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  • 1
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    Volcanic Stratigraphy, Geochronology, and Gold Deposits of the Archean Hope Bay Greenstone Belt, Nunavut, Canada (2012)
    Society of Economic Geologists (SEG)
    Details
    Publication Date: 2012-08-01
    Description: The Archean Hope Bay greenstone belt is located in the Bathurst Block of the northeastern part of the Slave Structural Province, a predominantly Archean, granite-greenstone-metasedimentary terrane. The greenstone belt is dominated by mafic volcanic rocks with less common felsic volcanic and volcaniclastic products and subordinate ultramafic bodies and metasedimentary rocks. Three main Au deposits have been defined in the greenstone belt, with a cumulative resource of over 10 million ounces (Moz) of Au, as of April 2007. The Hope Bay greenstone belt can be divided into a series of coherent panels of strata that tend to be fault bounded and collectively are used to construct a composite stratigraphic column of the belt constrained by U-Pb geochronology on felsic suites. The oldest felsic suite, the Flake Lake suite (ca. 2700 Ma), is a succession of felsic volcanic rocks that has a tholeiitic geochemical affinity, interpreted as a product of rift-related volcanism. Overlying this suite is a series of well-constrained calc-alkaline, mainly felsic volcanic rocks, which have ages of ca. 2690 Ma (Square Lake suite), ca. 2686 Ma (Windy felsic suite), ca. 2677 Ma (Koignuk suite), and ca. 2662 Ma (Clover Lake suite), all of which are interpreted as products of arc volcanism. The transition from rift- to arc-related volcanism divides the greenstone belt into upper and lower volcanic cycles with the transition occurring at about ca. 2690 Ma. The older cycle of volcanic rocks has a distinctive group of mafic rocks consisting of mafic pillowed flows which have an Fe-rich tholeiitic geochemical affinity which is not recognized in the younger volcanic cycle. These Fe-rich tholeiitic mafic volcanic rocks commonly show a spatial relationship to Au mineralization acting as host strata to the main Au deposits in the greenstone belt. The younger cycle (〈ca. 2690 Ma) of mafic volcanic rocks tends to have a tholeiitic affinity with some minor andesitic volcanic rocks near the top of the composite stratigraphic column. Detrital zircon work was carried out for all the main sedimentary successions recognized in the Hope Bay greenstone belt. The detrital zircon results show that in each case the sediments were derived mainly from local sources, as very few anomalously old zircons were recognized. A conglomerate outcropping in the north part of the belt is dominated by locally derived material, with detrital zircon work supporting this interpretation. The three main Au deposits at Hope Bay are all associated with the older cycle of volcanic rocks, interpreted as products of rift-related volcanism. The structural setting of each deposit is different but each is related to D 2 strain in structural and/or stratigraphic settings which provided dilational environments to localize auriferous vein-related mineralization or localized alteration and mineralization of favorable host lithologies. The older cycle of tholeiitic felsic and Fe-rich mafic volcanic rocks are rift-related volcanic products, which are time-equivalent to the Kam Group, in the Yellowknife Supergroup. Overlying these rocks are calc-alkaline felsic volcanic rocks and tholeiitic mafic volcanic rocks, which represent the transition to calc-alkaline arc-related volcanism, which correlates to the Banting Group of the Yellowknife Supergroup. Overlying the younger (ca. 2677 Ma) felsic volcanic rocks are a succession of conglomerates consisting mainly of locally derived clasts, representing collapse of the arc into a fluvial-dominated environment. This sedimentary succession is possibly equivalent to the regionally extensive Burwash Basin of the Yellowknife Supergroup.
    Print ISSN: 0361-0128
    Topics: Geosciences
    Published by Society of Economic Geologists (SEG)
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  • 2
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    Optical imaging of a tactile illusion in area 3b of the primary somatosensory cortex (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-09-23
    Description: In the tactile funneling illusion, the simultaneous presentation of brief stimuli at multiple points on the skin produces a single focal sensation at the center of the stimulus pattern even when no physical stimulus occurs at that site. Consistent with the funneling percept, we show with optical imaging in area 3b of the primary somatosensory cortex (SI) that simultaneous stimulation of two fingertips produces a single focal cortical activation between the single fingertip activation regions. Thus, in contrast to traditional views of the body map, topographic representation in the SI reflects the perceived rather than the physical location of peripheral stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Li M -- Friedman, Robert M -- Roe, Anna W -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):881-5. Epub 2003 Sep 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14500850" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Brain Mapping ; Diagnostic Imaging ; Electrophysiology ; Female ; Fingers ; Humans ; Illusions/*physiology ; Male ; Perception/*physiology ; Physical Stimulation ; Saimiri ; Somatosensory Cortex/*physiology ; Touch/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Green research labs: Zero net emissions from Venter facility (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Venter, J Craig -- Friedman, Robert M -- England -- Nature. 2015 Apr 16;520(7547):295. doi: 10.1038/520295d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. Craig Venter Institute, La Jolla, California, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25877193" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; California ; Carbon Footprint/*standards/*statistics & numerical data ; *Conservation of Natural Resources/methods/trends ; Facility Design and Construction/trends ; *Laboratories
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Lysyl oxidase and rrg messenger RNA (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenyon, K -- Contente, S -- Trackman, P C -- Tang, J -- Kagan, H M -- Friedman, R M -- P01 HL13262/HL/NHLBI NIH HHS/ -- R01 CA37351-04A1/CA/NCI NIH HHS/ -- R37 AR18880/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 16;253(5021):802.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1678898" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blotting, Northern ; Cell Line ; *Cell Transformation, Neoplastic ; Gene Expression ; *Genes, Tumor Suppressor ; In Vitro Techniques ; Mice ; Protein-Lysine 6-Oxidase/*physiology ; RNA, Messenger/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Pollution benefit-cost assessment (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedman, R M -- New York, N.Y. -- Science. 1991 Aug 9;253(5020):607.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17772347" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Expression of gene rrg is associated with reversion of NIH 3T3 transformed by LTR-c-H-ras (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-17
    Description: A partial complementary DNA was isolated for a gene (rrg) that is normally expressed in mouse NIH 3T3 cells, but is down-regulated after cellular transformation by long terminal repeat (LTR)-activated c-H-ras (LTR-c-H-ras). This gene was reexpressed in a nontumorigenic persistent revertant cell line created by prolonged treatment of the transformed cells with mouse interferon alpha/beta. Persistent revertants stably transfected with rrg complementary DNA antisense expression vectors appeared transformed, had decreased amounts of rrg messenger RNA, and were tumorigenic in nude mice. Stable transfection with sense constructs did not alter the normal morphology, message level, or nontumorigenicity of the persistent revertant cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Contente, S -- Kenyon, K -- Rimoldi, D -- Friedman, R M -- R01 CA 37351-04A1/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1990 Aug 17;249(4970):796-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1697103" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Transformed ; Cloning, Molecular ; DNA/genetics ; *Gene Expression ; *Genes, ras ; Humans ; Interferon Type I/pharmacology ; Mice ; Mice, Nude ; Neoplasms, Experimental/etiology ; Nucleic Acid Hybridization ; Proto-Oncogene Proteins/*genetics ; Proto-Oncogene Proteins p21(ras) ; RNA/analysis/genetics ; RNA, Antisense ; RNA, Messenger/genetics ; Rats ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Selective inhibition of glycoprotein and membrane protein of vesicular stomatitis virus from interferon-treated cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: A 200-fold inhibition in the titer of infectious vesicular stomatitis virus (VSV) was produced in cultures of Ly cells treated with 30 reference units of interferon per milliliter. Virus particle production, as measured by VSV particle-associated transcriptase, or nucleocapsid protein was inhibited by a maximum of tenfold. The glycoprotein and membrane protein content was reduced in VSV derived from interferon-treated cells. Thus interferon-treated cells may have produced VSV particles with low infectivity, which may be related to the reduced amount of glycoprotein incorporated into such particles. These findings resemble those reported in interferon-treated cells infected with murine leukemia viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maheshwari, R K -- Jay, F T -- Friedman, R M -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Defective Viruses/growth & development ; Glycoproteins/*biosynthesis ; Interferons/*pharmacology ; Membrane Proteins/*biosynthesis ; Mice ; RNA, Viral/metabolism ; Vesicular stomatitis Indiana virus/*growth & development ; Viral Proteins/*biosynthesis ; Virus Replication/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-23
    Description: A previously undescribed species of human leukocyte, or alpha, interferon is present in the serum of many patients with systemic lupus erythematosus. It was shown to be alpha-interferon by neutralization with specific antiserums, affinity column chromatography, and antiviral activity on bovine cells. However, 23 of 30 interferon samples tested were inactivated by incubation at pH 2, a characteristic of human "immune," or gamma, interferon. Multiple samples of interferon from the same patient had similar biological properties, but samples from different patients were not all identical, suggesting that several variants of this species of human alpha-interferon may exist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preble, O T -- Black, R J -- Friedman, R M -- Klippel, J H -- Vilcek, J -- R01-AI-07057/AI/NIAID NIH HHS/ -- R01-AI-12948/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):429-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6176024" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Hydrogen-Ion Concentration ; Interferons/*blood/immunology ; Lupus Erythematosus, Systemic/*blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Interferon (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedman, R M -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):326-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17819899" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Tunicamycin enhances the antiviral and anticellular activity of interferon (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-18
    Description: The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maheshwari, R K -- Sreevalsan, T -- Silverman, R H -- Hay, J -- Friedman, R M -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6187067" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/drug effects ; Cell Membrane/drug effects ; Cell Survival/*drug effects ; Drug Synergism ; Glucosamine/*analogs & derivatives ; Interferons/*pharmacology ; Mice ; Tunicamycin/*pharmacology ; Viral Interference/*drug effects ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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