Publication Date:
1970-08-01
Description:
Mild to moderate chronic hemolytic anemia in a mother and her two sons was found to be associated with the presence of about 40 per cent abnormal hemoglobin of rapid electrophoretic mobility: Hb-Seattle. Hb-Seattle was found to be unstable in vitro. It was shown to be due to a replacement of alanine by glutamic acid at position 76 of the β hemoglobin chain. The substitution occurs at the surface of the β hemoglobin chain. The hemoglobin instability was attributed to an abnormal interaction between the substituted glutamic acid and histidine at position β77.
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine