ISSN:
1573-4943
Keywords:
Specific cleavage
;
peptide hydrolysis
;
microwave irradiation
;
rate enhancement
;
weak acid hydrolysis
;
aspartyl residues
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A rapid and selective peptide-bond cleavage in weak acid, induced by microwave irradiation, has been developed. The specific cleavage sites of peptide bonds located only at the carboxyl-and amino-terminal ends of aspartyl residues along the peptide chain. A systematic study including the time course for the cleavage of various aspartyl-containing peptides, the effect of the acidity of the reaction solution on the completeness of peptide-bond cleavage, and the relationship between the power of microwave irradiation and the reaction time of cleavage are studied.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01025091
Permalink
