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  • 1
    Publication Date: 2014-07-04
    Description: Author(s): P. Zhang, P. Richard, T. Qian, X. Shi, J. Ma, L.-K. Zeng, X.-P. Wang, E. Rienks, C.-L. Zhang, Pengcheng Dai, Y.-Z. You, Z.-Y. Weng, X.-X. Wu, J. P. Hu, and H. Ding Measuring the superconducting gap of multiband materials is a difficult but important task. New results reveal a full characterization of the superconducting gap of Fe-based superconductors. [Phys. Rev. X 4, 031001] Published Thu Jul 03, 2014
    Electronic ISSN: 2160-3308
    Topics: Physics
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  • 2
    Publication Date: 2014-02-28
    Description: Akt and mTOR mediate programmed necrosis in neurons Cell Death and Disease 5, e1084 (February 2014). doi:10.1038/cddis.2014.69 Authors: Q Liu, J Qiu, M Liang, J Golinski, K van Leyen, J E Jung, Z You, E H Lo, A Degterev & M J Whalen
    Keywords: necroptosisneuronAktmTORRIPK1RIPK3
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
    Publication Date: 2015-04-03
    Description: The fluid flow in natural reservoirs mobilizes fine particles. Subsequent migration and straining of the mobilized particles in rocks greatly reduce reservoir permeability and well productivity. This chain of events typically occurs over the temperature ranges of 20-40°C for aquifers and 120-300°C for geothermal reservoirs. However, the present study might be the first to present a quantitative analysis of temperature effects on the forces exerted on particles and of the resultant fines migration. Based on torque balance between electrostatic and drag forces acting on attached fine particles, we derived a model for the maximum retention concentration and used it to characterize the detachment of multi-sized particles from rock surfaces. Results showed that electrostatic force is far more affected than water viscosity by temperature variation. An analytical model for flow toward wellbore that is subject to fines migration was derived. The experiment-based predictive modeling of the well impedance for a field case showed high agreement with field historical data (coefficient of determination R 2 =0.99). It was found that the geothermal reservoirs are more susceptible to fine particle migration than are conventional oilfields and aquifers.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉You, Zhong -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):623-4. doi: 10.1126/science.1257841.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX3 0PL, UK. zhong.you@eng.ox.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104372" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2011-02-05
    Description: p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA damage response, with dimethylation of histone H4 lysine 20 (H4K20me2) critical to the recruitment of 53BP1 to double-strand breaks (DSBs). However, it is not clear how 53BP1 is specifically targeted to the sites of DNA damage, as the overall level of H4K20me2 does not seem to increase following DNA damage. It has been proposed that DNA breaks may cause exposure of methylated H4K20 previously buried within the chromosome; however, experimental evidence for such a model is lacking. Here we found that H4K20 methylation actually increases locally upon the induction of DSBs and that methylation of H4K20 at DSBs is mediated by the histone methyltransferase MMSET (also known as NSD2 or WHSC1) in mammals. Downregulation of MMSET significantly decreases H4K20 methylation at DSBs and the subsequent accumulation of 53BP1. Furthermore, we found that the recruitment of MMSET to DSBs requires the gammaH2AX-MDC1 pathway; specifically, the interaction between the MDC1 BRCT domain and phosphorylated Ser 102 of MMSET. Thus, we propose that a pathway involving gammaH2AX-MDC1-MMSET regulates the induction of H4K20 methylation on histones around DSBs, which, in turn, facilitates 53BP1 recruitment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064261/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064261/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pei, Huadong -- Zhang, Lindsey -- Luo, Kuntian -- Qin, Yuxin -- Chesi, Marta -- Fei, Frances -- Bergsagel, P Leif -- Wang, Liewei -- You, Zhongsheng -- Lou, Zhenkun -- CA130996/CA/NCI NIH HHS/ -- CA151329/CA/NCI NIH HHS/ -- R01 AG020686/AG/NIA NIH HHS/ -- R01 AG020686-06A2/AG/NIA NIH HHS/ -- R01 AG020686-07/AG/NIA NIH HHS/ -- R01 CA130996/CA/NCI NIH HHS/ -- R01 CA130996-03/CA/NCI NIH HHS/ -- R01 CA133966/CA/NCI NIH HHS/ -- R01 CA133966-01A2/CA/NCI NIH HHS/ -- R01 CA133966-02/CA/NCI NIH HHS/ -- R01 CA133966-03/CA/NCI NIH HHS/ -- R01 CA136671/CA/NCI NIH HHS/ -- R01 CA136671-02/CA/NCI NIH HHS/ -- R01 CA136671-03/CA/NCI NIH HHS/ -- R01 CA151329/CA/NCI NIH HHS/ -- R01 CA151329-01/CA/NCI NIH HHS/ -- R56 AG020686/AG/NIA NIH HHS/ -- R56 AG020686-06A1/AG/NIA NIH HHS/ -- England -- Nature. 2011 Feb 3;470(7332):124-8. doi: 10.1038/nature09658.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21293379" target="_blank"〉PubMed〈/a〉
    Keywords: Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/metabolism ; Chromatin Immunoprecipitation ; *DNA Breaks, Double-Stranded ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Histone-Lysine N-Methyltransferase/chemistry/*metabolism ; Histones/*chemistry/*metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/*metabolism ; Lysine/*metabolism ; Methylation ; Nuclear Proteins/chemistry/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; Protein Transport ; Protein-Serine-Threonine Kinases/metabolism ; Repressor Proteins/chemistry/*metabolism ; Trans-Activators/chemistry/metabolism ; Tumor Suppressor Proteins/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2015-07-25
    Description: Origami patterns, including the rigid origami patterns in which flat inflexible sheets are joined by creases, are primarily created for zero-thickness sheets. In order to apply them to fold structures such as roofs, solar panels, and space mirrors, for which thickness cannot be disregarded, various methods have been suggested. However, they generally involve adding materials to or offsetting panels away from the idealized sheet without altering the kinematic model used to simulate folding. We develop a comprehensive kinematic synthesis for rigid origami of thick panels that differs from the existing kinematic model but is capable of reproducing motions identical to that of zero-thickness origami. The approach, proven to be effective for typical origami, can be readily applied to fold real engineering structures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Yan -- Peng, Rui -- You, Zhong -- New York, N.Y. -- Science. 2015 Jul 24;349(6246):396-400. doi: 10.1126/science.aab2870.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Mechanical Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China. ; Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK. zhong.you@eng.ox.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26206928" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2018-08-04
    Description: The Wenchuan Earthquake Fault Scientific Drilling Project, a scientific drilling project that first responded to the Earthquake, performed deep 3D in-situ stress measurements using the inelastic strain recovery of core method for the first time under conditions whereby the borehole breakout method and hydraulic fracturing method could not be applied. The inelastic deformation of the deephole cores under the action of 3D stresses was simulated based on the inelastic strain recovery of viscoelastic body theory and core testing theory and the direction & magnitude of 3 major stresses were calculated under the precondition of homogeneous isotropy. In the field laboratory of the WFSD Project, the testing system developed was used to test the normal strain of inelastic recovery strain of deephole cores in 6 independent directions and determine the direction & magnitude of 3D in-situ stresses of the test points. In order to verify the effectiveness of the inelastic strain recov...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 8
    Publication Date: 2018-05-10
    Description: A plug-in electrophoresis microchip for large-scale use aimed at improving maintainability with low fabrication and maintenance costs is proposed in this paper. The plug-in microchip improves the maintainability of a device because the damaged microchannel layer can be changed without needing to cut off the circuit wires in the detection component. Obviously, the plug-in structure reduces waste compared with earlier microchips; at present the whole microchip has to be discarded, including the electrode layer and the microchannel layer. The fabrication cost was reduced as far as possible by adopting a steel template and printed circuit board electrodes that avoided the complex photolithography, metal deposition and sputtering processes. The detection performance of our microchip was assessed by electrophoresis experiments. The results showed an acceptable gradient and stable detection performance. The effect of the installation shift between the microchannel layer and the electrode layer brought about by the plug-in structure was also evaluated. The results indicated that, as long as the shift was controlled within a reasonable scope, its effect on the detection performance was acceptable. The plug-in microchip described in this paper represents a new train of thought for the large-scale use and design of portable instruments with electrophoresis microchips in the future.
    Keywords: microsystems, analytical chemistry
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 9
    Publication Date: 2024-01-12
    Description: This paper develops a depth‐averaged theory to investigate submarine landslides and resulting water waves. The problems here consist of a pure fluid regime and a mixture regime of grains and fluid. Both regimes separate from one another by an interface, which is a material surface for grains. While the downslope velocities of the both phases are assumed to be identical in the mixture regime, the velocity shear causes a rearrangement of grains, which induces a vertical relative motion between the phases. The established theory consists of five coupled conservation equations, which describe the evolution of the pure fluid thickness, the mixture thickness, the solids volume fraction, and depth‐averaged velocities. To handle nonconservative products emerging in the equations, a new coordinate system is introduced to rewrite the equation system in an equivalent form, so that numerical solutions are insensitive to the choice of discretization of nonconservative products, which enables us to accurately characterize the dynamic behaviors of particles in the collapse experiments of underwater particles and describe free‐surface wave profiles. It is shown that the computed results are in good agreement with the experiments reported in previous literatures.
    Description: Plain Language Summary: Developing an accurate and rigorous model to describe the motion of submarine landslides and the evolution of the induced water wave remains a challenge to date. Existing models usually simplify the submarine mass as a sling box or a deformable rheological material which is unable to interpret certain fast‐moving and some slow‐moving granular flows that differ only in their compactness. In this paper, the existing models are improved by taking account of the dilatancy effects of the particles. Numerical results of underwater granular collapse show that the predictions of the temporal evolution of the thickness profiles and the final deposit morphology using the current model are in better agreement with experiments compared to the existing models. The present model also provides a better prediction in the wave profiles induced by submarine landslides, which makes the present theory very promising to investigate natural geophysical flows in the future.
    Description: Key Points: A depth‐averaged model is presented, which considers excess pore fluid pressure and fluid mass transfer across the avalanche surface. A robust numerical method is used, so that the computed solution is insensitive to the way nonconservative products are discretized. Significant improvements in the prediction of the grain thickness profiles and the free‐surface waves are found compared with existing models.
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Description: Fundamental Research Funds for the Central Universities http://dx.doi.org/10.13039/501100012226
    Description: National Key Research and Development Program of China http://dx.doi.org/10.13039/501100012166
    Description: https://doi.org/10.48328/tudatalib-931
    Keywords: ddc:551.3 ; submarine landslides ; granular dilatancy ; depth‐averaged theory ; nonoscillatory central‐upwind scheme ; free surface wave flow
    Language: English
    Type: doc-type:article
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cryobiology 22 (1985), S. 606-607 
    ISSN: 0011-2240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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