Description / Table of Contents: Preface -- Practical Aspects of NMR-Based Metabolomics -- Compound Identification in Mass Spectrometry-Based Metabolomics -- METABOLOMICS USING NMR – Avoiding the ‘Black-Box’ -- Natural products drug discovery: on silica or in silico?- Quantitative NMR Methods in Metabolomics -- Advancements in pulsed stable isotope resolved metabolomics -- Metabolomics in Cell Biology -- NMR-based metabolomics to evaluate individual response to treatments -- Pharmacometabolomics of Asthma as a road map to Precision Medicine -- Prospective metabolomic studies in precision medicine -- Chemotherapy-induced Peripheral Neuropathy -- Metabolomics of Respiratory Diseases.
    Abstract: This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.
    Type of Medium: Online Resource
    Pages: VIII, 384 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031268595
    Series Statement: Handbook of Experimental Pharmacology, 277
    URL: https://doi.org/10.1007/978-3-031-26859-5
    DOI: 10.1007/978-3-031-26859-5
    DDC: 615
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    Structure and Health Effects of Natural Products on Diabetes Mellitus (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Botanical chemistry. ; Bioorganic chemistry. ; Pharmacology. ; Plant Biochemistry. ; Bioorganic Chemistry.
    Description / Table of Contents: Chapter 1. Introduction of diabetes melitus and future prospects of natural products on diabetes melitus -- Chapter 2. Anoverview of hypoglycemic modern drugs -- Chapter 3. An overview of hypoglycemic biological drugs -- Chapter 4. An overview of hypoglycemic traditionaldrugs -- Chapter 5. Glycosides from natural sources in the treatment of diabetes mellitus -- Chapter 6. Isolation and Structure Elucidation of Hypoglycemic Compounds -- Chapter 7. Structural Characterization and Health Effects of Polysaccharides from Momordica charantia on Diabetes Mellitus -- Chapter 8. Effects of polysaccharides on reducing blood glucose based on gut microbiota alteration -- Chapter 9. An Overview of Polysaccharides and the influencefactors of Hypoglycemic Activity -- Chapter 10. Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity. - Chapter 11. Rhinacanthin-C and Its Potential to Control Diabetes Mellitus -- Chapter 12. Regeneration of beta cells by inhibition of pro-apoptotic proteins through phytocompound in STZ induced diabetic albino wistar rats-invivo and insilico approach. - Chapter 13. Nitrogenous Compounds from Plant Origin in Management of -- Chapter 14. Plant Alkaloids with Antidiabetic Potential -- Chapter 15. The role of Alkaloids in the Management of Diabetes Mellitus -- Chapter 16. Traditional Indian Herbs for the Management of Diabetes Mellitus and their Herb-Drug Interaction Potentials: An Evidence-Based Review -- Chapter 17. Role of Micronutrients and Trace elements in Diabetes mellitus: A Review.
    Abstract: The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.
    Type of Medium: Online Resource
    Pages: VIII, 307 p. 85 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811587917
    URL: https://doi.org/10.1007/978-981-15-8791-7
    DOI: 10.1007/978-981-15-8791-7
    DDC: 615
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    Bioprospecting of Enzymes in Industry, Healthcare and Sustainable Environment (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Industrial microbiology. ; Biotechnology. ; Pharmacology. ; Microbiology. ; Microbial Ecology. ; Industrial Microbiology. ; Biotechnology. ; Pharmacology.
    Description / Table of Contents: Chapter 1: Application of enzymes in bioremediation of contaminated hydrosphere and soil environment -- Chapter 2: Bioremediation Of Highly Toxic Hexavalent Chromium By Bacterial Chromate Reductases Family: An Structural And Functional Overview -- Chapter 3: An Overview Of Raw Starch Digesting Enzymes And Their Applications In Biofuel Development -- Chapter 4: Bamboo Valorization By Fermentation And Enzyme Treatment -- Chapter 5: Recent Developments In Pretreatment And Enzymatic Hydrolysis For Cellulosic Bioethanol Production -- Chapter 6: Production Of Biofuel From Disposed Food And Dairy Waste -- Chapter 7: Role of enzymes in synthesis of nanoparticles -- Chapter 8: Protein-Nanoparticle Interaction And Its Potential Biological Implications -- Chapter 9: Enzyme-Nanoparticle Corona: A Novel Approach, Their Plausible Applications And Challenges -- Chapter 10: Enzymes In Fuel Biotechnology -- Chapter 11: Role Of Enzymes In Deconstruction Of Waste Biomass For Sustainable Generation Of Value-Added Products -- Chapter 12: Thermostable Enzymes From Clostridium thermocellum -- Chapter 13: Hot And Cold Bacteria Of Sikkim: Biodiversity And Enzymology -- Chapter 14: Enzymes In Health Care: Cost Effective Production And Applications Of Therapeutic Enzymes In Health Care Sector -- Chapter 15: Significance Of Enzymes In Modern Healthcare: From Diagnosis To Therapy -- Chapter 16: L-Asparaginase And Methioninase As Prospective Anticancer Enzymes: Currentapplications And Production Approaches -- Chapter 17: Production Of Thrombolytic And Fibrinolytic Proteases: Current Advances And Future Prospective -- Chapter 18: Enzymes In Textile Industries -- Chapter 19: Role of Enzymes in Textile Processing.
    Abstract: The rapid urbanization and industrialization of developing countries across the globe have necessitated for substantial resource utilization and development in the areas of Healthcare, Environment, and Renewable energy. In this context ,this resourceful book serves as a definitive source of information for the recent developments in application of microbial enzymes in various sectors. It covers applications in fermentation processes and their products, extraction and utilisation of enzymes from various sources and their application in health and biomass conversion for production of value added products. Different chapters discuss various areas of bioprospecting in enzyme technology, and describe why these are the mainstays for industrial production of value added products. The rich compilation of the cutting-edge advances and applications of the modern industrial based techniques hold feasible solutions for a range of current issues in enzyme technology. This book will be of particular interest for scientists, academicians, technical resource persons, engineers and members of industry. Undergraduate and graduate students pursuing courses in the area of industrial biotechnology will find the information in the book valuable. General readers having interest towards biofuels, enzyme technology, fermented food and value added products, phytochemicals and phytopharmaceutical products will also find the book appealing. Readers will discover modern concepts of enzymatic bioprocess technology for production of therapeutics and industrial value added products.
    Type of Medium: Online Resource
    Pages: X, 410 p. 58 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341951
    URL: https://doi.org/10.1007/978-981-33-4195-1
    DOI: 10.1007/978-981-33-4195-1
    DDC: 579
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    Environmental Microbiology (2023)
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Details
    Keywords: Microbiology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Microbial ecology. ; Microbiology. ; Environmental Engineering/Biotechnology. ; Biotechnology. ; Microbial Ecology.
    Description / Table of Contents: Global Environment. Climate and microorganisms -- Microorganisms, actors in the environment -- Relationship between microbial energy production and material cycles -- Carbon cycle -- Environmental chemicals -- Microbial degradation of pollutants -- The microbial nitrogen cycle -- Cycles of sulfur, iron and manganese -- Heavy metals and other toxic inorganic ions -- Microorganisms at different sites: living conditions and adaptation strategies -- Microbial communities. Structural and functional analyses with classical approach -- Microbial communities. Structural and functional analyses with molecular biological approach -- Damage to inorganic materials by microbial activities, biocorrosion -- Biological wastewater treatment -- Biological exhaust air treatment -- Biological soil remediation -- Biological waste treatment -- Biotechnology and environmental protection -- Food for thought.
    Abstract: This textbook addresses global and local environmental problems and the involvement of microorganisms in their development and remediation. In particular, methodological aspects, some of them molecular genetic, for the study of microbial communities are considered. Overall, the prominent role of microorganisms in various material cycles is presented. In addition to biochemical principles for the degradation of environmental pollutants, the use of microorganisms in environmental biotechnological processes for the purification of air, water or soil as well as in environmentally friendly production processes is discussed. The book is intended for biologists with an interest in environmental microbiological issues, but also for students of process or environmental engineering, geoecology or geology, as well as students of other environmental science disciplines. For the 3rd edition, the authors have completely revised, corrected, updated and supplemented the book. The authors Professor Dr. Walter Reineke was Professor of Microbiology at the University of Wuppertal since 1982, where he was involved in teaching both the Food Chemistry and Chemistry courses. He has been retired since August 2013. Professor Dr. Michael Schlömann was appointed Endowed Professor of Environmental Microbiology of the Deutsche Bundesstiftung Umwelt at the Technische Universität Bergakademie Freiberg in 1998 and has been Deputy Director of the University's Interdisciplinary Ecological Centre since 1999. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XVI, 603 p. 379 illus., 104 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783662665473
    URL: https://doi.org/10.1007/978-3-662-66547-3
    DOI: 10.1007/978-3-662-66547-3
    DDC: 579
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    Fundamentals of Bacterial Physiology and Metabolism (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Microbiology. ; Industrial microbiology. ; Microbiology. ; Industrial Microbiology.
    Description / Table of Contents: Bacterial Growth -- Transport -- Central Metabolic Pathways and Their Regulation -- Electron Transport and Energy Generation -- Metabolic Diversity of Carbon and Energy Source in Prokaryotes -- Nitrogen Metabolism -- Lipid Metabolism -- Cell Wall Biosynthesis -- Metabolism of Nucleotides -- Secondary Metabolism -- Response to Environmental Signaling.
    Abstract: This book provides useful information on microbial physiology and metabolism. The key aspects covered are prokaryotic diversity, growth physiology, basic metabolic pathways and their regulation, metabolic diversity with details of various unique pathways. Another focus area is stress physiology with details on varying environmental stresses, signal transduction, adaptation and survival. For instructional purposes, the book provides case studies, interesting facts, techniques etc. which help in showcasing the inter-disciplinary nature and bridge the gap between various aspects of applied microbiology.
    Type of Medium: Online Resource
    Pages: XXII, 670 p. 397 illus., 262 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607233
    URL: https://doi.org/10.1007/978-981-16-0723-3
    DOI: 10.1007/978-981-16-0723-3
    DDC: 579
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    Organic Waste to Biohydrogen (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Biotechnology. ; Bioremediation. ; Microbiology. ; Biotechnology. ; Environmental Biotechnology.
    Description / Table of Contents: Chapter 1. Biohydrogen from the organic fraction of municipal solid waste -- Chapter 2. Biohydrogen from food waste -- Chapter 3. Biohydrogen from fruit and vegetable industry wastes -- Chapter 4. Biohydrogen from Distillery Wastewater: Opportunities and feasibility -- Chapter 5. Biohydrogen from pentose-rich lignocellulosic biomass hydrolysate -- Chapter 6. Biohydrogen Production using Cheese Industry Waste: Current trends and Challenges -- Chapter 7. Methods of biological hydrogen production from industrial waste -- Chapter 8. INNOVATIVE TECHNOLOGIES FOR BIOHYDROGEN PRODUCTION AT INDUSTRIAL LEVEL -- Chapter 9. Thermochemical conversion of lignocellulosic biomass for biohydrogen production -- Chapter 10. Nanotechnological approaches in biohydrogen production -- Chapter 11. Microalgal biomass as a promising feedstock for the production of Biohydrogen: A comprehensive review -- Chapter 12. Biohydrogen: Future energy source for the society.
    Abstract: This book provides an updated knowledge on the biohydrogen production from industrial and municipal organic waste materials. Microbes are increasingly being included in the hydrogen based biofuel production and this book covers the processes and protocols for biohydrogen production. There is an urgent need of alternative energy research to fulfill the global energy demand. Biohydrogen is a promising source of sustainable and clean energy as it harnessed by biological means. Biohydrogen may be produced by utilizing different waste materials as a substrate, and by optimization of various parameters of bioreactors such as temperature, pH, partial pressure etc. The waste materials used in hydrogen production are categorized as agricultural waste, municipal waste, industrial waste, and other hazardous wastes. Biohydrogen production from wastes materials opened a new opportunity for the widespread use of everlasting renewable energy source. This book is useful for professional scientists, academicians, biotechnologist and environmentalist along with research scholars in various biotechnology and bioenergy industries by addressing the latest research going on in the field of renewal bioenergy production from waste and their global impact on the environment.
    Type of Medium: Online Resource
    Pages: XI, 288 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811919954
    Series Statement: Clean Energy Production Technologies,
    URL: https://doi.org/10.1007/978-981-19-1995-4
    DOI: 10.1007/978-981-19-1995-4
    DDC: 579
    Language: English
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    Pharmacology of Immunosuppression (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Human physiology. ; Immunology. ; Surgery. ; Pharmacology. ; Human Physiology. ; Immunology. ; Surgery.
    Description / Table of Contents: Review of the Pathophysiology of the Alloimmune response -- A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation -- Anti-proliferative Agents -- Mechanistic Target of Rapamycin (mTOR) Inhibitors -- Corticosteroids -- Induction therapy and antibodies -- Immunosuppression and Heart Transplantation -- Immunosuppression and Lung Transplantation -- Immunosuppression and renal transplant recipients -- Immunosuppression in Rheumatologic and Auto-immune Disease -- Immunosuppression in Bone Marrow Transplantation -- Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders -- Novel immunosuppressive agents for the treatment of organ transplants -- Adverse Effects of Immunosuppression: Infections -- Malignancy: An Adverse Effect of Immunosuppression -- Adverse Effects of Immunosuppression:Nephrotoxicity, Hypertension and Metabolic Disease.
    Abstract: The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.
    Type of Medium: Online Resource
    Pages: VIII, 348 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031051180
    Series Statement: Handbook of Experimental Pharmacology, 272
    URL: https://doi.org/10.1007/978-3-031-05118-0
    DOI: 10.1007/978-3-031-05118-0
    DDC: 615
    Language: English
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    Evidence Based Validation of Traditional Medicines : A comprehensive Approach (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medical microbiology. ; Medicinal chemistry. ; Pharmacovigilance. ; Pharmacology. ; Medical Microbiology. ; Medicinal Chemistry. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Global Approach for Drug Discovery and Development from Indian Traditional Medicine -- Chapter 2. Bioactive Natural Leads TargetingCancer Cell Metabolism -- Chapter 3. Omics Technologies and Development of Anti-diabetic Therapies from Prospective Natural Products -- Chapter 4. Amaryllidaceae Alkaloids as Anti-inflammatory Agents Targeting Cholinergic Anti-inflammatory Pathway: Mechanisms and Prospects -- Chapter 5. Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin -- Chapter 6. Role of Phytomolecules on the Basic Biology of Aging -- Chapter 7. Role of phytomedicine in alleviating oxidative stress mediated vascular complications in diabetes -- Chapter 8. Plant Based -Secretase (BACE-1) Inhibitors: A Mechanistic Approach to Encounter Alzheimer's Disorder -- Chapter 9. Bioactive Compounds of Mangroves as Potent Drug and in Nanoparticle Synthesis - Play a Pivotal Role in Combating Human Pathogens. Chapter 10. Medicinal Plants: A Rich Source of Bioactive Molecules Used in Drug Development -- Chapter 11. Cell-based Assays in Natural Product-based Drug Discovery -- Chapter 12. Allelochemicals: An Emerging Tool for Weed Management -- Chapter 13. Secondary Metabolites of Higher Plants as Green Preservatives of Herbal Raw Materials and Their Active Principles During Postharvest Processing -- Chapter 14. Importance of Chromatography Techniques in Phytomedicine Research -- Chapter 15. Reverse Pharmacology – A Tool for Drug Discovery From Traditional Medicine -- Chapter 16. Role of Modern Biological Techniques in Evidence-Based Validation of Ayurvedic Herbometallic Preparations -- Chapter 17. HPTLC Fingerprinting analysis of Phytoconstituents from Indigenous Medicinal Plants -- Chapter 18. Climate Change,Geographical Location and Other Allied Triggering Factors Modulate the Standardization and Characterization of Traditional Medicinal Plants: AChallenges and Prospect for Phyto-Drug Development -- Chapter 19. Molecular Docking Studies of Plant-Derived Bioactive Compounds: A Comprehensive in silico Standardization Approach -- Chapter 20. Standardization and Quality Evaluation of Botanicals with Special Reference to Marker Components -- Chapter 21. Analytical Standardization of Haridra Formulation by UV-VIS Spectrophotometry and RP-HPLC -- Chapter 22. Ethnobotanical survey: the foundation to evidence based validation of medicinal plants -- Chapter 23. Phytotherapeutics: The Rising Role of Drug Transporters in Herb-Drug Interactions with Botanical Supplements -- Chapter 24. An Insight into Herb Interactions: Clinical Evidence Based Overview -- Chapter 25. Pharmacovigilance of Herbal Medicines: An Overview -- Chapter 26. Herbal Drugs: Efficacy, Toxicity and Safety Issues -- Chapter 27. Herbal Drug Patenting -- Chapter 28. Safety and Regulatory Issues on Traditional Medicine Entrusted Drug Discovery -- Chapter 29. Pharmacovigilance of Herbal Medicine: An Evolving Discipline -- Chapter 30. Toxicity Studies Related to Medicinal Plants -- Chapter 31. Herb-Drug Interactions -- Chapter 32. Plant Based Traditional Herbal Contraceptive Use in India: Safety and Regulatory Issues -- Chapter 33. Traditional Medicine Stability and Pharmacokinetic Issue -- Chapter 34. Pharmacovigilance: Methods in developing the safety and acceptability of traditional medicines -- Chapter 35. Zoopharmacognosy (Plant-Animal Interaction) -- Chapter 36. Significance of Stability and Pharmacokinetic issues in Traditional Medicine -- Chapter 37. Pharmaceutical Formulations Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health Care Services -- Chapter 38. Evaluation of bioactivity of green nanoparticles synthesized from traditionally used medicinal plants: a review -- Chapter 39. Physicochemical, Micromeritics, Biomedical and Pharmaceutical Applications of Assam Bora Rice Starch -- Chapter 40. Natural Excipients in Pharmaceutical Formulations -- Chapter 41. A Wonder Plant Withania: Pharmacological and Chemical Perspectives -- Chapter 42. Immunomodulators and Phyto Drugs -- Chapter 43. Combined Effects of Plant Extracts on Ovarian Cell Functioning -- Chapter 44. Pterocarpussantalinus: A Wonder Gift of Nature -- Chapter 45. Phytochemicals And Investigations On Traditionally Used Medicinal Mushrooms -- Chapter 46. A Review On Investigational Studies Of Marine Macroalgae Spogomorpha Indica L -- Chapter 47. Validation of Traditional Claim of Oxalis debilis Kunth., An Ethnomedicinal Plant from North-eastern Region of India -- Chapter 48. Traditional Herbal Medicine Practiced in Plateau-Fringe and Rarh Districts of West Bengal, India -- Chapter 49. Pharmacology and Mechanisms of Natural Medicine in Treatment of Type 2 Diabetes Mellitus -- Chapter 50. Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy. .
    Abstract: The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine. .
    Type of Medium: Online Resource
    Pages: XII, 1151 p. 378 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581274
    URL: https://doi.org/10.1007/978-981-15-8127-4
    DOI: 10.1007/978-981-15-8127-4
    DDC: 615
    Language: English
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    Microbial Polymers : Applications and Ecological Perspectives (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Molecular biology. ; Biotechnology. ; Microbiology Technique. ; Microbiology. ; Molecular Biology. ; Biotechnology. ; Microbiology Techniques.
    Description / Table of Contents: Chapter 1. The production and applications of microbial derived polyhydroxy butyrates -- Chapter 2. Fungal exopolysaccharides: types, production and application -- Chapter 3. Isolation and purification of microbial exopolysaccharides and their industrial applications -- Chapter 4. A review on properties and application of xanthan gum -- Chapter 5. Biosynthesis and characterization of poly-(3)-hydroxyalkanoic acid by Bacillus megaterium SF4 using different carbohydrates -- Chapter 6. Mushroom mycelia-based material: an environmental friendly alternative to synthetic packaging -- Chapter 7. An overview of microbial derived polyhydroxy butyrate (PHB): production and characterization -- Chapter 8. Insight of Biopolymers and applications of Polyhydroxyalkanoates -- Chapter 9. Microbial pigments and their application -- Chapter 10. Extracellular polymeric substances from agriculturally important microorganisms -- Chapter 11. Significance of bacterial polyhydroxy alkanoates in rhizosphere -- Chapter 12. Role of microbial biofilms in agriculture: perspectives on plant and soil health -- Chapter 13. Biological soil crusts to keep soil alive, rehabilitate degraded soil, and develop soil habitats -- Chapter 14. Fungal chitosan :the importance and beneficiation of this biopolymer in industrial and agriculture process -- Chapter 15. Role of microbial extracellular polymeric substances in soil fertility -- Chapter 16. Microbes derived exopolysaccharides play role in salt stress alleviation in plants -- Chapter 17. Microbial exopolysaccharides: structure and therapeutic properties -- Chapter 18. Microbial biopolymers: pharmaceutical, medical & biotechnological applications -- Chapter 19. Mycobacterium Biofilms synthesis, ultra structure and their perspectives in drug tolerance, environment and medicine -- Chapter 20. A comprehensive review on different microbial derived pigments and their multipurpose activities -- Chapter 21. Microbial polysaccharides with potential industrial applications: diversity, synthesis and their applications -- Chapter 22. Eco friendly microbial biopolymers: recent development, biodegradation and applications -- Chapter 23. Microbial biopolymers as an alternative construction binder -- Chapter 24. Genetic engineering approaches for high end application of biopolymers:Advances and future prospects -- Chapter 25. Microbial pigments: secondary metabolites with multifaceted roles -- Chapter 26. Bio-fermentative production of xanthan gum biopolymer and its application in petroleum sector -- Chapter 27. A comparative study on biodegradable packaging materials: current status and future prospects -- Chapter 28. Environmental implications of microbial bioplastics for a sustainable future.
    Abstract: This book cover all types of microbe based polymers and their application in diverse sectors with special emphasis on agriculture. It collates latest research, methods, opinion, perspectives, and reviews dissecting the microbial origins of polymers, their production, design, and processing at industrial level, as well as improvements for specific industrial applications. Book also discusses recent advances in biopolymer production and their modification for amplifying the value. In addition, understanding of the microbial physiology and optimal conditions for polymer production are also explained. This compilation of scientific chapters on principles and practices of microbial polymers fosters the knowledge transfer among scientific communities, industries, and microbiologist and serves students, academicians, researchers for a better understanding of the nature of microbial polymers and application procedure for sustainable ecosystem.
    Type of Medium: Online Resource
    Pages: XI, 710 p. 134 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811600456
    URL: https://doi.org/10.1007/978-981-16-0045-6
    DOI: 10.1007/978-981-16-0045-6
    DDC: 579
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    From Obesity to Diabetes (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Metabolism Disorders. ; Pharmacology. ; Metabolic Disease.
    Description / Table of Contents: Part I Obesity. Epidemiology of Obesity -- The Circadian Clock and Obesity -- Nutrition and Microbiome -- From Obesity to Diabetes: The Role of the Adipose Organ -- Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy -- The Enteroendocrine System in Obesity -- Insights from Studies of White Adipose Tissue Using Single-Cell Approaches -- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction -- Obesity, Senescence, and Senolytics -- Obesity and Obstructive Sleep Apnea -- Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance -- Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes -- NAFLD and NASH: The Metabolically Diseased Liver -- Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities -- Diabetic Peripheral Neuropathy -- Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies -- Physical Activity, Obesity and Weight Loss Maintenance -- Bariatric/Metabolic Surgery -- Drugs for Treating Obesity -- Novel Drugs for Diabetes Therapy -- Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function -- Precision Medicine and Obesity -- Targeting the Enteroendocrine System for Treatment of Obesity.
    Abstract: Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.
    Type of Medium: Online Resource
    Pages: VIII, 513 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030999957
    Series Statement: Handbook of Experimental Pharmacology, 274
    URL: https://doi.org/10.1007/978-3-030-99995-7
    DOI: 10.1007/978-3-030-99995-7
    DDC: 615
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    Microorganisms in the Deterioration and Preservation of Cultural Heritage (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Cultural property. ; Microbial ecology. ; Microbial genetics. ; Enzymology. ; Industrial microbiology. ; Microbiology. ; Cultural Heritage. ; Microbial Ecology. ; Microbial Genetics. ; Enzymology. ; Industrial Microbiology.
    Description / Table of Contents: Part 1: Occurrence of microorganisms in heritage materials -- Chapter 1: Microbial growth and its effects on inorganic heritage materials -- Chapter 2: Microbiota and biochemical processes involved for biodeterioration of cultural heritage and protection -- Chapter 3: Molecular-based techniques for the study of microbial communities in artworks -- Chapter 4: Extreme colonizers and rapid profiteers: the challenging world of microorganisms that attack paper and parchment -- Part 2: Green methods again biodeterioration -- Chapter 5: Novel antibiofilm non-biocide strategies -- Chapter 6: Green mitigation strategy for cultural heritage using bacterial biocides -- Chapter 7: New perspectives against biodeterioration through public lighting -- Part 3: Biocleaning and bio-based conservation methods -- Chapter 8: Bioremoval of graffiti in the context of current biocleaning research -- Chapter 9: Ancient textiles deterioration and restoration: the case of biocleaning of an Egyptian shroud held in the Torino Museum” -- Chapter 10: Advanced biocleaning system for historical wall paintings -- Chapter 11: Sustainable restoration through biotechnological processes: a proof of concept -- Chapter 12: The role microorganisms for the removal of nitrates and sulfates on artistic stoneworks -- Chapter 13: Protection and consolidation of stone heritage by bacterial carbonatogenesis -- Chapter 14: Siderophore-removal of iron corrosion products from wood and textiles -- Chapter 15: Bio-based corrosion inhibitors for metal heritage. .
    Abstract: This open access book offers a comprehensive overview of the role and potential of microorganisms in the degradation and preservation of cultural materials (e.g. stone, metals, graphic documents, textiles, paintings, glass, etc.). Microorganisms are a major cause of deterioration in cultural artefacts, both in the case of outdoor monuments and archaeological finds. This book covers the microorganisms involved in biodeterioration and control methods used to reduce their impact on cultural artefacts. Additionally, the reader will learn more about how microorganisms can be used for the preservation and protection of cultural artefacts through bio-based and eco-friendly materials. New avenues for developing methods and materials for the conservation of cultural artefacts are discussed, together with concrete advances in terms of sustainability, effectiveness and toxicity, making the book essential reading for anyone interested in microbiology and the preservation of cultural heritage. .
    Type of Medium: Online Resource
    Pages: XII, 367 p. 80 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030694111
    URL: https://doi.org/10.1007/978-3-030-69411-1
    DOI: 10.1007/978-3-030-69411-1
    DDC: 579
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    Immunity Boosting Medicinal Plants of the Western Himalayas (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Natural products. ; Botany. ; Ethnology. ; Pharmacology. ; Natural Products. ; Plant Science. ; Ethnography.
    Description / Table of Contents: 1. Introduction to Western Himalayas -- 2. Achillea millefolium L., Common Yarrow -- 3. Arisaema jacquemontii Blume, Jacquemont's Cobra Lily -- 4. Species of Arnebia genus found in the western Himalayas -- 5. Species of the Berberis genus found in the western Himalayas -- 6. Dactylorhiza hatagirea (D.Don) Soo – Himalayan Marsh Orchid -- 7. Fritillaria roylei Hook.f.: Himalayan Fritillary -- 8. Gentiana kurroo Royle: Himalayan Gentian -- 9. Habenaria intermedia D.Don and Habenaria edgeworthii Hook., f. ex Collett.: The Western Himalayan medicinal Plants -- 10. Humulus lupulus L.: Beer plant -- 11. Inula racemosa Hook. f. – Puskarmool: Its ethnobotanical uses, phytochemicals and pharmacological activities -- 12. Juniperus recurva Buch.-Ham. ex D.Don and Juniperus squamata D. Don: Himalayan Juniper -- 13. Lancea tibetica Hook.f. & Thomson: Ethnobotany, phytochemistry and pharmacology -- 14. Malaxis muscifera (Lindley) O. Kuntze. and Malaxis acuminata D. Don.: Jeevak -- 15. Picrorhiza kurroa Royle ex Benth.: Kutki -- 16. Species of the genus Polygonatum found in the Western Himalayas -- 17. Species of the genus Rhodiola found in the Western Himalayas -- 18. Saussurea lappa C.B. Clarke: Kushta/Kut -- 19. Saussurea lappa C.B. Clarke: Kushta/Kut -- 20. Species of the genus Selinum found in the western Himalayas -- 21. Swertia chirayita (Roxb. ex Flem.): Chirayata/Chiretta -- 22. Taxus wallichiana Zucc.: The Himalayan yew -- 23. Tribulus terrestris L.: Gokshur /Gokharu -- 24. Species the Genus Viola found in Western Himalayas.
    Abstract: This book presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology. The book offers a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, and the pharmaceutical sciences. The main purpose of the present book is to draw on the rich culture, folklore, and biodiversity of immunity-boosting medicinal plants of the Western Himalayas, with particular emphasis on the Indian Trans-Himalayan and Western Himalayan region. All the plants included in the present book are extensively used by the local tribes and people for their health-promoting properties from ancient times. This book will be a substantial contribution to the knowledge of the region and the country. Also, the book will be very useful to scientists, graduates, and undergraduates, along with researchers in the fields of natural products, herbal medicines, ethnobotany, pharmacology, chemistry, and biology. Further, it is an equally significant resource for a person working in different traditional medicinal systems; doctors (especially those engaged in Ayurveda, Chinese traditional medicinal system, Amchi, and allopathy); the pharmaceutical industry (for drug design and synthesis); biochemistry and biotechnology sciences; and the agricultural sciences. .
    Type of Medium: Online Resource
    Pages: XIX, 609 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995019
    URL: https://doi.org/10.1007/978-981-19-9501-9
    DOI: 10.1007/978-981-19-9501-9
    DDC: 615
    Language: English
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    The Marine Microbiome (2022)
    Cham :Springer International Publishing :
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    Keywords: Microbiology. ; Industrial microbiology. ; Microbial ecology. ; Biochemical engineering. ; Microbiology. ; Industrial Microbiology. ; Microbial Ecology. ; Bioprocess Engineering.
    Description / Table of Contents: Chapter 1: A Sea Of Microbes: What’s So Special About Marine Microbiology -- Part I: Diversity And Evolution Of Marine Microorganisms -- Chapter 2: Survival In A Sea Of Gradients: Bacterial And Archaeal Foraging In A Heterogeneous Ocean -- Chapter 3: Marine Cyanobacteria -- Chapter 4: Marine Protists: A Hitchhiker’s Guide To Their Role In The Marine Microbiome -- Chapter 5: Marine Fungi -- Chapter 6: Marine Viruses: Agents Of Chaos, Promoters Of Order -- Chapter 7: Evolutionary Genomics Of Marine Bacteria And Archaea -- Part II: Marine Habitats -- Chapter 8: Towards A Global Perspective Of The Marine Microbiome -- Chapter 9: The Pelagic Light-Dependent Microbiome -- Chapter 10: Microbial Inhabitants Of The Dark Ocean -- Chapter 11: The Subsurface And Oceanic Crust Prokaryotes -- Chapter 12: The Microbiome Of Coastal Sediments -- Chapter 13: Symbiosis In The Ocean Microbiome -- Chapter 14: Marine Extreme Habitats -- Part III: Marine Microbiome From Genomes To Phenomes: Biogeochemical Cycles, Networks, Fluxes, And Interaction -- Chapter 15: Marine Biogeochemical Cycles -- Chapter 16: A Holistic Approach For The Study Of The Role Of Microorganisms In The Marine Ecosystem -- Chapter 17: The Hidden Treasure: Marine Microbiome As Repository Of Bioactive Compounds -- Chapter 18: Ocean Restoration And The Strategic Plan Of The Marine Microbiome. .
    Abstract: This updated and expanded second edition reviews numerous aspects of the marine microbiome and its possible industrial applications. The marine microbiome is the total of microorganisms and viruses in the ocean and seas and in any connected environment, including the seafloor and marine animals and plants. In the first part of the book, diversity, origin and evolution of the marine microorganisms and viruses are discussed. The microbes presented originate from all three domains of life: Bacteria, Archaea, and Eukarya. The second part sheds some light on the different communities: it describes marine habitats and how their inhabitants control biogeochemical cycles. The third part finally examines the microbial ocean as a global system and evaluates methods of utilizing marine microbial resources. Adopting a translational approach, the book connects academic research with industrial applications, making it a fascinating read and valuable resource for microbiologists from both domains.
    Type of Medium: Online Resource
    Pages: XVI, 766 p. 92 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030903831
    Series Statement: The Microbiomes of Humans, Animals, Plants, and the Environment, 3
    URL: https://doi.org/10.1007/978-3-030-90383-1
    DOI: 10.1007/978-3-030-90383-1
    DDC: 579
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    Nanoformulations in Human Health : Challenges and Approaches (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Therapeutics. ; Pharmacology. ; Therapeutics.
    Description / Table of Contents: Nano-technological Platforms and Manipulations for the Emerging Ocular Manifestations -- Phytonanomedicines as Topical Alternatives for the Treatment of Skin Cancer -- Nano-sized Labile and Particulate Ingredients in Topical Formulations: A Strategic Approach Against Photoageing and Photocarcinogenisis -- Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances -- Nano-carriers for Natural Therapeutics in the Management of Neuropathic Pain -- Advances in the Delivery of Therapeutic Peptides -- Nanoformulations and Their Role in Colon Targeting -- Theranostic Nanoformulations: Merging Diagnostics and Therapeutics -- The Role of Nanoformulations in Nose-To-Brain Drug Delivery -- Cubic Lyotropic Liquid Crystalline Nanostructures: A Versatile Platform for Delivery -- Preformulation Challenges: The Concept Behind the Selection, Design, and Preparation of Nanoformulations -- Nanoethosomes for Topical Fungal Therapeutics -- Comparison of Therapeutic Efficiency of Nanoformulations of Curcumin vs. Tetrahydrocurcumin in Various Disorders -- Nanomedicinal Approaches of Phytotherapeutics to Treat Alzheimers Disease -- Nanoparticulate Approaches to Exploit the Pathophysiology of Rheumatoid and Osteoarthritis -- Emerging Nanotechnology in Chronic Respiratory Diseases -- Conventional and Non-conventional Approaches of Site-specific Targeting of Therapeutics in Some Infectious Diseases and Metabolic Disorders -- Nanoformulations in Human Health Conditions: The Paradigm Shift -- Magnetic Nanoparticles Nanoformulation for Alternative Therapy of Cancer by Super-paramagnetic Hyperthermia -- Nano-weapons Against Tuberculosis -- Drug-Excipient Interactions in Nanoformulations with Special Focus on Impurity Control per ICH guidelines.
    Abstract: This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
    Type of Medium: Online Resource
    Pages: XVIII, 548 p. 106 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030418588
    URL: https://doi.org/10.1007/978-3-030-41858-8
    DOI: 10.1007/978-3-030-41858-8
    DDC: 615
    Language: English
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    Emerging Technologies for Nanoparticle Manufacturing (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Nanotechnology. ; Nanochemistry. ; Pharmacology. ; Nanotechnology. ; Nanochemistry.
    Description / Table of Contents: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.
    Abstract: This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .
    Type of Medium: Online Resource
    Pages: XV, 611 p. 155 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030507039
    URL: https://doi.org/10.1007/978-3-030-50703-9
    DOI: 10.1007/978-3-030-50703-9
    DDC: 615
    Language: English
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    Antiviral Drug Discovery and Development (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    URL: https://doi.org/10.1007/978-981-16-0267-2
    DOI: 10.1007/978-981-16-0267-2
    DDC: 615
    Language: English
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    Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Human physiology. ; Pharmacology. ; Medical Genetics. ; Human Physiology.
    Description / Table of Contents: Preface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.
    Abstract: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
    Type of Medium: Online Resource
    Pages: XII, 316 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031384370
    Series Statement: Handbook of Experimental Pharmacology, 279
    URL: https://doi.org/10.1007/978-3-031-38437-0
    DOI: 10.1007/978-3-031-38437-0
    DDC: 615
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  • 88
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    Edible Plants in Health and Diseases : Volume II : Phytochemical and Pharmacological Properties (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Food science. ; Medicinal chemistry. ; Pharmacology. ; Food Science. ; Medicinal Chemistry.
    Description / Table of Contents: 1 Zingiber officinale - Its Ethanobotanical Uses, Phytochemistry and Pharmacology -- 2 An Insight in to the Phytochemistry, Traditional uses and Pharmacology of Ziziphus spina-christi (L) Willd. (Sidr): An Edible wild plant of Arabian Peninsula -- 3 Traditional Uses, Phytochemistry and Pharmacological Profile of Salvadora persica Linn -- 4 Phytochemistry, Pharmacology and Applications of Ocimum sanctum (Tulsi) -- 5 Nigella sativa: Its Ethnobotany, Phytochemistry and Pharmacology -- 6 A Review on Ethnomedicinal, Phytochemistry and Pharmacological Activities of Rumex hastatus D. Don -- 7 Chemical Composition and Biological Uses of Crocus sativus L.(Saffron) -- 8 Positive Health Benefits of Saponins from Edible Legumes: Phytochemistry and Pharmacology -- 9 Taraxcum officinale: The Esculent Dandelion as Herbal Medicine -- 10 Arctium lappa: A Review on its Phytochemistry and Pharmacology -- 12 Cichorium intybus: A Comprehensive Review on its Pharmacological Activity and Phytochemistry -- 13 Phytochemical and Pharmacological Properties of Picrorhiza kurroa -- 14 Lady's Purse (Capsella bursa-pastoris L.)-Current perspective on its ethanopharmacological, therapeutic potential and phytochemistry -- 15 Ethnopharmaology, Phytochemistry and Biological Activities of Achillea millefolium: A Comprehensive Review -- 16 A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Verbascum thapsus -- 17 Acorus calamus - A Review on Its Phytochemical and Pharmacological Profile.
    Abstract: The book provides essential information on some of the promising edible medicinal plants and how these possess both nutritional as well as therapeutic value. The significance of the edible plants in traditional medicine and the importance of the distribution of their chemical constituents are discussed systematically concerning the role of these plants in ethnomedicine in different regions of the world. The current volume deals with the individual plants' phytochemical and pharmacological properties, emphasizing human health. The title would demonstrate the value of natural edible plants and introduce readers to state-of-the-art developments and trends in omics-driven research. This book is a single-source scientific reference to explore the specific factors that contribute to these potential health benefits and discuss how to maximize those potential benefits. Chemists, food technologists, pharmacologists, phytochemists, and all professionals involved with quality control and standardization will find in this book a valuable and updated basis for their work.
    Type of Medium: Online Resource
    Pages: IX, 522 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811649592
    URL: https://doi.org/10.1007/978-981-16-4959-2
    DOI: 10.1007/978-981-16-4959-2
    DDC: 615
    Language: English
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    The Kappa Opioid Receptor (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: From the contents. Preface.-Part I: Molecular aspects of KOR -- Part II: Preclinical research on pharmacology of KOR agonists and antagonists in animals -- Part III: KOR agonists and antagonists in clinical use and in past and present clinical trials.
    Abstract: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 577 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030890742
    Series Statement: Handbook of Experimental Pharmacology, 271
    URL: https://doi.org/10.1007/978-3-030-89074-2
    DOI: 10.1007/978-3-030-89074-2
    DDC: 615
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  • 90
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    Microbiological Activity for Soil and Plant Health Management (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Microbial genetics. ; Bacteria. ; Microbiology. ; Microbial Ecology. ; Microbial Genetics. ; Bacteria.
    Description / Table of Contents: Chapter 1. Agriculturally important microbes –– Challenges and Opportunities -- Chapter 2. Agriculturally Important Microorganism: Understanding the Functionality and Mechanisms for Sustainable Farming -- Chapter 3. Microbial Diversity of Different Agroecosystems: Current Research and Future Challenges -- Chapter 4. Soil Microbial Biomass an Index of Soil Quality and Fertility in Different Land Use Systems of Northeast India -- Chapter 5. Microbes and Plant Mineral Nutrition -- Chapter 6. Drought Stress Alleviation in Plants by Soil Microbial Interactions -- Chapter 7. Role of Nitrogen-Fixing Microorganisms for Plant and Soil Health -- Chapter 8. Serendipita indica mediated drought and heavy metal stress tolerance in plants -- Chapter 9. Role of rhizosphere and endophytic microbes in alleviation of biotic and abiotic stress in plants -- Chapter 10. Augmentation of plant salt stress tolerance by microorganisms -- Chapter 11. Impact of Plant Exudates on Soil Microbiomes -- Chapter 12. Global climate change and microbial ecology: Current scenario and management -- Chapter 13. Biotic stress management by microbial interactions in soils -- Chapter 14. Interactions between plant genotypes and PGPR are a challenge for crop breeding and improvement inoculation responses -- Chapter 15. Significance of Microbial Enzyme Activities in Agriculture -- Chapter 16. Omics technology for plant stress management -- Chapter 17. Rhizosphere modeling and engineering for agricultural and environmental sustainability -- Chapter 18. Factors Affecting Soil Ecosystem and Productivity -- Chapter 19. Microbial Genes, Enzymes, and metabolites: to improve rhizosphere and Plant Health Management -- Chapter 20. Recent trends in organic farming -- Chapter 21. Advances in Microbial Applications in Safeguarding of Plant Health: Challenges and Future Perspective -- Chapter 22. Rhizosphere Modelling and Nanotechnology: New Outlooks in Sustainable Agriculture -- Chapter 23. New strategies for commercialization of microbial technologies -- Chapter 24. Techniques for improving microbial inoculants as a tool for sustainable development -- Chapter 25. Bioinoculants for Agricultural Sustainability.-.
    Abstract: Plants and the soil they grow in, are confronted with severe biotic and abiotic stresses viz. nutrient starvation, salt stress, drought, flooding, xenobiotic contamination, in order to sustain in an ecosystem. They also shape the microbial composition in their vicinity by modulating their secretions. This book discusses the pressing demand for novel and potential microorganisms to support an environment-friendly and cost-effective way of stress management in the plants. The book summarizes the processes and mechanisms involved in microbe-assisted plant and soil stress management. It discusses the challenges and opportunities in the application of microbial interactions in plant health. It describes in detail the nutrient dynamics of different soil systems. It includes important topics like agriculturally important genes and enzymes, rhizosphere modeling & engineering, genetically engineered bio-inoculants etc. It also talks about the application of next-generation technologies, omics and nano-based technologies. In the recent years, more than 50% of agricultural production relies on chemical fertilizers, leading to serious health issues and environmental concerns. This book provides natural solutions to these environmental concerns. This book is useful for researchers and students in the field of microbiology, agriculture, soil biology and plant sciences.
    Type of Medium: Online Resource
    Pages: XII, 641 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811629228
    URL: https://doi.org/10.1007/978-981-16-2922-8
    DOI: 10.1007/978-981-16-2922-8
    DDC: 579
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    Bacterial Endophytes for Sustainable Agriculture and Environmental Management (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Plant physiology. ; Botanical chemistry. ; Plant anatomy. ; Microbiology. ; Plant Physiology. ; Plant Biochemistry. ; Plant Anatomy and Morphology.
    Description / Table of Contents: 1 Endophytic Bacteria: Application against biotic and abiotic stresses and Plant Health Improvements for Sustainable Agriculture -- 2 Endophytic Bacteria: Mitigating Abiotic Stress from Inside -- 3 Diversity and bioactive potential of endophytic bacteria from high-value medicinal plants -- 4 Plant Growth Promoting Rhizobacteria (PGPR) Assisted Phytoremediation of Contaminated Soils -- 5 Endophytic Bacteria: Role in Phosphorous Solubilization -- 6 Endophytes of Medicinal plants: Diversity and Bioactivity -- 7 Title: Biotechnological applications of Bacterial Endophytes -- 8 Genetic Basis of Fungal Endophytic Bioactive Compounds Synthesis, Modulation, and Their Biotechnological Application -- 9 Endophytic bacteria for plant growth promotion -- 10 Bacterial Endophytes and Bio-nanotechnology -- 11 Role of Endophyte Metabolites in Plant Protection and other Metabolic Activities -- 12 Role of Bacterial Endophytes in the Promotion of Plant Growth -- 13 Bacterial endophytes and abiotic stress mitigation. .
    Abstract: This book is a comprehensive account of recent advances in the endophytic research. It covers recent perspective of endophytic research, molecular diversity, bioprospecting of novel genes using high throughput molecular techniques, and most importantly application of endophytes in practicing sustainable agriculture. Endophytic micro-organisms are mysterious living component associated mutually with plant roots and soil microbes. Various endophytic bacteria have attracted considerable attention for their ability to promote plant growth through direct mechanisms or by acting as biocontrol agents. Endophytes also find use in biocontrol, medicine, agriculture and food industry. This is a useful reading for the student of agriculture, environmental microbiology and biotechnology.
    Type of Medium: Online Resource
    Pages: VIII, 278 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811644979
    URL: https://doi.org/10.1007/978-981-16-4497-9
    DOI: 10.1007/978-981-16-4497-9
    DDC: 579
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    Behavioral Neurobiology of GABAB Receptor Function (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Abstract: It has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.
    Type of Medium: Online Resource
    Pages: VII, 329 p. 70 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030913359
    Series Statement: Current Topics in Behavioral Neurosciences, 52
    URL: https://doi.org/10.1007/978-3-030-91335-9
    DOI: 10.1007/978-3-030-91335-9
    DDC: 615
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    Probiotics, Prebiotics, Synbiotics, and Postbiotics : Human Microbiome and Human Health (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Biology. ; Molecular biology. ; Microbial ecology. ; Microbiology. ; Biological Sciences. ; Molecular Biology. ; Microbial Ecology.
    Description / Table of Contents: Part I: Current State of Knowledge regarding the Human Microbiome Structure, Function, and Diversity -- Chapter 1. Impact of Dietary Habits, Ethnicity and Geographical Provenance in Shaping Human Gut Microbiome -- Chapter 2. Methods Used for Studying Human Microbiome -- Chapter 3. Factors Affecting Composition of the Human Microbiome -- Part II: Correlation of the Human Microbiome to Specific Health/Disease Conditions -- Chapter 4. Mapping the Microbial Metabolites in Metabolic Disorders -- Chapter 5. Human Microbiome in Malnutrition -- Chapter 6. Human Microbiome and the Immune System Functioning -- Chapter 7. Human Microbiome and the Susceptibility to Infections -- Chapter 8. Human microbiome and the neurological disorders -- Chapter 9. Exploring the Unexplored Arena: Butyrate As a Dual Communicator in the Gut-Brain Axis -- Chapter 10. Human Microbiome and Lifestyle Disorders -- Chapter 11. Correlation of Human Microbiome and Immune Functioning to Covid-19 Infections: An Overview -- Chapter 12. Exploring the Pathoprofiles of SARS-COV-2-infected Human Gut-Lungs Microbiome Crosstalks -- Chapter 13. Role of Human Microbiome in Cardiovascular Disease: Therapeutic Potential and Challenges -- Chapter 14. The Human Microbiome and Respiratory Diseases -- Part-III: Manipulation of the Human Microbiome for Better Health -- Chapter 15. Probiotics: An Emerging Strategy for Oral Health Care -- Chapter 16. Dietary Modulation of Nervous and Immune System: Role of Prebiotics/ Synbiotics/ Postbiotics -- Chapter 17. Probiotics for Skin Health -- Chapter 18. Human Microbiome and Autism-Spectrum Disorders -- Chapter 19. Psychobiotics as an Emerging Category of Probiotic Products -- Chapter 20. Probiotics for Vaginal Health -- Chapter 21. Interactions between Microbial Therapeutics and the Endogenous Microbiome -- Part IV: Applied and Translational Aspects -- Chapter 22. The Role of a Multi-Spore Probiotic in the Management of Metabolic Endotoxemia - A Major Driver of Chronic Illness -- Chapter 23. Characterization and Authentication of Probiotic Preparations -- Chapter 24. A Survey of Commercially Available Probiotics and Prebiotics -- Chapter 25. Regulatory Aspects Relevant to Probiotic Products -- Chapter 26. Probiotic Identity from Spore – Focus on Bacillus Probiotics.
    Abstract: This book explains the potential value of microbiome and microbiome composition associated with human health and diseases. The opening chapters describe the current state of knowledge regarding the human microbiome structure, function, and diversity. The mechanisms of action and the various putative uses of human microbiome are then examined specific to healthy and disease conditions. Readers will find detailed information on its manipulation of human microbiome studies as well as its applied and translational aspects in the current field. The latest knowledge on probiotics, prebiotics, synbiotics, and postbiotics is presented, and specific cases to date are discussed. This book features knowledge from leading researchers working on different aspects of the human microbiome and its manipulation for better health. Overall, this book is an excellent source for microbiome researchers and students from all levels seeking the most up-to-date advancements in the field and also to point toward the future directions.
    Type of Medium: Online Resource
    Pages: XV, 588 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819914630
    URL: https://doi.org/10.1007/978-981-99-1463-0
    DOI: 10.1007/978-981-99-1463-0
    DDC: 579
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    Marine Biomaterials : Drug Delivery and Therapeutic Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Biomaterials. ; Pharmacy. ; Biomedical engineering. ; Pharmacology. ; Biomedical Research. ; Biomaterials. ; Pharmacy. ; Translational Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Marine biopolymers for oral delivery of drug -- Chapter 2. Marine polymer based nanocarriers for drug delivery application -- Chapter 3. Alginate: A promising biopolymer in drug delivery system -- Chapter 4. Chitosan Based Nanocomposite as Targeted drug delivery Carrier -- Chapter 5. Marine Biopolymer Based Oral In situ Gel: Drug Delivery Applications -- Chapter 6. Marine biopolymers for transdermal drug delivery -- Chapter 7. Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions -- Chapter 8. Marine collagen: promising biomaterial in delivery of therapeutics for cancer therapy -- Chapter 9. Chitosan based gel for ocular drug delivery. Chapter 10. Marine based biopolymers for central nervous system drug delivery -- Chapter 11. Marine Biopolymers Based Anticancer Drug Delivery Systems -- Chapter 12. Marine-Derived polysaccharides: prospects for future pharmaceuticals and drug delivery systems.
    Abstract: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 453 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647871
    URL: https://doi.org/10.1007/978-981-16-4787-1
    DOI: 10.1007/978-981-16-4787-1
    DDC: 615
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    Parkinsonism and the Environment (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Neurosciences. ; Pharmacology. ; Neuroscience.
    Description / Table of Contents: Experimental evidence for pesticide contribution in the pathogenesis of Parkinsonism: an update -- Epidemiological evidence for pesticide involvement in the etiology of Parkinson’s Disease: current state of affairs?” -- Manganese induced Parkinsonism: cellular and molecular mechanisms -- Manganese overexposures in occupational and environmental settings and Parkinsonism: where do we stand -- Aberrant dopamine metabolism as a focal point in the mechanism of environmental contaminant-induced dopaminergic dysfunction -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Protein kinase C-delta (PKC-delta): a major molecular target for disparate dopaminergic toxicants -- Environmental contribution to redox dyshomeostasis in Parkinsonism.
    Abstract: “The book is comprised of individual reviews with the common goal of providing up-to-date state of the knowledge information on the role the environment plays in the pathogenesis of parkinsonism. The reviews focus on recent advances in the quest of deciphering the molecular and cellular mechanisms of parkinsonian dysfunction, highlight specific emerging dopaminergic toxicants and an alternative experimental model to study the link between environmental exposures and parkinsonism, and provide an update from epidemiological and experimental points of view related to the pesticide exposures and parkinsonism/Parkinson’s Disease association. Foremost experts in their respective fields are the senior authors on each chapter and the book fills a critical void that now exists as a book of similar nature has not been published in the last 15 years. Researchers and clinicians with an interest in Parkinson's Disease and related disorders, as well as toxicologists, graduate students, and the general public who are interested in the contribution of environmental factors to neurological dysfunction are among the readership for this book.”.
    Type of Medium: Online Resource
    Pages: V, 158 p. 14 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030874513
    Series Statement: Molecular and Integrative Toxicology,
    URL: https://doi.org/10.1007/978-3-030-87451-3
    DOI: 10.1007/978-3-030-87451-3
    DDC: 615
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    Mineral Formation by Microorganisms : Concepts and Applications (2022)
    Cham :Springer International Publishing :
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    Keywords: Microbiology. ; Industrial microbiology. ; Earth sciences. ; Microbial genetics. ; Microbiology. ; Industrial Microbiology. ; Earth Sciences. ; Microbial Genetics.
    Description / Table of Contents: Microbial Domains and Their Role in the Formation of Minerals -- Intracellular and Extracellular Bacterial Biomineralization -- Geophysical Monitoring and Characterization of Biomineralization Processes -- The Molecular Genetics of Microbial Biomineralization -- Silicate Minerals Induced by Microorganisms -- Non-Silicate Minerals (Carbonates, Oxides, Phosphates, Sulfur-Containing, Oxalates and Other Organic Crystals) Induced by Microorganisms -- Magnetosome Biomineralization by Magnetotactic Bacteria -- Factors Affecting Biomineralization -- Experimental Modeling of Carbonate Mineral Precipitation in the Presence of Cyanobacteria -- Key Applications of Biomineralization.
    Abstract: This book explains how microorganisms play a pivotal role in the formation of biominerals, including carbonates, silicate minerals and oxides. As readers will learn, these minerals may be produced either intracellularly or extracellularly in order to sustain microbial life. Experienced scientists from the field show that some of these biominerals can be produced in an active form, which involves direct enzymatic intervention to form precipitates. In addition, passive mineral formation can be mediated by the presence of dead cells. Readers from Microbiology and Biochemistry will appreciate the thorough coverage on various types of microbial mineral formation and their roles in microbial domains. Furthermore, they will benefit from the authors’ first-hand knowledge regarding common techniques for studying biomineral-producing microorganisms, factors affecting biomineralization, and the use of this process in biotechnological applications.
    Type of Medium: Online Resource
    Pages: VIII, 387 p. 62 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030808075
    Series Statement: Microbiology Monographs, 36
    URL: https://doi.org/10.1007/978-3-030-80807-5
    DOI: 10.1007/978-3-030-80807-5
    DDC: 579
    Language: English
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  • 97
    Online Resource
    Online Resource
    Probiotic Bacteria and Postbiotic Metabolites: Role in Animal and Human Health (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Biotechnology. ; Food science. ; Microbiology. ; Biotechnology. ; Food Science.
    Description / Table of Contents: Chapter 1. Bacillus spp. In Aquaculture mechanisms and Applications: An Update View -- Chapter 2. Immunity and Gut Microbiome: role of Probiotics and Prebiotics -- Chapter 3. Preventive Effects of Probiotics and Prebiotics in Food Allergy: potentials and promises -- Chapter 4. An Overview of Dairy Probiotic Microflora -- Chapter 5. Remarkable Metabolic Versatility of the Commensal Bacteria Eubacterium hallii and Intestinimonas butyriciproducens, Potential Next Generation Probiotics -- Chapter 6. Anti-carcinogenic Potential of Probiotic, Postbiotic Metabolites and Paraprobiotics on Human Cancer Cells -- Chapter 7. Postbiotic Metabolites of Probiotic in Animal Health -- Chapter 8. Probiotics Application: Implication for Sustainable Aquaculture -- Chapter 9. Honeybees Gut as a Reservoir of Probiotic Bacteria -- Chapter 10. Role of Probiotic Bacteria on Bio-availability of Functional Ingredients Under Fermentation Process -- Chapter 11. Quality and Health Aspects of Dairy Foods Affected by Probiotic Microbes and Their Metabolites -- Chapter 12. Encountering the Antibiotic Resistance by Bioactive Components and Therapies: Probiotics, Phytochemicals and Phages -- Chapter 13. Probiotic Bacteria as a functional Delivery Vehicle for the Development of Live Oral Vaccines -- Chapter 14. Promising Aspects of Probiotics and Postbiotics Derived from Lactic Acid Bacteria as Pharma Foods -- Chapter 15. Non-Dairy Foods as Potential Carriers of Probiotic Bacteria and Postbiotics.
    Abstract: This book covers all aspects of probiotic bacteria and their metabolites, as well as their role and significance in human and animal health. Given the role of probiotic bacterial strains in the production of short chain fatty acids, butyrate etc probiotics may be considered as an alternative approach for the prevention or treatment of intestinal dysbiosis, cancers, cardiovascular diseases, hypertensions. Additionally, the significance of probiotics added in aquaculture systems for improving health, performance and growth of aquatic organisms has been highlighted. In this book, the multi-functional role of probiotics and their post-biotic metabolites in improving overall health status of man and animals, is discussed. It is a comprehensive compilation useful for researchers, academics, veterinarians and students in the field of microbiology, food technology and biotechnology.
    Type of Medium: Online Resource
    Pages: XIII, 373 p. 29 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602238
    Series Statement: Microorganisms for Sustainability, 2
    URL: https://doi.org/10.1007/978-981-16-0223-8
    DOI: 10.1007/978-981-16-0223-8
    DDC: 579
    Language: English
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  • 98
    Online Resource
    Online Resource
    Microbes for Natural Food Additives (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Microbiology. ; Food Microbiology. ; Food Analysis. ; Chemistry. ; Microbiology. ; Food Microbiology. ; Food Chemistry.
    Description / Table of Contents: 1. Microbial Food additives: Types, Functions and challenges -- 2. Applications of enzymes in food industries as additives -- 3. Microbial antioxidants in food products -- 4. Microbial and bio-based preservatives:recent advances in antimicrobial compounds -- 5. Prebiotic and Synbiotic Foods -- 6. Microbial stablizers in food processing -- 7. Biosurfactants: promising biomolecules in the food industry -- 8. Additives in Dairy Based Food -- 9. Hypersensitivity associated with food additives.
    Abstract: This book provides all the aspects of microbes for food additives, and a detailed description of their different categories. The chapters provide a step-by-step overview of microbial food additives as enzymes, antioxidants, stabilizers, emulsifiers, organic acids, colorants, sweeteners, flavoring compounds that have been used commercially by industrialists. In addition, an emphasis on the use of microbes as therapeutic agents such as probiotics and enzymes have also been given in the respective chapters. Furthermore, the book also comprises the detailed description of legislation and policies for the use of microbial additives at large scale in different food industries. Therefore, this book provides a comprehensive, state of art updated literature which can be used by the food scientists, nutritionists, microbiologists and a health-conscious layman to check the food additive list on a product for a nutritious and safer food.
    Type of Medium: Online Resource
    Pages: X, 227 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811957116
    Series Statement: Microorganisms for Sustainability, 38
    URL: https://doi.org/10.1007/978-981-19-5711-6
    DOI: 10.1007/978-981-19-5711-6
    DDC: 579
    Language: English
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  • 99
    Online Resource
    Online Resource
    Nanostructures for Antimicrobial and Antibiofilm Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Nanotechnology. ; Plant biotechnology. ; Plant genetics. ; Microbial genetics. ; Plants Evolution. ; Microbiology. ; Nanotechnology. ; Plant Biotechnology. ; Plant Genetics. ; Microbial Genetics. ; Plant Evolution.
    Description / Table of Contents: Preface -- Polymer Macromolecules to Polymeric Nanostructures: Efficient antibacterial candidates -- Algal Nanoparticles -- Green and bio-mechanochemical synthesis of silver nanoparticles and their antibacterial activity -- Novel antimicrobial compounds from indigenous plants and microbes -- Antimicrobial properties of prodigionins from bacteria -- Immobilized systems based on secondary metabolites produced by microorganisms -- Nanomaterials as Therapeutic agents for antimicrobial therapy -- Antivral natural compounds -- A Review of Next-Generation Nano-Antimicrobials in orthopaedics -- Recent advances in the design and synthesis of antibacterial and biofilm nanoplatforms -- Recent nanotechnological tools for irradication of biofilms on medical devices -- Recent Trends in Antimicrobial or Biofilms with Advanced Specificity at gene level treatment -- Current and Future Prospects of Nanotechnology for the Study of Infectious Diseases -- Nanostructures for antimicrobial and antibiofilm photodynamic therapy -- Nanoparticle-based antimicrobial coating on medical implants -- Anti-quorum sensing systems and biofilm formation -- Antibiofilm, antifouling and anticorrosive biomaterials and nanomaterials for marine applications -- A review of applications and challenges of silver nanoparticles as antimicrobial agents -- Estimating the effect of ZnO nanoparticles using CS/PVA/MC3 biofilms for antimicrobial activity -- Mesoporous silica nanomaterials as antibacterial and antibiofilm agents -- Index.
    Abstract: In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.
    Type of Medium: Online Resource
    Pages: XIV, 458 p. 99 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403379
    Series Statement: Nanotechnology in the Life Sciences,
    URL: https://doi.org/10.1007/978-3-030-40337-9
    DOI: 10.1007/978-3-030-40337-9
    DDC: 579
    Language: English
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  • 100
    Online Resource
    Online Resource
    Ethnopharmacology and Drug Discovery for COVID-19: Anti-SARS-CoV-2 Agents from Herbal Medicines and Natural Products (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Natural products. ; Nanobiotechnology. ; Bioinformatics. ; Diseases Causes and theories of causation. ; Molecular biology. ; Pharmacology. ; Natural Products. ; Nanobiotechnology. ; Bioinformatics. ; Pathogenesis. ; Molecular Biology.
    Description / Table of Contents: 1. COVID-19: An overview of virology, mutations, pathology, epidemiology, diagnosis, preventions and treatments -- 2. The recent development of therapeutic strategies against COVID-19 -- 3. Plant immunoenhancers: Promising ethnopharmacological candidates for anti-SARS-CoV-2 activity -- 4. Herbal formulations in fighting against the SARS-CoV-2 infection -- 5. Rejuvenation of traditional medicine in the 21st century against SARS-CoV-2 -- 6. Traditional herbal medicines and their active constituents in combating SARS-CoV-2 infection -- 7. Antiviral phytocompounds against animal-to-human transmittable SARS-CoV-2 -- 8. Plants-derived bioactive compounds as potential ACE-2 inhibitors against SARS-CoV-2 infection -- 9. Insights into in silico methods to explore plant bioactive substances in combating SARS-CoV-2 -- 10. Dietary plants, spices and fruits in curbing SARS-CoV-2 virulence -- 11. Therapeutic potential of selected medicinal plants for neurological disorders after the infection of COVID-19 -- 12. Glycyrrhizae Radix et Rhizoma (Gan Cao) for the management of COVID-19 -- 13. COVID-19-induced kidney disease: Ethnopharmacological intervention to ameliorate kidney damage and improve kidney function -- 14. Phytochemicals and nutraceuticals targeting SARS-CoV-2: An in silico analysis -- 15. Therapeutic and prophylactic effects of plant derivatives against SARS-CoV-2 -- 16. Therapeutic potential of essential oils against SARS-CoV-2 infection -- 17. Antiviral properties of South Indian plants against SARS-CoV-2 -- 18. Immune-boosting plants used in Turkish folk medicine and their potential against COVID-19 -- 19. A comparison study of medicinal plants used against SARS-CoV-2 and those recommended against malaria in Africa -- 20. Exploring the potential antiviral properties of Nigella sativa L. against SARS-CoV-2: Mechanisms and prospects -- .
    Abstract: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".
    Type of Medium: Online Resource
    Pages: IX, 590 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819936649
    URL: https://doi.org/10.1007/978-981-99-3664-9
    DOI: 10.1007/978-981-99-3664-9
    DDC: 615
    Language: English
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