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    Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-19
    Description: TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential for its proapoptotic effect. Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, H -- Kolluri, S K -- Gu, J -- Dawson, M I -- Cao, X -- Hobbs, P D -- Lin, B -- Chen, G -- Lu, J -- Lin, F -- Xie, Z -- Fontana, J A -- Reed, J C -- Zhang, X -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1159-64.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947977" target="_blank"〉PubMed〈/a〉
    Keywords: *Apoptosis ; Cell Fractionation ; Cell Nucleus/metabolism ; Cytochrome c Group/*metabolism ; DNA/metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Fatty Acids, Unsaturated/pharmacology ; Genes, Reporter ; Humans ; Intracellular Membranes/metabolism/physiology ; Mitochondria/*metabolism ; Mutation ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Protein Structure, Tertiary ; Receptors, Cytoplasmic and Nuclear ; Receptors, Steroid ; Recombinant Fusion Proteins/metabolism ; Transcription Factors/chemistry/genetics/*metabolism ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-16
    Description: The alpha subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ullah, H -- Chen, J G -- Young, J C -- Im, K H -- Sussman, M R -- Jones, A M -- New York, N.Y. -- Science. 2001 Jun 15;292(5524):2066-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11408654" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4-Dichlorophenoxyacetic Acid/pharmacology ; Alleles ; Arabidopsis/*cytology/genetics/growth & development/*metabolism ; *Arabidopsis Proteins ; Cell Size ; *GTP-Binding Protein alpha Subunits ; Genes, Plant ; Genes, Reporter ; Glucuronidase/analysis/genetics ; Guanosine Triphosphate/metabolism ; Heterotrimeric GTP-Binding Proteins/chemistry/genetics/*metabolism ; Indoleacetic Acids/pharmacology ; Light ; MAP Kinase Signaling System ; Morphogenesis ; Mutation ; Peptides/pharmacology ; Phenotype ; Plant Leaves/cytology/growth & development ; Plants, Toxic ; Protein Subunits ; Recombinant Proteins/metabolism ; Signal Transduction ; Tobacco
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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